Biomedical Devices and Instrumentation Commons^™

Evervital Patch: The Design And Development Of A Continuous Cardiac Monitoring Device For Post-Operative, In-Hospital Patients, Abigail Moeller, Jonathan Seid

Honors Theses

In the United States, due to the increasing prevalence of cardiovascular disease, over 900,000 cardiac surgeries are performed annually, with projections exceeding 1.3 million by 2029. Many post-surgical patients require continuous in-hospital cardiac monitoring, which is typically conducted using electrocardiograms (EKGs). However, traditional EKG systems such as bedside cardiac monitors and cardiac telemetry monitors rely on wired leads that can easily tangle, degrade signal quality, and require frequent readjustments or replacements due to wire breakage, and for the patient, this can cause discomfort from prolonged use. To overcome these challenges, our company, CardioSync, aims to develop a wireless cardiac monitoring …

Limbgod(Pat. Pending): Wearable Garment For Amputation Prevention, Naomi Choi Dpm, Mba, Phuc An Dinh Bs, Ms, Eric Lee Bs, Francois M. Lokenye Dpm

Posters

Approximately 1.6 million people in the U.S. have lower limb amputations, which is expected to double by 2050 (Wong et al.). Socio-economic factors: income, education, rural residency & race, impact amputation risk (Okesina et al.), with Black Americans 70% are more likely to undergo major lower limb amputations than white Americans, even after adjusting for care access & comorbidities (Feinglass et al., Holman et al., Regenbogen et al.). Within 5 years, up to 50% of first-time amputees require another amputation (Dilingham et al., Glaser et al.) & those with comorbidities face a 77% five-year mortality rate (Fortington et al.).

Next-Generation Biomedical Implants And Stimuli Responsive Soft Optical Arrays Via Surface Functionalized Elastomeric Materials, John M. Kapitan

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

The demands of emerging technologies, such as soft robotics, stretchable electronics, and next generation biomedical implants, has led to the development of diverse polymeric and hybrid organic/inorganic materials specifically tuned to meet these challenges. These materials typically have low Young’s moduli and are inert with high chemical stability. However, this has led to materials that are static in nature, lacking any meaningful way of responding to changes in their environment and adapting to these changes. This has driven a shift towards the design, manufacturing, and characterization of various stimuli responsive surfaces, relying on precise control of surface chemical coatings and …

Clinical Use Of Sit2stand Ai Application For Kinematic Analysis In Prosthesis Users., Samerial Brown

Posters - 2025

Biomechanical analysis is a tool to evaluate prosthetic and orthotic patient's. These tools offer the clinician capability of understanding the mechanism of injury, gait deviation or prosthesis problem. Video based analysis require expensive hardware, software, and training which sometimes costs $40-100,000.

The recent advent of artificial intelligence (AI) has opened up the possibility of acquiring high speed human motion video analysis using low-cost hardware and open-source machine learning algorithms. Still, free assessments like the Sit2Stand test is a current clinical outcome measure which assesses ability of a patient to stand and sit as fast as possible 5x. The faster the …

Development, Optimization, And Validation Of A High-Sensitivity Capillary Zone Electrophoresis System For Bioanalytical Applications, Aaron I. Mena

Electronic Theses and Dissertations

Capillary zone electrophoresis (CZE) is a powerful analytical technique widely used for biomolecular separation due to its high resolution, efficiency, and sensitivity. This report presents the development and validation of a novel CZE system designed to improve modularity, reproducibility, and operational efficiency. The system integrates a laser-induced fluorescence (LIF) detection method with a 488 nm laser, enhanced fluid control through a negative pressure system, and a user-friendly GUI for automated operation and data acquisition. Performance verification included pressure stability tests, fluorescence accuracy assessments, and electrophoretic reproducibility studies. Comparative analysis with a previous CZE iteration confirmed improved baseline stability, peak resolution, …

Sprinter Start Block Training Aid, Kayla Lovejoy, Kevin Almontes

Biomedical Engineering

Currently, track and field sprinters ranging from beginner level to world-class have no practical tool that provides quantitative feedback of value on quality of start and quality of the three distinct phases of their sprint race, such that they can quantify the value of their adjustments. Our team will create a device that integrates with the sprint starting block to provide quantifiable data on the quality of a sprinter’s start. This Statement of Work describes drawbacks of current solutions, existing patents, customer requirements, engineering specifications, and our project plan.

