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Immune Function And Metabolism Of Hibernating North American Bats With White-Nose Syndrome, Briana Nicole Anderson 2018 Missouri State University

Immune Function And Metabolism Of Hibernating North American Bats With White-Nose Syndrome, Briana Nicole Anderson

MSU Graduate Theses

White-nose syndrome (WNS) causes substantial mortality in certain species of hibernating North American bats. The responsible agent is Pseudogymnoascus destructans (Pd), a fungus which causes physiological complications such as increased arousals and energy depletion during the hibernation season. Tricolored bats (Perimyotis subflavus) and northern long-eared bats (Myotis septentrionalis) suffer extensive WNS mortality, while gray bats (Myotis grisescens) and big brown bats (Eptesicus fuscus) are infected, but mortality is rarely observed. It is hypothesized that there is a difference in immune responses and/or hibernation metabolism between these bat species, resulting in this interspecific variation in disease severity. To test these ...


Modeling Stochastic Viral Evolution: A Multiscale Wright Fisher Model, Marco Hamins-Puertolas 2018 North Carolina State University at Raleigh

Modeling Stochastic Viral Evolution: A Multiscale Wright Fisher Model, Marco Hamins-Puertolas

Biology and Medicine Through Mathematics Conference

No abstract provided.


Changes In The Microbial Community Of Lubomirskia Baicalensis Affected By Red Sponge Disease, Colin Rorex 2018 Stephen F Austin State University

Changes In The Microbial Community Of Lubomirskia Baicalensis Affected By Red Sponge Disease, Colin Rorex

Electronic Theses and Dissertations

Lake Baikal is the oldest known lake and a unique ecosystem, home to several species of fresh water sponge. A disease outbreak affecting the dominant species, Lubormirskia baialensis, was recently reported. The cause of the disease has not been determined but one of the current hypothesis is that the increase in methane concentration is correlated to the disease outbreak. This pilot study characterized the microbiomes of sick and healthy sponges through the use of 16S rRNA sequencing. Sick sponge microbiomes shared a conserved group of taxa while the healthy sponge microbiomes had greater diversity. Indicator species analysis identified two significant ...


A Forensic Investigation Into The Possible Origins Of Three Human Skeletons, Jefferson P. Sinnott 2018 State University of New York College at Buffalo - Buffalo State College

A Forensic Investigation Into The Possible Origins Of Three Human Skeletons, Jefferson P. Sinnott

Forensic Science Theses

The Anthropology Department at Buffalo State has three human skeletons that have been part of the department’s collection for several years. The origin of the skeletons is currently unknown. Modern DNA techniques coupled with forensic anthropological techniques may now allow us to determine with some certainty the geographic origin of the skeletons. Ancestry, sex, age, and stature were assessed using current anthropological techniques. Afterwards, one tooth from each of the three skeletons was extracted, pulverized and DNA was isolated. Y-STR fragment size analysis of the DNA samples can provide information about the patrilineage of male individuals. Mitochondrial DNA sequencing ...


Characterization Of The Roles Of Muscle-Synthesized Brain-Derived Neurotrophic Factor And Presynaptic Tyrosine Receptor Kinase B In Motor Neuron Axonal Transport, Luke A. VanOsdol 2018 Northern Michigan University

Characterization Of The Roles Of Muscle-Synthesized Brain-Derived Neurotrophic Factor And Presynaptic Tyrosine Receptor Kinase B In Motor Neuron Axonal Transport, Luke A. Vanosdol

All NMU Master's Theses

Brain-derived neurotrophic factor (BDNF) is a small, diffusible protein essential for the development and function of neurons. It is synthesized by many types of tissue, including muscle. BDNF actions are mediated via binding to its receptor, tyrosine receptor kinase B (TrkB). The BDNF-TrkB complex is endocytosed into a specialized vesicle, which induces downstream signaling cascades locally in the dendrites, or, more often, is delivered to the cell soma via retrograde axonal transport, where it modulates gene expression. BDNF activation of TrkB is critical for the initiation of axonal transport, and this cellular process relies on the interaction of numerous adaptor ...


