Engineering Commons^™

Identification And Characterization Of Two Novel Kcnh2 Mutations Contributing To Long Qt Syndrome, Anthony Owusu-Mensah, Jacqueline Treat, Joyce Bernardi, Ryan Pfeiffer, Robert Goodrow, Bright Tsevi, Victoria Lam, Michel Audette, Jonathan M. Cordeiro, Makarand Deo

Electrical & Computer Engineering Faculty Publications

We identified two different inherited mutations in KCNH2 gene, or human ether-a-go-go related gene (hERG), which are linked to Long QT Syndrome. The first mutation was in a 1-day-old infant, whereas the second was in a 14-year-old girl. The two KCNH2 mutations were transiently transfected into either human embryonic kidney (HEK) cells or human induced pluripotent stem-cell derived cardiomyocytes. We performed associated multiscale computer simulations to elucidate the arrhythmogenic potentials of the KCNH2 mutations. Genetic screening of the first and second index patients revealed a heterozygous missense mutation in KCNH2, resulting in an amino acid change (P632L) in the …

Numerical Study On The Dynamic Process Of Single Plume Flow In Thermal Convection With Polymers, Jian-Ping Cheng, Wei-Hua Cai, Hong-Na Zhang, Feng-Chen Li, Lian Shen, Shi-Zhi Qian

Mechanical & Aerospace Engineering Faculty Publications

A direct numerical simulation of single plume flow in thermal convection with polymers was carried out in a domain with 1:3 as the width to height ratio. The heat transport ability is weakened by adding polymers within the here-investigated governing parameter range. However, it is promoted when the maximum polymer extension L is increased. The distribution of vertical velocity and temperature indicates that the plume in the polymer solution case is speeded up and widens bigger as compared to that in the Newtonian fluid case. Inside the plume, polymer chains tend to release energy at the position where the …

Offshore Wind Energy: Simulating Local Offshore Wind Turbine, Ian P. Aquino

Mechanical & Aerospace Engineering Theses & Dissertations

Dominion Virginia Energy is looking at the possible creation of an offshore wind plant as a renewable source of electricity to be located off the coast of Virginia Beach. This thesis reports on a computer simulation based on local wind conditions and possible single wind turbine installation.

The National Buoy Data Center keeps records of the local wind conditions gathered in real time and available to the public. These data give a general overview of the wind conditions in Virginia Beach which is used to simulate atmospheric boundary layer (ABL) flow conditions and is subsequently used as input data for …

Impact Of A Localized Lean Six Sigma Implementation On Overall Patient Safety And Process Efficiency, Luvianca Gil, Pilar Pazos, Mamadou Seck, Rolando Delaguila

Engineering Management & Systems Engineering Faculty Publications

Continuous quality improvement tools have caught the attention of the Health Care Industry as a solution to process efficiency, patient safety and cost reduction. This research explores the impact of a Lean Six Sigma (LSS) process improvement initiative in overall process efficiency and patient safety in two Labor and Delivery (L+D) units of two large hospital providers. This study focuses on the application of modeling and simulation methodology to investigate the influence of a localized process improvement intervention on the overall L+D unit output, by considering patient flow, system capacity and unit performance. The simulation models capacity profiles and patient …

Integrating A Simple Traffic Incident Model For Rapid Evacuation Analysis, Andrew J. Collins, R. Michael Robinson, Peter Foytik, Craig Jordan, Barry C. Ezell

VMASC Publications

Road transportation networks are a segment of society's critical infrastructure particularly susceptible to service disruptions. Traffic incidents disrupt road networks by producing blockages and increasing travel times, creating significant impacts during emergency events such as evacuations. For this reason, it is extremely important to incorporate traffic incidents in evacuation planning models. Emergency managers and decision makers need tools that enable rapid assessment of multiple, varied scenarios. Many evacuation simulations require high-fidelity data input making them impractical for rapid deployment by practitioners. Since there is such variation in evacuation types and the method of disruption, evacuation models do not require the …

Java Animated Software For Teaching The Frank-Wolfe Algorithm For Static Traffic Network Equilibrium, Zhi Li

Computational Modeling & Simulation Engineering Theses & Dissertations

The popular Frank-Wolfe (FW) algorithm for solving the network equilibrium problems plays an important role in transportation simulation. Not only has the basic Frank Wolfe algorithm been studied, but also other variations of the FW algorithm (such as Conjugate Frank Wolfe and Bi-Conjugate Frank Wolfe algorithms) have been extensively studied by the research communities.

