Biomedical Engineering and Bioengineering Commons^™

Identification System For Heart Valve Manufacturing, Nicholas Robert Jensen, Edgar Davis Nix, Judith Evelyn Gonzalez, Albert Austin Liddicoat

Mechanical Engineering

Abstract withheld due to NDA constraints

Foot Stress And Blood Flow Sensing Under High-Loading During Hip Surgery, Chris Cardenas, Esther Chen, Claire Kingston, Katie Paswaters, Brianna Rodebaugh

Mechanical Engineering

The PolyHIPS team was tasked with integrating sensors into Stryker’s hip arthroscopy boot that monitor blood flow and heel slip during hip surgery. During hip arthroscopy, the femur head is distracted from the acetabulum to create space in the joint for the surgeon to operate. This requires the use of up to 200 lbf. In order to maintain this space, the foot is held tightly in the boot. Complications can result from the foot being held too tightly in the boot during the procedure. The most common complication is neuropraxia, or temporary nerve damage. PolyHIPS proposes a solution that utilizes …

Transcatheter Heart Valve Leaflet Assembly Tooling Improvement Final Design Report, James Craig Sherman, Zachary Robert Dicks, Luke Edward Williams

Mechanical Engineering

Statement of Confidentiality: The complete senior project report was submitted to the project advisor and sponsor. The results of this project are of a confidential nature and will not be published at this time.

Dynamic Model For Simulating Motion Of The Right Ventricle, Brian Michael Larsen, Sam Koopman Porter, John Francis D'Ambrosio

Mechanical Engineering

This report documents all the research, ideation, and mockups used to determine right ventricle motion and develop a system capable of reproducing that motion on a tissue sample. The model is intended for evaluating anchoring systems being developed by Edwards Lifesciences for use with tricuspid valve therapies. Several design solutions were considered for the primary functions of recreating motion of the right ventricle and attaching tissue to the device. From these ideas a primary means of producing motion and attaching tissue was selected. These ideas were then developed over the course of a school year to become the final system …

Detection Method Of Subclinical Atherosclerosis Of The Carotid Artery With A Hemodynamics Modeling Approach, Marisa Peressini

Master's Theses

Subclinical atherosclerosis is an important area of research to evaluate stroke risk and predict localization of plaque. The current methods for detecting atherosclerosis risk are insufficient because it is based on The Framingham Risk Score and carotid intima media thickness, therefore an engineering detection model based on quantifiable data is needed. Laminar and turbulent flow, dictated by Reynolds number and relative roughness, was modeled through the carotid artery bifurcation to compare shear stress and shear rate. Computer-aided design and fluid flow software were used to model hemodynamics through the carotid artery. Data from the model was derived from governing equations …

Elucidating The Mechanisms Of Two Unique Phenomena Governed By Particle-Particle Interaction Under Dep: Tumbling Motion Of Pearl Chains And Alignment Of Ellipsoidal Particles, Yu Zhao, Jozef Brcka, Jacques Faguet, Guigen Zhang

Biomedical Engineering Faculty Publications

Particle-particle interaction plays a crucial role in determining the movement and alignment of particles under dielectrophoresis (DEP). Previous research efforts focus on studying the mechanism governing the alignment of spherical particles with similar sizes in a static condition. Different approaches have been developed to simulate the alignment process of a given number of particles from several up to thousands depending on the applicability of the approaches. However, restricted by the simplification of electric field distribution and use of identical spherical particles, not much new understanding has been gained apart from the most common phenomenon of pearl chain formation. To enhance …

Urinalysis Screening For Rural Communities, Dana Bren-Cardali, Lilian Dao, Jeffrey Destruel, Ryan Fernandez

Interdisciplinary Design Senior Theses

Access to medical care and health screenings is a necessity for patients around the globe, but it can be difficult to provide this without screenings becoming costly or convoluted. In rural and underdeveloped areas, patients are often disadvantaged when it comes to finding reliable and affordable healthcare. The isolation provided by their location and the rising costs of physicians makes it impossible for most impoverished communities to attain personalized care. Because of this, treatable diseases often go unaddressed, allowing diseases to progress to a critical condition. Mortality rates have shown to be higher in communities located in rural areas and …