45442 (Gmr18d08), Neha Gogia, Ankita Sarkar, Amit Singh 2018 University of Dayton

45442 (Gmr18d08), Neha Gogia, Ankita Sarkar, Amit Singh

Development and Disease Lab Data

dpp enhancer - 45442

  • Id - GMR 18D08
  • Location - 2L:2446783,2449086
  • Base pairs – 2303 bp


48770 (Gmr17e04), Neha Gogia, Ankita Sarkar, Amit Singh 2018 University of Dayton

48770 (Gmr17e04), Neha Gogia, Ankita Sarkar, Amit Singh

Development and Disease Lab Data

dpp enhancer - 48770

  • Id - GMR17E04
  • Location 2L: 2428913..2432834
  • Base pairs – 3921 bp


48784 (Gmr17g08), Neha Gogia, Ankita Sarkar, Amit Singh 2018 University of Dayton

48784 (Gmr17g08), Neha Gogia, Ankita Sarkar, Amit Singh

Development and Disease Lab Data

dpp enhancer - 48784

  • Id - GMR 17G08
  • Location 2L:2450278,2451074
  • Base pairs – 796 bp


45833 (Gmr19d09), Neha Gogia, Ankita Sarkar, Amit Singh 2018 University of Dayton

45833 (Gmr19d09), Neha Gogia, Ankita Sarkar, Amit Singh

Development and Disease Lab Data

dpp enhancer - 45833

  • Id - GMR19D09
  • Location - 2L:2435128,2438996
  • Base pairs – 3868 bp


45437 (Gmr18b08), Neha Gogia, Ankita Sarkar, Amit Singh 2018 University of Dayton

45437 (Gmr18b08), Neha Gogia, Ankita Sarkar, Amit Singh

Development and Disease Lab Data

dpp enhancer - 45437

  • Id - GMR18B08
  • Location - 2L:2455899,2457734
  • Base pairs – 1835 bp


48839 (Gmr19b04), Neha Gogia, Ankita Sarkar, Amit Singh 2018 University of Dayton

48839 (Gmr19b04), Neha Gogia, Ankita Sarkar, Amit Singh

Development and Disease Lab Data

dpp enhancer - 48839

  • Id - GMR19B04,
  • Location - 2L:2432214,2435785
  • Base pairs – 3571 bp


47472 (Gmr16g02), Neha Gogia, Ankita Sarkar, Amit Singh 2018 University of Dayton

47472 (Gmr16g02), Neha Gogia, Ankita Sarkar, Amit Singh

Development and Disease Lab Data

dpp enhancer - 47472

  • Id - GMR16G02
  • Location 2L:2425041, 2428154
  • Base pairs – 3113 bp


49283 (Gmr19c03), Neha Gogia, Ankita Sarkar, Amit Singh 2018 University of Dayton

49283 (Gmr19c03), Neha Gogia, Ankita Sarkar, Amit Singh

Development and Disease Lab Data

dpp enhancer - 49283

  • Id - GMR19C03
  • Location - 2L:2440970,2444735
  • Base pairs – 3765 bp


Mrub_1675, Mrub_1676, Mrub_1677, And Mrub_1679 Genes Are Orthologs Of B_3458, B_3457, B_3456, And B_3454 Genes In E. Coli, Respectively, Coding For Abc Transporters. Mrub_1678 And B_3455, Though Perform Similar Tasks, Are Not Orthologous, Ravi Patel, Alaina Hofmann, Dr. Lori Scott 2018 Augustana College, Rock Island Illinois

Mrub_1675, Mrub_1676, Mrub_1677, And Mrub_1679 Genes Are Orthologs Of B_3458, B_3457, B_3456, And B_3454 Genes In E. Coli, Respectively, Coding For Abc Transporters. Mrub_1678 And B_3455, Though Perform Similar Tasks, Are Not Orthologous, Ravi Patel, Alaina Hofmann, Dr. Lori Scott

Meiothermus ruber Genome Analysis Project

In this project we investigated the biological function of the genes Mrub_1675, Mrub_1676, Mrub_1677, and Mrub_1679 (KEGG map number 02010). We predict these genes encode components of a Branched chain amino acid (ABC) transporter: Mrub_1675 (DNA coordinates 1711022..1712185 on the reverse strand) encodes the permease component, Mrub_1676 (DNA coordinates 1712313..1713170) encodes for the NBD (aka nucleotide binding domain), Mrub_1677 (DNA coordinates 1713167..1714075 on the reverse strand) encodes the NBD (aka nucleotide binding domain), Mrub_1678 (DNA coordinates 1713167..1714075 on the reverse strand) encodes the TMD (aka transmembrane domain) and Mrub_1679 (DNA coordinates 1714781..1715485 on the reverse ...


Effect Of Variation In An Essential Folding Element On The Cobalamin Riboswitch, Marcus Urquijo 2018 University of Colorado, Boulder

Effect Of Variation In An Essential Folding Element On The Cobalamin Riboswitch, Marcus Urquijo

Undergraduate Honors Theses

Riboswitches are RNA-based genetic regulatory elements that control gene expression without the need for protein cofactors. These RNA motifs are found within the 5’ untranslated regions of mRNA and promote genetic regulation by altering the structure of RNA through binding small molecule effector ligands that cause conformational changes that repress or activate translation/transcription. The env8 cobalamin riboswitch binds cyanocobalamin (CNCbl) to repress gene expression of the downstream mRNA. It accomplishes this through an interplay of two separate domains; an aptamer domain which binds the effector ligand and a regulatory domain which contains the genetic switch. Within the aptamer domain ...


