Engineering Commons^™

Prostate Cancer Region Prediction Using Maldi Mass Spectra, Ayyappa Vadlamudi, Shao-Hui Chuang, Xiaoyan Sun, Lisa Cazares, Julius Nyalwidhe, Dean Troyer, O. John Semmes, Jiang Li, Frederic D. Mckenzie

Electrical & Computer Engineering Faculty Publications

For the early detection of prostate cancer, the analysis of the Prostate-specific antigen (PSA) in serum is currently the most popular approach. However, previous studies show that 15% of men have prostate cancer even their PSA concentrations are low. MALDI Mass Spectrometry (MS) proves to be a better technology to discover molecular tools for early cancer detection. The molecular tools or peptides are termed as biomarkers. Using MALDI MS data from prostate tissue samples, prostate cancer biomarkers can be identified by searching for molecular or molecular combination that can differentiate cancer tissue regions from normal ones. Cancer tissue regions are …

Implementing Tablet Pcs In A Distance Learning Environment, Glenda Scales, Sharon Caraballo, James Groves, Rosalyn Hobson, Linda Vahala, Catherine Amelink

Electrical & Computer Engineering Faculty Publications

(First paragraph) The Commonwealth Graduate Engineering Program (CGEP) is a collaborative distance education program developed by leading Universities in the Commonwealth of Virginia. It is over 25 years old and its main goal is to deliver graduate engineering courses to qualified professionals located across the Commonwealth of Virginia. Traditionally, the courses delivered to students in this program are done through interactive video conferencing (IVC) technology and most students are required to drive to a physical location. However, an increasing number of working professionals are beginning to want more flexibility with the timing and locations of these classes. With these changes …

Rf And Structural Characterization Of Srf Thin Films, A.M. Valente-Feliciano, H.L. Phillips, C.E. Reece, J. Spradlin, X. Zhao, D. Gu, H. Baumgart, D. Beringer, R.A. Lukaszew, B. Xiao, K. Seo

Electrical & Computer Engineering Faculty Publications

In the past years, energetic vacuum deposition methods have been developed in different laboratories to improve Nb/Cu technology for superconducting cavities. JLab is pursuing energetic condensation deposition via Electron Cyclotron Resonance. As part of this study, the influence of the deposition energy on the material and RF properties of the Nb thin film is investigated. The film surface and structure analyses are conducted with various techniques like X-ray diffraction, Transmission Electron Microscopy, Auger Electron Spectroscopy and RHEED. The microwave properties of the films are characterized on 50 mm disk samples with a 7.5 GHz surface impedance characterization system. This paper …

Finite Element Analysis Of Ring-Shaped Emission Profile In Plasma Bullet, Yukinori Sakiyama, David B. Graves, Julien Jarrige, Mounir Laroussi

Electrical & Computer Engineering Faculty Publications

Using a one-way coupled model of neutral gas flow and plasma dynamics we report a mechanism to explain the ring-shaped emission pattern that has been observed experimentally in plasma bullets at atmospheric pressure. We solve a fluid model with the local field approximation in one-dimensional cylindrical coordinates, corresponding to a cross-section of a plasma bullet. Pulselike uniform electric field is assumed to be applied perpendicular to the simulation domain. Time and spatially resolved spectroscopic measurements support the simulation results.

Destruction Of Α -Synuclein Based Amyloid Fibrils By A Low Temperature Plasma Jet, Erdinc Karakas, Agatha Munyanyi, Lesley Greene, Mounir Laroussi

Electrical & Computer Engineering Faculty Publications

Amyloid fibrils are ordered beta-sheet aggregates that are associated with a number of neurodegenerative diseases such as Alzheimer and Parkinson. At present, there is no cure for these progressive and debilitating diseases. Here we report initial studies that indicate that low temperature atmospheric pressure plasma can break amyloid fibrils into smaller units in vitro. The plasma was generated by the plasma pencil, a device capable of emitting a long, low temperature plasma plume/jet. This avenue of research may facilitate the development of a plasma-based medical treatment.