The Human Keyboard, Derek Char, Thomas Chung, Alexander Mckee, Allen Pai

Interdisciplinary Design Senior Theses

Most products that implement features for user interactions utilize buttons or switches for the user to command to select actions to perform. Such designs are typically controlled with direct motions, such as touch or voice and are seldom designed in consideration of those unable to utilize direct control. In this project, we designed technology that reads naturally occuring biosignals from the body, which then can be apply those signals with any interface. For our specific application in this project, we decided to implement a keyboard. Instead of teaching the fingers how to type on a mechanical keyboard, the body can …

Analysis Of The Low-Cycle Fatigue Behavior Of Silicone Rubber For Biomedical Balloons, Chase Cooper

Materials Engineering

The development of a medical drug delivery device that allows for the deployment drugs into the adventitial tissue of blood vessels requires the inflation of a silicone elastomer. The inflated silicone must be able to consistently endure multiple loading cycles without failing so that the device can operate reliably. There are multiple methods of processing the silicone for the device and the goal of this study is to examine the effect of the various processing methods on the characteristics of the silicone. The Dynamic Mechanical Analysis Machine (DMA) is used to model the conditions of the device’s application by performing …

Multi-Purpose Heart Valve Therapy Assembly Fixture, Alec John Foster, John Patrick Hofstetter, Emily Lim

Mechanical Engineering

STATEMENT OF CONFIDENTIALITY: The complete senior project report was submitted to the project advisor and sponsors. The results of this project are of a confidential nature and will not be published at this time.

Enhancing Mobility And Independence Of Wheelchair Users, Briar Blake, Paul Nauleau

Interdisciplinary Design Senior Theses

Conditions as simple as a leg fracture or more severe impairments such as paralysis and stroke may confine a person to a wheelchair. Wheelchairs help people with limited mobility transport themselves to different locations, but do not help the person leave the wheelchair. Users would need to do this to enter a car, use the restroom, take a shower, and sit at a table comfortably with family. The following design is a wheelchair attachment that serves to provide the user with increased mobility and independence. Wheelchair users struggle to get into and out of their chairs due to the unassisted …

Posterior Cervical Spine Crisscross Fixation: Biomechanical Evaluation, Joseph F. Cusick, Frank A. Pintar, Joseph S. Cheng, Jason I. Lifshutz, Narayan Yoganandan

Biomedical Engineering Faculty Research and Publications

Background

Biomechanical/anatomic limitations may limit the successful implantation, maintenance, and risk acceptance of posterior cervical plate/rod fixation for one stage decompression-fusion. A method of posterior fixation (crisscross) that resolves biomechanical deficiencies of previous facet wiring techniques and not reliant upon screw implantation has been devised. The biomechanical performance of the new method of facet fixation was compared to the traditional lateral mass plate/screw fixation method.

Methods

Thirteen human cadaver spine segments (C2-T1) were tested under flexion-compression loading and four were evaluated additionally under pure-moment load. Preparations were evaluated in a sequence of surgical alterations with intact, laminectomy, lateral mass plate/screw …

Diffusion Tensor Imaging In A Large Longitudinal Series Of Patients With Cervical Spondylotic Myelopathy Correlated With Long-Term Functional Outcome, Avinash Rao, Hesham Soliman, Mayank Kaushal, Olesya Motovylyak, Aditya Vedantam, Matthew D. Budde, Brian D. Schmit, Marjorie C. Wang, Shekar N. Kurpad

Biomedical Engineering Faculty Research and Publications

BACKGROUND

Fractional anisotropy (FA) of the high cervical cord correlates with upper limb function in acute cervical cord injury. We investigated the correlation between preoperative FA at the level of maximal compression and functional recovery in a group of patients after decompressive surgery for cervical spondylotic myelopathy (CSM).

OBJECTIVE

To determine the usefulness of FA as a biomarker for severity of CSM and as a prognostic biomarker for improvement after surgery.

METHODS

Patients received diffusion tensor imaging (DTI) scans preoperatively. FA values of the whole cord cross-section at the level of maximal compression and upper cervical cord (C1-2) were calculated. …

Bioactive Polydimethylsiloxane Surface For Optimal Human Mesenchymal Stem Cell Sheet Culture, Zichen Qian, David Ross, Wenkai Jia, Qi Xing, Feng Zhao

Michigan Tech Publications, Part 1

Human mesenchymal stem cell (hMSC) sheets hold great potential in engineering three-dimensional (3D) completely biological tissues for diverse applications. Conventional cell sheet culturing methods employing thermoresponsive surfaces are cost ineffective, and rely heavily on available facilities. In this study, a cost-effective method of layer-by-layer grafting was utilized for covalently binding a homogenous collagen I layer on a commonly used polydimethylsiloxane (PDMS) substrate surface in order to improve its cell adhesion as well as the uniformity of the resulting hMSC cell sheet. Results showed that a homogenous collagen I layer was obtained via this grafting method, which improved hMSC adhesion and …

