Evaluating Cognition In Individuals With Huntington Disease: Neuroqol Cognitive Functioning Measures, 2018 Northwestern University
Evaluating Cognition In Individuals With Huntington Disease: Neuroqol Cognitive Functioning Measures, Jin-Shei Lai, Siera Goodnight, Nancy R Downing, Rebecca E Ready, Jane S Paulsen, Anna L Kratz, Julie C Stout, Michael K Mccormack, David Cella, Christopher Ross, Jenna Russell, Noelle E Carlozzi
Rowan-Virtua School of Osteopathic Medicine Faculty Scholarship
PURPOSE: Cognitive functioning impacts health-related quality of life (HRQOL) for individuals with Huntington disease (HD). The Neuro-QoL includes two patient-reported outcome (PRO) measures of cognition-Executive Function (EF) and General Concerns (GC). These measures have not previously been validated for use in HD. The purpose of this analysis is to evaluate the reliability and validity of the Neuro-QoL Cognitive Function measures for use in HD.
METHODS: Five hundred ten individuals with prodromal or manifest HD completed the Neuro-QoL Cognition measures, two other PRO measures of HRQOL (WHODAS 2.0 and EQ5D), and a depression measure (PROMIS Depression). Measures of functioning The Total …
Echocardiographic Detection Of Increased Ventricular Diastolic Stiffness In Pediatric Heart Transplant Recipients: A Pilot Study., 2018 Children's Mercy Hospital
Echocardiographic Detection Of Increased Ventricular Diastolic Stiffness In Pediatric Heart Transplant Recipients: A Pilot Study., Shahryar M. Chowdhury, Ryan J. Butts, Anthony M. Hlavacek, Carolyn L. Taylor, Karen S. Chessa, Varsha M. Bandisode, Girish S. Shirali, Arni Nutting, G Hamilton Baker
Manuscripts, Articles, Book Chapters and Other Papers
Background: Pediatric heart transplant recipients are at risk for increased left ventricular (LV) diastolic stiffness. However, the noninvasive evaluation of LV stiffness has remained elusive in this population. The objective of this study was to compare novel echocardiographic measures of LV diastolic stiffness versus gold-standard measures derived from pressure-volume loop (PVL) analysis in pediatric heart transplant recipients.
Methods: Patients undergoing left heart catheterization were prospectively enrolled. PVLs were obtained via conductance. The end-diastolic pressure-volume relationship was obtained via balloon occlusion. The stiffness constant, β, was calculated. Echocardiographic measures of diastolic function were derived from spectral and tissue Doppler and two-dimensional …
The Development Of A Patient-Reported Outcome Measure For Assessment Of Genital Psoriasis Symptoms: The Genital Psoriasis Symptoms Scale (Gpss), 2018 New York Medical College
The Development Of A Patient-Reported Outcome Measure For Assessment Of Genital Psoriasis Symptoms: The Genital Psoriasis Symptoms Scale (Gpss), Alice B. Gottlieb, Brian Kirby, Caitriona Ryan, April N. Naegeli, Russel Burge, Alison Potts Bleakman, Gil Yosipovitch
NYMC Faculty Publications
INTRODUCTION: Patient-reported outcome measures (PROs) specific for genital psoriasis (GenPs) have not been described. METHODS: In this cross-sectional, qualitative study in patients with moderate-to-severe GenPs, we sought to develop a PRO useful for GenPs symptom assessment. A literature review was performed to identify relevant psoriasis or GenPs symptoms and existing PROs that may be useful in the evaluation of symptom severity in GenPs patients. The literature review findings were discussed with clinicians, and then patients with GenPs. RESULTS: Relevant psoriasis or GenPs symptoms from the literature review included itch, pain, scaling, redness/erythema, and stinging/burning. The validity of these symptoms for …
Concussion Competencies: A Framework For School-Based Concussion Management (Flyer), 2018 University of Nebraska-Lincoln
Concussion Competencies: A Framework For School-Based Concussion Management (Flyer), Arthur C. Maerlender, Jonathan Lichtenstein, Jennifer Parent-Nichols
Center for Brain, Biology, and Behavior: Faculty and Staff Publications
This volume grew out of many years of clinical practice, research, and program projects. It is the culmination of more than 50 years of work with kids, brains, and schools. While there is research behind the Competencies and the underlying content, the intent was to create a user-friendly manual that cut across levels of responsibility and care. Concussion Competencies was not intended to be a textbook in the traditional manner; however, the Competencies have been shown to be a useful approach to teaching this material.
