Raman Spectroscopy Applied To The Noninvasive Detection Of Monosodium Urate Crystal Deposits,
2015
Missouri University of Science and Technology
Raman Spectroscopy Applied To The Noninvasive Detection Of Monosodium Urate Crystal Deposits, Declan J. Curran, Laurence Rubin, Mark R. Towler
Chemical and Biochemical Engineering Faculty Research & Creative Works
An off-the-shelf Raman Spectrometer (RS) was used to noninvasively determine the presence of monosodium urate (MSU) crystals on the metatarsophalangeal joint (MTPJ) of a single gout sufferer. The spectrum sourced from the clinically diagnosed gout sufferer was compared to that sourced from an age-matched healthy subject scanned using the same protocol. Minimal signal processing was conducted on both spectra. Peaks characteristic of MSU crystals were evident on the spectrum sourced from the gout sufferer and not on the spectrum from the healthy control.
An Implantable Device To Regulate Urination Through Deep Brain Stimulation,
2015
Purdue University
An Implantable Device To Regulate Urination Through Deep Brain Stimulation, Jesse E. Bucksot, Muhammad A. Arafat, Pedro Irazoqui
The Summer Undergraduate Research Fellowship (SURF) Symposium
Urinary Incontinence (UI) is a disease in which patients lose control of their bladder. It is particularly common in elderly women having a prevalence of as much as 30% to 50% [1]. Many of these patients are left without successful treatment. A recent study has shown a new option for treatment that consists of deep brain stimulation (DBS) at a site known as the periaqueductal gray (PAG) [2, 3]. To test the effectiveness of this treatment, chronic stimulation of the PAG should be used in animals to see if it can reliably prevent micturition in the long term. A device …
Simulating Low-Frequency Sonic Pulsations To Achieve Thrombolysis,
2015
Purdue University
Simulating Low-Frequency Sonic Pulsations To Achieve Thrombolysis, Joseph C. Muskat, Matthew C. Pharris, Charles F. Babbs
The Summer Undergraduate Research Fellowship (SURF) Symposium
Cardiovascular thrombosis may result in critical ischemia to a range of anatomical regions, constituting a leading cause of death in the United States. Current invasive treatments for such arterial blockages often yield blood clot recurrence, resulting in repeated hospitalization of patients. This research aims to show how internally introduced pressure oscillations may be used to initiate thrombolysis. We present a novel computational model for determining the resonant frequency and corresponding deformation of an idealized thrombus. Sinusoidal pressure differences across the thrombus induce axial displacements of frequency dependent amplitude. The maximum peak displacement occurs at a resonant frequency of 73 Hz …
An Investigation Of The Applicability Of Sugar And Wax Valves For Rapid Molecular Diagnostics,
2015
Purdue University
An Investigation Of The Applicability Of Sugar And Wax Valves For Rapid Molecular Diagnostics, Rui Shen, Jacqueline C. Linnes
The Summer Undergraduate Research Fellowship (SURF) Symposium
Paper-based Loop-mediated Isothermal Amplification (LAMP) of nucleic acids is a low-cost molecular diagnostic method to detect biological pathogens and has been successfully combined with lateral flow devices. This invention is a low-cost visual detection technique of various disease. However, existing assays require multiple user-activated steps and are relatively complicated to use at the point of care due to steps like the heating process. This project aimed to investigate an ideal valve for integrating LAMP onto the lateral flow assay. An ideal valve needs to be able to stop the fluid flow for 20-60 minutes under 65 degree to complete the …
Implantable Device For Wireless Regulation Of The Bladder Through Pelvic Nerve Stimulation,
2015
Purdue University
Implantable Device For Wireless Regulation Of The Bladder Through Pelvic Nerve Stimulation, Kelsey C. Bayer, Chris Quinkert, Pedro Irazoqui
The Summer Undergraduate Research Fellowship (SURF) Symposium
Urinary incontinence (UI) is the involuntarily urination that usually effects older people or is the result of an injury. UI affects more than eleven million people and the cost of incontinence management in the United States in 2000 was $19.5 billion. Where conventional physical therapies have failed, pelvic nerve stimulation is a promising form of regulating the bladder long term. Piezoresistive pressure sensors consist of two variable resistance values and two known resistance values that are represented on a daughterboard. This unknown resistance represents the change in pressure. The filling and voiding of the bladder was characterized through acute surgeries. …
A Non-Invasive Method Of Measuring Respiration While Providing Wireless Power For Rodents With Implantable Devices,
2015
Purdue University
A Non-Invasive Method Of Measuring Respiration While Providing Wireless Power For Rodents With Implantable Devices, Jynx O. Boyne, Daniel J. Pederson, Zhi Wang, Pedro Irazoqui Dr.
