Quantification Of Analyte Concentration From A Paper-Based Lateral Flow Assay Device Using Reflective Sensors,
2015
Purdue University
Quantification Of Analyte Concentration From A Paper-Based Lateral Flow Assay Device Using Reflective Sensors, Megan Z. Chiu, Jacqueline Linnes
The Summer Undergraduate Research Fellowship (SURF) Symposium
Paper-based point-of-care (POC) diagnostics is a growing field in global health due to the extreme portability, accuracy, affordability, and ease of use of these tests. Advancements in recent years have led to more accurate detection and improved functionality using multistep molecular diagnostics. Many such assays utilize lateral flow detection strips for visualization of diagnostic results by eye, which limits the results to qualitative Yes/No readouts. This project focused on combining recent developments in paper-based POC diagnostics to develop and optimize an in-house built quantitative paper-based diagnostic reader for lateral flow detection in low-resource settings. Initially different sensors, including photocell sensors, …
Direct Analysis Of Pharmaceutical Drugs In Biofluids Using Miniature Mass Spectrometry System,
2015
Purdue University
Direct Analysis Of Pharmaceutical Drugs In Biofluids Using Miniature Mass Spectrometry System, Spencer Chiang, Yue Ren, Zheng Ouyang
The Summer Undergraduate Research Fellowship (SURF) Symposium
Miniature mass spectrometry (MS) system is key for establishing MS as a point-of-care chemical and biological analysis within clinical settings. In order to provide point-of-care diagnostics, ionization methods for direct analysis of biofluids are required. We have previously introduced paper spray and developed the cartridges for direct MS ionization and sampling. Our goal of this research is to identify a viable way to improve the spray efficacy of paper spray for its coupling with miniature MS. As a result, paper capillary spray (PCS) was developed. PCS utilizes ET31 paper with a fused-silica capillary fixated to the tip. The design was …
Silver Nanoparticle Coated Bioactive Glasses - Composites With Dex/Cmc Hydrogels: Characterization, Solubility, And In Vitro Biological Studies,
2015
Missouri University of Science and Technology
Silver Nanoparticle Coated Bioactive Glasses - Composites With Dex/Cmc Hydrogels: Characterization, Solubility, And In Vitro Biological Studies, Anthony W. Wren, Pegah Hassanzadeh, Lana M. Placek, Timothy J. Keenan, Aisling Coughlan, Lydia R. Boutelle, Mark R. Towler
Chemical and Biochemical Engineering Faculty Research & Creative Works
Silver (Ag) coated bioactive glass particles (Ag-BG) were formulated and compared to uncoated controls (BG) in relation to glass characterization, solubility and microbiology. X-ray diffraction (XRD) confirmed a crystalline AgNP surface coating while ion release studies determined low Ag release (/L). Cell culture studies presented increased cell viability (127 and 102%) with lower liquid extract (50 and 100 ml/ml) concentrations. Antibacterial testing of Ag-BG in E. coli, S. epidermidis and S. aureus significantly reduced bacterial cell viability by 60-90%. Composites of Ag-BG/CMC-Dex Hydrogels were formulated and characterized. Agar diffusion testing was conducted where Ag-BG/hydrogel composites produced the largest inhibition zones …
Bioactive Glass Reinforced Elastomer Composites For Skeletal Regeneration: A Review,
2015
Missouri University of Science and Technology
Bioactive Glass Reinforced Elastomer Composites For Skeletal Regeneration: A Review, Ehsan Zeimaran, Sara Pourshahrestani, Ivan Djordjevic, Belinda Pingguan-Murphy, Nahrizul Adib Kadri, Mark R. Towler
Chemical and Biochemical Engineering Faculty Research & Creative Works
Biodegradable elastomers have clinical applicability due to their biocompatibility, tunable degradation and elasticity. The addition of bioactive glasses to these elastomers can impart mechanical properties sufficient for hard tissue replacement. Hence, a composite with a biodegradable polymer matrix and a bio glass filler can offer a method of augmenting existing tissue. This article reviews the applications of such composites for skeletal augmentation.
