Engineering Commons^™

Electrotransfer Of Single-Stranded Or Double-Stranded Dna Induces Complete Regression Of Palpable B16.F10 Mouse Melanomas, Loree Heller, Vesba Todorovic, Maja Cemazar

Bioelectrics Publications

Enhanced tumor delivery of plasmid DNA with electric pulses in vivo has been confirmed in many preclinical models. Intratumor electrotransfer of plasmids encoding therapeutic molecules has reached Phase II clinical trials. In multiple preclinical studies, a reduction in tumor growth, increased survival or complete tumor regression have been observed in control groups in which vector or backbone plasmid DNA electrotransfer was performed. This study explores factors that could produce this antitumor effect. The specific electrotransfer pulse protocol employed significantly potentiated the regression. Tumor regression was observed after delivery of single-stranded or double-stranded DNA with or without CpG motifs in both …

Quantifying Risks Of Climate Change And Sea Level Rise To Naval Station Norfolk (Serdp Rc-1701), Kelly Burks-Copes

October 2, 2013: Quantifying Risks and Moving Forward

No abstract provided.

Old Dominion University's Engineering Summer Camp's Effect On Students Interest In Engineering, Clair Dorsey

OTS Master's Level Projects & Papers

The problem of this study was to determine parents' perceptions of their child's experience in Old Dominion University's engineering summer camps to determine if their child generated an interest in engineering as a career choice.

Probabilistic Modeling Of Erroneous Human Response To In-Vehicle Route Guidance Systems: A Domain Decomposition-Based Algorithm, Abdullah Al Farooq

Computational Modeling & Simulation Engineering Theses & Dissertations

Drivers are generally assumed to follow the shortest route to their destinations prescribed by in-vehicle route navigation systems without mistake. However, it is not uncommon that drivers make mistakes when there are complex intersections along the route to miss turns. Such mistakes would result in following a longer route than the optimal one. In this thesis, research has been conducted to analyze the effects of the number of intersections in the shortest routes of different O-D (origin-destination) pairs. While different formulations can be employed to describe such "driving with error" model, a Domain Decomposition (DD) partitioning algorithm has been developed …

Dimensionless Criteria For Selecting Tidally-Influenced Advective-Dispersive Desalination Brine Mixing Plume Characterization Models, Alireza Shahvari

Civil & Environmental Engineering Theses & Dissertations

The very nature of requirements for implementing a desalination process is highly spatial due to the need to secure both a source for the operation and sink for brine dilution. Thus, the applicable coastal location is bound to natural tidal mixing characteristics and subjected to a near- or a far-field availability for source and sink. Mixing characteristics of coastal waters are very different from one point to another due to the spatiotemporal tidal characteristic in loco in a manner that it can vary from being highly advective to completely dispersive dominant. Once a location is identified, estimation of corresponding water …

Use Of Immersive Visualization For The Control Of Dental Anxiety During Dental Hygiene Treatment, Carmelo Padrino-Barrios

Dental Hygiene Theses & Dissertations

Purpose: The purpose of this study was to determine the effectiveness of immersive visualization (IV) therapy, a technique that provides visual and stereoscopic display through the use of eyewear, in anxious patients during an oral prophylaxis. Methods: A convenience sample of thirty adults was enrolled. A split mouth design was utilized. Subjects were randomly divided into two groups: group A (use of IV for the right side of the mouth), and group B (use of IV for the left side of the mouth). Subjects received a full mouth oral prophylaxis (removal of supra and subgingival calculus and selective polishing), always …

Using Real Property Layouts To Study The Foreclosure Contagion Effect In Real Estate With Agent-Based Modeling And Simulation, Daniele Vernon-Bido

Computational Modeling & Simulation Engineering Theses & Dissertations

Foreclosures in the United States increased sharply from 2007 to 2009. These foreclosures had a spillover effect on neighboring property values causing additional foreclosures. This is known as the foreclosure contagion effect.

Recent studies have quantified the discount attributed to foreclosure contagion using equation-based techniques. However, the discount varied between studies and markets. Further studies using agent-based modeling and simulation have demonstrated the relationship between the discounts, the time a foreclosure remains on the market, the prevailing interest rates and the average property values.