The Summer Undergraduate Research Fellowship (SURF) Symposium
Respiratory measurements can be used as diagnostic and research tools. Spirometry is the gold standard for gaining these measurements, but is difficult to use in rodents as it requires an invasive procedure. Total Body Plethysmograpy (TBP) is a non-invasive way to measure respiration rates that does not cause stress to the rodent. In this system, the subject is encased in a solid, constant volume chamber with measurements determining the subject’s respiration. When using TBP in medical or research settings, challenges occur in powering devices within the TBP chamber as wires and other recording equipment compromise the airtightness of the chamber. …
Quantification Of Analyte Concentration From A Paper-Based Lateral Flow Assay Device Using Reflective Sensors,
2015
Purdue University
Quantification Of Analyte Concentration From A Paper-Based Lateral Flow Assay Device Using Reflective Sensors, Megan Z. Chiu, Jacqueline Linnes
The Summer Undergraduate Research Fellowship (SURF) Symposium
Paper-based point-of-care (POC) diagnostics is a growing field in global health due to the extreme portability, accuracy, affordability, and ease of use of these tests. Advancements in recent years have led to more accurate detection and improved functionality using multistep molecular diagnostics. Many such assays utilize lateral flow detection strips for visualization of diagnostic results by eye, which limits the results to qualitative Yes/No readouts. This project focused on combining recent developments in paper-based POC diagnostics to develop and optimize an in-house built quantitative paper-based diagnostic reader for lateral flow detection in low-resource settings. Initially different sensors, including photocell sensors, …
Direct Analysis Of Pharmaceutical Drugs In Biofluids Using Miniature Mass Spectrometry System,
2015
Purdue University
Direct Analysis Of Pharmaceutical Drugs In Biofluids Using Miniature Mass Spectrometry System, Spencer Chiang, Yue Ren, Zheng Ouyang
The Summer Undergraduate Research Fellowship (SURF) Symposium
Miniature mass spectrometry (MS) system is key for establishing MS as a point-of-care chemical and biological analysis within clinical settings. In order to provide point-of-care diagnostics, ionization methods for direct analysis of biofluids are required. We have previously introduced paper spray and developed the cartridges for direct MS ionization and sampling. Our goal of this research is to identify a viable way to improve the spray efficacy of paper spray for its coupling with miniature MS. As a result, paper capillary spray (PCS) was developed. PCS utilizes ET31 paper with a fused-silica capillary fixated to the tip. The design was …
Silver Nanoparticle Coated Bioactive Glasses - Composites With Dex/Cmc Hydrogels: Characterization, Solubility, And In Vitro Biological Studies,
2015
Missouri University of Science and Technology
Silver Nanoparticle Coated Bioactive Glasses - Composites With Dex/Cmc Hydrogels: Characterization, Solubility, And In Vitro Biological Studies, Anthony W. Wren, Pegah Hassanzadeh, Lana M. Placek, Timothy J. Keenan, Aisling Coughlan, Lydia R. Boutelle, Mark R. Towler
Chemical and Biochemical Engineering Faculty Research & Creative Works
Silver (Ag) coated bioactive glass particles (Ag-BG) were formulated and compared to uncoated controls (BG) in relation to glass characterization, solubility and microbiology. X-ray diffraction (XRD) confirmed a crystalline AgNP surface coating while ion release studies determined low Ag release (/L). Cell culture studies presented increased cell viability (127 and 102%) with lower liquid extract (50 and 100 ml/ml) concentrations. Antibacterial testing of Ag-BG in E. coli, S. epidermidis and S. aureus significantly reduced bacterial cell viability by 60-90%. Composites of Ag-BG/CMC-Dex Hydrogels were formulated and characterized. Agar diffusion testing was conducted where Ag-BG/hydrogel composites produced the largest inhibition zones …
Breast Cancer/Stromal Cells Coculture On Polyelectrolyte Films
Emulates Tumor Stages And Mirna Profiles Of Clinical Samples,
2015
University of Nebraska–Lincoln
Breast Cancer/Stromal Cells Coculture On Polyelectrolyte Films Emulates Tumor Stages And Mirna Profiles Of Clinical Samples, Amita Daverey, Karleen M. Brown, Srivatsan Kidambi
Department of Chemical and Biomolecular Engineering: Faculty Publications