Comparative Analysis Of Physiological Measurements And Environmental Metrics On Predicting Heat Stress Related Events, Mckenzie Lee Barlow

Master's Theses

Exposure to high heat and humidity can lead to serious health risks, including heat exhaustion and heat stroke. Wet Bulb Globe Temperature (WBGT) and heat index have historically been used to predict heat stress events, but individualized factors are not included in the measurement. It has been shown that there is a relationship between cardiovascular measurements and heat stress, which could be used to measure heat stress risk on an individual level. Research has been done to find relationships between cardiovascular metrics in a workplace environment, however the study did not include the use of a controlled environment as a …

Assessing The Photoprotective Effects Of Fluorescent Sphingomyelin Against Uvb Induced Dna Damage In Human Keratinocytes, Rebecca Marie Kandell

Master's Theses

Non Melanoma Skin Cancer (NMSC) affects 3.3 million Americans each year and results from Ultra Violet Radiation (UVR) damage to DNA in the form of pyrimidine dimers and photoproducts [1]–[5]. Cells directly detect the damage and initiate apoptosis, cell cycle arrest, or DNA repair by modulating p53 and p21 levels [6]–[9]. Current methods of photoprotection include sunscreen, but controversy over safety of some active ingredients necessitates research into more natural alternatives [10]–[12]. In particular, 24 hour incubation with bovine milk sphingomyelin (BSM) has demonstrated photoprotective potential by reducing p21 and p53 levels in keratinocytes (KRTs) after UV radiation [13], [14]. …

Extended-Use Ecg Monitor, Daniel Aaron Soski

Master's Theses

In this thesis, a prototype ECG monitor was developed that is integrated into an elastic shirt and takes a 3-lead ECG for over 5 days. The high-quality measurements can be used to identify markers indicative of various detrimental heart conditions. Measurements recorded by the device are encrypted and stored onto a micro-SD card. Current Holter monitors are expensive and have functional lives less than 48 hours; however, extended duration monitoring has been proven more useful in diagnosis. The device designed demonstrates that ECG measurements can be taken over longer durations without sacrificing quality, comfort, or device cost.

Preparation Of Supramolecular Amphiphilic Cyclodextrin Bilayer Vesicles For Pharmaceutical Applications, Kate E. Frischkorn

Master's Theses

Recent pharmaceutical developments have investigated using supramolecular nanoparticles in order to increase the bioavailability and solubility of drugs delivered in various methods. Modification of the carbohydrate cyclodextrin increases the ability to encapsulate hydrophobic pharmaceutical molecules by forming a carrier with a hydrophobic core and hydrophilic exterior. Guest molecules are commonly added to these inclusion complexes in order to add stability and further increase targeting abilities of the carriers. One such guest molecule is adamantine combined with a poly(ethylene glycol) chain. Vesicles are formed by hydrating a thin film of amphiphilic cyclodextrin and guest molecules in buffer solution that mimics physiological …

Neuro-Silicon Interface Of A Hirudo Medicinalis Retzius Cell Integrated With Field Effect Transistor, Kurt Christian Sjoberg

Master's Theses

The focus of this thesis was to measure the intracellular voltage of a living neural cell using a silicon transistor. The coupling of neurological tissues with silicon devices is of interest to the fields of neurology, neuroscience, electrophysiology and cellular biology. In previous work by Peter Fromherz, single neurons were successfully coupled to transistors [1]. This thesis aims to show proof of concept of the fabrication of a simple neuro-silicon interface using wafer processing methods currently available at Cal Poly. The types of transistors and cells used, the methods for dissecting and preparing the cells, the electrophysiology methods for validating …

Characterization Of Arterial Flow For Junctional Bleeding Control, Nick Bosio

Master's Theses

This study investigated reducing volumetric flowrate under steady flow conditions by varying lengths of compression with constant cross-sectional area and varying cross-sectional area reduction with constant length in order to better understand how to control junctional hemorrhaging. The hypotheses of this study were that length reduction will have little effect on volumetric flowrate and that cross-sectional area reduction would need to be approximately 80 percent in order to obtain bleeding control. The study found that length reduction has little effect on changing the flowrate. However, in order to obtain at least 80 percent reduction in flow, the area needs to …