Biomedical Engineering and Bioengineering Commons^™

Ferroresonance In Three-Phase Electrical Networks, Shavkat Ernstovich Begmatov

Technical science and innovation

Possible modes of ferroresonance in three-phase electric networks and analysis of substitution schemes where ferroresonance voltage increase is observed are considered. The most complete magnetization curve of the transformer core and the analysis of the generalized equivalent substitution scheme are presented, as a result of which more accurate formulas for determining the values of equivalent parameters of the electrical network and voltage transformer in ferroresonance mode are obtained. Factor of ferroresonance voltage increase is introduced, which determines ratio between amplitude values of transformer phase voltage and mains voltage. The method of determination of boundary conditions of steady ferroresonance voltage increase …

Main Prospects Of Natural Gas Purification Technologies From Acidic Compounds, Oybek Yusupdjanovich Aripdjanov, Diyora Zokhid Qizi Khayrullaeva, Jonibek Avazek Ogli Abdumuminov

Technical science and innovation

The article discusses the main prospects for the technology of purifying natural gas from acidic components and the problems of ensuring the purity of oil and gas products in accordance with state standards. An increase in the degree of purification from H₂S, CO₂, elemental sulfur, carbonyl sulfide, ethyl mercaptans (thiols), methyl mercaptan, carbon disulfide, sulfides, disulfides (dithioethers), thiophene, sulfoxides and sulfones is considered. Also, the physicochemical properties of the absorbent for the purification of sulfur compounds (generated during natural gas processing) are studied. Based on the study of various absorbents (ethanolamine (EA), methylethanolamine (MEA), diethanolamine (DEA), …

Tunable Dual-Phase Dual-Drug Delivery System Using A Plga Microparticle/Pva Hydrogel Composite, Timothy John Eck

Theses and Dissertations

Current drug-eluting coatings have demonstrated controlled long-term, sustained release but have only tried to mitigate short-term burst release as a negative side effect. For applications like wound healing, there is a need for a drug-eluting coating which is adjustable in both short- and long-term release, independent of each other. We present a tunable dual-phase dual-drug delivery coating composed of drug-loaded polymer microparticles and drug-loaded hydrogel which can control short term and long term release individually in this study. This coating was created using lidocaine and dexamethasone encapsulated in poly(D,L-lactide-co-glycolide) particles combined with lidocaine- and dexamethasone-loaded poly(vinyl alcohol) hydrogel. Hydrogel drug …

Spatial Correspondence Of Cortical Activity Measured With Whole Head Fnirs And Fmri Toward Clinical Use Within Subject, Anthony Zinos, Julie C. Wagner, Scott A. Beardsley, Wei-Liang Chen, Lisa Conant, Marsha Malloy, Joseph Heffernan, Brendan Quirk, Robert W. Prost, Mohit Maheshwari, Jeffrey Sugar, Harry T. Whelan

Biomedical Engineering Faculty Research and Publications

Functional near infrared spectroscopy (fNIRS) and functional magnetic resonance imaging (fMRI) both measure the hemodynamic response, and so both imaging modalities are expected to have a strong correspondence in regions of cortex adjacent to the scalp. To assess whether fNIRS can be used clinically in a manner similar to fMRI, 22 healthy adult participants underwent same-day fMRI and whole-head fNIRS testing while they performed separate motor (finger tapping) and visual (flashing checkerboard) tasks. Analyses were conducted within and across subjects for each imaging approach, and regions of significant task-related activity were compared on the cortical surface. The spatial correspondence between …

Development Of Novel Radiotherapy Treatment Monitoring And Quantitative Cherenkov Surface Dosimetry For Diverse Populations, Savannah M. Decker

