The Effect Of Tantalum Incorporation On The Physical And Chemical Properties Of Ternary Silicon–Calcium–Phosphorous Mesoporous Bioactive Glasses,
2019
Missouri Univeristy of Science and Technology
The Effect Of Tantalum Incorporation On The Physical And Chemical Properties Of Ternary Silicon–Calcium–Phosphorous Mesoporous Bioactive Glasses, Andrew Mendonca, Md Saidur Rahman, Adel Alhalawani, Omar Rodriguez, Reid C. Gallant, Heyu Ni, Owen M. Clarkin, Mark R. Towler
Chemical and Biochemical Engineering Faculty Research & Creative Works
Synthesis and characterization of the first mesoporous bioactive glasses (MBGs) containing tantalum are reported here, along with their potential application as hemostats. Silica MBGs were synthesized using with the molar composition of (80-x)% Si, 15% Ca, 5% P, and x% Ta. It was found that incorporation of >1 mol % Ta into the MBGs changes their physical and chemical properties. Increasing Ta content from 0 to 10 mol % causes a decrease in the surface area and pore volume of ~20 and ~35%, respectively. This is due to the increase in nonbridging oxygens and mismatch of thermal expansion coefficient which …
Improving Paper-Based Microfluidic Mixing With The Incorporation Of Flow Disrupting Structures,
2019
Louisiana Tech University
Improving Paper-Based Microfluidic Mixing With The Incorporation Of Flow Disrupting Structures, Hannah C. Green
Master's Theses
Paper-based microfluidic devices provide a light-weight, cost effective platform for diagnostic and analytical testing. The goal of this project is to enhance paper-based microfluidic mixing by incorporating fluid flow disrupting structures (referred to here as rib bones) into the microdevice design to expand the analytical capabilities of paperbased microfluidic devices. The devices are fabricated on Whatman CHR-1 chromatography paper. The devices are designed in SolidWorks and printed using a solid ink printer (ColorQube 8580). The wax is penetrated into the paper to create hydrophobic barrier regions by heating in a convection oven until the wax is fully penetrated. The parameters …
Differential Cortical Activation During The Perception Of Moving Objects Along Different Trajectories,
2019
Boston University
Differential Cortical Activation During The Perception Of Moving Objects Along Different Trajectories, Finnegan J. Calabro, Scott A. Beardsley, Lucia M. Vaina
Biomedical Engineering Faculty Research and Publications
Detection of 3D object-motion trajectories depends on the integration of two distinct visual cues: translational displacement and looming. Electrophysiological studies have identified distinct neuronal populations, whose activity depends on the precise motion cues present in the stimulus. This distinction, however, has been less clear in humans, and it is confounded by differences in the behavioral task being performed. We analyzed whole-brain fMRI, while subjects performed a common time-to-arrival task for objects moving along three trajectories: moving directly towards the observer (collision course), with trajectories parallel to the line of sight (passage course), and with trajectories perpendicular to the line of …
Medical Dental Device: Biogeneric Implant Prototype,
2019
CUNY New York City College of Technology
Medical Dental Device: Biogeneric Implant Prototype, Ibeth Erazo, Aneeza Hussain, Renata Budny, Gaffar Gailani
Publications and Research
Teeth are lost due to tooth decay, injury, disease, or other causes. Today, dental implants extend the range of care to a variety of patients undergoing necessary prosthodontic rehabilitation. If the benefits of such treatments are to be maximized, then implants must be selected on logical basis and placed within the context of the full range of treatment modalities. However, modern dental implant systems are based on multiple components often leading to micro-movements which cause stress on the bone or bacterial infections, both of which compromise the success of osseointegration and consequently jeopardize the whole implant adaptation. Thus, a new …
Adipose Tissue Engineering: A Therapeutic Strategy For The Treatment Of Obesity And Glucose Intolerance,
2019
University of South Carolina
Adipose Tissue Engineering: A Therapeutic Strategy For The Treatment Of Obesity And Glucose Intolerance, Michael A. Hendley
Theses and Dissertations
