New Force Transducer For Mitral Valve Chordae Tendinea,
2021
University of Arkansas, Fayetteville
New Force Transducer For Mitral Valve Chordae Tendinea, Joseph Berryman
Biomedical Engineering Undergraduate Honors Theses
In order to inform the future of mitral valve repair and replacement, more investigation into the mechanics of the sub-valvular structure is needed. Understanding the roles of each chord during valve closure requires a sensor capable of detecting these small forces with enough sensitivity to determine the characteristics of each of the chordal types. The focus of the cantilever force transducer is to maximize this sensitivity while also minimizing the invasiveness of the sensor on the overall function of the chord. The design utilizes flexible yet strong 3D printed resin and cantilever arms to improve the strain exerted on a …
3d Printing Of High Viscosity Fluids And Its Application In 3d
Printing Of Prosthetic Teeth.,
2021
University of Texas at El Paso
3d Printing Of High Viscosity Fluids And Its Application In 3d Printing Of Prosthetic Teeth., Abhilash Aditya
Open Access Theses & Dissertations
The advancement in technology has brought forward non-conventional manufacturing methods that are efficient and advantageous for specific applications. 3D printing is one such outcome, whose applications stretch from biomedical applications to daily products. 3D printing is a rapidly growing technology, and innovative research developments have proven versatility in creating physical objects. Simplification and constant improvement in Fused Deposition Modeling (FDM) operation result from decades of research. However, 3D printing is material-specific and contributes to shortcomings in the technology. The build-material dictates the extrusion parameters, including the material discharge rate and head speed for a continuous flow. Customization being the prime …
Engineering Cardiac Tissues With Three-Dimensional Bioprinting For Biomedical Applications,
2021
University of Texas at El Paso
Engineering Cardiac Tissues With Three-Dimensional Bioprinting For Biomedical Applications, Matthew Alonzo
Open Access Theses & Dissertations
The role of a biomedical engineer is to solve unmet health-related needs that face society. For the past couple of decades, heart disease (HD) has remained the leading cause of mortality and morbidity worldwide. The disease is characterized by various pathologies that affect the heart. Indeed, malfunction of one of the bodyâ??s most vital organs is bound to manifest poor health and even death in patients. Despite advances in medicine and technology, heart disease continues to be prevalent and diminishes the quality of life for many around the world. Certainly, there exists a need for developing new tools to better …
Evaluation Of The Cytotoxyc Effects Of Lmdf5-7 On A Human T-Cell Leukemia Cell Line,
2021
University of Texas at El Paso
Evaluation Of The Cytotoxyc Effects Of Lmdf5-7 On A Human T-Cell Leukemia Cell Line, Andrea F. Ibarra Chacon
Open Access Theses & Dissertations
According to World Health Organization (WHO), cancer is the second leading cause of death worldwide, with 9.6 million deaths in 2018 . In the United States, an estimated 434,982 people were living with cancer during 2017 . Leukemia is the most common blood cancer in children from birth to 14 years old . In particular, Hispanic children in the United States experience a higher incidence rate of leukemia . Therefore, the discovery of novel cancer therapies is necessary to help those affected survive the disease. A new compound, LMDF5-7 was investigated and found to have anticancer properties that can help …
Husky Hand: A Low-Cost Electro-Mechanical Prosthetic Arm For The Underprivileged,
2021
University of Southern Maine
Husky Hand: A Low-Cost Electro-Mechanical Prosthetic Arm For The Underprivileged, Adam Robert
Thinking Matters Symposium
A continuation of a low-cost prosthetic upper limb prototype design which was investigated in EGN 301. The prosthetic is specifically designed for the needs and requirements of under privileged individuals in the Dominican Republic with upper limb amputations. The project focuses on the creation of an open-source computer aided prosthetic hand/arm model. The design allows consumer-grade fused filament fabrication (FFF) 3-D printers to be used. The improved design allows for the integration of the PQ-12 linear actuator for grasp and finger control. This simplifies the assembly, while, also reducing the size and mass of the whole unit. Producing a low-cost …
Role Of Ahr Ligands In Immune Modulation To Suppress Inflammation Through The Regulation Of Microrna And Gut Microbiome,
2021
University of South Carolina
Role Of Ahr Ligands In Immune Modulation To Suppress Inflammation Through The Regulation Of Microrna And Gut Microbiome, Osama Azeldeen Abdulla
Theses and Dissertations