This volume is organized around a set of Competencies that have been shown to be …
Indicators For Early Assessment Of Palliative Care In Lung Cancer Patients: A Population Study Using Linked Health Data, 2018 National Cancer Registry Ireland and Graduate Entry Medical School, University of Limerick, Limerick, Ireland
Indicators For Early Assessment Of Palliative Care In Lung Cancer Patients: A Population Study Using Linked Health Data, Maria Kelly, Katie M. O'Brien, Michael Lucey, Kerri Clough-Gorr, Ailish Hannigan
Department of Mathematics Publications
Analysing linked, routinely collected data may be useful to identify characteristics of patients with suspected lung cancer who could benefit from early assessment for palliative care. The aim of this study was to compare characteristics of newly diagnosed lung cancer patients dying within 30 days of diagnosis (short term survivors) with those surviving more than 30 days. To identify indicators for early palliative care assessment we distinguished between characteristics available at diagnosis (age, gender, smoking status, marital status, comorbid disease, admission type, tumour stage and histology) from those available post diagnosis. A second aim was to examine the association between …
Kallikrein-Related Peptidases Are Dysregulated In Pleomorphic Adenoma, 2018 The University of Western Ontario
Kallikrein-Related Peptidases Are Dysregulated In Pleomorphic Adenoma, Matthew D. Morrison
Electronic Thesis and Dissertation Repository
Objectives: Pleomorphic adenoma (PA) is the most common benign salivary gland tumor. Kallikrein-related peptidases (KLKs) have been identified as biomarkers in many human tumors and may influence tumor behavior. We investigated KLK1-15 messenger ribonucleic acid (mRNA) and proteins in PA specimens to determine a KLK expression profile for this tumor.
Methods: Fresh frozen PA tissue specimens (n = 26) and matched controls were subjected to RT-qPCR to detect KLK1-15 mRNA. Expression of KLK1, KLK12, KLK13 and KLK8 proteins were then evaluated via immunostaining techniques. Statistical analyses were performed with the level of significance set at P < .05.
Results: We observed downregulation …
Mechanical Pleurodesis Is Not A Contraindication To Lung Transplantation, 2018 Wayne State University School of Medicine
Mechanical Pleurodesis Is Not A Contraindication To Lung Transplantation, Alexa Thibodeau
Clinical Research in Practice: The Journal of Team Hippocrates
A critical appraisal and clinical application of Shigemura N, Bhama J, Gries CJ, et al. Lung transplantation in patients with prior cardiothoracic surgical procedures. American Journal of Transplantation. 2012;12(5):1249-1255. doi: 10.1111/j.1600-6143.2011.03946.x
Assessment Of Chronic Disease To Determine Appropriateness Of Implantable Cardioverter-Defibrillator Therapy, 2018 Aurora Cardiovascular Services
Assessment Of Chronic Disease To Determine Appropriateness Of Implantable Cardioverter-Defibrillator Therapy, Bilal M. Omery, Maharaj Singh, Randy S. Turkel, Robyn Shearer, Arshad Jahangir, M. Eyman Mortada, Jasbir S. Sra, Indrajit Choudhuri
Indrajit Choudhuri, MD
Background: Implantable cardioverter-defibrillator (ICD) therapy is considered appropriate when a patient is felt to have a reasonable expectation of 1-year survival. Chronic diseases have been estimated to be associated with greater than 10% annual mortality and may reduce benefits of ICD therapy. Frailty has been estimated to be associated with greater than 20% annual mortality and has been suggested to contraindicate ICD therapy.
Purpose: Determine a risk score that may identify patients in whom ICD implantation may not be appropriate.
Methods: Patients who received an ICD for primary and secondary prevention from 2008 through 2013 at the Aurora Health Care …
Merk Obat Sipilis De Nature Indonesia, 2018 Selected Works
Merk Obat Sipilis De Nature Indonesia, Denature Khamim
denature khamim
Randomized Controlled Trials Evaluating Patient-Reported Outcomes After Cholecystectomy: A Systematic Review, 2018 Department of Surgery, and Center for Surgical Trials and Evidence-based Practice (C-STEP), McGovern Medical School at the University of Texas Health Science Center at Houston
Randomized Controlled Trials Evaluating Patient-Reported Outcomes After Cholecystectomy: A Systematic Review, Krislynn M Mueck, Deepa V Cherla, Amy Taylor, Tien C Ko, Mike K Liang, Lillian S Kao
Library Staff Publications
There has been growing interest in patient-reported outcomes (PROs) in benign biliary disease. A PRO is any report of the status of a patient's health condition that comes directly from the patient, without interpretation by a clinician.1 The PRO assessments are increasingly being measured in addition to traditional surgical outcomes.2-8 Furthermore, PROs may be useful for shared decision-making. In order to effectively counsel patients about expected surgical outcomes, physicians need to be able to easily access information on PROs from high quality trials and be able to judge the methodologic quality of PRO assessment.
