การวิเคราะห์ผลกระทบทางชีวกลศาสตร์ของการใช้เครื่องมือผูกในการผ่าตัดเชื่อมข้อกระดูกสันหลังแบบสั้นด้วยวิธีการทางไฟไนต์เอลิเมนต์,
2024
คณะวิศวกรรมศาสตร์
การวิเคราะห์ผลกระทบทางชีวกลศาสตร์ของการใช้เครื่องมือผูกในการผ่าตัดเชื่อมข้อกระดูกสันหลังแบบสั้นด้วยวิธีการทางไฟไนต์เอลิเมนต์, ณัฐภัทร วิริยะ
Chulalongkorn University Theses and Dissertations (Chula ETD)
งานวิจัยนี้มุ่งเน้นการทดสอบผลกระทบของการใช้อุปกรณ์ผูกมัดที่มีการปรับแต่งแต่ละรูปแบบต่อการผ่าตัดเชื่อมข้อแบบสั้นบริเวณกระดูกสันหลังส่วนเอวด้วยวิธีการทางไฟไนต์เอลิเมนต์ โดยจำลองลักษณะของกระดูกสันหลังส่วนเอวตั้งข้อ L1-L5 ของมนุษย์ และจำลองลักษณะการผ่าตัดด้วยวิธีการเชื่อมข้อผ่านลักษณะการผ่าตัดแบบ Posterior lumbar interbody fusion หรือ PLIF และ Posterolateral lumbar fusion หรือ PLF ซึ่งเป็นเทคนิคการผ่าตัดที่ได้รับความนิยมในการรักษาในปัจจุบัน ซึ่งจะเปรียบผ่านการใส่และไม่ใส่อุปกรณ์ผูกมัดรูปแบบใหม่นี้ ผลการวิจัยนำเสนอผ่านปัจจัยทางชีวกลศาสตร์ที่สำคัญได้แก่ ความสามารถในการเคลื่อนไหว (Range of motion, ROM), ความดันภายในหมอนรองกระดูกสันหลัง (Intradiscal pressure, IDP) และ แรงที่กระทำบนข้อต่อ Facet (Facet joints force, FJF) ซึ่งสูงขึ้นเมื่อผ่านการผ่าตัดด้วยวิธีการดังกล่าว ผ่านการปรับแต่งของตำแหน่งการตรึง, แรงตรึงตั้งต้น และ ลักษณะการตรึง จากผลการวิจัยพบว่าการใช้อุปกรณ์ผูกมัดดังกล่าวประกอบกับการผ่าตัดทั้ง 2 รูปแบบสามารถลดผลกระทบทางชีวกลศาสตร์ได้มากกว่าการผ่าตัดแบบไม่ใช้อุปกรณ์ควบคู่ ซึ่งให้ผลที่แตกต่างกันตามแต่ลักษณะการปรับแต่งของอุปกรณ์ดังกล่าว ซึ่งการค้นพบดังกล่าวสามารถต่อยอดและสร้างความเข้าใจมากขึ้นถึงปัจจัยหรือผลกระทบการใช้อุปกรณ์ผูกมัดประกอบกับการผ่าตัดเชื่อมข้อของกระดูกสันหลังเพื่อประโยชน์สูงสุดของการผ่าตัดและการรักษาให้มีประสิทธิภาพ
การพัฒนาท่อถ่างขยายทางเดินอาหารชนิดย่อยสลายได้ที่เคลือบผิวด้วยโปรตีนไฟโบรอินไหม,
2024
คณะวิศวกรรมศาสตร์
การพัฒนาท่อถ่างขยายทางเดินอาหารชนิดย่อยสลายได้ที่เคลือบผิวด้วยโปรตีนไฟโบรอินไหม, ธันยพร ฉันทโรจน์ศิริ
Chulalongkorn University Theses and Dissertations (Chula ETD)
งานวิจัยนี้มีจุดมุ่งหมายในการพัฒนาท่อขยายหลอดอาหารชนิดย่อยสลายได้จากวัสดุ polydioxanone (PDO) ให้มีการย่อยสลายช้าลง โดยทำการขึ้นรูปด้วยเทคนิคการถักทอแบบ Hook cross เพื่อให้ได้ท่อถ่างขยายที่มีสมบัติเชิงกลเหมาะสมสำหรับการใช้ในทางเดินอาหาร ทำการศึกษาการบำบัดด้วยพลาสม่าเพื่อเปลี่ยนแปลงโครงสร้างพื้นผิว ทดสอบสมบัติเชิงกลของท่อถ่างขยายที่ขึ้นรูปด้วยโครงสร้างที่ต่างกัน การเคลือบโปรตีนไฟโบรอินลงบนเส้นไหม PDO และทดสอบอัตราการย่อยสลายของท่อถ่างขยายทางเดินอาหารที่เคลือบผิวด้วยโปรตีนไฟโบรอิน การศึกษานี้พบว่า มีการเพิ่มขึ้นของแรงขยายออกด้านข้างของท่อถ่างขยายเมื่อมีการเพิ่มความหนาแน่นของการถัก แต่เมื่อเพิ่มความหนาแน่นของการถักมากขึ้นจะทำให้แรงขยายลดลง และการขึ้นรูปแบบ Hook cross จะสามารถปรับรูปร่างของท่อถ่างขยายขึ้นกับรอยตีบได้ดีกว่าวิธีถักแบบ braided การบำบัดด้วยพลาสมานั้นถึงแม้จะช่วยเปลี่ยนแปลงสมบัติพื้นผิวของเส้นไหม PDO แต่ไม่ได้ช่วยเรื่องการเคลือบโปรตีนไฟโบรอิน การที่จะเคลือบโปรตีนไฟโบรอินลงบนท่อถ่างขยาย PDO ต้องใช้วิธีการเคลือบโดยใช้ไนโตรเจนเหลวและเอธานอล เมื่อผ่านการเคลือบด้วยโปรตีนไฟโบรอินแล้ว เส้นไหม PDO มีการเปลี่ยนแปลงสมบัติพื้นผิวทั้งในด้านโมเลกุลพื้นผิวและความชอบน้ำ และท่อถ่างขยายทางเดินอาหาร PDO ที่ผ่านการเคลือบด้วยโปรตีนไฟโบรอินมีการย่อยสลายช้ากว่าท่อถ่างขยายทางเดินอาหารที่ไม่ได้เคลือบด้วยโปรตีนไฟโบรอิน 4 สัปดาห์ และมีการละลายของโปรตีนไฟโบรอินออกมาอย่างรวดเร็วใน 4-8 สัปดาห์แรก และได้ทดสอบการใส่ท่อถ่างขยายทางเดินอาหาร PDO ในลำไส้สุกร ซึ่งพบว่าการเคลือบโปรตีนไฟโบรอินอาจทำให้การกางของท่อถ่างขยายนั้นน้อยกว่าแบบที่ไม่ได้ผ่านการเคลือบ ซึ่งจะสามารถนำไปพัฒนาใช้ในทางคลินิกได้ต่อไป
Development Of Spinal Tethering Device For Posterior Lumbar Interbody Fusion: A Finite Element Study,
2024
Faculty of Engineering