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and an environmental sensor that is highly conserved evolutionarily. It was first discovered in the early 1970s for its ability to bind with high affinity to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), an environmental pollutant and induce a xenobiotic-metabolizing enzyme known as aryl hydrocarbon hydroxylase (AHH). AhR was shown to regulate TCDD-mediated toxicity against a variety of tissues including the immune system. More recently, AhR has been characterized as key regulator of the immune system, specifically the differentiation of T cells. Also, several AhR ligands have been characterized in addition to TCDD such as …
Correlating The Effect Of Dynamic Variability In The Sensor Environment On Sensor Design,
2021
Florida International University
Correlating The Effect Of Dynamic Variability In The Sensor Environment On Sensor Design, Pulak Bhushan
FIU Electronic Theses and Dissertations
This dissertation studies the effect of biofluid dynamics on the electrochemical response of a wearable sensor for monitoring of chronic wounds. The research investigates various dynamic in vivo parameters and correlates them with experimentally measured behavior with wound monitoring as a use case. Wearable electrochemical biosensors suffer from several unaddressed challenges, like stability and sensitivity, that need to be resolved for obtaining accurate data. One of the major challenges in the use of these sensors is continuous variation in biofluid composition. Wound healing is a dynamic process with wound composition changing continuously. This dissertation investigates the effects of several in …
Who Will Be Liable For Medical Malpractice In The Future? How The Use Of Artificial Intelligence In Medicine Will Shape Medical Tort Law,
2021
University of Minnesota Law School
Who Will Be Liable For Medical Malpractice In The Future? How The Use Of Artificial Intelligence In Medicine Will Shape Medical Tort Law, Scott J. Schweikart
Minnesota Journal of Law, Science & Technology
No abstract provided.
Biological Semantic Segmentation On Ct Medical Images For Kidney Tumor Detection Using Nnu-Net Framework,
2021
Cal Poly, SLO
Biological Semantic Segmentation On Ct Medical Images For Kidney Tumor Detection Using Nnu-Net Framework, Andres Bergsneider
Master's Theses
Healthcare systems are constantly challenged with bottlenecks due to human-reliant operations, such as analyzing medical images. High precision and repeatability is necessary when performing a diagnostics on patients with tumors. Throughout the years an increasing number of advancements have been made using various machine learning algorithms for the detection of tumors helping to fast track diagnosis and treatment decisions. “Black Box” systems such as the complex deep learning networks discussed in this paper rely heavily on hyperparameter optimization in order to obtain the most ideal performance. This requires a significant time investment in the tuning of such networks to acquire …
The Hsp90 Inhibitor, Auy-922, Protects And Repairs Human Lung Microvascular Endothelial Cells From Hydrochloric Acid-Induced Endothelial Barrier Dysfunction,
2021
Old Dominion University
The Hsp90 Inhibitor, Auy-922, Protects And Repairs Human Lung Microvascular Endothelial Cells From Hydrochloric Acid-Induced Endothelial Barrier Dysfunction, Ruben M.L. Colunga Biancatelli, Pavel Solopov, Betsy Gregory, John D. Catravas
Bioelectrics Publications
Exposure to hydrochloric acid (HCl) leads acutely to asthma-like symptoms, acute respiratory distress syndrome (ARDS), including compromised alveolo-capillary barrier, and respiratory failure. To better understand the direct effects of HCl on pulmonary endothelial function, we studied the characteristics of HCl-induced endothelial barrier dysfunction in primary cultures of human lung microvascular endothelial cells (HLMVEC), defined the involved molecular pathways, and tested the potentially beneficial effects of Heat Shock Protein 90 (HSP90) inhibitors. HCl impaired barrier function in a time- and concentration-dependent manner and was associated with activation of Protein Kinase B (AKT), Ras homolog family member A (RhoA) and myosin light …
The Antitumor Effects Of Plasma-Activated Saline On Muscle-Invasive Bladder Cancer Cells In Vitro And In Vivo Demonstrate Its Feasibility As A Potential Therapeutic Approach,
2021
Old Dominion University
The Antitumor Effects Of Plasma-Activated Saline On Muscle-Invasive Bladder Cancer Cells In Vitro And In Vivo Demonstrate Its Feasibility As A Potential Therapeutic Approach, Hao Zhang, Jishen Zhang, Bo Guo, Hailan Chen, Dehui Xu, Michael G. Kong
Bioelectrics Publications
Muscle-invasive bladder cancer (MIBC) is a fast-growing and aggressive malignant tumor in urinary system. Since chemotherapy and immunotherapy are only useable with a few MIBC patients, the clinical treatment of MIBC still faces challenges. Here, we examined the feasibility of plasma-activated saline (PAS) as a fledgling therapeutic strategy for MIBC treatment. Our data showed that plasma irradiation could generate a variety of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in saline. In vivo tests revealed that pericarcinomatous tissue injection with PAS was effective at preventing subcutaneous bladder tumor growth, with no side effects to the visceral organs after …
