Biomechanics and Biotransport Commons^™

Peak Vertical Ground Reaction Force & Stance Phase Time To Assess Post-Tka Interlimb Asymmetry, Abderrahman Ouattas

UNO Student Research and Creative Activity Fair

In the US, more than 500,000 TKA surgeries are performed annually, to which 97% of those are led by OA¹. Although knee pain is diminished post-TKA, unilateral efficiency and walking asymmetry is still unresolved several years after the surgery². In fact, within a minimum of 10 years after the primary TKA, almost 50% of patients undergo a secondary TKA on the contralateral limb due to OA progression³. The purpose of this study was to determine if post-Total Knee Arthroplasty peak vertical ground reaction force (pVGRF) asymmetry could be identified using stance phase time differences …

Acl Reconstruction Results In Alterations For Force Control Variability During Multidirectional Force Production, Amelia S. Lanier

UNO Student Research and Creative Activity Fair

After anterior cruciate ligament (ACL) rupture most will undergo reconstructive surgery. Within the first year after surgery 25% of patients will re-tear their ACL. Most of those injured attempt to return to sports which include running and cutting. The ability to produce appropriate ground reaction forces may be crucial for the successful return to sports without re-injury. Understanding stability of multidirectional ground reaction force (mGRF) production in healthy and ACL reconstructed (ACL-r) patients can lend insight to the high instance of re-injury. Typically, stability has been measured using linear analyses, but these analyses cannot capture the subtle time varying changes …

The Effects Of Walking Speed On Gait Propulsion When Wearing An Ankle-Foot Orthosis, Alli Kalina

UNO Student Research and Creative Activity Fair

Peripheral artery disease (PAD) is a cardiovascular disease that results from blockage of one or more arteries in the lower extremity. Often, patients with PAD have reduced ability to push off with the foot at the end of the gait cycle. When walking, the ankle contributes the majority of the power to propel the body into the next step. An ankle-foot orthosis (AFO) is a device that aids in ankle propulsion by increasing the energy return, thus decreasing the ankle deficit in pathological individuals. The purpose is to investigate the effect of walking speed on ankle propulsion during walking. Subjects …

Fluid Flow Characterization And In Silico Validation In A Rapid Prototyped Abdominal Aortic Aneurysm Model, Dean Thomas Wampler

Master's Theses

Aortic aneurysms are the 14^th leading cause of death in the United States. Annually, abdominal aortic aneurysm (AAA) ruptures are responsible for 4500 deaths. There are another 45,000 repair procedures performed to prevent rupture, and of these approximately 1400 lead to deaths. With proper detection, the aneurysm may be treated using endovascular aneurysm repair (EVAR). Understanding how the flow of the blood within the artery is affected by the aneurysm is important in determining the growth of the aneurysm, as well as how to properly treat the aneurysm. The goal of this project was to develop a physical construct …

Design Of A Device For Measuring Bulk Fluid Flow In Spine Segments Under Tensile Loads, Tysum Ruchti, Anton Bowden

Biomedical Engineering Western Regional Conference

No abstract provided.

Effect Of Multiple Confined Compression/Stress Relaxation Cycles On Cross-Linked Alginate Pore Size., Sindhu Kolar Venkat, Erik L. Risa, Bergren Antell, Maryam Mobed-Miremadi

Biomedical Engineering Western Regional Conference

No abstract provided.

Modeling The Combined Effect Of Convection And Diffusion In Cross-Linked Alginate Capsules, Erik L. Risa, Sindhu Kolar Venkat, Bergren Antell, Maryam Mobed-Miremadi

Biomedical Engineering Western Regional Conference

No abstract provided.

Biophysical Tools To Study Cellular Mechanotransduction, Ismeel Muhamed, Farhan Chowdhury, Venkat Maruthamuthu

Mechanical & Aerospace Engineering Faculty Publications

The cell membrane is the interface that volumetrically isolates cellular components from the cell's environment. Proteins embedded within and on the membrane have varied biological functions: reception of external biochemical signals, as membrane channels, amplification and regulation of chemical signals through secondary messenger molecules, controlled exocytosis, endocytosis, phagocytosis, organized recruitment and sequestration of cytosolic complex proteins, cell division processes, organization of the cytoskeleton and more. The membrane's bioelectrical role is enabled by the physiologically controlled release and accumulation of electrochemical potential modulating molecules across the membrane through specialized ion channels (e.g., Na^⁺, Ca²⁺, K^⁺ channels). …