Development Of Spinal Tethering Device For Posterior Lumbar Interbody Fusion: A Finite Element Study, Nuttawut Janwimaluang
Chulalongkorn University Theses and Dissertations (Chula ETD)
Adjacent Segment Disease (ASDis) is the complication occurring after Posterior Lumbar Interbody Fusion (PLIF) surgery due to increased mechanical stress at adjacent unfused segments. Tethering techniques have been studied to mitigate the risk of ASDis by adjusting the spinal load distribution. This study investigates the biomechanical effects of tethering with Finite Element Analysis (FEA), using a validated L1-L5 spine finite element model focusing on Intervertebral Disc (IVD) pressure and Range of Motion (ROM). The model was applied in four movement directions (Flexion, Extension, Lateral bending, Axial rotation) with tethering applied at the spinous process under two pretension forces (25 N …
Non-Invasive Monitoring Device For Early Detection Of Breast Cancer Related Lymphedema,
2024
University of New Hampshire
Non-Invasive Monitoring Device For Early Detection Of Breast Cancer Related Lymphedema, Amy Prendergast
Honors Theses and Capstones
Breast Cancer Related Lymphedema (BCRL) is a common co-morbidity in cancer survivors following neoadjuvant therapies such as chemotherapy, radiation, and/or surgery. It is brought about by the disruption in the lymphatic system (think lymph node biopsy) that leads to a buildup of lymphatic fluid in the arm. Current diagnostic strategies for this condition are merely retroactive, and fairly limited in the parameters that are examined to ensure patient well-being long term. We hypothesize that with an approach that mimics bioimpedance spectroscopy analysis, we will be able to provide a clinical support tool that would better determine early stages of lymphedema …
Advancements And Challenges In Additively Manufactured Functionally Graded Materials: A Comprehensive Review,
2024
Old Dominion University
Advancements And Challenges In Additively Manufactured Functionally Graded Materials: A Comprehensive Review, Suhas Alkunte, Ismail Fidan, Vivekanand Naikwadi, Shamil Gudavasov, Mohammad Alshaikh Ali, Mushfig Mahmudov, Seymur Hasanov, Muralimohan Cheepu
Engineering Technology Faculty Publications
This paper thoroughly examines the advancements and challenges in the field of additively manufactured Functionally Graded Materials (FGMs). It delves into conceptual approaches for FGM design, various manufacturing techniques, and the materials employed in their fabrication using additive manufacturing (AM) technologies. This paper explores the applications of FGMs in diverse fields, including structural engineering, automotive, biomedical engineering, soft robotics, electronics, 4D printing, and metamaterials. Critical issues and challenges associated with FGMs are meticulously analyzed, addressing concerns related to production and performance. Moreover, this paper forecasts future trends in FGM development, highlighting potential impacts on diverse industries. The concluding section summarizes …
Compton Scattering Of Mammographic Soft X-Ray Beams By Alkali And Transition Metal Salt Filters Produce X-Ray Interference Zones That May Have Treatment Potential For Localized Cancer Lesions,
2024
CUNY New York City College of Technology
Compton Scattering Of Mammographic Soft X-Ray Beams By Alkali And Transition Metal Salt Filters Produce X-Ray Interference Zones That May Have Treatment Potential For Localized Cancer Lesions, Subhendra N. Sarkar, Eric Lobel, Sabina Rakhmatova, Derbie Desir, Somdat Kissoon, Daler Djuraev, Katie Tam