Experimental Studies On The Plasma Bullet Propagation And Its Inhibition, Erdinc Karakas, Mounir Laroussi

Electrical & Computer Engineering Faculty Publications

Plasma bullets generated by atmospheric pressure low temperature plasma jets have recently been an active research topic due to their unique properties and their enhanced plasma chemistry. In this paper, experimental insights into the plasma bullet lifetime and its velocity are reported. Data obtained from intensified charge-coupled device camera and time-resolved optical emission spectroscopy (OES) elucidated the existence of a weakly ionized channel between the plasma bullet and its source (such as the plasma pencil). Factors responsible for the inhibition of the propagation of the bullet, such as low helium mole fraction, the magnitude of the applied voltage, and the …

Structure Prediction For The Helical Skeletons Detected From The Low Resolution Protein Density Map, Kamal Al Nasr, Weitao Sun, Jing He

Computer Science Faculty Publications

Background: The current advances in electron cryo-microscopy technique have made it possible to obtain protein density maps at about 6-10 Å resolution. Although it is hard to derive the protein chain directly from such a low resolution map, the location of the secondary structures such as helices and strands can be computationally detected. It has been demonstrated that such low-resolution map can be used during the protein structure prediction process to enhance the structure prediction.

Results: We have developed an approach to predict the 3-dimensional structure for the helical skeletons that can be detected from the low resolution protein density …

Investigating The Factors That Influence Injury Severity During Large Truck Crashes, Irina Olegovna Hoag

Civil & Environmental Engineering Theses & Dissertations

Large trucks and passenger cars share the transportation infrastructure. The diversity of mass, size and maneuverability of vehicles on roads makes truck involved collisions very dangerous and causes injury and fatality of drivers and passengers. Considering that large trucks are usually traveling for a long distance and cross country, Large Truck Crash Causation Study (LTCCS) collected data to analyze and predict injury or fatality from a set of predictor (independent) variables. Data were collected at 24 sites in 17 States and 2,284 vehicles were involved in crashes and have up to 1,000 variables for each crash. Sixty-nine percent of these …

Focusing Electromagnetic Radiation In Dielectric Media, Mark A. Migliaccio Jr.

Electrical & Computer Engineering Theses & Dissertations

Bioelectrics and microwave imaging requires an ultra-wideband (UWB) antenna to deliver intense, short electromagnetic pulses into biological targets for the purpose of therapy and imaging. Two antennas with different focal distances, predicted by a two­ dimensional model, have been designed for focusing electromagnetic radiation in the near field.

Focusing is achieved through the use of prolate spheroidal reflector antennas with a conical wave launcher submerged in water. For an ultra-wideband feed signal, with a rise time of 200 picoseconds, the maximum electric field was found to be close to the edge of the reflector, a result that differs from the …

Ekg Tracking For Augmented Standardized Patient Virtual Pathology Stethoscope Heart Auscultation, Sujith Surendran

Electrical & Computer Engineering Theses & Dissertations

In recent years, a lot of research has focused on improving the clinical skills of medical students and medical practitioners using standardized patients. Standardized patients (SP's) are used by the medical students and physicians in place of mannequins for a more realistic experience. SP's are real people trained to simulate specific illnesses and conditions to a high degree of accuracy which makes it difficult for the medical students to distinguish them from real patients. This research will enhance the capabilities of the standardized patients by providing a non-invasive, natural, harmless and realistic appearing tracking method for placing virtual pathologies using …

A Job-Shop Scheduling Model Using Genetic Algorithm And Giffler Thompson Approach, Nikhil Deepak Bumb

Mechanical & Aerospace Engineering Theses & Dissertations

The major objective of this thesis topic is to study the challenging research subject of job shop scheduling with the intent of optimizing the makespan. The job - shop scheduling problem is one of the hardest combinatorial optimization problems. The main aim of scheduling is an efficient allocation of shared resources like machines, operators or both over time for competing activities.

This research focuses on developing a model for optimizing job shop scheduling problem using genetic algorithm and the Giffler Thompson (priority dispatching rule) technique. Considering different parameters, the model comes up with an appropriate way to schedule the tasks …

Development Of A Supersonic Nozzle For A Compressed Carbon Dioxide Propulsion System Intended For Mars Surface Applications, Erin K. Blass

Mechanical & Aerospace Engineering Theses & Dissertations

This work focuses on the development of a reusable rocket nozzle unit for near-term Mars surface applications, utilizing Mars atmosphere as a propellant source. Mars atmosphere is more than 95% carbon dioxide, and its low ambient temperatures facilitate the condensation of dry ice out of the atmosphere. Furthermore, the low critical temperature of carbon dioxide enables . the production of a supercritical fluid by heating dry ice at constant volume to temperatures on the order of 400 K. The goal of this research was to develop a supersonic nozzle for reusable high-thrust propulsion. Due to the complex behavior of supercritical …