Mechanical Effects Of Surgical Adhesives On Ascending Thoracic Aortic Aneurysm Replacement, Dong Qiu

Electronic Theses and Dissertations

Ascending thoracic aortic aneurysm (aTAA) is a potentially lethal disease which grows gradually over time and may lead to aortic dissection and rupture. Currently, aTAA surgical repair using Dacron graft is a well-established treatment. In addition, surgical adhesives are frequently used in the surgeries to seal the anastomotic site. This study aims to investigate mechanical effects of four commonly used surgical adhesives, namely BioGlue, CoSeal, Crosseal, and Tisseel, on the suture site using in-vitro digital image correlation (DIC) method and finite element (FE) simulations in an ovine model. In this study, first, mechanical properties of ovine ascending aorta were obtained …

Age-Related Differences In The Lumbopelvic Kinematics During The Trunk Motions In The Anatomical Planes, Milad Vazirian

Theses and Dissertations--Biomedical Engineering

Management and control of the low back pain as an important health problem in the industrial societies necessitates to investigate how the risk of this disease is affected by aging. Since the abnormalities of the lumbopelvic kinematics are related to the existence or risk of low back injuries, the objective of this dissertation was set to find the age-related differences in lumbopelvic kinematics when performing basic trunk motions reaching to range of motion in different anatomical planes.

A cross-sectional study was designed where sixty asymptomatic individuals between 20–70 years old with no confounding health condition, no current or previous highly …

Computational Studies On Biomechanics Of Concussion And On Efficacy Of Football Helmets, David Labyak

Dissertations, Master's Theses and Master's Reports

Football helmets have been used for many years to prevent head injuries to players. Over the years, the helmet design has evolved from a crude leather head covering to the more recent form fitting helmets that are seen today. The one design feature that has been common in the majority of all helmets is a hard polycarbonate shell with a foam cushion padding. The main goal of the padding layer was to reduce the amount of linear acceleration during an impact event. The one feature that has been overlooked is how stiff the padding is in rotation.

The purpose of …

The Impact Of Active Aerodynamics On Motorcycles Using Computational Fluid Dynamics Simulations, Aditya Sripathi

All Graduate Theses, Dissertations, and Other Capstone Projects

Motorcycles are mostly utilized by commuters whose requirements are cheap and affordable transportation from point A to point B. Motorcycles also provide means to tour various places and have a leisure time for the majority of motorcyclists. Unfortunately, with pros also come cons such as accidents which are disabling or life-taking. According to motorcycle crash statistics produced every year, the majority of motorcycle crashes are caused due to facing unexpected obstacles in the path causing collisions due to insufficient braking time. Thus, this thesis serves as a mean to overcome this issue and provide a technological solution to the world …

Statistical Shape And Intensity Modeling Of The Shoulder, Irene Sintini

Electronic Theses and Dissertations

Anatomical variability in the shoulder is inherently present and can influence healthy and pathologic biomechanics and ultimately clinical decision-making. Characterizing variation in bony morphology and material properties in the population can support treatment and specifically the design, via shape and sizing, of shoulder implants. Total Shoulder Arthroplasty (TSA) is the treatment of choice for glenohumeral osteoarthritis as well as bone fracture. Complications and poor outcomes in TSA are generally influenced by the inability of the implant to replicate the natural joint biomechanics and by the bone quality around the fixation features. For this reason, knowledge of bony morphology and mechanical …

Specimen-Specific Natural, Pathological, And Implanted Knee Mechanics Using Finite Element Modeling, Azhar Akber Ali

Electronic Theses and Dissertations

There is an increasing incidence of knee pain and injury among the population, and increasing demand for higher knee function in total knee replacement designs. As a result, clinicians and implant manufacturers are interested in improving patient outcomes, and evaluation of knee mechanics is essential for better diagnosis and repair of knee pathologies. Common knee pathologies include osteoarthritis (degradation of the articulating surfaces), patellofemoral pain, and cruciate ligament injury and/or rupture. The complex behavior of knee motion presents unique challenges in the diagnosis of knee pathology and restoration of healthy knee function. Quantifying knee mechanics is essential for developing successful …

