Biomechanical Engineering Commons^™

Du Undergraduate Showcase: Research, Scholarship, And Creative Works, Caitlyn Aldersea, Justin Bravo, Sam Allen, Anna Block, Connor Block, Emma Buechler, Maria De Los Angeles Bustillos, Arianna Carlson, William Christensen, Olivia Kachulis, Noah Craver, Kate Dillon, Muskan Fatima, Angel Fernandes, Emma Finch, Colleen Cassidy, Amy Fishman, Andrea Francis, Stacia Fritz, Simran Gill, Emma Gries, Rylie Hansen, Shannon Powers, Jacqueline Martinez, Zachary Harker, Ashley Hasty, Mykaela Tanino-Springsteen, Kathleen Hopps, Adelaide Kerenick, Colin Kleckner, Ci Koehring, Elijah Kruger, Braden Krumholz, Maddie Leake, Lyneé Alves, Seraphina Loukas, Yatzari Lozano Vazquez, Haley Maki, Emily Martinez, Sierra Mckinney, Audrey Mitchell, Kipling Newman, Audrey Ng, Megan Lucyshyn, Andrew Nguyen, Stevie Ostman, Casandra Pearson, Alexandra Penney, Julia Gielczynski, Tyler Ball, Anna Rini, Christina Rorres, Simon Ruland, Helayna Schafer, Emma Sellers, Sarah Schuller, Claire Shaver, Kevin Summers, Isabella Shaw, Madison Sinar, Claudia Pena, Apshara Siwakoti, Carter Sorensen, Madi Sousa, Anna Sparling, Alexandra Revier, Brandon Thierry, Dylan Tyree, Maggie Williams, Lauren Wols

DU Undergraduate Research Journal Archive

DU Undergraduate Showcase: Research, Scholarship, and Creative Works

Steam Gasification Of Biochar To Produce Hydrogen-Rich Syngas, Nnamdi Ofuani

Honors College Theses

A key greenhouse gas (GHG) emission contributing to climate change is carbon dioxide (CO₂) emission. This emission is largely due to the use of fossil fuel as a major energy source. Biomass is an alternative energy source. Biochar, a byproduct of the pyrolysis process (of biomass), could be gasified to produce syngas (a mixture of CO and H₂). This syngas can further be used to produce different kinds of fuels like biodiesel, bio-gasoline, bioethanol, etc. In the steam gasification of biochar, the quality and yield of syngas is dependent on parameters such as temperature, particle size, …

A Proof Of Concept For Detection Of Palato-Lingual Contact Without Intraoral Electrodes In A Human Participant, Amitava Biswas

Master's Theses

The author of this thesis conceived and investigated an unexpected electrical signal that may not be noticed during regular electroglottography (EGG) when electrodes are conventionally placed on the anterior surface of the throat. It appears that there is a measurable electrical signal from the EGG equipment when electrodes are placed over the frontal cheek (belly of zygomatic muscle), and the tongue is elevated to contact the hard palate, or the tongue is lowered to break the contact. Therefore, this phenomenon is designated as unconventional electroglottography (UEGG, Dr. Steven Cloud, private communication, July 17, 2022).

Two distinctive patterns of waveforms were …

Structure And Movement Design To Build A Functional Prosthetic Hand, John Campbell

Honors College Theses

This project aims to create a functional prosthetic hand that will improve upon the previous design for this project. The previous design included four fingers which were moved using a four-bar linkage and slider crank mechanism in combination with a linear actuator to move all four fingers in unison. Two servo motors were used to create an opposable thumb that could be used to grasp objects. Movement of the prosthetic hand was activated using a signal received from a myoelectric sensor. The goal of this project is to study this design and attempt to upgrade the prosthetic hand utilizing a …

Engineered Material Systems For Mimicking Tissue And Disease, Margrethe Ruding

McKelvey School of Engineering Graduate Student Theses & Dissertations

This thesis comprises two studies involving design and application of soft material systems. The goal of the first study was to design, fabricate, and characterize hydrogel lattice structures with consistent, controllable, anisotropic mechanical properties. Lattices, based on four types of unit cells (cubic, diamond, vintile, and Weaire-Phelan), were printed using stereolithography (SLA) of polyethylene glycol diacrylate (PEGDA). In order to create structural anisotropy in the lattices, unit cell design files were scaled in one direction by a factor of two in each layer and then printed. The mechanical properties of the scaled lattices were measured in shear and compression and …

Blood Flow Regulates Atherosclerosis Progression And Regression, Morgan A. Schake

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

Atherosclerosis is the most prevalent pathology of cardiovascular disease with no known cure. Despite the many systemic risk factors for atherosclerosis, plaques do not form randomly in the vasculature. Instead, they form around bifurcations and the inner curvature of highly curving arterial segments that contain so-called disturbed blood flow that is low in magnitude and multidirectional over the cardiac cycle. Conversely, straight, non-bifurcated arterial segments that contain moderate-to-high and unidirectional (i.e., normal) blood flow are protected from plaque development. Thus, blood flow is a key regulator of atherosclerosis that may be able to be leveraged to develop new therapeutics. Towards …

