Finding Of Polysaccharide-Peptide Complexes In Cordyceps Militaris And Evaluation Of Its Acetylcholinesterase Inhibition Activity,
2020
Taiwan Food and Drug Administration
Finding Of Polysaccharide-Peptide Complexes In Cordyceps Militaris And Evaluation Of Its Acetylcholinesterase Inhibition Activity, C.-H. Tsai, Y.-H. Yen, J.P.-W. Yang
Journal of Food and Drug Analysis
Acetylcholinesterase (AChE) inhibition enhances learning and cognitive ability for treatment of Alzheimer's disease. Polysaccharide-peptide complexes were identified in Cordyceps militaris (CPSPs) and characterized for their AChE inhibitory properties. Three polymers (CPSP-F1, -F2, and -F3) were extracted and separated by ultrasound-assisted extraction and diethylaminoethanol (DEAE)-Sepharose CL-6B column chromatography. Polysaccharide-peptide complexes were identified by DEAE-Sepharose CL-6B column chromatography and high-performance gel-filtration chromatography, Fourier transform infrared spectra, amino sugar composition analysis, and β-elimination reaction to identify polysaccharide-peptide bond categories. Separation of CPSP can increase AChE inhibitory activity from the crude polysaccharide of C. militaris. CPSP-F1 and CPSP-F2 exhibited half maximal inhibitory concentrations of …
Inhibitory Activity Of Sargassum Hemiphyllum Sulfated Polysaccharide In Arachidonic Acid-Induced Animal Models Of Inflammation,
2020
Taiwan Food and Drug Administration
Inhibitory Activity Of Sargassum Hemiphyllum Sulfated Polysaccharide In Arachidonic Acid-Induced Animal Models Of Inflammation, P.-A. Hwang, Y.-L. Hung, S.-Y. Chien
Journal of Food and Drug Analysis
Sargassum hemiphyllum is a common plant found on the coasts of Taiwan; it has been used as an anti-inflammatory agent in traditional herbal medicine. This study aimed to evaluate the anti-inflammatory effects of S. hemiphyllum sulfated polysaccharide (SHSP) using two different mouse models. In both arachidonic acid-induced ear inflammatory gavage and paint models, SHSP decreased ear swelling and erythema. In addition, SHSP decreased the production of myeloperoxidase, nitric oxide, interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α in a dose-dependent manner. Histological examination results showed that SHSP reduced the area of neutrophilic infiltration in inflamed ears. The anti-inflammatory activity of SHSP …
Current Development In Medical Devices Postmarket Surveillance In Taiwan,
2020
Taiwan Food and Drug Administration
Current Development In Medical Devices Postmarket Surveillance In Taiwan, C.-W. Lan, M.-K. Yeh, S.-I. Wu, P.-W. Tu
Journal of Food and Drug Analysis
[No abstract available]
Analysis Of Lipophilic Compounds Of Tea Coated On The Surface Of Clay Teapots,
2020
Taiwan Food and Drug Administration
Analysis Of Lipophilic Compounds Of Tea Coated On The Surface Of Clay Teapots, T.-Y. Chung, P.-C. Kuo, Z.-H. Liao, Y.-E. Shih, M.-L. Yang, M.-L. Cheng, C.-C. Wu, J.T.C. Tzen
Journal of Food and Drug Analysis
The surface of a clay teapot tends to be coated with a waterproof film after constant use for tea preparation. The waterproof films of two kinds of teapots (zisha and zhuni) used for preparing oolong tea and old oolong tea were extracted and subjected to gas chromatography-mass spectrometry analysis. The results showed that comparable constituents were detected in these films; they were primarily fatty acids and linear hydrocarbons that were particularly rich in palmitic acid and stearic acid. To explore the source of these two abundant fatty acids, the fatty acid compositions of fresh tea leaves, granules, infusion, and vapor …
Effects Of Indium Chloride Exposure On Sperm Morphology And Dna Integrity In Rats,
2020
Taiwan Food and Drug Administration
Effects Of Indium Chloride Exposure On Sperm Morphology And Dna Integrity In Rats, K.-H. Lee, H.-P. Chen, C.-M. Leung, H.-L. Chen, S.-S. Tsai, P.-C. Hsu
Journal of Food and Drug Analysis
Indium, a Group IIIA element of the periodic chart and a rare earth metal characterized by high plasticity, corrosion resistance, and a low melting point, is widely used in the electronics industry where released streams can contaminate the environment. Consequently, indium can reach humans mainly by natural ways, which could result in a health hazard. Although reproductive toxicities have been surveyed in some studies in animal models, the infertility effects of sperm function induced by indium compounds have not been greatly investigated. We designed a study to investigate the toxicities of subacute exposure to indium compounds on male sperm function …