Dartmouth College Ph.D Dissertations

In the U.S. alone, nearly 2 million people will be diagnosed with cancer annually, and over half of them will receive radiation therapy throughout the course of their care. While widely regarded as safe, radiation therapy presents unique challenges that other procedures, such as surgery, lack. Namely, the invisible nature of the radiation itself makes it impossible to directly visualize treatment. Many immobilization and localization techniques exist to minimize the chance of incorrect radiation dose delivery, yet incidents still occur. Within the last decade, Cherenkov imaging has emerged as a new radiation therapy delivery verification technique. Cherenkov imaging is unique …

Testing Resilience Of Microalgae Biofilms When Exposed To Hydrothermal Liquefaction Aqueous Phase, Davis Haag

Student Research Symposium

Hydrothermal liquefaction (HTL) is a process that transforms wet biomass into a mixture of aqueous phase (AP), biochar solids, biocrude oil, and biogas.

The HTL process is not economically viable on a large scale partially because the HTL-AP is a toxic waste product with no current use.

The HTL-AQ contains high amounts of nitrogen (N) and phosphorus (P), but also environmental toxins such as phenolic compounds. The N and P could potentially be used to grow algae if it can survive the toxins.

Rotating algal biofilm reactors (RABRs) provide a method to grow algae biomass as a biofilm on plastic …

Investigating The Role Of Fluid Shear Stress During Metastasis On Enhanced Breast Cancer Extravasation, Alejandra M. Ham

LSU Master's Theses

In 2022, ~288,000 American women were diagnosed with metastatic breast cancer which was the leading cause of patient mortality with ~43,000 American women succumbing to the disease. Women can be diagnosed with four different molecular subtypes of breast cancer: luminal A, luminal B, human epithelial growth receptor type 2 enriched (HER2+), and triple-negative breast cancer (TNBC). TNBC accounts for ~12% of all breast cancers, yet it has the worst outcomes. TNBC is highly invasive, with ~46% of TNBC patients developing metastatic disease. A further understanding of metastatic TNBC is needed to provide a greater understanding of how to treat this …

Profiling Of Voltage-Gated Sodium Channel Subtype Expression And Resulting Susceptibility To Targeted Osmotic Lysis In Cancer, Spencer Gerard Lemoine

LSU Doctoral Dissertations

Cancer is a disease characterized by a wide array of dysregulated cellular function, activity, and growth. At times, specific dysregulations associated with cancer can be exploited as avenues of potential treatment. The sodium handling mechanisms and their associated proteins in cancer have received closer attention recently closely as such a potential mechanism to exploit for treating advanced cancer. Some novel treatments aim to inhibit the expression or activity of these sodium handling proteins in an attempt to prevent the cancer from advancing or becoming more aggressive; however, such approaches have had limited success. Targeted osmotic lysis (TOL) is a new …

Formulation, Characterization, And In Vivo Immunogenicity Evaluation Of Heat-Stabilized Dissolvable Polymeric Microneedles, Aidan Lane Leyba

Biomedical Engineering ETDs

Since its introduction, vaccination has improved health outcomes tremendously. However, modern vaccination efforts are still difficult to implement, particularly in developing countries with warm climates. This includes complex and expensive cold-chain management of vaccines to maintain stability, a lack of medical personnel to administer parental vaccines, and needle phobia. As an alternative, dissolvable microneedles have recently been studied for their simple and painless application. In this thesis, I present a novel manufacturing process for polymer-based dissolvable microneedles, loaded with virus-like particles vaccines conjugated to TRIO or Sialokinin peptides to target malaria and arboviruses, respectively. We have performed multiple characterization studies …

Use Of Mathematical Skills For Technical Condition Assessment Of Power Autotransformers, Dilafruz Rustamjon Qizi Abdullabekova, Nurali Berdiyorovich Pirmatov

Technical science and innovation

In this paper, we review innovative approaches to assess the technical condition of autotransformers using mathematical methods. The main purpose of these methods is to increase the efficiency of diagnostics and prevent possible failures in power systems. The developed mathematical expression is based on complex data analysis, application of statistical methods and machine learning technologies. This makes it possible to achieve more accurate and earlier detection of potential problems. As a result of these innovative approaches, the possibilities for early detection and prevention of faults are significantly increased. This is important for ensuring the smooth operation of power systems and …