This study uses agent-based modeling and simulation (ABMS) to explore the differences that varying neighborhood densities …

Correlational Study Of Open Circuit Resonant (Sansec) Sensor’S Electric Field Distribution On Lightning Attachment, Kayla M. Farrow, Linda L. Vahala

Electrical & Computer Engineering Faculty Publications

NASA Langley Research Center (LaRC) is conducting research to develop an open circuit SansEC (Sans Electric Connection) sensor to provide lightning strike protection (LSP) in conjunction with damage detection and diagnosis for composite aircraft. SansEC sensors are simplistic devices consisting of an open circuit conductive trace shaped in a planar geometric spiral. The length and width of the conductive trace as well as the gap separation between adjacent turns determines the inductance, resistance and capacitance of the LRC circuit and its associated resonant response. When the sensor is placed on a composite substrate, the electric impedance of the substrate is …

Attitudes Of Virginia Technology Education Teachers Toward The Effectiveness Of Their Curriculum, Glenn Patton

OTS Master's Level Projects & Papers

The problem of this study was to determine Virginia technology education teachers' attitudes regarding the effectiveness of their curriculum and resources.

A Sociotechnical Systems-Based Process To Facilitate The Development Of A Change Intervention Deployment Plan, Jorge Luis Nadal

Engineering Management & Systems Engineering Projects for D. Eng. Degree

The purpose of this project was to formulate a process to facilitate the development of an effective change intervention deployment plan. The premise is that without a proper deployment plan, the successful implementation of a change intervention in an organization will be slow and require multiple revisions. This research utilized a Sociotechnical Systems (STS) approach to analyze the implementation of a major change intervention.

This research was in part prompted by a request by management of the U.S. Army Corps of Engineers (USACE) for the researcher to examine why it has taken so long to successfully implement this large-scale change …

Improving The Stability Of High And Low Bandgap Polymers Organic Photovoltaic Devices Using A Solution Based Titanium Sub-Oxide Interfacial Layer, Kurniawan Foe

Electrical & Computer Engineering Theses & Dissertations

The improvement in device efficiency has brought organic photovoltaic (OPV) devices closer to commercial viability, highlighting the importance of studying the lifetime and stability of OPV devices. At present, the lifetime and stability of OPV devices is much shorter and poor mainly caused by oxygen, moisture, and light resulting in the oxidation on low work function electrodes and the degradation of the morphology of the photoactive layer. To improve the lifetime and stability of the OPV devices, we used newly developed low bandgap polymer, PCDTBT, as the electron acceptor material and a solution based titanium sub-oxide (TiOx) interfacial layer inserted …

Complementarities Of Probabilistic And Evidence Approaches: An Uncertainty Assessment For Selection Of Composite Material, Stella B. Bondi, Resit Unal, Patrick T. Hester, Trina M. Chytka

Engineering Technology Faculty Publications

A complimentary probabilistic and evidence theory approach is utilized to enhance uncertainty assessments in the area of critical safety characteristics for conceptual design. This research provides additional exploration into the failure modes necessary to utilize Fiber Reinforced Polymer (FRP) and various composites to their fullest potential and to minimize uncertainty by comparing probability and evidence theories. This combined approach has been applied to a selection of composite material that could provide uncertainty assessment design for a space transportation system. Uncertainty estimates presented are bounded by belief and plausibility functions. The results may provide additional information to the decision makers in …

Subtalar Joint Instability: Diagnosis And Conservative Treatment, Julie Choisne

Mechanical & Aerospace Engineering Theses & Dissertations

Subtalar instability may be caused by various ligamentous injuries. Combined instability at the ankle and subtalar joint is not adequately diagnosed. Further, isolated subtalar instability is usually misdiagnosed which may lead to long term damage to the joint. Developing a non-invasive and clinically practical tool to diagnose subtalar joint instability would be an important asset. The ability of an ankle brace, a common treatment for hindfoot instability, to promote stability for the subtalar joint was not well established. The purposes of this study were to 1) assess the kinematics of the subtalar, ankle, and hindfoot in the presence of isolated …

Use Of A Rolling Road System In Crosswind Conditions, Mau-Kuo Chen

Mechanical & Aerospace Engineering Theses & Dissertations

Wind tunnel testing continues to play an important role in vehicle aerodynamic development. Accurate results are strongly associated with whether the wind tunnel can closely simulate the on-road conditions, including the Reynolds number and all boundary conditions. Rolling road systems (or moving belts) have been a successful tool for many auto makers and racing teams to simulate the relative motion between the stationary vehicle model and the floor in the test section. The mechanism of the rolling road system is simple, but how it affects the adjacent flow field and how this flow interacts with the flow underneath the vehicle …

Approximate Algorithms For The Combined Arrival-Departure Aircraft Sequencing And Reactive Scheduling Problems On Multiple Runways, Gulsah Hancerliogullari

Engineering Management & Systems Engineering Theses & Dissertations

The problem addressed in this dissertation is the Aircraft Sequencing Problem (ASP) in which a schedule must be developed to determine the assignment of each aircraft to a runway, the appropriate sequence of aircraft on each runway, and their departing or landing times. The dissertation examines the ASP over multiple runways, under mixed mode operations with the objective of minimizing the total weighted tardiness of aircraft landings and departures simultaneously. To prevent the dangers associated with wake-vortex effects, separation times enforced by Aviation Administrations (e.g., FAA) are considered, adding another level of complexity given that such times are sequence-dependent. Due …