Design Development And Performance Study Of A Novel Assistive Device For Mobility Of Toddlers And Children With Visual Impairments, Joowon Jun

Dissertations and Theses

Being able to see allows mankind tremendous access to learn about the world, and because so much learning comes visually, children with visual impairments are delayed in developing range of skills: learning own languages, doing activities, socializing with peers, and etc. While children with vision can do virtually all the activities and tasks for granted, children with visual impairment require different types of tools or materials to do same tasks most of time. Amongst all the disadvantages that children with visual impairment have, one of the most critical disadvantageous area that visual impairment brings to toddler is learning to walk. …

Multi-Scale Assessment Of Bone Mechanics And The Mineral Phase Of Intramuscular Bone Of Atlantic Herring Fish, Svetlana Zeveleva

Dissertations and Theses

Bone tissue is a complex composite structure made up of a soft organic phase consisting of collagen I and non-collagenous proteins, and a hard inorganic phase consisting of mineral nanoplatelets. Given it’s compositional properties, bone is a unique stiff, tough, and strong biomaterial, making it exceptionally difficult to synthesize ex vivo. While the complete hierarchical structure may change with age and population, the basic building block components of mineralized collagen fibrils, are preserved. This study uses a model of intramuscular bone of the Atlantic herring fish, which present a simple structure, and no process of remodeling.

A multi-scale approach …

Development And Validation Of A Novel Resonant Energy Transfer (Fret) Biosensor To Measure Tensile Forces At The Linc Complex In Live Cells, Paul Arsenovic

Theses and Dissertations

There is a large body of evidence supporting the theory that cell physiology largely depends on the mechanical properties of its surroundings or micro-environment. More recently studies have shown that changes to intra-cellular mechanical properties can also have a meaningful impact on cell function and in some cases lead to the progression of ailments or disease. For example, small changes to the protein sequence of a structural nuclear envelope protein called lamin-A is known to cause a variety of neurological and musculoskeletal diseases referred to as laminopathies. Currently, there is little incite into how these mutations lead to disease progression …

The Effect Of Twist On The Mechanical Properties Of The Intervertebral Disc, Maxine Harvey-Burgess

Theses and Dissertations (Comprehensive)

Introduction: Intervertebral disc (IVD) herniation is a common injury to the IVD and a frequent source of low back pain. IVD herniation occurs when the nucleus pulposus migrates through both the inter- and intralamellar matrices of the annulus fibrosus (AF). There are a number of mechanical risk factors associated with herniation, including repetitive flexion and twist. In vivo, twist combined with repetitive flexion has been associated with increased experience of low back pain and herniation. Additionally, in vitro, when repetitive flexion is combined with twist, IVD herniation occurs more easily than repetitive flexion alone. However, the mechanisms behind …

An Enhanced Spring-Particle Model For Red Blood Cell Structural Mechanics: Application To The Stomatocyte–Discocyte– Echinocyte Transformation, Mingzhu Chen, Fergal Boyle

Articles

Red blood cells (RBCs) are the most abundant cellular element suspended in blood. Together with the usual biconcave-shaped RBCs, i.e., discocytes, unusual-shaped RBCs are also observed under physiological and experimental conditions, e.g., stomatocytes and echinocytes. Stomatocytes and echinocytes are formed from discocytes and in addition can revert back to being discocytes; this shape change is known as the stomatocyte–discocyte–echinocyte (SDE) transformation. To-date, limited research has been conducted on the numerical prediction of the full SDE transformation. Spring- particle RBC (SP-RBC) models are commonly used to numerically predict RBC mechanics and rheology. However, these models are incapable of predicting the full …

Characterization Of Molecular Communication Based On Cell Metabolism Through Mutual Information And Flux Balance Analysis, Zahmeeth Sayed Sakkaff

School of Computing: Dissertations, Theses, and Student Research

Synthetic biology is providing novel tools to engineer cells and access the basis of their molecular information processing, including their communication channels based on chemical reactions and molecule exchange. Molecular communication is a discipline in communication engineering that studies these types of communications and ways to exploit them for novel purposes, such as the development of ubiquitous and heterogeneous communication networks to interconnect biological cells with nano and biotechnology-enabled devices, i.e., the Internet of Bio-Nano Things. One major problem in realizing these goals stands in the development of reliable techniques to control the engineered cells and their behavior from the …