Quantitative Assessment And Characterization Of Tool Wear Phenomena In Advanced Manufacturing Processes, Oybek Valijonovich Tuyboyov

Technical science and innovation

This paper explores the quantitative assessment and characterization of tool wear phenomena in advanced manufacturing processes, employing a multifaceted approach encompassing traditional measurements, image processing, machine learning, and predictive modeling. The study emphasizes the intricate dynamics of tool wear and its direct impact on cutting tool performance, addressing challenges in real-time monitoring and optimization of machining operations. Traditional methods like VBmax measurement are juxtaposed with advanced techniques such as the improved conditional generative adversarial net with a high-quality optimization algorithm (CGAN-HQOA), efficient channel attention destruction and construction learning (ECADCL), and shape descriptors based on contour, moments, orientations, and texture. Artificial …

Implementing A Solar Photovoltaic Station In Watering Systems Utilizing Complex Software, Akbarxon Sarvar O'G'Li Uroqov, Faxriddin Jaylovovich Nosirov, G'Olibjon Pardayevich Arzikulov, Zarina Amriddin Qizi Sayfutdinova

Technical science and innovation

This article explores the benefits of transitioning from traditional agricultural irrigation systems to more cost-effective alternatives powered by renewable energy sources. By integrating solar photovoltaic technology into irrigation processes, significant reductions in resource wastage, estimated at 45-50%, are achievable through the implementation of drip irrigation techniques. This results in enhanced agricultural productivity. Moreover, the utilization of solar panels in green zones mitigates surface temperature increases, contributing to a 2-5% boost in electricity production. Currently, irrigation facilities primarily rely on the main energy grid. However, transitioning to renewable energy sources decreases reliance on non-renewable fuels, reduces greenhouse gas emissions, and fosters …

Selective Oxidation Of Iron In Chalcopyrite For Enhanced Copper Recovery, Khojiakbar Shuxrat O'G'Li Sultonov, Shokhrukh Toshpulatovich Khojiev, Gulnoza Berdiyor Qizi Beknazarova, Malika Sayfullayevna Saidova

Technical science and innovation

This study explores the thermodynamic feasibility of selectively oxidizing iron contained in chalcopyrite mineral while preventing the oxidation of copper sulphide, with the ultimate goal of enhancing the copper concentration in the sulphide concentrate. A redox reaction in the solid phases between chalcopyrite and copper (I) oxide was constructed and subjected to thermodynamic analysis. The research identifies a crucial temperature range of 498-598 K (225-325 °C) as the most favourable for the redox reaction. The equilibrium constants at the selected optimal temperatures, 1.152 for chalcopyrite and 1.137 for copper (I) oxide, indicate that the redox reaction adheres to the expected …

Solving Water Resources Problems - Water Saving In The Republic Of Uzbekistan, Rustam Muxammatdjanovich Raximov

Technical science and innovation

In this article we will talk about the problems of water resources in the Republic of Uzbekistan. The problem of drinking water supply, solutions to provide drinking water to the population of Uzbekistan. The largest consumers of fresh water in Uzbekistan are farmers. Due to outdated infrastructure, 40% of water is wasted. Rising food prices and the risk of spreading disease are the first signs of water shortages that we may experience in the coming еars. Uzbekcosmos told how to solve the problem. Water is an invaluable resource used not only in the home, but also in the production and …

Modelling Of Heat Transfer In An Air Solar Collector, Shakhnoza Abduvaxitovna Sultanova, Jasur Esirgapovich Safarov, A.A. Mambetsheripova

Technical science and innovation

This study is the prediction, depending on time and different geographical and climatic situations, of different operating parameters: solar radiation, ambient and outlet coolant temperature, heat exchange coefficients and losses. All these determine, in the absence of measurements, the efficiency of the system modelled with existing models with respect to these parameters. These models are usually compared with experimental results. Before modelling, it is necessary to investigate the different heat transfer and exchange regimes that exist between the different elements of this system in order to eventually have a system of equations governing this exchange. The modelling principle is to …