In this work, the basic Frank Wolfe algorithm is re-visited for the purpose of developing a useful, user-friendly, and appealing Java computer animation for enhancing the teaching effectiveness of this fundamental transportation static network equilibrium algorithm. Since the shortest path (SP) algorithms (such as the well-known …

Discretized Agent-Based Model Of Infectious Disease Spread That Uses Contact Probability, Tyrell L. Gardner

Computational Modeling & Simulation Engineering Theses & Dissertations

This study uses contact probability in an agent-based model to simulate the spread of an infectious disease. In order to perform the study, the agent-based model must first be discretized into events. Each agent in the model is given its own infectious disease state machine taken from the Susceptible-Exposed-Infected-Recovered (SEIR) model. The agents move between squares in a grid environment where each square represents a group. Groups have a contact probability as an attribute that is used to predict whether an agent comes in close contact with another agent. The transitions between the states in the SEIR model are easily …

Simulation Modeling And Analysis Of Customs-Regulated Container Terminal Operations With Multimodal Transportation, Mariam A. Kotachi

Engineering Management & Systems Engineering Theses & Dissertations

World trade has been increasing dramatically in the past two decades and, as a result, container exchange has grown significantly. Consequently and to meet this increase, several container terminals are expanding and many new ones are being established. A port with one or more container terminals is considered a complex system in which many entities interact to accomplish seamless handling of containers inbound and outbound. The level of complexity is drastically heightened for container terminals containing multimodal transportation systems as they typically involve ships, rail, and trucks arriving to one or more terminals delivering containers of different sizes to several …

Using Real Property Layouts To Study The Foreclosure Contagion Effect In Real Estate With Agent-Based Modeling And Simulation, Daniele Vernon-Bido

Computational Modeling & Simulation Engineering Theses & Dissertations

Foreclosures in the United States increased sharply from 2007 to 2009. These foreclosures had a spillover effect on neighboring property values causing additional foreclosures. This is known as the foreclosure contagion effect.

Recent studies have quantified the discount attributed to foreclosure contagion using equation-based techniques. However, the discount varied between studies and markets. Further studies using agent-based modeling and simulation have demonstrated the relationship between the discounts, the time a foreclosure remains on the market, the prevailing interest rates and the average property values.

This study uses agent-based modeling and simulation (ABMS) to explore the differences that varying neighborhood densities …

Semi-Automatic Simulation Initialization By Mining Structured And Unstructured Data Formats From Local And Web Data Sources, Olcay Sahin

Computational Modeling & Simulation Engineering Theses & Dissertations

Initialization is one of the most important processes for obtaining successful results from a simulation. However, initialization is a challenge when 1) a simulation requires hundreds or even thousands of input parameters or 2) re-initializing the simulation due to different initial conditions or runtime errors. These challenges lead to the modeler spending more time initializing a simulation and may lead to errors due to poor input data.

This thesis proposes two semi-automatic simulation initialization approaches that provide initialization using data mining from structured and unstructured data formats from local and web data sources. First, the System Initialization with Retrieval (SIR) …

Anchoring Of Drifting Spiral And Scroll Waves To Impermeable Inclusions In Excitable Media, Christian W. Zemlin, Arkady M. Pertsov

Bioelectrics Publications

Anchoring of spiral and scroll waves in excitable media has attracted considerable interest in the context of cardiac arrhythmias. Here, by bombarding inclusions with drifting spiral and scroll waves, we explore the forces exerted by inclusions onto an approaching spiral and derive the equations of motion governing spiral dynamics in the vicinity of inclusion. We demonstrate that these forces nonmonotonically depend on distance and can lead to complex behavior: (a) anchoring to small but circumnavigating larger inclusions; (b) chirality-dependent anchoring.