Mediation And Moderation Of Intergenerational Epigenetic Effects Of Trauma, Stefanie Renee Pilkay 2017 University of Tennessee, Knoxville

Mediation And Moderation Of Intergenerational Epigenetic Effects Of Trauma, Stefanie Renee Pilkay

Doctoral Dissertations

Trauma and early-life stress have been linked to poor mental and physical health outcomes. In fact, research has identified trauma and stress can influence epigenetic marks on genes that can alter gene activity. It is suspected that epigenetically altered gene activity is involved in behavior and mental health. This may help explain why some individuals don’t experience great benefit from treatment for the effects of stress, and severe mental health symptoms can be chronic for decades or a lifetime. Moreover, some trauma-related mental health symptoms have shown generational patterns that appear linked to epigenetic marks. Therefore, this study sought ...


Characterizing Mekk1: Candidate Behavioural Isolation Gene, Caryn Dooner 2017 The University of Western Ontario

Characterizing Mekk1: Candidate Behavioural Isolation Gene, Caryn Dooner

Electronic Thesis and Dissertation Repository

Behavioural isolation can occur due to divergence in aspects of courtship and mating, and can contribute to reproductive isolation. The purpose of this study is to determine how a gene, Mekk1, contributes to female rejection behaviour between D. melanogaster and D. simulans. Unique polymorphisms were identified within D. simulans Mekk1 that could contribute to behaviour, most of which are non-coding. Both transcripts of Mekk1 appear to be expressed at similar levels in D. simulans and D. melanogaster. These data also indicate that Mekk1 may be expressed in a specific region of the brain called the mushroom body, which has previously ...


Genomic Data Reveal A Loss Of Diversity In Two Species Of Tuco-Tucos (Genus Ctenomys) Following A Volcanic Eruption, Jeremy L. Hsu, Jeremy Chase Crawford, Mauro N. Tammone, Uma Ramakrishnan, Eileen A. Lacey, Elizabeth A. Hadly 2017 Chapman University

Genomic Data Reveal A Loss Of Diversity In Two Species Of Tuco-Tucos (Genus Ctenomys) Following A Volcanic Eruption, Jeremy L. Hsu, Jeremy Chase Crawford, Mauro N. Tammone, Uma Ramakrishnan, Eileen A. Lacey, Elizabeth A. Hadly

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Marked reductions in population size can trigger corresponding declines in genetic variation. Understanding the precise genetic consequences of such reductions, however, is often challenging due to the absence of robust pre- and post-reduction datasets. Here, we use heterochronous genomic data from samples obtained before and immediately after the 2011 eruption of the Puyehue-Cordón Caulle volcanic complex in Patagonia to explore the genetic impacts of this event on two parapatric species of rodents, the colonial tuco-tuco (Ctenomys sociabilis) and the Patagonian tuco-tuco (C. haigi). Previous analyses using microsatellites revealed no post-eruption changes in genetic variation in C. haigi, but an unexpected ...


Linking Taxonomic Diversity And Trophic Function: A Graph-Based Theoretical Approach, Marcella M. Jurotich, Kaitlyn Dougherty, Barbara Hayford, Sally Clark 2017 Wayne State College

Linking Taxonomic Diversity And Trophic Function: A Graph-Based Theoretical Approach, Marcella M. Jurotich, Kaitlyn Dougherty, Barbara Hayford, Sally Clark

Transactions of the Nebraska Academy of Sciences and Affiliated Societies

The purpose of this study is to develop a novel, visual method in analyzing complex functional trait data in freshwater ecology. We focus on macroinvertebrates in stream ecosystems under a gradient of habitat degradation and employ a combination of taxonomic and functional trait diversity analyses. Then we use graph theory to link changes in functional trait diversity to taxonomic richness and habitat degradation. We test the hypotheses that: 1) taxonomic diversity and trophic functional trait diversity both decrease with increased habitat degradation; 2) loss of taxa leads to a decrease in trophic function as visualized using a bipartite graph; and ...


Recognizing Challenges And Opportunities In The Quest To End Hunger, Jennifer Williams Zwagerman 2017 Texas A&M University School of Law

Recognizing Challenges And Opportunities In The Quest To End Hunger, Jennifer Williams Zwagerman

Texas A&M Law Review

As an attorney and professor that does not focus on intellectual property law, I was a bit apprehensive about providing a keynote address for a Symposium focusing on “Agriculture, Intellectual Property, and Feeding the World in the 21st Century.” As I thought about this topic, knowing that there were other speakers who would focus more on the IP issues and technical aspects of various topics, I kept coming back to the importance of technology as we worktowards the goal of feeding the world, and the many ways in which innovation plays a role in meeting that goal. It also brought ...


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