Publications and Research
In breast x-ray imaging scattered radiation adds 50% of harmful radiation dose from anisotropic Compton scattering mechanism. We have been working with double layered inorganic salt materials that can induce Compton scattering to the incident mammographic x ray beams (in 20-30 kVp range) with adequate isotropy (angular control). Typically metal nitrates and alkali halide salt layers are shown here to cause low energy radiation interference zones with high and low photon intensities and local flux heterogeneity in terms of flux covariance. Spatial variation of low energy photon flux creates concentrated and sparse radiation zones that may be used to induce …
Fluid Dynamics And Leukocyte Transit In The Lymphatic System,
2024
Guillin University of Electronic Technology
Fluid Dynamics And Leukocyte Transit In The Lymphatic System, Huabing Li, Jingjing Zhang, Timothy Padera, James W. Baish, Lance Munn
Faculty Journal Articles
The lymphatic system plays a vital role in maintaining fluid balance in living tissue and serves as a pathway for the transport of antigen, immune cells, and metastatic cancer cells. In this study, we investigate how the movement of cells through a contracting lymphatic vessel differs from steady flow, using a lattice Boltzmann-based computational model. Our model consists of cells carried by flow in a 2D vessel with regularly spaced, bi-leaflet valves that ensure net downstream flow as the vessel walls contract autonomously in response to calcium and nitric oxide levels regulated by stretch and shear stress levels. The orientation …
Development Of A Two-Finger Haptic Robotic Hand With Novel Stiffness Detection And Impedance Control,
2024
University of Nebraska
Development Of A Two-Finger Haptic Robotic Hand With Novel Stiffness Detection And Impedance Control, Vahid Mohammadi, Ramin Shahbad, Mojtaba Hosseini, Mohammad Hossein Gholampour, Saeed Shiry Ghidary, Farshid Najafi, Ahad Behboodi
Mechanical & Aerospace Engineering Faculty Publications
Haptic hands and grippers, designed to enable skillful object manipulation, are pivotal for high-precision interaction with environments. These technologies are particularly vital in fields such as minimally invasive surgery, where they enhance surgical accuracy and tactile feedback: in the development of advanced prosthetic limbs, offering users improved functionality and a more natural sense of touch, and within industrial automation and manufacturing, they contribute to more efficient, safe, and flexible production processes. This paper presents the development of a two-finger robotic hand that employs simple yet precise strategies to manipulate objects without damaging or dropping them. Our innovative approach fused force-sensitive …
Identification And Characterization Of Two Novel Kcnh2 Mutations Contributing To Long Qt Syndrome,
2024
Old Dominion University
Identification And Characterization Of Two Novel Kcnh2 Mutations Contributing To Long Qt Syndrome, Anthony Owusu-Mensah, Jacqueline Treat, Joyce Bernardi, Ryan Pfeiffer, Robert Goodrow, Bright Tsevi, Victoria Lam, Michel Audette, Jonathan M. Cordeiro, Makarand Deo
Electrical & Computer Engineering Faculty Publications