Despite available treatment options, the number of people afflicted by type 2 diabetes has steadily risen for decades. Nearly 90% of the diabetic population also suffers from obesity and the link between the two diseases is undeniable. Characterized by rapid expansion of the adipose tissue and improper lipid storage, the mishandling of lipids by adipose tissue promotes the diabetic state. Excess lipids, unable to be properly stored, build up in peripheral tissues promoting insulin resistance and type 2 diabetes. Therapeutic strategies designed to address adipose tissue lipid handling could represent a promising treatment strategy for obesity associated type 2 diabetes. …
Characterization Of The 2-Phase Turning Response Of Madagascar Hissing Cockroach Biobots To Antennal Stimulation,
2019
Rose-Hulman Institute of Technology
Characterization Of The 2-Phase Turning Response Of Madagascar Hissing Cockroach Biobots To Antennal Stimulation, Stefanie Jane Panzenhagen
Graduate Theses - Biology & Biomedical Engineering
Biobots are living insects that are controlled via neurostimulation applied through implanted electrodes and have a variety of potential applications such as search and rescue operations. Madagascar Hissing Cockroaches (MHCs) are commonly used as biobots; however, their use remains under investigation due to lack of a comprehensive motion profile in response to neurostimulation, which makes consistent control a challenge. MHC biobots often exhibit a 2-phase turning response to antennal stimulation, with an initial turn (primary) in the desired direction followed by a “corrective” turn (secondary) in the undesired direction. The purpose of this research is to characterize the 2-phase turning …
Milk Oligopeptide Inhibition Of (Α)-Tocopherol Fortified Linoleic Acid Oxidation,
2019
Zhejiang University of Science and Technology
Milk Oligopeptide Inhibition Of (Α)-Tocopherol Fortified Linoleic Acid Oxidation, Haina Yuan, Jinyan Gong, Kun Tang, Jinge Huang, Gongnian Xiao, Jianmin Lv
Biological Engineering Student Research
This study investigated the effect of milk oligopeptides and (α)-tocopherol on inhibition of linoleic acid oxidation using Fe2+-vitamin C induced linoleic acid oxidation model through analysis of malondialdehyde, peroxide value, and conjugated diene and triene in the model. The alteration of milk oligopeptides maximal absorption wavelength, fluorescent feature, and secondary structure were further investigated to elucidate the interactions between milk oligopeptide and (α)-tocopherol that altered the inhibitory effect of linoleic acid oxidation. Results showed that Pro-Tyr-Tyr-Ala-Lys (PYYAK) and Ile-Pro-Ile-Gln-Tyr (IPIQY) with (α)-tocopherol significantly inhibited the oxidation of linoleic acid and reduced the formation of malondialdehyde by 38% and …
The Impact Of Patient-Specific Vascular Structure On Localized Cooling In The Human Heart,
2019
Rowan University
The Impact Of Patient-Specific Vascular Structure On Localized Cooling In The Human Heart, Nathan Paul Spangenberg
Theses and Dissertations
Acute Myocardial Infarction (AMI) is the leading cause of worldwide death and disability, and approximately 720,000 Americans will experience an AMI in 2018. Studies have shown that rapid hypothermia therapy (<35°C) before reperfusion in patients with AMI can reduce infarct size by 37%. Localized therapeutic hypothermia has proven the potential to cool heart tissue rapidly following AMI, 3°C in 5 minutes. Using Materialise Mimics digital imaging software and the finite volume method we analyzed temperature distributions in six patient-specific left main coronary artery (LMCA) models. A mock circulatory loop was used to determine the exiting temperatures of a standard 7 Fr catheter to feed into our model with flow rates ranging from 29.2 ml/min to 68.85 ml/min. Our work showed that therapeutic hypothermia (TH) temperatures were evident at the outlets of three out of all six heart models, which varied in each left anterior descending (LAD) and left circumflex (LCX) artery depending on flowrate. Results of this study indicate that biovariability in patient-specific vascular structures significantly impacts therapeutic hypothermia (TH) treatment methods. These results indicate that further research is needed to examine more accurate physiological effects, such as pulsatile flow and vessel wall thickness. Future models will be used to provide insight to guide more efficient TH device designs and operation parameters to optimize patient outcomes following AMI.