Hybrid Fes-Exoskeleton Control: Using Mpc To Distribute Actuation For Elbow And Wrist Movements, Nathan Dunkelberger, Jeffrey Berning, Eric M. Schearer, Marcia K. O'Malley

Mechanical Engineering Faculty Publications

Introduction: Individuals who have suffered a cervical spinal cord injury prioritize the recovery of upper limb function for completing activities of daily living. Hybrid FES-exoskeleton systems have the potential to assist this population by providing a portable, powered, and wearable device; however, realization of this combination of technologies has been challenging. In particular, it has been difficult to show generalizability across motions, and to define optimal distribution of actuation, given the complex nature of the combined dynamic system. Methods: In this paper, we present a hybrid controller using a model predictive control (MPC) formulation that combines the actuation of both …

Concurrent Validity Study Of 3d Motion Measurement Systems: Vicon Vs. Xsens, Pias Das

Masters Theses

As the Inertial Measurement System (IMS) being a potential alternative to the Optoelectronic Measurement System (OMS) in terms of capturing comprehensive and objective musculoskeletal data, they need to be verified concurrently with the OMS before we start using the IMS in clinical motion analysis. To achieve this, a concurrent validity experiment of the Xsens system (IMS) in comparison to the Vicon system (OMS) was conducted for both upper and lower extremity movements during walk, squat, and lateral lunge (left and right) to quantify the degree of similarity of kinematic data between the two systems by direct comparison, root mean square …

Effects Of Exciting And Relaxing Music On Heart Rate Variability, Pratik S. Mahajan

Honors Undergraduate Theses

Heart rate variability (HRV) and music have been demonstrated to have a relationship in previous literature. The primary objective of this study is to further investigate that relationship by observing HRV during periods of listening to relaxing and exciting music and comparing the results to a baseline as well as the other condition. The secondary objective of this study is to investigate the efficacy and potential usage of the Polar H10 chest strap monitor in measuring HRV parameters. The results of the Polar H10 will be compared to the iWorx TA-220 and iWorx-ECG12, the existing gold standard in HRV and …

Semi-Robotic Knee Arthroscopy System With Braking Mechanism, Thai Hua

Honors Undergraduate Theses

To alleviate the poor ergonomics which surgeons suffer during knee arthroscopy, a semi-robotic device with braking mechanism is created for intraoperative assistance. A slitted ball joint assembly is developed to transmit the clamping force to the arthroscope inside. Ball deformation and stress at various angles to the vertical and clamping forces is recorded through Abaqus Finite Element Analysis (FEA). Contact forces between the scope and inner surfaces of the ball is also computed in FEA at different clamping forces. The von Mises stress occurring in the ball joint is under the yield stress limit for polyethylene, and there is noticeable …

Variational Autoencoder And Sensor Fusion For Robust Myoelectric Controls, Keith A. Currier

Honors Undergraduate Theses

Myoelectric control schemes aim to utilize the surface electromyography (EMG) signals which are the electric potentials directly measured from skeletal muscles to control wearable robots such as exoskeletons and prostheses. The main challenge of myoelectric controls is to increase and preserve the signal quality by minimizing the effect of confounding factors such as muscle fatigue or electrode shift. Current research in myoelectric control schemes are developed to work in ideal laboratory conditions, but there is a persistent need to have these control schemes be more robust and work in real-world environments. Following the manifold hypothesis, complexity in the world can …

Investigation Of Endothelial Mechanics On Primary Cell Functions: Endothelium Permeability And Wound Healing, Sean Beverung

Electronic Theses and Dissertations, 2020-2023

The endothelium composes the inner lining of blood vessels, the heart, and lymphatic vessels. Within the cardiovascular system, it is an extremely important structure, aiding in the regulation of blood pressure with the vascular tone, recruiting immune response, regulating the transfer of material in and out of the bloodstream, and the creation of new blood vessels through angiogenesis. The endothelium is composed entirely of endothelial cells. These cells lay in a flat squamous formation and are in direct contact with blood and aid in the regulation and transfer of material in and out of the bloodstream via active and passive …

A Review Of Piezoelectric Footwear Energy Harvesters: Principles, Methods, And Applications, Bingqi Zhao, Feng Qian, Alexander Hatfield, Lei Zuo, Tian-Bing Xu

Mechanical & Aerospace Engineering Faculty Publications

Over the last couple of decades, numerous piezoelectric footwear energy harvesters (PFEHs) have been reported in the literature. This paper reviews the principles, methods, and applications of PFEH technologies. First, the popular piezoelectric materials used and their properties for PEEHs are summarized. Then, the force interaction with the ground and dynamic energy distribution on the footprint as well as accelerations are analyzed and summarized to provide the baseline, constraints, potential, and limitations for PFEH design. Furthermore, the energy flow from human walking to the usable energy by the PFEHs and the methods to improve the energy conversion efficiency are presented. …

Design And Validation Of A Variable, Speed-Dependent Resistance Training Method For Muscle Hypertrophy, Alvaro Andres Aracena Alvial

