Biomedical Engineering and Bioengineering Commons^™

Impedance Analysis Of Tissues In Nspef Treatment For Cancer Therapy, Edwin Ayobami Oshin

Biomedical Engineering Theses & Dissertations

Nanosecond pulsed electric field (nsPEF) for cancer therapy is characterized by applications of high voltage pulses with low pulsed energy to induce non-thermal effects on tissues such as tumor ablation. It nonthermally treats tissues via electroporation. Electroporation is the increase in permeabilization of a cell membrane due to the application of high pulsed electric field. The objective of this study was to investigate the effect of nsPEF on tissue by monitoring the tissue’s impedance in real-time. Potato slices (both untreated and electroporated), and tumors extracted from female BALBc mice were studied. 100ns, 1-10kV pulses were applied to the tissues using …

Deep Cellular Recurrent Neural Architecture For Efficient Multidimensional Time-Series Data Processing, Lasitha S. Vidyaratne

Electrical & Computer Engineering Theses & Dissertations

Efficient processing of time series data is a fundamental yet challenging problem in pattern recognition. Though recent developments in machine learning and deep learning have enabled remarkable improvements in processing large scale datasets in many application domains, most are designed and regulated to handle inputs that are static in time. Many real-world data, such as in biomedical, surveillance and security, financial, manufacturing and engineering applications, are rarely static in time, and demand models able to recognize patterns in both space and time. Current machine learning (ML) and deep learning (DL) models adapted for time series processing tend to grow in …

System Reliability Analysis Of The Scoliosis Disorder., Fatemeh Nouri, Seyed Hooman Ghasemi, Ji Yun Lee

Henry M. Rowan College of Engineering Departmental Research

BACKGROUND: Scoliosis is a spine abnormal deviation, which is an idiopathic disorder among children and adolescents. As a matter of the fact, distribution of loads on the patient's spine and load-carrying capacity of the vertebral column are both random variables. Therefore, the probabilistic approach may consider as a sophisticated method to deal with this problem.

METHOD: Reliability analysis is a probabilistic-based approach to consider the uncertainties of load and resistance of the vertebral column. The main contribution of this paper is to compare the reliability level of a normal and scoliosis spinal. To do so, the numerical analyses associated with …

Modern Model For Assessing The Efficiency Of Investments Attracted In Railway Transport, M.S. Saitkamolov, Z.T. Gaibnazarova, J. Cowie

Technical science and innovation

The article analyzes the modern model for evaluating the improvement of investment activity efficiency and provides conclusions on the level of development of the current state of railway transport in the Republic of Uzbekistan.

The economic effect of intensive investments is the equivalent of the costs and benefits of the difference between the result and the costs of achieving it.

The economic efficiency of intensive investments is defined as the ratio of investment costs to achieving a profitable result (economic effect).

The indicators characterizing the economic efficiency of intensive investments: the integrated effect, the need for additional financing, the internal …

A Micro-Optic Stalk (Muos) System To Model The Collective Migration Of Retinal Neuroblasts, Stephanie Zhang, Miles Markey, Caroline D. Pena, Tadmiri Venkatesh, Maribel Vasquez

Publications and Research

Contemporary regenerative therapies have introduced stem-like cells to replace damaged neurons in the visual system by recapitulating critical processes of eye development. The collective migration of neural stem cells is fundamental to retinogenesis and has been exceptionally well-studied using the fruit fly model of Drosophila Melanogaster. However, the migratory behavior of its retinal neuroblasts (RNBs) has been surprisingly understudied, despite being critical to retinal development in this invertebrate model. The current project developed a new microfluidic system to examine the collective migration of RNBs extracted from the developing visual system of Drosophila as a model for the collective motile processes …

Fibration Symmetries Uncover The Building Blocks Of Biological Networks, Flaviano Morone, Ian Leifer, Hernán A. Makse

Publications and Research

A major ambition of systems science is to uncover the building blocks of any biological network to decipher how cellular function emerges from their interactions. Here, we introduce a graph representation of the information flow in these networks as a set of input trees, one for each node, which contains all pathways along which information can be transmitted in the network. In this representation, we find remarkable symmetries in the input trees that deconstruct the network into functional building blocks called fibers. Nodes in a fiber have isomorphic input trees and thus process equivalent dynamics and synchronize their activity. Each …

Development Of A Monolithic Implantable Neural Interface From Cubic Silicon Carbide And Evaluation Of Its Mri Compatibility, Mohammad Beygi

USF Tampa Graduate Theses and Dissertations

One of the main issues with micron-sized intracortical neural interfaces (INIs) is their long-term reliability, with one major factor stemming from device material failure caused by the heterogeneous integration of multiple materials used to realize the implant. Single crystalline cubic silicon carbide (3C-SiC) is a semiconductor material that has been long recognized for its mechanical robustness and chemical inertness. It has the benefit of demonstrated biocompatibility, which makes it a promising candidate for chronically-stable, implantable INIs. In the first section of this dissertation, the fabrication and initial electrochemical characterization of a monolithic, Michigan-style 3C-SiC microelectrode array (MEA) probe is reported. …