Model Based Analysis Of The Accuracy And Precision Of Auscultatory Blood Pressure Measurements In Patients With Atrial Fibrillation,
2019
Purdue University
Model Based Analysis Of The Accuracy And Precision Of Auscultatory Blood Pressure Measurements In Patients With Atrial Fibrillation, Charles F. Babbs
Weldon School of Biomedical Engineering Faculty Working Papers
Accurate measurement of blood pressure in the presence of atrial fibrillation remains an open problem. The present study combines the techniques of stochastic mathematical modeling with physiological models of the systemic circulation, cuff, and arm (1) to explore mechanisms underlying both the lack of accuracy and the lack of precision in cuff-based arterial pressure measurements during atrial fibrillation and (2) to develop strategies to correct for errors. Both the cardiovascular system and the measurement technique are described using mathematics, including both numerical techniques and analytical probability theory. Preliminary results with numerical models suggested that, despite variability, average systolic pressures tend …
Identifying Patients With Coronary Artery Disease Using Rest And Exercise Seismocardiography,
2019
University of North Dakota
Identifying Patients With Coronary Artery Disease Using Rest And Exercise Seismocardiography, Parastoo Dehkordi, Erwin P. Bauer, Kouhyar Tavakolian, Vahid Zakeri, Andrew P. Blaber, Farzad Khosrow-Khavar
Electrical Engineering Faculty Publications
Coronary artery disease (CAD) is the most common cause of death globally. Patients with suspected CAD are usually assessed by exercise electrocardiography (ECG). Subsequent tests, such as coronary angiography and coronary computed tomography angiography (CCTA) are performed to localize the stenosis and to estimate the degree of blockage. The present study describes a non-invasive methodology to identify patients with CAD based on the analysis of both rest and exercise seismocardiography (SCG). SCG is a non-invasive technology for capturing the acceleration of the chest induced by myocardial motion and vibrations. SCG signals were recorded from 185 individuals at rest and immediately …
Measurement Of Adhesion Of Sternal Wires To A Novel Bioactive Glass-Based Adhesive,
2019
Missouri University of Science and Technology
Measurement Of Adhesion Of Sternal Wires To A Novel Bioactive Glass-Based Adhesive, Varinder Pal Singh Sidhu, Mark R. Towler, Marcello Papini
Chemical and Biochemical Engineering Faculty Research & Creative Works
Stainless steel wires are the standard method for sternal closure because of their strength and rigidity, the simplicity of the process, and the short healing time that results from their application. Despite this, problems still exist with sternal stability due to micromotion between the two halves of the dissected and wired sternum. Recently, a novel glass-based adhesive was developed which, in cadaveric trials and in conjunction with wiring, was shown to restrict this micromotion. However, in order to avoid complications during resternotomy, the adhesive should adhere only to the bone and not the sternal wire. In this study, sternal wires …
Developmental And Sex Modulated Neurological Alterations In Autism Spectrum Disorder,
2019
New Jersey Institute of Technology
Developmental And Sex Modulated Neurological Alterations In Autism Spectrum Disorder, Azeezat Azeez
Dissertations
Autism Spectrum Disorder (ASD) was first described in 1943 by Dr. Leo Kranner in a case study published in The Nervous Child. It is a neurodevelopment disorder, with a range of clinical symptoms. According to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), used by clinicians to diagnose mental disorders, a child needs to have persistent social deficits, language impairments, and repetitive behaviors, that cannot be explained by neurological damage or intellectual disability. It is known that children diagnosed with ASD are often are developmentally delayed therefore alterations in the typical developmental trajectory should be a major factor in …
Modulation Of Corticospinal Excitability Induced By Paired Associative Stimulation Combined With Movement,
2019
New Jersey Institute of Technology
Modulation Of Corticospinal Excitability Induced By Paired Associative Stimulation Combined With Movement, Ahmad O. Alokaily
Dissertations
