Biomechanical Engineering Commons^™

Multiscale Modeling Of Cardiac Growth And Baroreflex Control, Hossein Sharifi

Theses and Dissertations--Mechanical and Aerospace Engineering

The heart functions within a complex system that adapts its function to any alteration in loading via several mechanisms. For example, the baroreflex is a short-term feedback loop that modulates the heart's function on a beat-to-beat basis to control arterial pressure. On the other hand, cardiac growth is a long-term adaptive response that occurs over weeks or months in response to changes in left ventricular loading. Understanding the mechanisms that drive ventricular growth and biological remodeling is critical to improving patient care. Multiscale models of the cardiovascular system have emerged as effective tools for investigating G&R, offering the ability to …

Optimizing Biomechanical Models: Estimation Of Muscle Tendon Parameters And Ankle Foot Orthosis Stiffness, Sepehr Ramezani

Electronic Theses and Dissertations, 2020-2023

The complexity of the human musculoskeletal system presents challenges in accurately identifying its characteristics, particularly due to the presence of redundant actuators on a single joint. Non-invasive measures are necessary to overcome these challenges. Optimization algorithms have emerged as a crucial tool to advance subject-specific musculoskeletal modeling allows a more realistic representation of biomechanical behaviors, enhancing our understanding of human movement and enabling better clinical decision-making. Furthermore, optimization algorithms play a vital role in customizing rehabilitation and assistive devices, such as orthoses and prostheses. The current ankle-foot orthosis (AFO) stiffness measurement methods require bulky, complex designs, and often permanent modification …

Nanomaterials For Cardiovascular Engineering, Roya Bagheri

Dissertations, Master's Theses and Master's Reports

Cardiovascular diseases and disorders (i.e., those related to heart and blood vessels) are the main reasons for mortality worldwide. Nanomaterials, with their unique morphologies and properties, have a great potential for advancing cardiovascular engineering to treat diseases and disorders. In this dissertation, several cardiovascular applications of conductive nanomaterials were investigated. First, a conductive nanomaterial was explored to fabricate biohybrid nanomaterial-cardiomyocyte (CM – heart muscle cell) systems. Using Carbon Nanotube (CNT) forest as a 3D porous and conductive scaffold was investigated. The influence of the CNT forest on the viability, attachment, and spreading of CMs and their genetic information was …

Microfluidic Dual-Gel Cell Culture Model For Studying Cell Migration Under Controlled Interstitial Flow, Alimohamamd Anbari

Dissertations and Theses

Abstract

Interstitial flow, the slow flux of fluid occurring in the interstitial space of the extracellular matrix (ECM), affects the migration of many cell types through individual and synergistic contributions of several biophysical and biochemical phenomena. Notably, interstitial flow is linked to ECM permeability and provides direct mechanical cues via shear and normal stress. Additionally, the flow also couples with biomolecular diffusion to provide chemotactic signals to the cells. Recent in vitro studies have indicated that tumor cell migration is affected by interstitial fluid velocity and ECM permeability through the mechanisms of (1) autologous chemotaxis and (2) integrin-mediated focal adhesion …

Finite Element Analysis Of 3d-Printed Pcl Scaffolds, Ireolu K. Orenuga, Joao Soares, Phillip D. Glass, Daeha Joung Ph.D.

UROP Posters

Finite Element Analysis of 3D-printed PCL Scaffolds for Synergizing Cellular Micro-Environment and Mechanical Stimuli to Enhance Engineered Tissue Growth in Vitro

Ireolu Orenuga,1 Phillip Glass,2 Daeha Joung,2 Joao S. Soares1

1. Department of Mechanical and Nuclear Engineering, College of Engineering, Virginia Commonwealth University
2. Department of Physics, College of Humanities & Sciences, Virginia Commonwealth University

Introduction: Tissue engineering aims to create viable and functional engineered tissues via biodegradable scaffolds and autologous cells. Scaffolds play an essential part in organizing the architecture of developing tissues and aid in the proper function of implants acutely by serving as mechanical support and long-term by …

Biologically – Plausible Load Feedback From Dynamically Scaled Robotic Model Insect Legs, William Zyhowski

Graduate Theses, Dissertations, and Problem Reports (ETD)

Researchers have been studying the mechanisms underlying animal motor control for many years using computational models and biomimetic robots. Since testing some theories in animals can be challenging, this approach can enable unique contributions to the field. An example of a system that benefits from this modeling and robotics approach is the campaniform sensillum (CS), a kind of sensory organ used to detect the loads exerted on an insect's legs. The CS on the leg are found in groups on high-stress areas of the exoskeleton and have a major influence on the adaptation of walking behavior. The challenge for studying …

Better Tools For Women: Serving Local Gynecologic Cancer Patients, Caitlin Crowley

Purdue Journal of Service-Learning and International Engagement

Introduction: Cervical patients require a mirror to view anatomy between doctor visits. Existing mirrors have inadequate light and magnification, limit available free hands, or require another individual’s assistance.