Inactivation Of Myeloma Cancer Cells By Helium And Argon Plasma Jets: The Effect Comparison And The Key Reactive Species, 2018 Old Dominion University
Inactivation Of Myeloma Cancer Cells By Helium And Argon Plasma Jets: The Effect Comparison And The Key Reactive Species, Zeyu Chen, Qingjie Cui, Chen Chen, Dehui Xu, Dingxin Liu, H. L. Chen, Michael G. Kong
Bioelectrics Publications
In plasma cancer therapy, the inactivation of cancer cells under plasma treatment is closely related to the reactive oxygen and nitrogen species (RONS) induced by plasmas. Quantitative study on the plasma-induced RONS that related to cancer cells apoptosis is critical for advancing the research of plasma cancer therapy. In this paper, the effects of several reactive species on the inactivation of LP-1 myeloma cancer cells are comparatively studied with variable working gas composition, surrounding gas composition, and discharge power. The results show that helium plasma jet has a higher cell inactivation efficiency than argon plasma jet under the same discharge …
Word-List Intrusion Errors Predict Progression To Mild Cognitive Impairment, 2018 Veterans Affairs San Diego Healthcare System
Word-List Intrusion Errors Predict Progression To Mild Cognitive Impairment, Kelsey R Thomas, Joel Eppig, Emily C Edmonds, Diane M Jacobs, David J Libon, Rhoda Au, David P Salmon, Mark W Bondi, Alzheimer’S Disease Neuroimaging Initiative
Rowan-Virtua School of Osteopathic Medicine Faculty Scholarship
OBJECTIVE: Preclinical Alzheimer's disease (AD) defined by a positive AD biomarker in the presence of normal cognition is presumed to precede mild cognitive impairment (MCI). Subtle cognitive deficits and cognitive inefficiencies in preclinical AD may be detected through process and error scores on neuropsychological tests in those at risk for progression to MCI.
METHOD: Cognitively normal participants (n = 525) from the Alzheimer's Disease Neuroimaging Initiative were followed for up to 5 years and classified as either stable normal (n = 305) or progressed to MCI (n = 220). Cox regressions were used to determine whether baseline process scores on …
Female Autistic Perspectives: Limits In Diagnosis And Understanding, 2018 The Graduate Center, City University of New York
Female Autistic Perspectives: Limits In Diagnosis And Understanding, Alexandra Helmers
Dissertations, Theses, and Capstone Projects
The diagnosis of autism spectrum disorder has increased dramatically within the last two decades, with males being diagnosed, on average, four to five times more than females. Although researchers in the medical community have searched for a biological explanation for this discrepancy, no definitive cause has been found. I argue that our understanding of autism is primarily a social and cultural construction, in addition to a diagnosable medical disorder. The gender disparity in diagnosis reflects cultural narratives surrounding social interaction and the widespread belief in two distinct gender roles. Furthermore, narratives surrounding the topic of autism tend to unintentionally highlight …
Relationships Between Clinical Scales And Binge Eating Days In Adults With Moderate To Severe Binge Eating Disorder In Two Phase Iii Studies, 2018 New York Medical College
Relationships Between Clinical Scales And Binge Eating Days In Adults With Moderate To Severe Binge Eating Disorder In Two Phase Iii Studies, Leslie L. Citrome, Judith C. Kando, Caleb Bliss
NYMC Faculty Publications
OBJECTIVES:
In two Phase III studies, lisdexamfetamine dimesylate (LDX) reduced binge eating (BE) days/week in adults with moderate to severe binge eating disorder (BED) and was associated with improvement based on the Clinical Global Impressions-Improvement (CGI-I) scale. In this study, post hoc analyses examined the relationships between clinical observations and clinical rating scales in individuals with BED.
CLINICAL TRIAL REGISTRATION:
NCT01718483 (ClinicalTrials.gov/ct2/show/NCT01718483); NCT01718509(ClinicalTrials.gov/ct2/show/NCT01718509).
METHODS:
Two 12-week, double-blind, placebo-controlled studies randomized (1:1) adults meeting Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision, BED criteria and with protocol-defined moderate to severe BED (study …
In-Home Delivery Of Constraint-Induced Movement Therapy Via Virtual Reality Gaming, 2018 College of St. Scholastica
In-Home Delivery Of Constraint-Induced Movement Therapy Via Virtual Reality Gaming, Alexandra L. Borstad, Roger Crawfis, Kala Phillips, Linda Pax Lowes, David Maung, Ryan Mcpherson, Amelia Siles, Lise Worthen-Chaudhari, Lynne V. Gauthier
Journal of Patient-Centered Research and Reviews
Purpose: People with chronic hemiparesis are frequently dissatisfied with the recovery of their hand and arm, yet many lack access to effective treatments. Constraint-induced movement therapy (CI therapy) effectively increases arm function and spontaneous use in persons with chronic hemiparesis. The purpose of this study was to determine the feasibility and measure safety and outcomes of an in-home model of delivering CI therapy using a custom, avatar-based virtual reality game.