Design Of An Affordable Rotating Drum Electrospinner For Classroom Education, Peder Solberg

The Journal of Undergraduate Research

Electrospinning is a technology used to generate small fibers down to nano-scale size. This method of fiber creation has been around for many years. However, in recent years electrospinning has found increased applications, especially in the area of tissue engineering due to its ability to create fibers with properties similar to the extracellular matrix in tissue. An electrospinning platform can illustrate concepts of engineering, electro-mechanical system design, manufacturing, and biomedical applications in one single package. Hence, it provides an excellent opportunity to integrate into secondary (middle and high school) and post-secondary (undergraduate) technology education.

Furthermore, just as integration of 3D …

Application Of 3-D Printing To Multiple Sclerosis: Lesion Detection And Brain Modeling, Makenzie Fogle, Micheho Guitierrez-Carpio

Research Horizons Day Posters

No abstract provided.

Review Of Living Learning Communities And Their Impact On First Year Engineering College Students, Samantha Schauer, Krishna Pakala, Kim M.B. Tucker

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Traditionally, first-year college students do not have a community of like-minded peers with whom they are able to learn. Adding to first-year engineering college students’ (FYECS) struggles is the fact that many students do not have a mentor in their related field and are unable to start building their professional repertoire, network, and/or practical skills. Living Learning Communities (LLC) can offer a platform for postsecondary institutions to increase recruitment, engagement, and sense of belonging for students who live in an LLC. LLCs have been described in the literature as themed living and learning communities where students take a common course(s), …

Transcutaneous Auricular Vagus Nerve Stimulation-Paired Rehabilitation For Oromotor Feeding Problems In Newborns: An Open-Label Pilot Study, Bashar W. Badran, Dorothea D. Jenkins, Daniel Cook, Sean Thompson, Morgan Darcy, William H. Devries, Georgia Mappin, Philipp Summers, Marom Bikson, Mark S. George

Publications and Research

Neonates born premature or who suffer brain injury at birth often have oral feeding dysfunction and do not meet oral intake requirements needed for discharge. Low oral intake volumes result in extended stays in the hospital (>2 months) and can lead to surgical implant and explant of a gastrostomy tube (G-tube). Prior work suggests pairing vagus nerve stimulation (VNS) with motor activity accelerates functional improvements after stroke, and transcutaneous auricular VNS (taVNS) has emerged as promising noninvasive form of VNS. Pairing taVNS with bottle-feeding rehabilitation may improve oromotor coordination and lead to improved oral intake volumes, ultimately avoiding the …

Fetal Evoked Responses: Improved Attenuation Of Cardiac Interference And Verification By Magnetic Dipole Fitting, Neslihan Bisgin

Theses and Dissertations

Early detection of fetal neurological disorders is of significant importance however, accessing the fetal brain signal has been a challenging issue. With highly sensitive Superconducting Quantum Interference Device (SQUID) sensors, fetal magnetoencephalography (fMEG) can be recorded and there have been many studies on understanding fetal brain activity through fMEG. The major problem about fMEG data is its low signal to noise ratio. fMEG is extracted from the mixture of maternal heart, fetal heart, fetal brain, and other biological signals from mother and the fetus. Effective removal of interferences is crucial in detecting the low amplitude fetal neurological signals. The objective …

Biomechanical Behavior Of A Variable Angle Locked Tibiotalocalcaneal Construct, Farah Hamandi, Gerard Simon, Richard T. Laughlin, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

This paper examines the mechanics of the tibiotalocalcaneal construct made with a PHILOS plating system. A failed device consisting of the LCP plate and cortical, locking, and cannulated screws was used to perform the analysis. Visual, microstructure, and fractographic examinations were carried out to characterize the fracture surface topology. These examinations revealed the presence of surface scratching, inclusions, discoloration, corrosion pits, beach marks, and cleavage and striations on the fracture surface. Further examination of the material crystallography and texture revealed an interaction of S, Ni, and Mo-based inclusions that may have raised pitting susceptibility of the device made with Stainless …

Coating Topologically Complex Electrospun Fibers With Nanothin Silk Fibroin Enhances Neurite Outgrowth In Vitro, Alexis M. Ziemba, Tanner D. Fink, Mary Clare Crochiere, Devan L. Puhl, Samichya Sapkota, Ryan J. Gilbert, R. Helen Zha

Chemical and Biochemical Engineering Faculty Research & Creative Works

Electro spun poly-l-lactic acid (PLLA) fibers are commonly used for tissue engineering applications because of their uniform morphology, and their efficacy can be further enhanced via surface modification. In this study, we aimed to increase neurite outgrowth along electro spun fibers by coating with silk fibroin (SF), a bioinert protein derived from Bombyx mori cocoon threads, shown to be neuro compatible. Aligned PLLA fibers were electro spun with smooth, pitted, and devoted surface nano topographies and coated with SF by immersion in coating solution for either 12 or 24 h. Specifically, thin-film coatings of SF were generated by leveraging the …