Modeling And Evaluating Role And Team Work Processes Using The Improved Performance Research And Integration Tool, Holly A. H. Handley, Pilar Pazos

Engineering Management & Systems Engineering Faculty Publications

The Human View architecture was designed to capture the human requirements of a system and to answer questions about the interactions between humans and systems. Data captured in the Human View can be used to populate a simulation model to evaluate the performance of the humans interacting in a work process. The work process model can be used to investigate different types of human system analyses, at both the role and team levels, and to identify the appropriate metrics to evaluate the results. This study examined individual role performance using the metrics readily available in the simulation tool, and then …

A Probabilistic Analysis Of Misparking In Reservation Based Parking Garages, Vikas G. Ashok

Computer Science Theses & Dissertations

Parking in major cities is an expensive and annoying affair, the reason ascribed to the limited availability of parking space. Modern parking garages provide parking reservation facility, thereby ensuring availability to prospective customers. Misparking in such reservation based parking garages creates confusion and aggravates driver frustration. The general conception about misparking is that it tends to completely cripple the normal functioning of the system leading to chaos and confusion. A single mispark tends to have a ripple effect and therefore spawns a chain of misparks. The chain terminates when the last mispark occurs at the parking slot reserved by the …

Determining The Utility Of Technology For Education, Brian Spencer Dillon

Computational Modeling & Simulation Engineering Theses & Dissertations

There is a substantial debate concerning the place of technology in education. This debate has been going on over every technology introduced through at least three millennia although the modern version takes place in journal articles. Technology, in the general sense, is already in the educational arena 1n ways which have become so commonplace that we hardly question them today. More modern technologies, however, meet perpetual resistance in achieving their potential. This paper calls into question the most recent trend in research and suggests a new research paradigm which focuses not only on student achievement, but on a variety of …

Engineering Management Framework In Support Of Modeling & Simulation Application For Domain Specific Procurement, Thomas Guy Litwin

Engineering Management & Systems Engineering Theses & Dissertations

A strategic process is desirable for project-based organizations in order for them to be efficient and effective when developing Modeling & Simulation (M&S) systems. This thesis proposes an overarching process that combines traditional M&S and Engineering Management methodologies in a new framework to support M&S organizations during the procurement process.

This thesis proposes both a Strategic Project Management Process (SPMP) and a systems engineering process for M&S federation development projects. The systems engineering process utilizes the artifacts of Model Driven Architecture (MDA) to support building M&S federations driven by operational requirements. Detailed research of this systems engineering process revealed a …

Integrating Game Technology And Discrete Event Simulation To Analyze Mass Casualty Scenarios, Jason Loveland

Computational Modeling & Simulation Engineering Theses & Dissertations

In the last 10 years, video games have become complex simulation environments with high resolution 3D graphics enabled by powerhouse rendering engines, multi-player client server networks, user friendly displays and graphical user interface , while remaining relatively inexpensive. There is a critical need for systems engineering analysis and rapid trade studies due to changes in operations caused by current events such as terrorist attacks, asymmetric threats, natural disasters, etc. Modem games provide a unique way to visualize and interact with these complex environments, scenarios, missions, and operations. A discrete event simulator (DES) provides an environment to model system architecture behavior, …

Enhancing Student Learning In Engineering Technology Programs? A Case For Physical Simulations, Alok Verma

Engineering Technology Faculty Publications

Physical simulations have a proven record as a teaching tool. Concepts that are often hard to grasp are made easy by the use of physical simulation activities. The constructivism learning theory suggests that people learn better by actively participating in the process of learning. According to the Encyclopedia of Educational Technology, "Simulation-based learning involves the placement of a student into a realistic scenario or situation. The student is then responsible for any changes that occur as a result of their decisions." A number of physical simulation based tools have been developed by the author for use as instructional tools to …

Tio2 Breakdown Under Pulsed Conditions, G. Zhao, R. P. Joshi, V. K. Lakdawala, E. Schamiloglu, H. Hjalmarson

Electrical & Computer Engineering Faculty Publications

Model studies of current conduction and breakdown in TiO₂ were carried out. Our simulation results indicate that electrical breakdown of TiO₂ under multiple-pulsed conditions can occur at lower voltages as compared to quasi-dc biasing. This is in agreement with recent experimental data and is indicative of a cumulative phenomena. We demonstrate that the lower breakdown voltages observed in TiO₂ under pulsed conditions is a direct rise-time effect, coupled with successive detrapping at the grain boundaries. 2007 American Institute of Physics.