The Rq-Tech Methodology: A New Paradigm For Conceptualizing Strategic Enterprise Architectures, Christine Ann Hoyland

Engineering Management & Systems Engineering Theses & Dissertations

The purpose of this research is to develop and apply a system-theoretic based methodology and corresponding model for Enterprise Architecture development. Enterprise Architectures can assist managers by illustrating the systemic relationships within an organization and the impact changes to the organization could make. Unfortunately, today's modeling practices are proprietary, time-consuming, and generally ineffective as tools for understanding the consequences of strategic-level planning decisions across all levels of the enterprise. This research supports the conclusion that system-specific solutions produce islands of technology and can be prevented by employing better enterprise change planning.

This research combined the practice of Enterprise Architectures with …

New Types Of Morpho-Physiological Changes In Cells Exposed To Nanosecond Pulsed Electric Field, Mikhail A. Rassokhin

Theses and Dissertations in Biomedical Sciences

Exposure of cells to a pulsed electric field (PEF) is the basis of multiple techniques and treatments. Nanosecond pulsed electric field (nsPEF) poses unique characteristics to induce subtle cellular effects while preserving cell integrity. Improving understanding of the mechanisms triggered by nsPEF in cells inspires new applications for the nanosecond pulse technology. Although many effects of nsPEF remain unknown, they can be inferred from morpho-physiologic changes, or cell reshaping, that accompany nsPEF exposure. During the exposure cells undergo reshaping that is manifested in swelling and diffuse blebbing. Recently we identified two new distinct forms of reshaping, pseudopod-like blebbing and microvesiculation, …

Micro To Macro Dynamics Of Shared Awareness Emergence In Situations Theory: Towards A General Theory Of Shared Awareness, Samuel F. Kavacic

Engineering Management & Systems Engineering Theses & Dissertations

Engineering Management is an interdisciplinary field of study. As such, Engineering Management must rely on the energies of its participants to integrate toward the problem being solved. Many techniques exist to aid the researcher towards a common goal; however, it can only be surmised on how effective the techniques have been. Not until the activity is over and the participants reflect back on their results can they know whether they shared a common understanding of the problem. This study explores the emergence of shared awareness based the interactions of disparate perspectives at a particulate level. The study builds from observations …

Protein Loop Length Estimation From Medium Resolution Cryoem Images, Andrew R. Mcknight

Computer Science Theses & Dissertations

In the post-genomic era, proteomics research presents a new frontier in life science. Proteins play roles in virtually every biological process, and understanding their atomic structures is the key to unraveling how they carry out their work. Compared to the over half million protein sequences in UniProt, only around 25,000 unique sequences have been atomically modeled and deposited to PDB (Protein Databank). Cryoelectron Microscopy (cryoEM) is an important biophysical technique that produces 3D subnanometer resolution images of molecules not amenable to past approaches like x-ray crystallography or nuclear magnetic resonance. De novo modeling is becoming a promising approach to derive …

Http Mailbox - Asynchronous Restful Communication, Sawood Alam

Computer Science Theses & Dissertations

Traditionally, general web services used only the GET and POST methods of HTTP while several other HTTP methods like PUT, PATCH, and DELETE were rarely utilized. Additionally, the Web was mainly navigated by humans using web browsers and clicking on hyperlinks or submitting HTML forms. Clicking on a link is always a GET request while HTML forms only allow GET and POST methods. Recently, several web frameworks/libraries have started supporting RESTful web services through APIs. To support HTTP methods other than GET and POST in browsers, these frameworks have used hidden HTML form fields as a workaround to convey the …

Field Emission Studies Toward Improving The Performance Of Dc High Voltage Photoelectron Guns, Mahzad Bastaninejad

Mechanical & Aerospace Engineering Theses & Dissertations

Field emission is the main mechanism that prevents DC high voltage photoemission electron guns from operating at the very high bias voltages required to produce low emittance beams. Gas conditioning is shown to eliminate field emission from cathode electrodes used inside DC high voltage photoelectron guns. Measurements and simulation results indicate that gas conditioning eliminates field emission from cathode electrodes via two mechanisms: sputtering and implantation, with the benefits of implantation reversed by heating the electrode. The field emission characteristics of 5 stainless steel electrodes varied significantly upon the initial application of voltage but improved to nearly the same level …

A Multi-Configuration Display Methodology Incorporating Reflection For Real-Time Haptic-Interactive Virtual Environments, Mohammad F. Obeid