We identified two different inherited mutations in KCNH2 gene, or human ether-a-go-go related gene (hERG), which are linked to Long QT Syndrome. The first mutation was in a 1-day-old infant, whereas the second was in a 14-year-old girl. The two KCNH2 mutations were transiently transfected into either human embryonic kidney (HEK) cells or human induced pluripotent stem-cell derived cardiomyocytes. We performed associated multiscale computer simulations to elucidate the arrhythmogenic potentials of the KCNH2 mutations. Genetic screening of the first and second index patients revealed a heterozygous missense mutation in KCNH2, resulting in an amino acid change (P632L) in the …
Domain Adaptive Federated Learning For Multi-Institution Molecular Mutation Prediction And Bias Identification,
2024
Old Dominion University
Domain Adaptive Federated Learning For Multi-Institution Molecular Mutation Prediction And Bias Identification, W. Farzana, M. A. Witherow, I. Longoria, M. S. Sadique, A. Temtam, K. M. Iftekharuddin
Electrical & Computer Engineering Faculty Publications
Deep learning models have shown potential in medical image analysis tasks. However, training a generalized deep learning model requires huge amounts of patient data that is usually gathered from multiple institutions which may raise privacy concerns. Federated learning (FL) provides an alternative to sharing data across institutions. Nonetheless, FL is susceptible to a few challenges including inversion attacks on model weights, heterogenous data distributions, and bias. This study addresses heterogeneity and bias issues for multi-institution patient data by proposing domain adaptive FL modeling using several radiomics (volume, fractal, texture) features for O6-methylguanine-DNA methyltransferase (MGMT) classification across multiple institutions. The proposed …
Estimation Of Differential Pathlength Factor From Nirs Measurement In Skeletal Muscle,
2024
Old Dominion University
Estimation Of Differential Pathlength Factor From Nirs Measurement In Skeletal Muscle, B. Koirala, A. Concas, A. Cincotti, Yi Sun, A. Hernández, M. L. Goodwin, L. B. Gladden, N. Lai
Electrical & Computer Engineering Faculty Publications
The utilization of continuous wave (CW) near-infrared spectroscopy (NIRS) device to measure non-invasively muscle oxygenation in healthy and disease states is limited by the uncertainties related to the differential path length factor (DPF). DPF value is required to quantify oxygenated and deoxygenated heme groups' concentration changes from measurement of optical densities by NIRS. An integrated approach that combines animal and computational models of oxygen transport and utilization was used to estimate the DPF value in situ. The canine model of muscle oxidative metabolism allowed measurement of both venous oxygen content and tissue oxygenation by CW NIRS under different oxygen delivery …
Wavelet-Based Harmonization Of Local And Global Model Shifts In Federated Learning For Histopathological Images,
2024
Old Dominion University
Wavelet-Based Harmonization Of Local And Global Model Shifts In Federated Learning For Histopathological Images, W. Farzana, A. Temtam, K. M. Iftekharuddin
Electrical & Computer Engineering Faculty Publications
Federated Learning (FL) is a promising machine learning approach for development of data-driven global model using collaborative local models across multiple local institutions. However, the heterogeneity of medical imaging data is one of the challenges within FL. This heterogeneity is caused by the variation in imaging scanner protocols across institutions, which may result in weight shift among local models leading to deterioration in predictive accuracy of global model. The prevailing approaches involve applying different FL averaging techniques to enhance the performance of the global model, ignoring the distinct imaging features of the local domain. In this work, we address both …