Entopic Lattice Boltzmann Representations Required To Recover Navier Stokes Flows, Brian Keating, George Vahala, Jeffrey Yepez, Min Soe, Linda L. Vahala

Electrical & Computer Engineering Faculty Publications

There are two disparate formulations of the entropic lattice Boltzmann scheme: one of these theories revolves around the analog of the discrete Boltzmann H function of standard extensive statistical mechanics, while the other revolves around the nonextensive Tsallis entropy. It is shown here that it is the nonenforcement of the pressure tensor moment constraints that lead to extremizations of entropy resulting in Tsallis-like forms. However, with the imposition of the pressure tensor moment constraint, as is fundamentally necessary for the recovery of the Navier-Stokes equations, it is proved that the entropy function must be of the discrete Boltzmann form. Three-dimensional …

A Comparative Analysis Of Air-To-Ground Engagement Outcomes In The Joint Warfare System (Jwars) And The Jwars-Joint Semi-Automated Forces Federation, Melissa Anne St. Peter

Computational Modeling & Simulation Engineering Theses & Dissertations

Multi-resolution modeling is the process by which a single model is created by connecting multiple individual models to describe phenomena at different levels of resolution [1]. "When we change resolutions, replacing a detailed model by a more aggregate one, we must ask whether results are 'consistent'" [2].

There are many methods of determining if the results of two simulations are 'consistent'. However, they are very entailed and require a detailed understanding of the individual models including their functionality, algorithms, and inner workings. A straight forward and rapid way of assessing potential inconsistencies is through a statistical comparison of the model …

Teaching Lean Manufacturing Concepts Using Physical Simulations Within Engineering Technology Program, Alok Verma

Engineering Technology Faculty Publications

Physical Simulations have a proven record as a teaching tool. Concepts that are often hard to grasp are made easy by the use of physical simulation activities. The constructivism learning theory suggests that people learn better by actively participating in the process of learning. Effectiveness of simulation-based learning is well recognized. According to the Encyclopedia of Educational Technology, "Simulation-based learning involves the placement of a student into a realistic scenario or situation. The student is then responsible for any changes that occur as a result of their decisions." The computer integrated manufacturing course in the mechanical engineering technology program was …

Simulations Of Nanopore Formation And Phosphatidylserine Externalization In Lipid Membranes Subjected To A High-Intensity, Ultrashort Electric Pulse, Q. Hu, R. P. Joshi, K. H. Schoenbach

Bioelectrics Publications

A combined MD simulator and time dependent Laplace solver are used to analyze the electrically driven phosphatidylserine externalization process in cells. Time dependent details of nanopore formation at cell membranes in response to a high-intensity (100kV∕cm), ultrashort (10ns) electric pulse are also probed. Our results show that nanosized pores could typically be formed within about 5ns. These predictions are in very good agreement with recent experimental data. It is also demonstrated that defect formation and PS externalization in membranes should begin on the anode side. Finally, the simulations confirm that PS externalization is a nanopore facilitated event, rather than the …

Lessons Learned And Best Practices For Using An Analytic Strategy Approach For The Creation Of Virtual Laboratories For Distance Learning In Engineering Technology, Anthony W. Dean, Carol L. Considine, Gary R. Crossman

Engineering Technology Faculty Publications

This paper describes the use of an Analytic Strategy Approach used in the development of a Virtual Automation and Controls Lab in the Mechanical Engineering Technology Program of the Engineering Technology Department at Old Dominion University. This paper looks at the three phases, as applied to the development of a virtual lab using an analytic strategy design:

(1) Formulation of the quantitative and qualitative approach to assist in decision process,

(2) Quantitative and qualitative analysis of the decision alternatives - within the decision context,

(3) Interpretation of the analysis results and implications for decision.