A Study On The Influence Of Cutting Parameters On Surface Roughness And Visualization Through Contour Plots And 3d Surface Profiles, Zayniddin Nosirovich Muxiddinov

Technical science and innovation

This research investigates the intricate relationship between cutting parameterscutting speed, feed rate, and depth of cut and surface roughness in machining processes. Surface roughness is a key determinant of machined surface quality, and optimizing cutting parameters is crucial for achieving superior finishes. Employing advanced visualization techniques, including contour plots and 3D surface profiles, the study offers a comprehensive exploration of surface topography dynamics. Statistical analyses and regression modeling enhance the quantitative understanding of how cutting parameters interact to shape surface roughness. The research affirms the significant influence of cutting speed, feed rate, and depth of cut, providing practical insights for …

Theory Of Development And Improvement Of The Mathematical Model Of The Methodology Of Public Control In The Management Of Occupational Safety And Industrial Risks, Aliakbar Khamidullaevich Rasulev, Sunnatilla Suleymanovich Suleymanov, Nodira Bakhadirzhanovna Gaibnazarova

Technical science and innovation

The article develops and analyzes a mathematical model based on a logical flowchart of the methodology of public control in the management of occupational safety and industrial risks and probability theory, according to the model, the results of compliance with the requirements of social cooperation on occupational safety lead to a sharp increase in the probability of reliability, management efficiency becomes higher. Analysis of the mathematical model of the developed logical flowchart based on probability theory has shown that when the parties cooperate to monitor the results of compliance with labor protection requirements, they lead to a sharp increase in …

Research Of The Influence Of Dust On Photovoltaic Modules, Anvarjon Mirolimov, Xalmurat Iliev

Technical science and innovation

The influence of dust concentrations on the current-voltage characteristics (voltampere characteristics) of photovoltaic modules (PVM) based on crystalline silicon in laboratory conditions. It was investigated how an uncleaned panel affects the output power. The tests were carried out in the city of Tashkent on the territory of the “National Research Institute of Renewable Energy Sources”. The objects were located co-plurally as specified in GOST R 60904-1 Photoelectric devices. Part 1. Measurement of current-voltage characteristics. Measurements of a cleaned photovoltaic module with a maximum power of 330 W and not a cleaned one of 236 W were obtained. Based on the …

Novel Nano-Binders Treating Alzheimer’S Disease, Katie Ching, Sophie Criscione

Bioengineering Senior Theses

The objective of our project is to engineer exosomes to be an effective therapeutic agent as a possible new treatment option for the neurodegenerative disease, Alzheimer’s Disease (AD). Among the various causes of AD, we are focusing on treating the pathogenesis linked to the build-up of amyloid-beta plaques in the brain, which disrupts neural connections and ultimately kills nerve cells. Currently, the most widely available treatment options for AD only provide symptomatic relief and targeting amyloid plaques in the brain is a promising new therapeutic approach in the field. Even the partial clearance of plaques could significantly improve the prognosis …

Skin Phantom Development For Electrophysiological Wearable Device Testing, Rohan Sodha, Kiet Vu, Jonathan Nguy

Bioengineering Senior Theses

This senior design project aimed to develop a skin phantom suitable for testing electrophysiological wearable devices. Our skin phantom consisted of a porous paper PDMS as the epithelial layer, initially paired with agarose gel as the tissue layer, and later with gelatin based on comparative analysis. Through rigorous experimentation and leveraging data from the IT’IS Foundation’s interactive database, we identified that gelatin exhibited superior electrical properties compared to agarose, making it a more effective medium for replicating human tissue. Our work not only validated the use of paper PDMS with both agarose and gelatin but also demonstrated that gelatin's lower …