Realistic Bionic Arm Development For Transradial Amputation, Bailey A. Wall, Lilly Noel Curdy, Ruthie Mccall, Courtney Mahoney, Andres Trejo

Biomedical Engineering

The VeraLimb realistic bionic arm is intended for use by individuals with a trans-radial amputation or congenital limb deficiency below the elbow to provide functional hand and arm movements. This advanced prosthetic device is designed to mimic a biological hand's natural motion, dexterity, control, and aesthetic, giving the user a higher sense of restored limb functionality. It offers an experience that closely restores motor function in a way that resembles having a natural hand rather than interacting with a mechanical device. The VeraLimb is suitable for daily activities, allowing users to grasp, manipulate, and interact with objects. It is designed …

Unified Adaptive Cross-Attention Multimodal Network, Mahesh Sunuwar

Shelby Hall Graduate Research Forum Posters

Accurately diagnosing appendicitis remains a significant challenge in emergency medicine due to its varied clinical presentation and overlap with other abdominal conditions. Existing diagnostic models often rely on unimodal data, such as computed tomography (CT) images or clinical notes, limiting their ability to capture the full complexity of patient information. This study proposes a novel multimodal framework, a Unified Adaptive Cross-Attention Multimodal Framework (u-ACM), that integrates CT images and clinical notes using hybrid fusion strategies to improve diagnostic accuracy for appendicitis. The u-ACM leverages adaptive contextual filtering to dynamically remove irrelevant features, crossattention mechanisms to align features between modalities, and …

Peripheral Vagus Nerve Stimulation (Pvns) Device For Epilepsy, Logan P. Beckstrand, Alexander P. Crary, Grace E. Heller

Biomedical Engineering

Our research team developed a PVNS for Epilepsy device which is intended to act as a preventative measure against seizures for patients with epilepsy. The device is a less invasive alternative to the VNS device on the market using electroacupuncture at the Shenmen and Xin points along the posterior pinna to stimulate the vagus nerve.

Tiny Temp Neonatal Intensive Care Unit Infant Temperature Monitor, Alexandria Lukacsffi, Sydney Dedrick

Biomedical Engineering

This document outlines the key steps taken in the specification, design, and functionality of the Tiny Temp Neonatal Intensive Care Unit Infant Temperature Monitor. The BICEP team identified temperature monitors for infants in incubators in the NICU as an area of need after surveying hospitals in the San Luis Obispo area. Current thermometers are oversimplified in design, consisting of only the temperature probe and a piece of adhesive holding the probe directly onto the infant's skin. As a result, the adhesive is weak to prevent harm to the infant and, therefore, falls off the infant easily and frequently, posing a …

Operating Room Forcing Function, Olivia Rankin, Makena Moragne, Sasha Rovinsky

Biomedical Engineering

The Operating Room Forcing Function system aims to address the persistent issue of wrong-site, wrong-procedure, and wrong-patient errors (WSPEs) in surgical settings. WSPEs are largely caused by circumvention of the timeout procedure (a planned pause before incision to stop and confirm crucial details of the procedure to be performed known as ‘The Universal Protocol’). The goal set forth by our sponsor, Dr. Robert Turbow, is to develop a lock-out mechanism that requires a timeout to be performed by all appropriate personnel before an operation can begin.

Hospitals are extremely complex systems with competing values, productivity pressures, fast paced work, tight-coupled …

The Suture Guide, Nicole Schnettler, Ciara Murphy, Jocelyn Corona Cabrera

Biomedical Engineering

In the surgical field and specifically wound closure, there is a growing demand for techniques that allow surgeons to quickly, accurately, and ergonomically close surgical wounds while still optimizing patient recovery and not compromising the cosmetic appearance in wound closure. Currently more advanced and developed products exist for laparoscopic suturing, but not for superficial suturing. This project aims to find a way to close the most superficial layer of the skin in surgical incisions that is faster and more comfortable than current suturing techniques. The design process began with stakeholder interviews and market research, identifying key shortcomings of current manual …

Identifying Breathing, Swallowing, And Speech Biosignatures In Parkinson’S Disease Patients With Wearable Devices, Amanda Brandaris, Katherine Shishido, Rohaan Manzoor, Ethan Hampton, Karthik Jasty, Kelvin Guo, Anna Fish, Spencer Peterson, Ulrike H. Mitchell Phd, Phillip Sechtem Phd, Ccc-Slp, Paula Johnson Phd, Anton E. Bowden Phd, Miriam Cortez-Cooper Pt, Phd, Pamela I. Barney Msrt, Rrt, Ae-C, Nps, John A. Kriak Pharmd

Annual Research Symposium

No abstract provided.