Honors Undergraduate Theses

Muscle disorders and induced muscle atrophy impose critical risks to the well-being of an individual, limiting normal activities of daily living. Several resistance training methods have effectively reversed the progression of muscle atrophy. Weightlifting and hydrotherapy are the two widely practiced schemes for resistance training; however, there is the potential risk of excessive loads exerted on the muscles during weightlifting, and limited accessibility and cost are barriers to hydrotherapy. An alternative is using a resistance band. Some limitations include engaging multiple muscles/joints while only unidirectional resistance is feasible. To address these limitations, a VAriable Resistance Suit (VARS) was designed to …

Audible And Subaudible Components Of The First And Second Heart Sounds Using Phonocardiography And Seismocardiography, Daniella King

Honors Undergraduate Theses

Cardiovascular disease continues to be a leading cause of death in the United States, and a source of financial strain on the healthcare system. This prompts the need for new methods of low-cost, noninvasive technologies for cardiac monitoring to improve patient health and reduce healthcare costs. While the first and second heart sounds are common references that are listened to during auscultation of heart, seismocardiography (SCG) is a technology that detects chest sound vibrations with an accelerometer and may offer more information beyond the audible heart sounds. There is currently limited information regarding both the relationship between audible heart sounds …

Data-Driven Dynamic Motion Planning For Practical Fes-Controlled Reaching Motions In Spinal Cord Injury, Derek N.N. Wolf, Antonie J. Van Den Bogert, Eric M. Schearer

Mechanical Engineering Faculty Publications

Functional electrical stimulation (FES) is a promising technology for restoring reaching motions to individuals with upper-limb paralysis caused by a spinal cord injury (SCI). However, the limited muscle capabilities of an individual with SCI have made achieving FES-driven reaching difficult. We developed a novel trajectory optimization method that used experimentally measured muscle capability data to find feasible reaching trajectories. In a simulation based on a real-life individual with SCI, we compared our method to attempting to follow naive direct-to-target paths. We tested our trajectory planner with three control structures that are commonly used in applied FES: feedback, feedforward-feedback, and model …

Multiscale Modeling Of Cardiac Growth And Baroreflex Control, Hossein Sharifi

Theses and Dissertations--Mechanical and Aerospace Engineering

The heart functions within a complex system that adapts its function to any alteration in loading via several mechanisms. For example, the baroreflex is a short-term feedback loop that modulates the heart's function on a beat-to-beat basis to control arterial pressure. On the other hand, cardiac growth is a long-term adaptive response that occurs over weeks or months in response to changes in left ventricular loading. Understanding the mechanisms that drive ventricular growth and biological remodeling is critical to improving patient care. Multiscale models of the cardiovascular system have emerged as effective tools for investigating G&R, offering the ability to …

Optimizing Biomechanical Models: Estimation Of Muscle Tendon Parameters And Ankle Foot Orthosis Stiffness, Sepehr Ramezani

Electronic Theses and Dissertations, 2020-2023

The complexity of the human musculoskeletal system presents challenges in accurately identifying its characteristics, particularly due to the presence of redundant actuators on a single joint. Non-invasive measures are necessary to overcome these challenges. Optimization algorithms have emerged as a crucial tool to advance subject-specific musculoskeletal modeling allows a more realistic representation of biomechanical behaviors, enhancing our understanding of human movement and enabling better clinical decision-making. Furthermore, optimization algorithms play a vital role in customizing rehabilitation and assistive devices, such as orthoses and prostheses. The current ankle-foot orthosis (AFO) stiffness measurement methods require bulky, complex designs, and often permanent modification …

Microfluidic Dual-Gel Cell Culture Model For Studying Cell Migration Under Controlled Interstitial Flow, Alimohamamd Anbari

Dissertations and Theses

Abstract

Interstitial flow, the slow flux of fluid occurring in the interstitial space of the extracellular matrix (ECM), affects the migration of many cell types through individual and synergistic contributions of several biophysical and biochemical phenomena. Notably, interstitial flow is linked to ECM permeability and provides direct mechanical cues via shear and normal stress. Additionally, the flow also couples with biomolecular diffusion to provide chemotactic signals to the cells. Recent in vitro studies have indicated that tumor cell migration is affected by interstitial fluid velocity and ECM permeability through the mechanisms of (1) autologous chemotaxis and (2) integrin-mediated focal adhesion …

Biologically – Plausible Load Feedback From Dynamically Scaled Robotic Model Insect Legs, William Zyhowski

Graduate Theses, Dissertations, and Problem Reports (ETD)

Researchers have been studying the mechanisms underlying animal motor control for many years using computational models and biomimetic robots. Since testing some theories in animals can be challenging, this approach can enable unique contributions to the field. An example of a system that benefits from this modeling and robotics approach is the campaniform sensillum (CS), a kind of sensory organ used to detect the loads exerted on an insect's legs. The CS on the leg are found in groups on high-stress areas of the exoskeleton and have a major influence on the adaptation of walking behavior. The challenge for studying …