Solvent Dependent Morphologies In Thiol-Ene Photopolymerization: A Facile Route To Synthesis Of Resorcinarene Nanocapsules, Zaharoula Marie Kalaitzis

Chemistry & Biochemistry Theses & Dissertations

Synthesis of morphologically distinct polymeric nanostructures is vital for their wide ranging applications from nanomedicine to material science. Among various polymeric nanostructures, nanocapsules in particular have attracted a lot of attention as nanoreactors and drug delivery vehicles in nanomedicine. Often, synthesis of nanocapsules is achieved by template-based approaches. A direct, template-free method for the fabrication of nanocapsules and a variety of other morphologically distinct polymeric architectures was developed. The photopolymerization of a resorcinarene thiol-ene surfactant in various solvents lead to the formation of nanocapsules, nanoparticles, fibers, distorted honeycomb-like lattices, and sheets. The progress of the polymerization reaction and the morphology …

Indentation Creep Analysis For Self Similar Indenters, Sandeep V. Thube

Mechanical & Aerospace Engineering Theses & Dissertations

In indentation creep experiments, it is difficult to characterize the mechanical properties of small size specimens using conventional methods. This study uses finite element modeling to investigate rate-sensitive deformation of materials with different hardness and strain rate sensitivities for self similar indenter tip geometries. The simulation model is developed using commercially available finite element software Abaqus/Standard. Our study investigates the difference between strain rate sensitivity of hardness (vH) and of flow stress (vu) and their relation to the hardness/modulus ratio. It reveals that the commonly held assumption that vH = vu is violated except for materials with low hardness/modulus …

Aerodynamic Analysis Of An Urban Magnetic Levitation Vehicle, John Matthew Wells

Mechanical & Aerospace Engineering Theses & Dissertations

This thesis will detail the aerodynamic qualities of a magnetic levitation concept vehicle designed to be installed on Old Dominion University's campus. The vehicle is representative of a class of small, low-speed Maglev systems commonly referred to as Urban Maglev. A 1:12 scale model underwent testing in Old Dominion's low speed wind tunnel. Force and moment coefficients were measured over a wide range of yaw angles. Results give insight into crosswind effects and how these forces affect vehicle dynamics. An analysis of this type is important in understanding the ride quality and safety of the system. Force Coefficients range from …

Capacity Improvement Of A Small-Scale Cryogenic System Using Exergy Analysis, Errol L. Yuksek

Mechanical & Aerospace Engineering Theses & Dissertations

There is a demand for reliable and cost-effective small-scale helium liquefiers and refrigerators with higher capacity and efficiency in universities, government, and industry. Among the most common of these small-scale cryogenic systems is the Linde model 1600 helium liquefier and refrigerator.

The goal of this study is to increase the capacity of the model 1600. To achieve this goal, this study focuses on reducing the irreversibilities of the model 1600's fin-tube heat exchangers (FTHXs). Modification of fin-tube passes is the most practical means by which to reduce FTHX irreversibilities. Expressions relating FTHX geometry to FTHX irreversibilities identify model 1600 heat …

Rapid Prototyping Augmented Skin Pathology For Medical Simulation And Training, Annette Castelino

Electrical & Computer Engineering Theses & Dissertations

The goal of this research is to study how augmented reality technology could be applied in training medical students for better clinical practice and diagnosis in the treatment of skin conditions using skin pathology prototypes. Described within this thesis is an innovative method of producing skin abscess prototypes that augment the Standardized Patient (SP) for simulation purposes.