Breast Cancer/Stromal Cells Coculture On Polyelectrolyte Films
Emulates Tumor Stages And Mirna Profiles Of Clinical Samples,
2015
University of Nebraska–Lincoln
Breast Cancer/Stromal Cells Coculture On Polyelectrolyte Films Emulates Tumor Stages And Mirna Profiles Of Clinical Samples, Amita Daverey, Karleen M. Brown, Srivatsan Kidambi
Department of Chemical and Biomolecular Engineering: Faculty Publications
In this study, we demonstrate a method for controlling breast cancer cells adhesion on polyelectrolyte multilayer (PEM) films without the aid of adhesive proteins/ ligands to study the role of tumor and stromal cell interaction on cancer biology. Numerous studies have explored engineering coculture of tumor and stromal cells predominantly using transwell coculture of stromal cells cultured onto coverslips that were subsequently added to tumor cell cultures. However, these systems imposed an artificial boundary that precluded cell−cell interactions. To our knowledge, this is the first demonstration of patterned coculture of tumor cells and stromal cells that captures the temporal changes …
Biplanar Fluoroscopic Analysis Of In Vivo Hindfoot Kinematics During Ambulation,
2015
Marquette University
Biplanar Fluoroscopic Analysis Of In Vivo Hindfoot Kinematics During Ambulation, Janelle Ann Cross
Dissertations (1934 -)
The overall goal of this project was to develop and validate a biplanar fluoroscopic system and integrated software to assess hindfoot kinematics. Understanding the motion of the foot and ankle joints may lead to improved treatment methods in persons with foot and ankle pathologies. During gait analysis, skin markers are placed on the lower extremities, which are defined as four rigid-body segments with three joints representing the hip, knee and ankle. This method introduces gross assumptions on the foot and severely limits the analysis of in depth foot mechanics. Multi-segmental models have been developed, but are susceptible to skin motion …
The Effect Of Posterior Foot Positions On Electromyography, Joint Kinetics And Energetics During A Sit-To-Stand In Young And Older Adults,
2015
Old Dominion University
The Effect Of Posterior Foot Positions On Electromyography, Joint Kinetics And Energetics During A Sit-To-Stand In Young And Older Adults, Eric A. Pitman
Human Movement Studies & Special Education Theses & Dissertations
The sit-to-stand (STS) movement, defined as standing up from a chair to an upright posture, is a common task performed daily. The inability to accomplish this task may lead to dependence, institutionalization and even death in older adults. A common strategy change for the STS is positioning the feet posteriorly by increasing flexion at the knee joint. This reduces the displacement of the center of mass to the base of support while increasing the joint moment of force at the knee while decreasing it at the hip. The aims of this study were to: 1) examine the joint kinetics, joint …
Compression Transmission Collar For Fastening,
2015
Kettering University
Compression Transmission Collar For Fastening, Patrick Atkinson, David Lecronier
Mechanical Engineering Patents
A compression transmission collar apparatus (20) for implantation into a bone (22) with a hole (28) having a hole wall (32) comprising an intramedullary nail (34) defining a bore (40) and a threaded fastener (42) and a compression transmission collar (58) including an exterior face (64) and a top edge (60) and a bottom edge (62) and a first end (70) intersecting the top edge (60) at an acute angle and the bottom edge …
Effects Of Strontium Substitution On Bioactivity Of Hydroxyapatite,
2015
Missouri University of Science and Technology
Effects Of Strontium Substitution On Bioactivity Of Hydroxyapatite, Chokchai Yatongchai, Lana M. Placek, Mark R. Towler, Anthony W. Wren
Chemical and Biochemical Engineering Faculty Research & Creative Works
Effect of strontium (Sr) substitution on bioactivity of hydroxyapatite (HA) was investigated. The substitution of Sr2+ for Ca2+ in the HA lattice increases biodegradability of Sr-substituted HA (Sr-HA) and accelerates the formation of apatite crystals on the Sr-HA surface. Moreover, the dissolution products from HA and Sr-HA samples are not cyto-toxic.
Self-Contained Breathing Apparatus For Firefighter With A Permanent Stoma,
2015
California Polytechnic State University, San Luis Obispo
Self-Contained Breathing Apparatus For Firefighter With A Permanent Stoma, Jason Delgadillo, Aaron Wheeler, Zachary Wishbow
Biomedical Engineering
The purpose of this project was to create a unique SCBA (self-contained breathing apparatus) for a firefighter named Chris Gauer. This prototype consists of a SCBA headgear connected to a polycarbonate-formed stoma mask with a medical-grade sanitary silicone hose.
Sapien3 Comb Stitch Improvement For Edwards Lifesciences,
2015
California Polytechnic State University - San Luis Obispo
Sapien3 Comb Stitch Improvement For Edwards Lifesciences, William Harley, Thomas Pluschkell, John Mctigue, Garrett Reed
Mechanical Engineering
The complete senior project report was submitted to the project advisor and sponsor. The results of this project are of a confidential nature and will not be published at this time.
