Biomedical Engineering and Bioengineering Commons^™

Multi-Modal Investigation Of The Bone Micro- And Ultrastructure, And Elemental Distribution In The Presence Of Mg-Xgd Screws At Mid-Term Healing Stages, Kamila Iskhakova, Hanna Cwieka, Svenja Meers, Heike Helmholz, Anton Davydok, Malte Storm, Ivo Matteo Baltruschat, Silvia Galli, Daniel Pröfrock, Olga Will, Mirko Gerle, Timo Damm, Sandra Sefa, Weilue He, Keith Macrenaris, Malte Soujon, Felix Beckmann, Julian Moosmann, Thomas O'Hallaran, Roger J. Guillory, D. C.Florian Wieland, Berit Zeller-Plumhoff, Regine Willumeit-Römer

Michigan Tech Publications

Magnesium (Mg) – based alloys are becoming attractive materials for medical applications as temporary bone implants for support of fracture healing, e.g. as a suture anchor. Due to their mechanical properties and biocompatibility, they may replace titanium or stainless-steel implants, commonly used in orthopedic field. Nevertheless, patient safety has to be assured by finding a long-term balance between metal degradation, osseointegration, bone ultrastructure adaptation and element distribution in organs. In order to determine the implant behavior and its influence on bone and tissues, we investigated two Mg alloys with gadolinium contents of 5 and 10 wt percent in comparison to …

Flow Dynamic Factors Correlated With Device-Related Thrombosis After Left Atrial Appendage Occlusion, Brennan Vogl, Emily Vitale, Sunyoung Ahn, Agata Sularz, Alejandra Chavez Ponce, Gerardo V. Lo Russo, Jeremy Collins, Alessandra Maria Bavo, Ahmed El Shaer, Anders Kramer, Yuheng Jia, Davorka Lulic, Matthieu De Beule, Jens Erik Nielsen-Kudsk, Ole De Backer, Mohamad Alkhouli, Hoda Hatoum

Michigan Tech Publications

Background: Device-related thrombosis (DRT) occurs in up to 4% of patients undergoing left atrial appendage occlusion (LAAO) and is associated with substantial morbidity and mortality. However, its pathophysiology, predictors, and optimal management remain unclear. Objectives: This study aims to assess flow dynamic factors correlating to DRT. Methods: A multicenter registry of patients who underwent LAAO and had pre- and post-computed tomography imaging was used. Patient-specific 3-dimensional digital models of the left atrium were created, and finite element simulations were performed to implant an LAAO device into each model in a position that matched the clinical deployment. Computational fluid dynamic simulations …

Noncontact Diffuse Reflectance Spectroscopy Of Synovial Fluid Samples For Rapid Identification Of Infections, Erin E. Drewke, Robert L. Brand, Caroline G. Geels, Hanna K. Jensen, Kevin Wong, Jarret D. Sanders, Narasimhan Rajaram

Biomedical Engineering Faculty Publications and Presentations

Severe joint infections, such as septic arthritis, require rapid diagnostic testing of the synovial fluid aspirated from joints level so that a surgical team can be assembled quickly. We present a diffuse reflectance spectroscopy (DRS) system for noncontact determination of infection. Using a light-tight syringe holder and fiber optic probe, diffusely reflected light from 475 to 655 nm was acquired from 18 patient samples through the wall of a syringe in a noncontact and sterile manner. We determined the reflectance ratios at two different wavelengths—R ₄₉₀/R ₆₀₀ and R ₅₈₀/R ₆₀₀ and found statistically significant …

Expanded Combined Loading Injury Criterion For The Human Lumbar Spine Under Dynamic Compression, Maria Ortiz-Paparoni, Joost Op't Eynde, Christopher Eckersley, Concetta Morino, Mitchell Abrams, Derek Pang, Jason Kait, Frank A. Pintar, Narayan Yoganandan, Jason Moore, David Barnes, Kathryn Loftis, Cameron R. Bass

Biomedical Engineering Faculty Research and Publications

Contemporary injury tolerance of the lumbar spine for under-body blast references axial compression and bending moments in a limited range. Since injuries often occur in a wider range of flexion and extension with increased moment contribution, this study expands a previously proposed combined loading injury criterion for the lumbar spine. Fifteen cadaveric lumbar spine failure tests with greater magnitudes of eccentric loading were incorporated into an existing injury criterion to augment its applicability and a combined loading injury risk model was proposed by means of survival analysis. A loglogistic distribution was the most representative of injury risk, resulting in optimized …