An essential feature of the brain is its capacity to undergo long-lasting morphological or functional changes in response to experiences or trauma. Advances in noninvasive brain stimulation techniques have led to increased interest in understanding neural mechanisms of neuroplasticity at the network level. Paired associative stimulation (PAS) is one of the most commonly used applications for noninvasive brain stimulation because of its clinical potential as an adjuvant rehabilitative intervention. However, the optimal method for incorporating PAS into rehabilitative activities remains unknown. This dissertation explores different approaches to combining PAS with movement and investigates the enhancement of the specificity of conventional …
Modelling In Vitro Dissolution And Release Of Sumatriptan Succinate From Polyvinylpyrrolidone-Based Microneedles Aided By Iontophoresis,
2019
New Jersey Institute of Technology
Modelling In Vitro Dissolution And Release Of Sumatriptan Succinate From Polyvinylpyrrolidone-Based Microneedles Aided By Iontophoresis, James Paul Ronnander
Dissertations
A novel dissolving microneedle array system is developed to investigate permeation of a sumatriptan succinate formulations through the skin aided by iontophoresis. Three formulations consisting of hydrophilic, positively charged drug molecules encapsulated in a water-soluble biologically suitable polymer, polyvinylpyrrolidone (PVP), have been accepted by the U.S. Food and Drug Administration (FDA). The microneedle systems are fabricated with 600 pyramid-shaped needles, each 500 µm tall, on a 0.785-cm2 circular array. In vitro transdermal studies with minipig skin and vertical Franz diffusion cells show > 68% permeation of sumatriptan over a 24-hour period. A combination of microneedle and electrical current density ranging …
Exercise-Induced Alterations In Sympathetic-Somatomotor Coupling In Incomplete Spinal Cord Injury,
2019
Marquette University
Exercise-Induced Alterations In Sympathetic-Somatomotor Coupling In Incomplete Spinal Cord Injury, Tanya Onushko, Gordhan B. Mahtani, Gabrielle Brazg, T. George Hornby, Brian D. Schmit
Biomedical Engineering Faculty Research and Publications
The aim of this study was to understand how high- and low-intensity locomotor training (LT) affects sympathetic-somatomotor (SS) coupling in people with incomplete spinal cord injury (SCI). Proper coupling between sympathetic and somatomotor systems allows controlled regulation of cardiovascular responses to exercise. In people with SCI, altered connectivity between descending pathways and spinal segments impairs sympathetic and somatomotor coordination, which may have deleterious effects during exercise and limit rehabilitation outcomes. We postulated that high-intensity LT, which repeatedly engages SS systems, would alter SS coupling. Thirteen individuals (50 ± 7.2 years) with motor incomplete spinal cord injuries (American Spinal Injury Association …
Initial Development Of A Prototype Sensor Testbed For Fetal Monitoring,
2019
Rowan University
Initial Development Of A Prototype Sensor Testbed For Fetal Monitoring, Christian Beauvais
Theses and Dissertations
The objective of this research is to design and manufacture a device that exhibits some of the bio-physiological signals relevant to fetal health monitoring. Currently, limited options exist for testing the performance of monitoring devices such as the tocodynamometer (TOCO) and electrocardiograph (ECG) that measure the bio-physiological signals of a woman and her fetus. Sensor designers need ways of generating and acquiring signals that do not carry the ethical burden of human testing. The development of such a device, as considered in this work, may involve using muscle wire or an inflatable tube as prospective foundations for simulating uterine contraction. …
Ex Vivo Electrochemical Measurement Of Glutamate Release During Spinal Cord Injury,
2019
Purdue University
Ex Vivo Electrochemical Measurement Of Glutamate Release During Spinal Cord Injury, James K. Nolan, Tran N. H. Nguyen, Mara Fattah, Jessica C. Page, Riyi Shi, Hyowon Lee
Weldon School of Biomedical Engineering Faculty Publications
Excessive glutamate release following traumatic spinal cord injury (SCI) has been associated with exacerbating the extent of SCI. However, the mechanism behind sustained high levels of extracellular glutamate is unclear. Spinal cord segments mounted in a sucrose double gap recording chamber are an established model for traumatic spinal cord injury. We have developed a method to record, with micro-scale printed glutamate biosensors, glutamate release from ex vivo rat spinal cord segments following injury. This protocol would work equally well for similar glutamate biosensors.