Autocorrelation And Probability Distributions In Gait-Metronome Synchronization, Charles Sloan

UNO Student Research and Creative Activity Fair

Recent research has shown that the structure of different pacing signals influences gait dynamics during coordination to those signals. Those studies, however, have not looked at the impact that probability distribution functions play in influencing our gait. This study looks at how both autocorrelation functions and probability distribution has in noisy metronomes to look for sources of synchronization. 10 healthy subjects volunteered to complete this study. The participants were required to wear custom-built glasses with a small screen projected on the lens. The screen showed a visual stimulus that correlated with various signals. The results of the study suggest that …

Effects Of Novel Tool Use: Cortical And Functional Measures In Children Using A Prosthetic Simulator, Chris Copeland

UNO Student Research and Creative Activity Fair

As of 2005, there were a total of 1.6 million people living with the loss of a limb, with this population projected to double to 3.6 million by 2050 [1]. While prostheses aim to enhance the function of these individuals, it is estimated that 45% of pediatric prosthetic users reject their prosthesis [2]. The literature which describes the neurological control mechanisms of prosthetic use is sparse and often low-powered due to an inadequate number of participants. However, prosthetic simulators may be a solution to chronically low-powered prosthetic-centric studies by serving as functional homologues, though this has yet to be tested. …

Inverse Dynamics Analysis Of Youth Pitching Arm Kinetics Using Body Composition Imaging, Jay A. Sterner, Scott K. Reaves, Arnel L. Aguinaldo, Scott Hazelwood, Stephen M. Klisch

Biomedical Engineering

This study’s objectives were to: (1) assess whether dual energy X-ray absorptiometry (DXA)-mass inverse dynamics (ID) alters predictions of youth pitching arm kinetics and (2) investigate correlations between kinetics and body composition. Eighteen 10- to 11-year-olds pitched 10 fastballs. DXA scans were conducted to obtain participant-specific upper arm, forearm, and hand masses. Pitching arm segment masses and kinetics calculated with scaled and DXA masses were compared with paired t-tests and correlations were investigated with linear regression. Hand (p < 0.001) and upper arm (p < 0.001) DXA masses were greater, while forearm (p < 0.001) DXA masses were lesser, than their scaled masses. Shoulder compressive force (p < 0.001), internal rotation torque (p < 0.001), and horizontal adduction torque (p = 0.002) increased when using DXA masses. Shoulder compressive force correlated with body mass (p < 0.001) and body mass index (BMI; p = 0.002) and elbow varus torque correlated with body mass (p < 0.05). The main conclusions were that (1) using participant-specific mass ratios leads to different predictions of injury-related pitching arm kinetics and, thus, may improve our understanding of injury risk factors; and (2) pitching arm kinetics were correlated with body composition measures and a relatively high total body mass and/or BMI may increase shoulder and/or elbow injury risk.

Subject-Specific Finite Element Models Of The Human Knee For Transtibial Amputees To Analyze Tibial Cartilage Pressure For Gait, Cycling, And Elliptical Training, Jonathon Stearns

Master's Theses

It is estimated that approximately 10-12% of the adult population suffers from osteoarthritis (OA), with long reaching burdens personally and socioeconomically. OA also causes mild discomfort to severe pain in those suffering from the disease. The incidence rate of OA for individuals with transtibial amputations is much than average in the tibiofemoral joint (TF). It is well understood that abnormal articular cartilage stress, whether that be magnitude or location, increases the risk of developing OA. Finite element (FE) simulations can predict stress in the TF joint, many studies throughout the years have validated the technology used for this purpose. This …

Diy Incubator, Aryan Zia, Grace Spurlock, Garrett Janney

Biomedical Engineering

This project report provides detailed information on designing and building a DIY Incubator. The device is indicated for growing and maintaining BSL-1 mammalian or bacterial cell culture with a temperature control in the range of 25-45°C ± 1°C. The device is made fully programmable via an Arduino, and is structurally designed to fit two T75 cell culture flasks at a time. The device is able to return to a specified temperature set point within 10 minutes and maintains 5% CO2 partial pressure conditions. The incubator has a small physical footprint, with an overall dimension of 22in x 16in x 15.5in …

Theoretical Analysis Of The Leakage Through The Cement Line Of A Single Osteon, Gaffar Gailani, Stephen Cowin

Publications and Research

This work focuses on the Lacunar–Canalicular Porosity (PLC) of cortical bone which includes the osteons. Osteons are semicylindrical porous structures saturated with fluid within the bone and are approximately 250" role="presentation">μ" role="presentation">μm in diameter. The outer boundary of the osteon is called the cement line. Some studies suggested that the cement line is less highly mineralized and produced evidence that it has less calcium and phosphorus and more sulfur than the neighboring bone lamellae. Most authors assume that the cement line is impermeable, while others assume that some canaliculi are crossing the cement line which will make it …