Mesenchymal-Type Genetic Mutations Are Likely Prerequisite For Glioblastoma Multiforme To Metastasize Outside The Central Nervous System: An Original Case Series And Systematic Review Of The Literature, Bryce J. Laurin, Randall Treffy, Jennifer M. Connelly, Michael Straza, Wade Mueller, Max O. Krucoff

Biomedical Engineering Faculty Research and Publications

Background

Glioblastoma Multiforme (GBM) is the most aggressive and prevalent type of malignant brain tumor, yet it metastasizes outside the central nervous system (CNS) in only 0.4% of cases. Little is known about what enables this subset of GBMs to take root outside the CNS, but genetic mutations likely play a role.

Methods

We conducted a PRISMA-compliant systematic review of metastatic GBM wherein we reviewed 3579 search results and 1080 abstracts, analyzing data from 139 studies and 211 unique patients. In addition, we describe 4 cases of patients with pathologically confirmed GBM metastases outside the CNS treated at our institution. …

Seasonal Variation In Atp-Induced Retinal Damage In The Cone-Dominant 13-Lined Ground Squirrel, Owen R. Bowie, Hannah M. Follett, Ching Tzu Yu, Chloe Guillaume, Phyllis M. Summerfelt, Nicole Manfredonia, Jenna Grieshop, Dana K. Merriman, Sergey Tarima, Joseph Carroll

Biomedical Engineering Faculty Research and Publications

Purpose: To examine whether time of year (relative to hibernation emergence) influences the retinal degenerative effects of intravitreal injection of adenosine triphosphate (ATP) in the 13-lined ground squirrel (13-LGS).

Methods: Eighteen (9 male, 9 female) 13-LGS in three experimental cohorts (early season, mid-season, late season) (n = 6 each) underwent baseline imaging using scanning light ophthalmoscopy (SLO) and optical coherence tomography (OCT). Animals then received a 10-µL intravitreal injection of 0.723 M ATP, followed by OCT and SLO imaging at 3, 10, and 21 days. Adaptive optics SLO (AOSLO) was performed in animals without retinal damage after the 21-day …

Investigating The Effect Of Microwave Pretreatment On Bastnasite Grinding For Comminution Energy Reduction And Rare Earth Recovery, Kaveh Asgari, Qingqing Huang, Rick Q. Honaker, Edward Sabolsky

Chemical and Materials Engineering Faculty Publications

This study explored the impact of microwave pretreatment on the grinding efficiency of bastnaesite ore using a stirred mill. Bastnaesite ore was prepared using a staged crushing and sieving process, followed by microwave pretreatment in a specially designed microwave furnace system. Representative samples of the crushed ore underwent stirred mill grinding, with power draw measurements recorded and adjusted to reflect only the specific energy input required for grinding. Particle size distribution was analyzed periodically using laser particle size analysis. In addition, a Box–Behnken design was used to statistically assess the effects of various parameters on the results, ensuring a robust …

Beyond 2d: Novel Biomaterial Approaches For Modeling The Placenta, Samantha G. Zambuto, Adrienne K. Scott, Michelle L. Oyen

Biomedical Engineering Faculty Publications

This review considers fully three-dimensional biomaterial environments of varying complexity as these pertain to research on the placenta. The developments in placental cell sources are first considered, along with the corresponding maternal cells with which the trophoblast interact. We consider biomaterial sources, including hybrid and composite biomaterials. Properties and characterization of biomaterials are discussed in the context of material design for specific placental applications. The development of increasingly complicated three-dimensional structures includes examples of advanced fabrication methods such as microfluidic device fabri- cation and 3D bioprinting, as utilized in a placenta context. The review finishes with a discussion of the …

Editorial To Advances In Minimally Invasive Spine Surgery, Gabriel C. Tender, George A. Crabill

School of Medicine Faculty Publications

No abstract provided.