Comprehensive Collagen Crosslinking Comparison Of Microfluidic Wet-Extruded Microfibers For Bioactive Surgical Suture Development,
2021
Old Dominion University
Comprehensive Collagen Crosslinking Comparison Of Microfluidic Wet-Extruded Microfibers For Bioactive Surgical Suture Development, Amrita Dasgupta, Nardos Sori, Stella Petrova, Yas Maghdouri-White, Nick Thayer, Nathan Kemper, Seth Polk, Delaney Leathers, Kelly Coughenour, Jake Dascoli, Riya Palikonda, Connor Donahue, Anna A. Bulysheva, Michael P. Francis
Bioelectrics Publications
Collagen microfiber-based constructs have garnered considerable attention for ligament, tendon, and other soft tissue repairs, yet with limited clinical translation due to strength, biocompatibility, scalable manufacturing, and other challenges. Crosslinking collagen fibers improves mechanical properties; however, questions remain regarding optimal crosslinking chemistries, biocompatibility, biodegradation, long-term stability, and potential for biotextile assemble at scale, limiting their clinical usefulness. Here, we assessed over 50 different crosslinking chemistries on microfluidic wet-extruded collagen microfibers made with clinically relevant collagen to optimize collagen fibers as a biotextile yarn for suture or other medical device manufacture. The endogenous collagen crosslinker, glyoxal, provides extraordinary fiber ultimate tensile …
Cardioporation Enhances Myocardial Gene Expression In Rat Heart,
2021
Old Dominion University
Cardioporation Enhances Myocardial Gene Expression In Rat Heart, Carly Boye, Sezgi Arpag, Nina Burcus, Cathryn Lundberg, Scott Declemente, Richard Heller, Michael Francis, Anna Bulysheva
Bioelectrics Publications
Damage from myocardial infarction (MI) and subsequent heart failure are serious public health concerns. Current clinical treatments and therapies to treat MI damage largely do not address the regeneration of cardiomyocytes. In a previous study, we established that it is possible to promote regeneration of cardiac muscle with vascular endothelial growth factor B gene delivery directly to the ischemic myocardium. In the current study we aim to optimize cardioporation parameters to increase expression efficiency by varying electrode configuration, applied voltage, pulse length, and plasmid vector size. By using a surface monopolar electrode, optimized pulsing conditions and reducing vector size, we …
Four Channel 6.5 Kv, 65 A, 100 Ns-100 Μs Generator With Advanced Control Of Pulse And Burst Protocols For Biomedical And Biotechnological Applications,
2021
Old Dominion University
Four Channel 6.5 Kv, 65 A, 100 Ns-100 Μs Generator With Advanced Control Of Pulse And Burst Protocols For Biomedical And Biotechnological Applications, Aleh Kandratsyeu, Uladzimir Sabaleuski, Luis Redondo, Andrei G. Pakhomov
Bioelectrics Publications
Pulsed electric fields in the sub-microsecond range are being increasingly used in biomedical and biotechnology applications, where the demand for high-voltage and high-frequency pulse generators with enhanced performance and pulse flexibility is pushing the limits of pulse power solid state technology. In the scope of this article, a new pulsed generator, which includes four independent MOSFET based Marx modulators, operating individually or combined, controlled from a computer user interface, is described. The generator is capable of applying different pulse shapes, from unipolar to bipolar pulses into biological loads, in symmetric and asymmetric modes, with voltages up to 6.5 kV and …
Deep Neural Network Analysis Of Pathology Images With Integrated Molecular Data For Enhanced Glioma Classification And Grading,
2021
Old Dominion University
Deep Neural Network Analysis Of Pathology Images With Integrated Molecular Data For Enhanced Glioma Classification And Grading, Linmin Pei, Karra A. Jones, Zeina A. Shboul, James Y. Chen, Khan M. Iftekharuddin
Electrical & Computer Engineering Faculty Publications
Gliomas are primary brain tumors that originate from glial cells. Classification and grading of these tumors is critical to prognosis and treatment planning. The current criteria for glioma classification in central nervous system (CNS) was introduced by World Health Organization (WHO) in 2016. This criteria for glioma classification requires the integration of histology with genomics. In 2017, the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy (cIMPACT-NOW) was established to provide up-to-date recommendations for CNS tumor classification, which in turn the WHO is expected to adopt in its upcoming edition. In this work, we propose a novel …
Low-Temperature Gas Plasma Combined With Antibiotics For The Reduction Of Methicillin-Resistant Staphylococcus Aureus Biofilm Both In Vitro And In Vivo,
2021
Old Dominion University