The method adopted is a combination of the cost-effective technique of rapid prototyping (RP) — 3D inkjet printing and 3D graphics modeling. The visual and haptic realism of these developed prototypes along with the use of moulage enable the SP to exhibit realistic …

A Smart-Phone Application For Improving Communication Skills In Children With Autism, Lakshmi Padmaja Battagiri

Electrical & Computer Engineering Theses & Dissertations

The prevalence of autism, a complex neurobiological disorder, has grown at a staggering rate in the recent past. Today, one out of 150 American children is diagnosed with autism. Generally, the disorder appears during an individual's first three years of life of and persists through his/her entire life span. The individual faces various social interaction, communication and behavioral problems. Developmental disabilities, extreme withdrawal, lack of social behaviour, severe language and attention deficits, repetitive behaviours and limited interests are the characteristics of this disorder. There is no verified cure yet, but several therapies and intervention systems especially focused on the early …

Image Registration Using Conformal Log Polar Mapping, Bala Krishna Vadapally

Electrical & Computer Engineering Theses & Dissertations

Image Registration is the process of aligning, or overlaying two images of the same scene that were taken at different times and/or from different viewing angles and/or by sensors with different modalities or resolutions. The variations in the imaging environment induce the difference between the images of the same scene. In our situation, we have two images of the same scene taken with two sensors, one in the visible and the other in the infrared (IR) domain. The cameras are placed adjacent to each other on a stable platform, and the images are captured almost simultaneously. This means that the …

Fault-Tolerance And Recovery In Wireless Sensor Networks, Kevin M. Somervill

Electrical & Computer Engineering Theses & Dissertations

The topic of Wireless Sensor Networks (WSNs) has gained considerable attention in the research community due to the variety of applications and interesting challenges in developing and deploying such networks. The typical WSN is significantly energy constrained and often deployed in harsh or even hostile environments, resulting in sensor nodes that are prone to failure. Failing nodes alter the topology of the network resulting in segmented routing paths and lost messages, ultimately reducing network efficiency. These issues spur the desire to develop energy-efficient, Fault-Tolerant (FT) algorithms that enable the network to persist in spite of the failed nodes. This work …

Unplanned Maintenance Scheduling A Lean Application Using Group Technology And Adaptive Conflict Resolution, Manish Shashibhushan Mittal

Mechanical & Aerospace Engineering Theses & Dissertations

Historically, production of ships is based on Group Technology (GT) with product oriented work breakdown structure. Recent GT applications have been effectively adapted to ship maintenance operations. In this thesis we have developed a GT based classification and coding system for the three basic requirements for maintenance operations: personnel, resources and space.

Traditionally unplanned maintenance activities are executed as and when the resources are available. This thesis presents a method for planning and scheduling these jobs with many of the traditional Lean manufacturing principles first adapted appropriately and then applied to Lean Maintenance. This method begins with identifying the priority …

Dynamic Interaction Of Elevated Guideway With Uncontrolled Maglev Vehicles, Sumanth Reddy Velma

Mechanical & Aerospace Engineering Theses & Dissertations

A flexible guideway on an elevated foundation is a key to affordable maglev urban transit. The flexible guideway can undergo significant dynamic motion, either when a vehicle solely relies on an open-loop control system or when a vehicle equipped with feedback control system experiences failure, due to fluctuating magnetic forces between the vehicle and the guideway. In an attempt to understand the effect of the uncontrolled vehicle on the structural response of the guideway, its dynamic interaction with maglev vehicles is investigated under various operating conditions. To this end, two vehicle models using Electrodynamic suspension (EDS) and Electromagnetic suspension (EMS) …

Monte Carlo Model Of Light Propagation In Tissues And The Effects Of Phase Changes On The Light Intensity, Rakesh Choula

Electrical & Computer Engineering Theses & Dissertations

Lasers, due to their unique properties, have a wide range of applications in the medical field. For accurate laser treatments that focus on bio-tissues, prior knowledge of the amount of laser power, spot size and its irradiation time are necessary. In order to predict the effects of lasers on tissues and their bio-effects, a first necessary step is the creation of a model that can predict the temperature distributions within the tissue following laser excitation. This involves modeling light propagation through the tissue with inclusion of internal scattering, and assessment of the energy deposited by the incoming photons. The next …

A Robust Method To Detect Concealed Weapons, Anand Gone

Electrical & Computer Engineering Theses & Dissertations

Concealed weapons detection is a large problem that is faced by the Police Department nowadays. There are many disasters caused by poor detection of the weapons. Since public safety is at risk there is a need to design an efficient detector that can detect the weapons hidden under the clothing. This thesis presents a novel method for detecting concealed weapons under clothing using image processing techniques. In this thesis IR imagery is used to capture an image which works on the principle of law of black body radiation. Image thresholding is performed on the captured data using Sauvola's adaptive thresholding …