Skin lesion size is tracked over time to record advances in healing or disease progression. Current options are inadequate for cutaneous lesion documentation. Parkview Cancer Institute asked me to develop a better self-examination tool for cervical patients. The new device may be used by all women for wellness checks.

Materials and Methods: A hands free illuminated cleanable mirror with magnification was designed after anthropometric and regulatory review.

Device performance was established by …

Hypoxic Incubation Chamber, Simone Lisette Helfrich, Makenzie Nicole Jones

Master's Theses

This paper describes the design, manufacturing, and testing of a novel controllable hypoxic incubator with fully functional oxygen gas control and temperature control in a humid environment. On the current market, a majority of the few hypoxic incubators use pre-mixed gas that does not offer precise control over gas concentration. The objective for this project was to create a chamber that allows the user to set the O2 concentration to varying set points of % O2 while maintaining the chamber at a constant body temperature, CO2 level, humidity, and sterility. To start the project, multiple concepts were developed for the …

3d-Printed Piezoelectric Porous Bioactive Scaffolds And Clinical Ultrasonic Stimulation Can Help In Enhanced Bone Regeneration, Prabaha Sikder, Phaniteja Nagaraju, Harsha P.S. Naganaboyina

Mechanical Engineering Faculty Publications

This paper presents a comprehensive effort to develop and analyze first-of-its-kind design-specific and bioactive piezoelectric scaffolds for treating orthopedic defects. The study has three major highlights. First, this is one of the first studies that utilize extrusion-based 3D printing to develop design-specific macroporous piezoelectric scaffolds for treating bone defects. The scaffolds with controlled pore size and architecture were synthesized based on unique composite formulations containing polycaprolactone (PCL) and micron-sized barium titanate (BaTiO3) particles. Second, the bioactive PCL-BaTiO3 piezoelectric composite formulations were explicitly developed in the form of uniform diameter filaments, which served as feedstock material for the fused filament fabrication …

Computational Simulations Of The Effects Of Gravity On Lymphatic Transport, Huabing Li, Huajian Wei, Timothy P. Padera, James W. Baish, Lance L. Munn

Faculty Journal Articles

Physical forces, including mechanical stretch, fluid pressure, and shear forces alter lymphatic vessel contractions and lymph flow. Gravitational forces can affect these forces, resulting in altered lymphatic transport, but the mechanisms involved have not been studied in detail. Here, we combine a lattice Boltzmann-based fluid dynamics computational model with known lymphatic mechanobiological mechanisms to investigate the movement of fluid through a lymphatic vessel under the effects of gravity that may either oppose or assist flow. Regularly spaced, mechanical bi-leaflet valves in the vessel enforce net positive flow as the vessel walls contract autonomously in response to calcium and nitric oxide …

Atherogenic Potential Of Microgravity Hemodynamics In The Carotid Bifurcation: A Numerical Investigation, Philippe Sucosky, Varun Vinayak Kalaiarasan, Graham B. Quasebarth, Patricia Strack, Jason A. Shar

Open Access Publishing Fund Collection

Long-duration spaceflight poses multiple hazards to human health, including physiological changes associated with microgravity. The hemodynamic adaptations occurring upon entry into weightlessness have been associated with retrograde stagnant flow conditions and thromboembolic events in the venous vasculature but the impact of microgravity on cerebral arterial hemodynamics and function remains poorly understood. The objective of this study was to quantify the effects of microgravity on hemodynamics and wall shear stress (WSS) characteristics in 16 carotid bifurcation geometries reconstructed from ultrasonography images using computational fluid dynamics modeling. Microgravity resulted in a significant 21% increase in flow stasis index, a 22–23% decrease in …

Effects Of Imu Sensor Location And Number On The Validity Of Vertical Acceleration Time-Series Data In Countermovement Jumping, Dianne Althouse

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Many devices are available for measuring the height of a CMJ. An inertial measurement unit (IMU) measures linear acceleration, orientation, and angular velocity. As an alternative to using IMU estimates of flight time, CMJ height could be estimated by integrating the IMU time-series signal for vertical acceleration to derive CMJ take-off velocity in order to track whole-body center of mass (WBCoM) movement, yet this approach would require valid IMU acceleration data. Thus, the purpose of this study was to quantify the effects of IMU sensor location and number on the validity of vertical acceleration estimation in CMJ. Thirty young adults …

Development Of A Reverse Engineered, Parameterized, And Structurally Validated Computational Model To Identify Design Parameters That Influence American Football Faceguard Performance, William Ferriell

All Dissertations

Traumatic brain injury (TBI) continues to have the greatest incidence among athletes participating in American football. The headgear design research community has focused on developing accurate computational and experimental analysis techniques to better assess the ability of headgear technology to attenuate impacts and protect athletes from TBI. Despite efforts to innovate the headgear system, minimal progress has been made to innovate the faceguard. Although the faceguard is not the primary component of the headgear system that contributes to impact attenuation, faceguard performance metrics, such as weight, structural stiffness, and visual field occlusions, have been linked to athlete safety. To improve …