Investigation Of The Effect Of Preparation Parameters On The Structural And Mechanical Properties Of Gelatin/Elastin/Sodium Hyaluronate Scaffolds Fabricated By The Combined Foaming And Freeze-Drying Techniques,
2024
Marquette University
Investigation Of The Effect Of Preparation Parameters On The Structural And Mechanical Properties Of Gelatin/Elastin/Sodium Hyaluronate Scaffolds Fabricated By The Combined Foaming And Freeze-Drying Techniques, Mansour Qamash, S. Misagh Imani, Meisam Omidi, Ciara Glancy, Lobat Tayebi
Electrical & Computer Engineering Faculty Publications
This paper aimed to evaluate the effects of different preparation parameters, including agitation speed, agitation time, and chilling temperature, on the structural and mechanical properties of a novel gelatin/elastin/sodium hyaluronate tissue engineering scaffold, recently developed by our research group. Fabricated using a combination of foaming and freeze-drying techniques, the scaffolds were assessed to understand how these parameters influence their morphology, internal microstructure, porosity, mechanical properties, and degradation behavior. The fabrication process used in this study involved preparing a homogeneous aqueous solution containing 8% gelatin, 2% elastin, and 0.5% sodium hyaluronate (w/v), which was then subjected to mechanical agitation at speeds …
Advancing Chronic Kidney Disease Prediction Through Machine Learning And Deep Learning With Feature Analysis,
2024
CSE Leading University
Advancing Chronic Kidney Disease Prediction Through Machine Learning And Deep Learning With Feature Analysis, Shiddarth Dey Tusar, S. M. Ahad Ali Chowdhury, Md. Jalal Uddin Chowdhury, Rana M. Pir, H. M. Nur A. Alam, Muhammad Rezaur Rahman, Md. Nural Absar Siddiky, Muhammad Enayetur Rahman
Electrical & Computer Engineering Faculty Publications
Chronic Kidney Diesease (CKD) is a significant health issue, ranking as the fourth leading cause of mortality worldwide. The traditional diagnosis and treatment process, reliant on medical experts, is time-consuming. Therefore, thereis an urgent need for more efficient diagnostic methods to improve patient outcomes and reduce mortality rates. In this study, we employ Machine Learning (ML) and Deep Learning (DL) techniques to predict CKD based on important features. Feature analysis was performed using a correlation matrix and the LASSO algo-rithm to identify the most relevant features for model training. We evaluated several ML and DL classifiers, including Logistic Regression (LR), …
Polarizable Amoeba Force Field Predicts Thin And Dense Hydration Layer Around Monosaccharides,
2024
Virginia Tech
Polarizable Amoeba Force Field Predicts Thin And Dense Hydration Layer Around Monosaccharides, Luke A. Newman, Mackenzie G. Patton, Breyanna A. Rodriguez, Ethan W. Summer, Valerie Vaissier Welbourn
Chemistry & Biochemistry Faculty Publications
Polarizable force fields crucially enhance the modeling of macromolecules in polar media. Here, we present new parameters to model six common monosaccharides with the polarizable AMOEBA force field. These parameters yield a thinner, but denser, hydration layer than that previously reported. This denser hydration layer results in eliminating non-physical aggregation of glucose in water-an issue that has plagued molecular dynamics simulations of carbohydrates for decades.