Computational Modeling & Simulation Engineering Theses & Dissertations

There is a natural need for real-time min-or reflection in many interactive virtual reality applications to achieve visuo-haptic collocation through optical reflection. Its use, however, calls for adjustments to the original model since a mirror reverses image characteristics. This thesis introduces a design and implementation of a generic configuration component for virtual environments that adjusts image characteristics and haptic interfaces to accommodate various display setups while preserving the correct orientation and properties of the original models in the graphical scene. Four different but related approaches were developed for image connection and are compared and contrasted against primary criteria. The haptic …

Atmospheric Pressure He-Air Plasma Jet: Breakdown Process And Propagation Phenomenon, Asma Begum, Mounir Laroussi, Mohammad Rasel Pervez

Electrical & Computer Engineering Faculty Publications

In this paper He-discharge (plasma jet/bullet) in atmospheric pressure air and its progression phenomenon has been studied experimentally using ICCD camera, optical emission spectroscopy (OES) and calibrated dielectric probe measurements. The repetitive nanosecond pulse has applied to a plasma pencil to generate discharge in the helium gas channel. The discharge propagation speed was measured from the ICCD images. The axial electric field distribution in the plasma jet is inferred from the optical emission spectroscopic data and from the probe measurement. The correlation between the jet velocities, jet length with the pulse duration is established. It shows that the plasma jet …

Section Abstracts: Biomedical And General Engineering

Virginia Journal of Science

Abstracts of the Biomedical and General Engineering Section for the 91st Annual Virginia Journal of Science Meeting, May 2013

Section Abstracts: Aeronautical And Aerospace Sciences

Virginia Journal of Science

Abstracts of the Aeronautical and Aerospace Sciences Section for the 91st Annual Virginia Journal of Science Meeting, May 2013

An Engineering Design Stem Project: T-Shirt Launcher, Todd D. Fantz, Melva R. Grant

STEMPS Faculty Publications

Technology education has the potential to be the glue for integrating science, technology, engineering, and mathematics (STEM) education through the use of the design process. This should result in increased student interest in science and math, resulting in increased standardized science and math scores (Silk, C. Schunn, & Strand, 2009). In order for this to happen, students need to integrate their grade-level mathematics and science content knowledge in their technology and/or engineering design (Tran & Nathan, 2010). Hopefully, this can be accomplished without losing student interest generated by hands-on, kinesthetic learning. This article provides one example of getting technology education …

Proceedings, Msvscc 2013, Old Dominion University, Department Of Modeling, Simulation & Visualization Engineering, Old Dominion University, Virginia Modeling, Analysis & Simulation Center

Modeling, Simulation and Visualization Student Capstone Conference

Proceedings of the 7th Annual Modeling, Simulation & Visualization Student Capstone Conference held on April 11, 2013 at VMASC in Suffolk, Virginia.

The Influence Of Social Networking Technology In An Engineering Organization, Derrick Marcus Tepaske

Engineering Management & Systems Engineering Projects for D. Eng. Degree

Computer facilitated Social Networking (SN) is becoming more prevalent in our society, both in our personal and professional lives. As its use grows, there is a desire to determine how it will impact an organization. If it can positively impact an organization then it is an initiative that could be embraced and leveraged for any number of business related activities from marketing to engineering. This project develops and implements a social networking treatment for an engineering organization in order to determine how it impacts the responsiveness and performance of the organization. The treatment includes an online tool, a training package, …

Tdma Slot Reservation In Cluster-Based Vanets, Mohammad Salem Almalag

Computer Science Theses & Dissertations

Vehicular Ad Hoc Networks (VANETs) are a form of Mobile Ad Hoc Networks (MANETs) in which vehicles on the road form the nodes of the network. VANETs provide several services to enhance the safety and comfort of drivers and passengers. These services can be obtained by the wireless exchange of information among the vehicles driving on the road. In particular, the transmission of two different types of messages, safety/update and non-safety messages.

The transmission of safety/update message aims to inform the nearby vehicles about the sender's current status and/or a detected dangerous situation. This type of transmission is designed to …

An Expert Based Multi Attribute Group Decision Making (Magdm) Model For Portfolio Evaluation: Application On Ground Force Units, Metin Gultekin

Engineering Management & Systems Engineering Theses & Dissertations

This main objective of this dissertation is to propose an expert based multi attribute group decision making model (MAGDM) for portfolio evaluation and demonstrate it by applying it to evaluate brigade types under different military missions. Specifically, currently used Heavy, Mechanized Infantry, Airborne Infantry, and Stryker brigades are evaluated under a set of possible future military missions. The purpose of the study is to provide a model for decision makers, engaged in a force development process.

This study combined MAGDM and simulation by using expert judgments to create distributions rather than aggregating them into point values. Excel and Monte Carlo …