3d Printed Microfluidic Fabrication Methodology, Characterization, Mechanical Design, And Applications In Electrostatic Artificial Muscles And Benthic Microbial Fuel Cells, Terak B. Hornik

Master's Theses

The fabrication of microfluidic devices often requires specialized methods. The development of these methods requires careful characterization and understanding of the processes involved. Using primarily PolyJet 3D printing technology, microfluidics offers a wide scope of applications such as microfluidic benthic microbial fuel cells (MBMFCs) and electrostatic artificial muscles. MBMFCs benefit from the confinement of the microbes resulting in close proximity between the electrode and the organisms. Using a modular design called the Sponge, assembly and upscaling is possible. Electrostatic artificial muscles benefit from a microfluidic approach due to the non-linearity of electrostatic attraction creating disproportionate benefits when miniaturized. When designed …

Personalized Bioceramic Grafts For Craniomaxillofacial Bone Regeneration, Ana Beatriz G. De Carvalho, Maedeh Rahimnejad, Rodrigo L. M. S. Oliveira, Prabaha Sikder, Guilherme S. F. A. Saavedra, Et. Al.

Mechanical Engineering Faculty Publications

The reconstruction of craniomaxillofacial bone defects remains clinically challenging. To date, autogenous grafts are considered the gold standard but present critical drawbacks. These shortcomings have driven recent research on craniomaxillofacial bone reconstruction to focus on synthetic grafts with distinct materials and fabrication techniques. Among the various fabrication methods, additive manufacturing (AM) has shown significant clinical potential. AM technologies build three-dimensional (3D) objects with personalized geometry customizable from a computer-aided design. These layer-by-layer 3D biomaterial structures can support bone formation by guiding cell migration/proliferation, osteogenesis, and angiogenesis. Additionally, these structures can be engineered to degrade concomitantly with the new bone tissue …

Lifetimes Of Stable Solutions To The Planar Three-Body Problem, Revealed In Patterns Of Fractal Art, Charles F. Babbs

Weldon School of Biomedical Engineering Faculty Working Papers

This preliminary study explores statistical prediction of the lifetimes of apparently stable orbits of three particle masses, mutually attracted by gravity in the planar three body problem. Most orbits eventually break up, commonly in an end state with two of the bodies orbiting each other and moving together in one direction, with the third body moving in the opposite direction. Studies of such escape events led to a novel hypothesis, emerging from the intersection of probability, statistics, chaos, and fractal art. Statistical estimates of a constant probability of breakup per unit time allow prediction of the times of breakup of …

Advances In Electrospun Poly(Ε-Caprolactone)-Based Nanofibrous Scaffolds For Tissue Engineering, Karla N. Robles, Fatima Tuz Zahra, Richard Mu, Todd Giorgio

Agricultural and Environmental Sciences Faculty Research

Tissue engineering has great potential for the restoration of damaged tissue due to injury or disease. During tissue development, scaffolds provide structural support for cell growth. To grow healthy tissue, the principal components of such scaffolds must be biocompatible and nontoxic. Poly(ε-caprolactone) (PCL) is a biopolymer that has been used as a key component of composite scaffolds for tissue engineering applications due to its mechanical strength and biodegradability. However, PCL alone can have low cell adherence and wettability. Blends of biomaterials can be incorporated to achieve synergistic scaffold properties for tissue engineering. Electrospun PCL-based scaffolds consist of single or blended-composition …

A Simple And Fast Optical Clearing Method For Whole-Mount Fluorescence In Situ Hybridization (Fish) Imaging, Junwoo Suh, Yehe Liu, Jordan Smith, Michiko Watanabe, Andrew M. Rollins, Michael W. Jenkins

Faculty Scholarship

We report a single-step optical clearing method that is compatible with RNA fluorescence in situ hybridization (FISH) imaging. We previously demonstrated microscopy imaging with immunohistochemistry and genetic reporters using a technique called lipid-preserving refractive index matching for prolonged imaging depth (LIMPID). Our protocol reliably produces high-resolution three-dimensional (3D) images with minimal aberrations using high magnification objectives, captures large field-of-view images of whole-mount tissues, and supports co-labeling with antibody and FISH probes. We also custom-designed FISH probes for quail embryos, demonstrating the ease of fabricating probes for use with less common animal models. Furthermore, we show high-quality 3D images using a …

Study Of The Synthesis Mechanism And Some Properties Of Oligomers Based On Epichlorohydrin And Diphenylguanidine, Rovshan Israilovich Ismailov, Normuhamad Edgarov, Alisher Israilovich Ismailov