A Systematic Study Of Atomic Layer Deposition Of Platinum Nano-Scale Metallization Films And Their Application To Electrical Contacts In Porous Alumina Templates, Ngoc H. Tran

Electrical & Computer Engineering Theses & Dissertations

ln this thesis a comprehensive analysis is presented on nano-scale thin films of platinum deposited with Angstrom resolution by Atomic Layer Deposition (ALD) technology utilizing the Cambridge Nanotech Savannah 100 ALD system. Physical characterizations of film thickness, film morphology, and surface roughness of the deposited platinum were all performed before and after rapid thermal annealing (RTA) and as a function of forming gas annealing (FGA). Noble metal thin films of platinum were deposited on four inch wafers of p-type boron doped &100& oriented silicon (Si) substrates. The ALD film thickness was measured with a novel method utilizing the linear dependence …

Effects Of Non-Equilibrium Plasma On Eukaryotic Cells (Final Report: Grant Fa9550-06-1-0004), Mounir Laroussi, Fred C. Dobbs, Old Dominion University

Electrical & Computer Engineering Faculty Publications

This document is our final report describing the research activities carried out under AFOSR Grant FA9550-06-1-0004. First, descriptions of our cold plasma generation systems are presented. Two systems, developed with past and present AFOSR support, are available in our laboratory. The first is a pulsed device capable of emitting a cold plasma plume in room air. The second is an air plasma generator the core of which is a dielectric barrier discharge excited by a high AC voltage. Following these brief descriptions we first present the effects of an atmospheric pressure air plasma on four different types of eukaryotic microalgae. …

Towards The Efficient Probabilistic Characterization Of Tropical Cyclone-Generated Storm Surge Hazards Under Stationary And Nonstationary Conditions, Senanu Kudjo Agbley

Civil & Environmental Engineering Theses & Dissertations

The scarcity of observations at any single location confounds the probabilistic characterization of tropical cyclone-generated storm surge hazards using annual maxima and peaks-over-threshold methods. The EST and the JPM are indirect approaches aimed at estimating the probability distribution of the response variable of interest (i.e. storm surge) using the probability distributions of predictor variables (e.g. storm size, storm intensity etc.). In the first part of this work, the relative performance of the empirical simulation technique (EST; Borgman et al., 1992) and the joint probability method (JPM; Myers, 1970) is evaluated via stochastic simulation methods. It is shown that the JPM …

An Analytical Framework And Model Formulation For Measuring Risk In Engineering Enterprise Systems: A Capability Portfolio Perspective, Paul Raphael Garvey

Engineering Management & Systems Engineering Theses & Dissertations

This work formulates an analytical framework and computational model for assessing risk in engineering enterprise systems. It addresses the engineering management problem of how to represent, model, and measure risk in large-scale, complex systems engineered to function in enterprise-wide environments.

The research in this dissertation extends current practice in the management of risk for traditional systems and creates new constructs and protocols for the management of risk in engineering large-scale, complex, and highly networked enterprise systems. This work advances engineering management theory and analytic practice as applied to the measurement and management of risk for enterprise systems engineered within capability …

A Study Of Decision Analysis Methods In Aerospace Technology Assessments, Sharon Monica Jones

Engineering Management & Systems Engineering Theses & Dissertations

Managers of aerospace technology programs and projects are faced with the challenge of making technology portfolio decisions under conditions of limited data, rapidly changing macro level factors and organizational uncertainties. To help make these technology investment decisions, some aerospace managers and analysts have used techniques from the field of decision analysis. In addition, there have been a limited number of research studies of real decision problems.

This dissertation presents the results of a non-experimental examination of the use of decision analysis methods for the assessment of aerospace technology portfolios. A web-based survey instrument was developed based on the results of …

Reconciling Discontinuities And Disruptions: The Construction Of An Integrated Typology, David Jeffery Kern

Engineering Management & Systems Engineering Theses & Dissertations

Radical innovations are often characterized by a rapid shift from one dominant design to another. The theories of discontinuous and disruptive innovation present two important and independent explanations for why these shifts occur. This research tests the usefulness of combining these two theories into a single integrated typology. First, a typology is constructed that classifies shifts in dominant designs according to the theories of discontinuous and disruptive innovation. Next, the usefulness of this typology is tested with a taxonomy derived from 100 randomly selected shifts in dominant designs from across a broad range of industries. This research reconciles the theories …