A Comprehensive Review Of The Food And Drug Administration, The 510(K) Application Process, And Fda Certification For A Diagnostic Device,
2015
California Polytechnic State University, San Luis Obispo
A Comprehensive Review Of The Food And Drug Administration, The 510(K) Application Process, And Fda Certification For A Diagnostic Device, Taylor Davis
Biomedical Engineering
The company G-Force CRC LLC is currently experiencing the dichotomy of the FDA's conflicting role right now as they begin to approach FDA approval. G-Force CRC LLC is a small medical device company headquartered in San Diego, CA. The owner of the company, Dr. Ian Purcell, is an Otoneurologist apart of Alvarado Hospital. His medical practice mainly deals with patients who have balance disorders and therefore the devices that he has developed over the last 6+ years are primarily used to assist in the diagnosis of those balance disorders. G-Force CRC LLC was officially created in the summer of 2013 …
Design And Fabrication Techniques Of Devices For Embedded Power Active Contact Lens,
2015
California Polytechnic State University, San Luis Obispo
Design And Fabrication Techniques Of Devices For Embedded Power Active Contact Lens, Errol Heradio Leon
Master's Theses
This thesis designed and fabricated various devices that were interfaced to an IC for an active contact lens that notifies the user of an event by detection of an external wireless signal. The contact lens consisted of an embedded antenna providing communication with a 2.4GHz system, as well as inductive charging at an operating frequency of 13.56 MHz. The lens utilized a CBC005 5µAh thin film battery by Cymbet and a manufactured graphene super capacitor as a power source. The custom integrated circuit (IC) was designed using the On Semiconductor CMOS C5 0.6 µm process to manage …
Micro Electrostatic Actuation Of A Silicon Diaphragm,
2015
California Polytechnic State University, San Luis Obispo
Micro Electrostatic Actuation Of A Silicon Diaphragm, Matthew W. Samples
Master's Theses
There are a number of applications, from hearing aids to microfluidic pumps, which utilize micro-scale actuating diaphragms. These MEMS (micro-electromechanical system) devices can be actuated by electrostatic forces, which utilize an induced electric field to pull two charged plates towards one another. Such devices were fabricated and electrostatic actuation of the diaphragms was performed to analyze its viability as a micro-speaker. The long-term performance of such products requires adequate diaphragm deflection to create audible pressure waves with relatively low maximum stresses to ensure a high cycle fatigue life. With these requirements, initial calculations and FEA (finite element analysis) were performed …
Analysis Of Particles Thorough The Aortic Arch During Transcatheter Aortic Valve Replacement,
2015
California Polytechnic State University, San Luis Obispo
Analysis Of Particles Thorough The Aortic Arch During Transcatheter Aortic Valve Replacement, Andrew Joseph Janicki
Master's Theses
Ischemia caused by particles becoming dislodged during transcatheter aortic valve replacement (TAVR) is a possible complication of TAVR. The particles that become dislodged can travel out of the aortic valve, into the aortic arch, and then into either the brachiocephalic artery, the left common carotid artery, the left subclavian artery or continue into the descending aorta. If the particles continue into the descending aorta it poses no risk of causing ischemia however if it travels into the other arteries then it increases the possibility of the particle causing an ischemic event. The goal of this study is to determine what …
Renal Artery Stent Fatigue Test,
2015
California Polytechnic State University - San Luis Obispo
Renal Artery Stent Fatigue Test, Braden Cooper, Munir Eltal, Jennifer Hawthorne, Ashley Schaefer
Mechanical Engineering
In today’s world of medical innovation, regulations and requirements set by organizations such as the Food and Drug Administration (FDA), the International Organization for Standardization (ISO), and ASTM International (American Society for Testing and Materials) can inhibit rapid innovation by demanding rigorous testing of new designs. For arterial stents, the standard is that each design must be tested to simulate 10 years of life in an environment congruent to an in vivo environment. Endologix in Irvine, California develops and manufactures minimally invasive treatments for aortic diseases, with a focus on stent grafts for the treatment of abdominal aortic aneurysms (AAA). …
Heart Valve Leaflet Deflection Testing Apparatus,
2015
California Polytechnic State University - San Luis Obispo
Heart Valve Leaflet Deflection Testing Apparatus, Brandon Cunnane, Andrew Krasts, Jackson Kunz, Steven Warnert
Mechanical Engineering
The information contained in this report is confidential and proprietary information of Edwards Lifesciences.
Method And Apparatus For Treating Centralized Pain,
2015
Kettering University
Method And Apparatus For Treating Centralized Pain, Jeffrey Hargrove
Mechanical Engineering Patents
A method for alleviating centralized pain in human subjects includes assessing the brain of a subject suffering from pain, diagnosing abnormal brain function associated with centralized pain, locating at least one area of abnormal brain function associated with the centralized pain, and alleviating the abnormal brain function by applying a cortical stimulation signal to tissues corresponding to the at least one area of abnormal brain function.
3d Printing In Healthcare,
2015
St. John Fisher University
3d Printing In Healthcare, Caleb Branch
The Review: A Journal of Undergraduate Student Research
Technology is everywhere. Technology surrounds every aspect of 21st century life. It is in the cell phones we use, the cars we drive, and even the food we eat. A large portion of modern technology used is taken for granted and overlooked. Despite this, some technology fields continue to grow. Biomedical engineering, specifically 3D printing’s applications to healthcare, has been often overlooked until. Regardless of its status in the mainstream, 3D printing is prosperous in healthcare and its future looks bright. This piece analyzes 3D printing in healthcare. It hones in on the finer details of each specific topic, …
Mobile Health Sensing With Smart Phones,
2015
University of Arkansas, Fayetteville
Mobile Health Sensing With Smart Phones, Abby Logan Wise
Electrical Engineering Undergraduate Honors Theses
Depression is a serious mental condition affecting many Americans and people across the world. Postpartum depression is a form of depression affecting women who have recently gone through childbirth. Postpartum depression can have serious symptoms that may affect not only the mother, but her newborn as well. Early detection of these symptoms is of critical importance to the welfare of the mother and her child. Many medical professionals express the need for postpartum screening being that treatment has proven to be very effective. This project aims to make early symptom detection convenient and reliable for mothers with newborns. This will …