In this study, we demonstrate a method for controlling breast cancer cells adhesion on polyelectrolyte multilayer (PEM) films without the aid of adhesive proteins/ ligands to study the role of tumor and stromal cell interaction on cancer biology. Numerous studies have explored engineering coculture of tumor and stromal cells predominantly using transwell coculture of stromal cells cultured onto coverslips that were subsequently added to tumor cell cultures. However, these systems imposed an artificial boundary that precluded cell−cell interactions. To our knowledge, this is the first demonstration of patterned coculture of tumor cells and stromal cells that captures the temporal changes …
Bioactive Glass Reinforced Elastomer Composites For Skeletal Regeneration: A Review,
2015
Missouri University of Science and Technology
Bioactive Glass Reinforced Elastomer Composites For Skeletal Regeneration: A Review, Ehsan Zeimaran, Sara Pourshahrestani, Ivan Djordjevic, Belinda Pingguan-Murphy, Nahrizul Adib Kadri, Mark R. Towler
Chemical and Biochemical Engineering Faculty Research & Creative Works
Biodegradable elastomers have clinical applicability due to their biocompatibility, tunable degradation and elasticity. The addition of bioactive glasses to these elastomers can impart mechanical properties sufficient for hard tissue replacement. Hence, a composite with a biodegradable polymer matrix and a bio glass filler can offer a method of augmenting existing tissue. This article reviews the applications of such composites for skeletal augmentation.
Biplanar Fluoroscopic Analysis Of In Vivo Hindfoot Kinematics During Ambulation,
2015
Marquette University
Biplanar Fluoroscopic Analysis Of In Vivo Hindfoot Kinematics During Ambulation, Janelle Ann Cross
Dissertations (1934 -)
The overall goal of this project was to develop and validate a biplanar fluoroscopic system and integrated software to assess hindfoot kinematics. Understanding the motion of the foot and ankle joints may lead to improved treatment methods in persons with foot and ankle pathologies. During gait analysis, skin markers are placed on the lower extremities, which are defined as four rigid-body segments with three joints representing the hip, knee and ankle. This method introduces gross assumptions on the foot and severely limits the analysis of in depth foot mechanics. Multi-segmental models have been developed, but are susceptible to skin motion …
The Effect Of Posterior Foot Positions On Electromyography, Joint Kinetics And Energetics During A Sit-To-Stand In Young And Older Adults,
2015
Old Dominion University
The Effect Of Posterior Foot Positions On Electromyography, Joint Kinetics And Energetics During A Sit-To-Stand In Young And Older Adults, Eric A. Pitman
Human Movement Studies & Special Education Theses & Dissertations
The sit-to-stand (STS) movement, defined as standing up from a chair to an upright posture, is a common task performed daily. The inability to accomplish this task may lead to dependence, institutionalization and even death in older adults. A common strategy change for the STS is positioning the feet posteriorly by increasing flexion at the knee joint. This reduces the displacement of the center of mass to the base of support while increasing the joint moment of force at the knee while decreasing it at the hip. The aims of this study were to: 1) examine the joint kinetics, joint …
Compression Transmission Collar For Fastening,
2015
Kettering University
Compression Transmission Collar For Fastening, Patrick Atkinson, David Lecronier
Mechanical Engineering Patents
A compression transmission collar apparatus (20) for implantation into a bone (22) with a hole (28) having a hole wall (32) comprising an intramedullary nail (34) defining a bore (40) and a threaded fastener (42) and a compression transmission collar (58) including an exterior face (64) and a top edge (60) and a bottom edge (62) and a first end (70) intersecting the top edge (60) at an acute angle and the bottom edge …
Effects Of Strontium Substitution On Bioactivity Of Hydroxyapatite,
2015
Missouri University of Science and Technology
Effects Of Strontium Substitution On Bioactivity Of Hydroxyapatite, Chokchai Yatongchai, Lana M. Placek, Mark R. Towler, Anthony W. Wren
Chemical and Biochemical Engineering Faculty Research & Creative Works
Effect of strontium (Sr) substitution on bioactivity of hydroxyapatite (HA) was investigated. The substitution of Sr2+ for Ca2+ in the HA lattice increases biodegradability of Sr-substituted HA (Sr-HA) and accelerates the formation of apatite crystals on the Sr-HA surface. Moreover, the dissolution products from HA and Sr-HA samples are not cyto-toxic.