Methods: Seventeen individuals with chronic hemiparesis participated in this pretest/posttest quasi-experimental design study. The 10-day intervention had three components: 1) high-repetition motor practice using virtual reality gaming; 2) constraint of …
A Practicality Analysis Pertaining To Minimally Invasive Robot-Assisted Urologic Surgery, 2018 University of Central Florida
A Practicality Analysis Pertaining To Minimally Invasive Robot-Assisted Urologic Surgery, Chase Cavayero
The Pegasus Review: UCF Undergraduate Research Journal
Minimally invasive robot-assisted surgery is a technological development that has changed the field of medicine in the past decade. The introduction of the da Vinci® by Intuitive Surgical Inc. has opened up many interesting options in several different fields. Specifically, the field of urology has seen increased utilization of the robotic technique due to the precision allowed by the technology. Although many perioperative and postoperative benefits have been documented within the literature pertaining to robotic surgery, some surgeons contend that the extra cost associated with the procedures is not practical. To this point the extra cost has not been prohibitive, …
Simulating Human Pleura Performance In Medical Training Using Measured Tissue Mechanical Properties, 2018 University of Central Florida
Simulating Human Pleura Performance In Medical Training Using Measured Tissue Mechanical Properties, Jack Norfleet
Electronic Theses and Dissertations
Medical simulations provide hands-on training at various levels of medical expertise. Yet these simulators fail to accurately mimic the look, feel and behavior of human tissue. Applying measured mechanical properties from human cadaver tissues promises to improve the fidelity of simulated tissue behaviors when subjected to medical procedures. Samples of human parietal pleura were tested under uniaxial tension to failure and measured characteristics were replicated in synthetic pleura. Context specific parameters were then collected and compared between human pleura and the new synthetics. These comparisons tested the hypothesis; H1 Gaps exist between synthetic and human pleura performance, H2: Human tissue …
Optical Coherence Tomography Application To Alopecia In The Scalp, 2018 Wayne State University
Optical Coherence Tomography Application To Alopecia In The Scalp, Elizabeth Melcher
Research Opportunities for Engineering Undergraduates (ROEU) Program 2017-18
Alopecia is the loss of hair, whether it be from the scalp or other regions of the body. Current techniques used to best diagnose and track alopecia are often invasive, requiring a biopsy for results. The use of the OCT, or optical coherence tomography, could drastically improve a patient’s experience in undergoing a diagnosis while proving accurate results. The objective of this study is to develop diagnostic algorithms for the rapid, non-invasive diagnosis of alopecia with OCT. The first step is collecting OCT images of a healthy scalp to understand the anatomical structures with the imaging technique.
A Comparison Of Hamstring Injury Recovery Rates In Male And Female Athletes, 2018 Gardner-Webb University
A Comparison Of Hamstring Injury Recovery Rates In Male And Female Athletes, Amanda Hall
Undergraduate Honors Theses
Excerpt from Introduction
Hamstring injuries are among the most common muscular injuries sustained by athletes across multiple levels of various sports (Askling et al). Most hamstring injuries occur during similar movements and under similar conditions, where the muscle is required to be explosive. Thus, athletes that participate in sports where “sprinting, kicking, or high-speed skilled movements” are required, experience an increased likelihood of suffering a hamstring injury (Erickson and Sherry). After injury, athletes are then subjected to different methods of rehabilitation to heal and strengthen the afflicted area. However, some athletes take longer than others to return and impatience may …
Conceptualización Integral De La Ambliopía, 2018 Universidad Latina de Costa Rica
Conceptualización Integral De La Ambliopía, Esteban Goñi-Boza, Rebeca Ortiz Barrantes
Ciencia y Tecnología para la Salud Visual y Ocular
En este artículo se desarrolla una discusión sobre la conceptualización del término ambliopía, sobre la base de que en la actualidad las definiciones que abundan se limitan a enfocarse en aspectos muy estrechos de todo lo que engloba. Mediante una revisión analítica de los principales estudios y documentos relacionados con el tema, se procede a unificar las ideas principales con el fin de desarrollar un concepto integral de la ambliopía. La importancia de una conceptualización inclusiva radica en la influencia que esto puede tener a la hora de abordarlo clínicamente, pues podría determinar los elementos en los cuales el optómetra …