Advancing Prosthetic Technology: 3d-Printed Robotic Arm With Micro Linear Actuators, Vu Tran, Nathan Reed, Mahdi Yazdanpour

Posters-at-the-Capitol

The increasing demand for affordable and accessible prosthetic solutions has driven innovation in the field of robotics. In this project, we present the design and development of a 3D-printed robotic prosthetic arm aimed at addressing the challenges faced by individuals with upper limb amputations. Our prosthetic arm utilizes five micro linear actuators to achieve precise and naturalistic movement. The design of the prosthetic arm prioritizes affordability and accessibility, with a focus on leveraging 3D printing technology to reduce manufacturing costs and enable customization. The use of micro linear actuators offers advantages in terms of compactness, lightweight construction, and efficient power …

Adaptation Of The Biodent For Spherical Microindentation To Determine Elastic Modulus In Small Rodent Bones, Mixame E. Jerome

Dissertations and Theses

Mechanical and material properties of bone are essential for understanding both normal skeletal function and the progression of bone-related diseases. Microindentation has become a widely used method for evaluating tissue mechanical properties of bone, as it samples the contributions of microarchitecture and composition. Microindentation using a standard pointed tip inherently introduces both elastic and plastic deformation into the material. In contrast, indentation with a spherical tip can be operated entirely in the elastic range, providing for a non-damaging test that has significant advantages over sharp indentation techniques. Moreover, a key advantage of using spherical indentation lies in its operation under …

Advancing Electrical Stimulation: Full-Head Mri Segmentation For Abnormal Brain Anatomy With Tdcs, Andrew Birnbaum

Dissertations and Theses

Evaluating the effectiveness of transcranial direct current stimulation (tDCS) is essential for guiding its integration into therapeutic and performance-enhancement applications. In our laboratory, we investigate the efficacy of tDCS across multiple experimental models, including both animal and human studies. I have contributed significantly to the execution and analysis of these experiments, which include studies in rats and healthy human participants aimed at evaluating whether electrical stimulation of the motor cortex can enhance motor learning. These studies assess improvements in fine motor performance resulting from tDCS. In stroke patients, I contribute to our investigation of tDCS as a rehabilitative intervention, particularly …

Viscoelastic Property Analysis Of A Magnetorheological Elastomer Micropump For Insulin Delivery In Type 1 Diabetes, Victor Buitimea

College of Graduate Studies: Theses & Dissertations

Over two decades, there has been a significant rise in awareness regarding Type 1 Diabetes (T1D), leading to a deeper comprehension of numerous variables, including hereditary factors, patterns of occurrence, and health challenges. According to the Type 1 Diabetic Index, around 8.7 million people worldwide are affected by this chronic autoimmune illness marked by a lack of insulin and hyperglycemia. The introduction of artificial pancreas systems could save more than half a million patients by 2040. Despite the availability of various insulin delivery technologies that are offered to diabetic patients, many still are skeptical of this modern system. The issues …

Development And Clinical Validation Of The Sensor-E Exoskeleton For Objective Hand Function Assessment In Stroke Rehabilitation, Madison Bates

Theses and Dissertations--Biomedical Engineering

Hand function is often impaired following neurological trauma or in conditions such as stroke, limiting independence and the ability to perform activities of daily living (ADLs). Current clinical assessments rely heavily on subjective rating scales that lack the resolution to detect subtle changes in motor performance, which can limit access to rehabilitation. Recent advances in wearable technologies highlight the potential for hand-worn devices to provide objective, real-time measures of hand function. However, most systems focus solely on kinematics and rarely capture both movement and exerted force. Moreover, integration into rehabilitation frameworks and brain-computer interface (BCI) protocols remains limited. To address …

Cost-Effective Hierarchical Cobalt Nanostructured Laser-Induced Graphene For Enhanced Uric Acid Detection, Anju Joshi, Gymama Slaughter

Center for Bioelectronics Publications

This study presents an innovative, cost-effective strategy to develop a flexible, enzyme-free biosensor for the sensitive detection of uric acid (UA). Utilizing electrochemically modified cobalt nanostructured on laser-induced graphene electrodes (CoNCs/LIG), this approach surpasses traditional noble metal-based electrocatalysts in sensitivity and affordability. The one-step electrochemical modification method is efficient and straightforward, enabling the uniform deposition of hierarchical flower-like cobalt nanostructures. These structures synergistically enhance the performance of the LIG, resulting in a broad detection range of 5 to 700 µM with a sensitivity of 6.75 µA µM^-¹ cm^-² and a low detection limit of 3.66 µM for UA. …

Laser-Induced Graphene For Early Disease Detection: A Review, Sri Ramulu Torati, Gymama Slaughter

Center for Bioelectronics Publications

Electrochemical biosensors have been instrumental in early disease detection, facilitating effective monitoring and treatment. The emergence of graphene has significantly advanced sensor technology in various fields, including biomedicine, electronics, and energy. In this landscape, laser‐induced graphene (LIG) has emerged as a superior alternative to conventional graphene synthesis methods. Its straightforward fabrication process and compatibility with wearable devices boost its practicality and potential for real‐world applications. This review highlights the transformative potential of LIG in biosensing, showcasing its contributions to the development of next‐generation diagnostic tools for early disease detection. An overview of the LIG synthesis process and its applications in …