Analysis Of Particles Thorough The Aortic Arch During Transcatheter Aortic Valve Replacement,
2015
California Polytechnic State University, San Luis Obispo
Analysis Of Particles Thorough The Aortic Arch During Transcatheter Aortic Valve Replacement, Andrew Joseph Janicki
Master's Theses
Ischemia caused by particles becoming dislodged during transcatheter aortic valve replacement (TAVR) is a possible complication of TAVR. The particles that become dislodged can travel out of the aortic valve, into the aortic arch, and then into either the brachiocephalic artery, the left common carotid artery, the left subclavian artery or continue into the descending aorta. If the particles continue into the descending aorta it poses no risk of causing ischemia however if it travels into the other arteries then it increases the possibility of the particle causing an ischemic event. The goal of this study is to determine what …
Sapien3 Comb Stitch Improvement For Edwards Lifesciences,
2015
California Polytechnic State University - San Luis Obispo
Sapien3 Comb Stitch Improvement For Edwards Lifesciences, William Harley, Thomas Pluschkell, John Mctigue, Garrett Reed
Mechanical Engineering
The complete senior project report was submitted to the project advisor and sponsor. The results of this project are of a confidential nature and will not be published at this time.
A Comprehensive Review Of The Food And Drug Administration, The 510(K) Application Process, And Fda Certification For A Diagnostic Device,
2015
California Polytechnic State University, San Luis Obispo
A Comprehensive Review Of The Food And Drug Administration, The 510(K) Application Process, And Fda Certification For A Diagnostic Device, Taylor Davis
Biomedical Engineering
The company G-Force CRC LLC is currently experiencing the dichotomy of the FDA's conflicting role right now as they begin to approach FDA approval. G-Force CRC LLC is a small medical device company headquartered in San Diego, CA. The owner of the company, Dr. Ian Purcell, is an Otoneurologist apart of Alvarado Hospital. His medical practice mainly deals with patients who have balance disorders and therefore the devices that he has developed over the last 6+ years are primarily used to assist in the diagnosis of those balance disorders. G-Force CRC LLC was officially created in the summer of 2013 …
Renal Artery Stent Fatigue Test,
2015
California Polytechnic State University - San Luis Obispo
Renal Artery Stent Fatigue Test, Braden Cooper, Munir Eltal, Jennifer Hawthorne, Ashley Schaefer
Mechanical Engineering
In today’s world of medical innovation, regulations and requirements set by organizations such as the Food and Drug Administration (FDA), the International Organization for Standardization (ISO), and ASTM International (American Society for Testing and Materials) can inhibit rapid innovation by demanding rigorous testing of new designs. For arterial stents, the standard is that each design must be tested to simulate 10 years of life in an environment congruent to an in vivo environment. Endologix in Irvine, California develops and manufactures minimally invasive treatments for aortic diseases, with a focus on stent grafts for the treatment of abdominal aortic aneurysms (AAA). …
Heart Valve Leaflet Deflection Testing Apparatus,
2015
California Polytechnic State University - San Luis Obispo
Heart Valve Leaflet Deflection Testing Apparatus, Brandon Cunnane, Andrew Krasts, Jackson Kunz, Steven Warnert
Mechanical Engineering
The information contained in this report is confidential and proprietary information of Edwards Lifesciences.