Technical science and innovation

In this work, the synthesis and the scheme for obtaining an oligomer based on epiiodhydrin with diphenylguanidine were studied, the proportions of epiiodhydrin in the initial mixture, the yield of oligomers, and the reduced viscosity were studied. The results of spectroscopic and elemental analyzes are obtained, which show that changes in the ratio of monomers have almost no effect on the iodine content in the oligomer. This is apparently due to the fact that epiiodhydrin is much more active in reactions than amino compounds. By studying the degree of conversion on the viscosity of the oligomerization products, the effects on …

Justification Of The Effectiveness Of Software For The Design Of Open-Pit Mining, Tolib Olimovich Komilov, Bobirjon Nabijonovich Ashurov, Ulugbek Bakhtiyorovich Sattarov, Ma’Ruf Ixtiyorovich Karimov

Technical science and innovation

The article notes that the economic feasibility of implementing a project based on deposits directly affects the economy of the country and the region, as well as the construction of new facilities, the use of the most balanced approaches and design solutions in a complex will allow achieving the set goal of increasing production volumes and bringing the enterprise to a new level of development. In order to achieve the above goals, it has been proven with the implementation of investment projects using software for the design of open-pit mining, it is possible to further develop the region, agriculture with …

Study Of The Physical-Chemical Properties Of Chitosan Synthesized By The Cryogenic Method From Apis Mellifera Bees, Dilnoza Sohibovna Isomitdinova, Gulnora Akmalovna Ikhtiyarova, Jahongir Mustaqim O’G’Li Sharopov

Technical science and innovation

Chitosan was synthesized from Apis Mellifera dead bees by traditional and cryogenic methods, and the degree of deacetylation, viscosity, and molecular mass of the synthesized sample was studied. Chitosan was synthesized by deacetylation of chitin under cryogenic conditions. NaOH concentration 40%, temperature 90 ± 3 °C, time 120 min. The degree of deacetylation, and molecular mass was determined using an Ubbelode viscometer. DDA was determined by conductometric titration under standard conditions. The degree of deacetylation of Apis Mellifera chitosan was 87%. synthesized by cryogenic method DDA of chitosan was 83% synthesized by traditional method. Conducting the synthesis in liquid nitrogen …

Development Of A Universal Humidity Converter At Ultra High Frequency, Hulkar Asadullayevna Usmonova, Asadulla Turgunbayev

Technical science and innovation

The article proposes the and principle of operation of a universal primary measuring transducer of humidity at an ultra-high frequency with reciprocating motion along the vertical axis of rotation, which allows increasing the information redundancy of the primary measuring transducer (the influence of inhomogeneities, including humidity in the composition of the material, on the measurement result is averaged). The design of the primary measuring transducer under consideration provides for correction of the moisture measurement result by the mass (density) of the material, which will make it possible to carry out measurements without preliminary weighing the sample. The obtained results of …

Impulse, Fall 2024, Jill Fier, Micayla Standish, Jerome J. Lohr College Of Engineering

Impulse (Jerome J. Lohr College of Engineering Publication)

2 | Math Teacher Counts Her Blessings
3 | New Roles for Burckhard
4 | Three New Department Heads
6 | New Faculty and Staff
8 | Taking Engineering on The Road
10 | Dennis Helder Named Distinguished Alum
12 | Mccomish Endowment Making an Impact
14 | Innovate Sodak Supports Local Projects
16 | R1 the SDSU Way
18 | Nation’s Top Civil Engineering Student Chapter
22 | Hunter Wallster Setting Records
24 | Jenna Currier: When Passion Meets Talent
28 | Student Teams Compete
30 | RASC-AL Team Overcomes Setback
32 | Break the Ice Team Comes Home …

Advances In Biomedical Research And Treatments: What Is Acceptable?, Michael L. Clancy, Khalid M. Iskandarani, Mitchell C. Mccrea

Journal of Health Ethics

This study investigated the technology acceptance (TA) of twenty-first century biomedical treatments by adults in the United States. A new TA instrument was created, using five distinct levels: (1) Healing and Prevention, (2) Replacement Organs, (3) Enhancements-Medical, (4) Enhancements-Discretionary, and (5) Transhumans. An on-line survey produced 353 usable responses, which showed distinct patterns for each of five biomedical treatment levels. There was clear support for Levels 1–3, but very strong opposition to Levels 4–5. The TA finding draws the line between which human interventions are acceptable versus others that should be prohibited through public policies and medical guidelines.