Low-Temperature Gas Plasma Combined With Antibiotics For The Reduction Of Methicillin-Resistant Staphylococcus Aureus Biofilm Both In Vitro And In Vivo, Li Guo, Lu Yang, Yu Qi, Gulimire Niyazi, Jianbao Zheng, Ruobing Xu, Xusong Chen, Jingye Zhang, Wang Xi, Dingxin Liu, Xiaohua Wang, Hailan Chen, Michael G. Kong
Electrical & Computer Engineering Faculty Publications
Biofilm infections in wounds seriously delay the healing process, and methicillin-resistant Staphylococcus aureus is a major cause of wound infections. In addition to inactivating micro-organisms, low-temperature gas plasma can restore the sensitivity of pathogenic microbes to antibiotics. However, the combined treatment has not been applied to infectious diseases. In this study, low-temperature gas plasma treatment promoted the effects of different antibiotics on the reduction of S. aureus biofilms in vitro. Low-temperature gas plasma combined with rifampicin also effectively reduced the S. aureus cells in biofilms in the murine wound infection model. The blood and histochemical analysis demonstrated the biosafety of …
Plasma-Treated Solutions (Pts) In Cancer Therapy,
2021
Old Dominion University
Plasma-Treated Solutions (Pts) In Cancer Therapy, Hiromasa Tanaka, Sander Bekeschus, Dayun Yan, Masaru Hori, Michael Keidar, Mounir Laroussi
Electrical & Computer Engineering Faculty Publications
Cold physical plasma is a partially ionized gas generating various reactive oxygen and nitrogen species (ROS/RNS) simultaneously. ROS/RNS have therapeutic effects when applied to cells and tissues either directly from the plasma or via exposure to solutions that have been treated beforehand using plasma processes. This review addresses the challenges and opportunities of plasma-treated solutions (PTSs) for cancer treatment. These PTSs include plasma-treated cell culture media in experimental research as well as clinically approved solutions such as saline and Ringer’s lactate, which, in principle, already qualify for testing in therapeutic settings. Several types of cancers were found to succumb to …
Joint Modeling Of Rnaseq And Radiomics Data For Glioma Molecular Characterization And Prediction,
2021
Old Dominion University
Joint Modeling Of Rnaseq And Radiomics Data For Glioma Molecular Characterization And Prediction, Zeina A. Shboul, Norou Diawara, Arastoo Vossough, James Y. Chen, Khan M. Iftekharuddin
Electrical & Computer Engineering Faculty Publications
RNA sequencing (RNAseq) is a recent technology that profiles gene expression by measuring the relative frequency of the RNAseq reads. RNAseq read counts data is increasingly used in oncologic care and while radiology features (radiomics) have also been gaining utility in radiology practice such as disease diagnosis, monitoring, and treatment planning. However, contemporary literature lacks appropriate RNA-radiomics (henceforth, radiogenomics) joint modeling where RNAseq distribution is adaptive and also preserves the nature of RNAseq read counts data for glioma grading and prediction. The Negative Binomial (NB) distribution may be useful to model RNAseq read counts data that addresses potential shortcomings. …
Design Of A 10 Mev Beamline At The Upgraded Injector Test Facility For E-Beam Irradiation,
2021
Old Dominion University
Design Of A 10 Mev Beamline At The Upgraded Injector Test Facility For E-Beam Irradiation, Xi Li, Helmut Baumgart, Gianluigi Ciovati, F.E. Hannon, S. Wang
Electrical & Computer Engineering Faculty Publications
Electron beam irradiation near 10 MeV is suitable for wastewater treatment. The Upgraded Injector Test Facility (UITF) at Jefferson Lab is a CW superconducting linear accelerator capable of providing an electron beam of energy up to 10 MeV and up to 100 µA current. This contribution presents the beam transport simulations for a beamline to be used for the irradiation of wastewater samples at the UITF. The simulations were done using the code General Particle Tracer with the goal of obtaining an 8 MeV electron beam of radius (3-σ) of ~2.4 cm. The achieved energy spread is ~74.5 keV. The …
The Resistive Barrier Discharge: A Brief Review Of The Device And Its Biomedical Applications,
2021
Old Dominion University
The Resistive Barrier Discharge: A Brief Review Of The Device And Its Biomedical Applications, Mounir Laroussi
Electrical & Computer Engineering Faculty Publications
This paper reviews the principles behind the design and operation of the resistive barrier discharge, a low temperature plasma source that operates at atmospheric pressure. One of the advantages of this plasma source is that it can be operated using either DC or AC high voltages. Plasma generated by the resistive barrier discharge has been used to efficiently inactivate pathogenic microorganisms and to destroy cancer cells. These biomedical applications of low temperature plasma are of great interest because in recent times bacteria developed increased resistance to antibiotics and because present cancer therapies often are accompanied by serious side effects. Low …