Comparison Of Different Methods For Estimating Cardiac Timings: A Comprehensive Multimodal Echocardiography Investigation,
2019
University of North Dakota
Comparison Of Different Methods For Estimating Cardiac Timings: A Comprehensive Multimodal Echocardiography Investigation, Parastoo Dehkordi, Farad Khosrow-Khavar, Marco Di Rienzo, Omer T. Inan, Samuel E. Schmidt, Andrew P. Blaber, Kasper Sorensen, Johannes J. Struijk, Vahid Zakeri, Prospero Lombardi, Md. Mobaskir H. Shandhi, Mojtaba Borairi, John M. Zanetti, Kouhyar Tavakolian
Biomedical Sciences Faculty Publications
Cardiac time intervals are important hemodynamic indices and provide information about left ventricular performance. Phonocardiography (PCG), impedance cardiography (ICG), and recently, seismocardiography (SCG) have been unobtrusive methods of choice for detection of cardiac time intervals and have potentials to be integrated into wearable devices. The main purpose of this study was to investigate the accuracy and precision of beat-to-beat extraction of cardiac timings from the PCG, ICG and SCG recordings in comparison to multimodal echocardiography (Doppler, TDI, and M-mode) as the gold clinical standard. Recordings were obtained from 86 healthy adults and in total 2,120 cardiac cycles were analyzed. For …
Lactonic Sophorolipid Increases Surface Wettability Of Poly- L -Lactic Acid Electrospun Fibers,
2019
Missouri University of Science and Technology
Lactonic Sophorolipid Increases Surface Wettability Of Poly- L -Lactic Acid Electrospun Fibers, Alexis M. Ziemba, Keith P. Lane, Bailey Balouch, Anthony R. D'Amato, Filbert Totsingan, Richard A. Gross, Ryan J. Gilbert
Chemical and Biochemical Engineering Faculty Research & Creative Works
The hydrophobicity of electro spun poly-l-lactic acid (PLLA) fibers hinders their integration with surrounding tissue for a variety of applications. In this study, we increased PLLA fiber hydrophilicity by incorporating the natural surfactant, lactonic sophorolipid (LSL). PLLA+LSL fibers had similar fiber morphology but significantly greater surface wettability, which suggested LSL accumulation on the fiber surface. Differential scanning calorimetry results also suggested that LSL was phase separated from PLLA. Despite the altered surface wettability of these fibers, there was no change in fibroblast adhesion. Future studies may explore the use of this natural surfactant to deliver bioactive factors to enhance fibroblast …
Assessment Of The Biocompatibilty, Stability, And Suitability Of Natural And Synthetic Polymers And Drugs In The Fda Approval Process,
2019
University of New Mexico
Assessment Of The Biocompatibilty, Stability, And Suitability Of Natural And Synthetic Polymers And Drugs In The Fda Approval Process, Phuong Anh Hoang Nguyen
Biomedical Engineering ETDs
Regulation of the development, production, marketing, and sales of medical pharmaceuticals and devices in the United States fall under the regulatory functions of the Food and Drug Administration (FDA). The current FDA approval process takes an average of 10 years from start to completion, and costs over $100 million. As a result, companies use many different methods to find additional use of their drugs through marketing directly to the physician, or recycling of previously approved drug moieties. In this work, an evaluation of the in vitro and ex vivo biocompatibility of polymers and drugs in different phases of FDA approval …