Borophene And Graphene For Non-Enzymatic Biosensor- Ab-Initio Study,
2023
American University in Cairo
Borophene And Graphene For Non-Enzymatic Biosensor- Ab-Initio Study, Omar A. Ismail
Theses and Dissertations
Non-enzymatic glucose sensing holds promise to overcome limitations associated with glucose oxidase, such as oxygen dependence and short shelf life. This study explores the potential sensing capabilities of borophene and graphene through direct interaction with various compounds, including β-glucose, uric acid, ascorbic acid, fructose, and acetaminophen. Using Density Functional Theory (DFT), we calculated binding energies and the respective Density of States (DOS) for these adsorbates on both graphene and borophene surfaces. Preliminary results suggest that borophene might exhibit nearly twice the affinity for β-glucose compared to graphene. Moreover, the calculated Density of States reveals distinct distortions in the electronic states …
The Interaction Of The Cotton Piece With The Piles Of The Scrabble Cotton Drum,
2023
Jizzakh Polytechnic Institute, Jizzakh city, Republic of Uzbekistan
The Interaction Of The Cotton Piece With The Piles Of The Scrabble Cotton Drum, Fazliddin Egamberdiev, Ilkhom Abbazov, Oybek Kholmuratov, Rashid Kaldybaev
Technical science and innovation
This article presents the results of an analytical study of the process of loosening and cleaning raw cotton from small debris by pileging working bodies of purifiers, on the basis of which directions for further research were chosen to optimize the parameters of the developed pile drum with spherical piles and rubber strips. Cotton entering production contains impurities. The processes of loosening and cleaning the fiber shreds are key in the initial stages of ginning, as they prepare the raw cotton for ginning and directly affect the reliability, productivity of these processes and the quality of the resulting fiber. Weed …
Adaptation Algorithm For Self-Tuning Of Parameters Of Models Of Multi-Stage Flotation Processes,
2023
Turin Polytechnic University, Tashkent city, Republic of Uzbekistan;
Adaptation Algorithm For Self-Tuning Of Parameters Of Models Of Multi-Stage Flotation Processes, Nilufar Sharifzhanova, Maksadhan Yakubov, Francesco Gregoretti
Technical science and innovation
Modern methods for solving problems of planning the execution of batches of tasks in multi-stage systems are characterized by the presence of restrictions on their dimensionality, the impossibility of guaranteed obtaining better results in comparison with fixed packages for different values of the input parameters of the problem. In the article, the author solved the problem of optimizing the composition of job packages running in multi-stage systems using the branch and bound method. Research has been carried out on various ways to form package execution orders tasks in multi-stage systems (heuristic rules for ordering packages tasks in the sequence of …
An Experimental Investigation Of The New Vibration Viscometer,
2023
Tashkent State Technical University, Tashkent city, Republic of Uzbekistan
An Experimental Investigation Of The New Vibration Viscometer, Jamshidbek Ulugbek Ugli Shamuratov
Technical science and innovation
The characteristics of the new oscillating-plate viscometer have been investigated experimentally. The results obtained are as follows: the resonant frequency of plate oscillation decreases with increasing viscosity; the apparatus constant 𝐾 determined experimentally includes the end and slip effects; the dimensions of the plate should be determined by referring to empirical relations between 𝜌𝜇 and Λ(≡{(𝐸𝑎𝐸)−1}𝑛) for various dimensions of the plate; where 𝜌 is the density, 𝜇 is the viscosity; 𝐸𝑎 the resonant amplitude of plate in the air; E the amplitude of plate in a liquid, and 𝑛 a constant. If the distance between the plate and the …
Indicators Affecting Passenger Service Processes And Their Scientific Interpretation,
2023
Tashkent State Transport University, Tashkent city, Republic of Uzbekistan)
Indicators Affecting Passenger Service Processes And Their Scientific Interpretation, Maxliyoxon Madaminova Maxamatjon Qizi, Saidazim Amanullayevich Ganihodjayev
Technical science and innovation
Many traffic flow parameters affect the performance of the road network at high voltage. These are low vehicle speeds, high vehicle distances relative to road capacity, and density per unit time (lane occupancy). In turn, a number of factors affect the decrease in traffic speed: the presence of slow-moving vehicles in the stream; pedestrians crossing the road irregularly; increase in traffic flow, etc. The issues of public transportation depend on many factors, each of which requires a separate approach and a complex solution. In large cities around the world, the quality indicators of public transport services, including the issues of …