Optimization Of Ultraviolet Emission And Chemical Species Generation From A Pulsed Dielectric Barrier Discharge At Atmospheric Pressure, Xinpei Lu, Mounir Laroussi

Electrical & Computer Engineering Faculty Publications

One of the attractive features of nonthermal atmospheric pressure plasmas is the ability to achieve enhanced gas phase chemistry without the need for elevated gas temperatures. This attractive characteristic recently led to their extensive use in applications that require low temperatures, such as material processing and biomedical applications. The agents responsible for the efficient plasma reactivity are the ultraviolet (UV) photons and the chemically reactive species. In this paper, in order to optimize the UV radiation and reactive species generation efficiency, the plasma was generated by a dielectric barrier discharge driven by unipolar submicrosecond square pulses. To keep the discharge …

Automation Laboratory Development With Design Implementation Scheme And Simulation Software, Cheng Y. Lin, Gary R. Crossman

Engineering Technology Faculty Publications

This paper describes the development of the Automation Control Lab in the Mechanical Engineering Technology Program of the Engineering Technology Department at Old Dominion University. The reorganization goal of the development is to help students design, test, and implement their automation designs effectively. Three processes are adopted to achieve this goal: (1) floor-plan design and inventory control of the components, (2) using Automation Studio to dynamically check each design, and (3) using industrial Programmable Logic Controllers (PLC) controllers to download PLC programs.

Project-Based Freshmen Engineering Courses In Civil Engineering Technology, Vernon W. Lewis Jr., Carol L. Considine

Engineering Technology Faculty Publications

Old Dominion University (ODU) has developed two fundamental courses for freshmen engineering students. The first course introduces the fundamentals of the practice of engineering including innovation, creativity, design and manufacturing, commercialization, teaming skills, environmental impact, and ethics. The second course is an exploration of engineering and engineering technology disciplines with an emphasis on projects. The purpose of these courses is to engage the students in the application of engineering early in their course of study with the hope that their interest will be reinforced and the likelihood of their being retained as students will increase. The courses are divided into …

The Development Of An Enterprise Supply Chain Model For Naval Warship Construction, Rex A. Wallen

Computational Modeling & Simulation Engineering Theses & Dissertations

The utilization of computer simulation in the shipbuilding industry is not a new concept and many shipyards in the US and around the world are using simulation tools in a variety of ways with various levels of success. In other industries, computer simulation has proven itself as a powerful tool for reducing non-value added activities and promises to become more prominent in its use as a resource management tool. Its use in the manufacturing of outfitting components in the construction of Naval warships has had limited success due mainly to the inherent nature of ship construction, especially shipyards engaged in …

Entropy Generation Method To Quantify Thermal Comfort, S. C. Boregowda, S. N. Tiwari, S. K. Chaturvedi

Mechanical & Aerospace Engineering Faculty Publications

The present paper presents a thermodynamic approach to assess the quality of human-thermal environment interaction and quantify thermal comfort. The approach involves development of entropy generation term by applying second law of thermodynamics to the combined human-environment system. The entropy generation term combines both human thermal physiological responses and thermal environmental variables to provide an objective measure of thermal comfort. The original concepts and definitions form the basis for establishing the mathematical relationship between thermal comfort and entropy generation term. As a result of logic and deterministic approach, an Objective Thermal Comfort Index (OTCI) is defined and established as a …

Selection Of Curricular Topics Using Extensions Of Quality Function Deployment, Paul Kauffmann, Abel Fernandez, Charles Keating, Derya Jacobs, Resit Unal

Engineering Management & Systems Engineering Faculty Publications

Decision science can be an effective tool for enhancing organizational participation during strategic and complex decision making. This involvement develops a group consensus for relating organizational goals and the methods to achieve them. This paper describes an application of Quality Function Deployment (QFD) to define curricular topics that meet program objectives. Based on the ability of QFD to establish relationships, the model identifies the most important topics and quantifies their impact on meeting program goals. The model was developed to support restructuring of a Masters of Engineering Management degree program. The model supported decisions in selecting and prioritizing the required …