Tunable Passive Shock And Vibration Isolators For Rotational Isolation, Chase B. Lemaire

LSU Master's Theses

Shock and vibration isolation are a critical need in helmets, which are widely used to protect athletes, workers, soldiers, and astronauts. Passive vibration isolation systems are a good option when mass and volume should be minimized and when the experienced loadings can be predicted. However, it is frequently challenging to find materials and structures which exhibit the optimal vibration and impact isolation properties for an application. As a case study illustrating a novel design paradigm for rotational shock absorption, a family of optimal solutions for the physical properties of American football helmets is presented. Lumped parameter Simulink models simulate a …

Estimation Of Joint Moments During Turning Maneuvers In Alpine Skiing Using A Three Dimensional Musculoskeletal Skier Model And A Forward Dynamics Optimization Framework, Dieter Heinrich, Antonie J. Van Den Bogert, Werner Nachbauer

Mechanical Engineering Faculty Publications

In alpine skiing, estimation of the joint moments acting onto the skier is essential to quantify the loading of the skier during turning maneuvers. In the present study, a novel forward dynamics optimization framework is presented to estimate the joint moments acting onto the skier incorporating a three dimensional musculoskeletal model (53 kinematic degrees of freedom, 94 muscles). Kinematic data of a professional skier performing a turning maneuver were captured and used as input data to the optimization framework. In the optimization framework, the musculoskeletal model of the skier was applied to track the experimental data of a skier and …

Design Improvement Of Transcatheter Aortic Valves For Aortic Stenosis Patients, Samantha K. Shoun, Ali N. Azadani

DU Undergraduate Research Journal Archive

Aortic valve disease is a common condition in patients above 60 years of age and is associated with significant morbidity and mortality. Aortic valve stenosis is characterized by the narrowing of the aortic valve, which can be quite debilitating. This disease is treated with transcatheter aortic valve replacement (TAVR), which is a rapidly expanding alternative to open-heart surgical aortic valve replacement (SAVR). Although TAVR is a less invasive than SAVR, long-term durability of the transcatheter aortic valves could be the Achilles heel of the procedure. Thus, the main objective of this research was to improve the design of transcatheter aortic …

Developing New Crutch Tip Design For Overall Increased Stability And Improved Movement On Different Terrains, Lauren Skinner

Honors Theses

Crutches are a mobility assistive device that are often used in various situations, such as post- surgical rehabilitation and recovery after injury. The current crutch tip design that is used on today’s crutches are often unstable and do not provide quality movement on different terrains, such as snow, ice, mud, and wet surfaces. These problems would be solved with a new tip design that could be attached to existing crutches or manufactured with the crutch itself. The team’s solution to this problem is a crutch tip with modular parts. The tip would attach to the shaft of the crutch like …

Efficient Energy Harvesting With Applications In Vibration And Implantable Biosensors, Mohammad Atmeh

Mechanical Engineering Theses

The world has stepped into the fourth industrial revolution in many ways such as using the internet of things (IoT) in various applications, and removing the rechargeable power sources seeking for batteryless systems. Since energy is widely abundant around us and it is going to waste, numerous of recent studies have been conducted to propose sustainable solutions to harvest the free ambient power from the surrounding and convert it into electricity. Heat energy, kinetic energy, and radio waves are examples of these potentially harvestable energy sources. Mechanical vibrations represent one of the most plentiful forms of kinetic energy that can …

Corrosion Assessment Of Biodegradable Metal Implants For Orthopedic Applications, Wendy B. Reynoso-Diaz

Honors Theses

Magnesium alloys are the most promising materials to be used as biodegradable implants mainly due to their superior biocompatibility and lower specific density compared to other biodegradable metals (i.e., zinc and iron-based alloys). This study is investigating the effect of two different manufacturing methods and purity levels on the corrosion rates of a novel Mg-Zn-Ca-Mn-based alloy. Experimental in vitro corrosion tests were conducted on the biocompatible Mg-Zn-Ca-Mn-based alloy fabricated using conventional casting and hot rolling with low and high purity levels. The experimental research conducted, assessed the corrosion rates of the following Mg-1.2Zn-0.5Ca-0.5Mn-based alloys: Hot Rolled High Purity, As-Cast High …

Predicting The Progression Of Diabetes Mellitus Using Dynamic Plantar Pressure Parameters, Mathew Sunil Varre

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction: Diabetic peripheral neuropathy is one of the common complications of type-2 diabetes mellitus (DM). Changes in the intrinsic plantar tissue coupled with repetitive mechanical loads and loss of sensation may lead to foot related complications (skin break down, ulcerations, and amputations) in persons with neuropathy if left untreated. The purpose of this dissertation was to stratify individuals with pre-diabetes, diabetes with and without neuropathy using dynamic plantar pressure parameters during walking, using machine learning algorithms.Methods: Plantar pressure data was collected from one hundred participants during walking with pressure measuring insoles fixed between the feet and thin socks. Simultaneously high-definition …