Quality Analysis Of Polygala Tenuifolia Root By Ultrahigh Performance Liquid Chromatography-Tandem Mass Spectrometry And Gas Chromatography-Mass Spectrometry,
2020
Taiwan Food and Drug Administration
Quality Analysis Of Polygala Tenuifolia Root By Ultrahigh Performance Liquid Chromatography-Tandem Mass Spectrometry And Gas Chromatography-Mass Spectrometry, D. Wu, J. He, Y. Jiang, B. Yang
Journal of Food and Drug Analysis
Polygala tenuifolia root is used as a functional food due to its attractive health benefits. In this study, ultrahigh-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and gas chromatography-mass spectrometry (GC-MS) were utilized to characterize the bioactive compounds in P. tenuifolia root. The UPLC-MS/MS information revealed 36 bioactive compounds, including oligosaccharide esters, polygalasaponins, and polygalaxanthones. GC-MS identified 34 volatile compounds with fatty acids as the main chemicals. The leading compound judged by UPLC-MS/MS was tenuifoliside A, and oleic acid was the leading volatile from GC-MS profiles. All samples tested showed similar bioactive compound compositions, but the level of each compound varied. Principal …
Significant Elevation Of Antiviral Activity Of Strictinin From Pu'er Tea After Thermal Degradation To Ellagic Acid And Gallic Acid,
2020
Taiwan Food and Drug Administration
Significant Elevation Of Antiviral Activity Of Strictinin From Pu'er Tea After Thermal Degradation To Ellagic Acid And Gallic Acid, G.-H. Chen, Y.-L. Lin, W.-L. Hsu, S.-K. Hsieh, J.T.C. Tzen
Journal of Food and Drug Analysis
Compared with abundant catechins, strictinin is a minor constituent in teas and has been demonstrated to possess inhibitory potency on influenza virus. In this study, strictinin was found as the major phenolic compound in Pu'er teas produced from leaves and buds of wild trees. Due to its thermal instability, strictinin, in tea infusion or in an isolated form, was completely decomposed to ellagic acid and gallic acid after being autoclaved for 7 minutes. A plaque reduction assay was employed to compare the relative inhibitory potency between strictinin and its thermally degraded products against human influenza virus A/Puerto Rico/8/34. The results …
Authenticity Analysis Of Citrus Essential Oils By Hplc-Uv-Ms On Oxygenated Heterocyclic Components,
2020
Taiwan Food and Drug Administration
Authenticity Analysis Of Citrus Essential Oils By Hplc-Uv-Ms On Oxygenated Heterocyclic Components, H. Fan, Q. Wu, J.E. Simon, S.-N. Lou, C.-T. Ho
Journal of Food and Drug Analysis
Citrus essential oils are widely applied in food industry as the backbone of citrus flavors. Unfortunately, due to relatively simple chemical composition and tremendous price differences among citrus species, adulteration has been plaguing the industry since its inception. Skilled blenders are capable of making blends that are almost indistinguishable from authentic oils through conventional gas chromatography analysis. A reversed-phase high performance liquid chromatography (HPLC) method was developed for compositional study of nonvolatile constituents in essential oils from major citrus species. The nonvolatile oxygenated heterocyclic components identified in citrus oils were proved to be more effective as markers in adulteration detection …
Efficacy And Safety Of Tumor Necrosis Factor-Α Blockers For Ulcerative Colitis: A Systematic Review And Meta-Analysis Of Published Randomized Controlled Trials,
2020
Taiwan Food and Drug Administration
Efficacy And Safety Of Tumor Necrosis Factor-Α Blockers For Ulcerative Colitis: A Systematic Review And Meta-Analysis Of Published Randomized Controlled Trials, Y.-N. Song, P. Zheng
Journal of Food and Drug Analysis
To evaluate the efficacy and safety of TNF-α blockers for ulcerative colitis. A systematic search for randomized controlled trials (RCTs) of TNF-α blockers for treatment of ulcerative colitis (UC) were performed in PubMed, Web of Science, Embase and cochrane clinical trial. We estimated Pooled estimates of the odds ratio (OR) and relevant 95% confidence interval (CI) using fixed effects model or random effects model as appropriate. Heterogeneity, publication bias, and subgroup analyses were conducted. Nine randomized controlled studies met the selection criteria with a total of 2518 patients. Five studies compared Infliximab with placebo. Two studies compared Infliximab to corticosteroids. …
Development Of Two Reference Materials For All Trans-Retinol, Retinyl Palmitate, Α- And Γ-Tocopherol In Milk Powder And Infant Formula,
2020
Taiwan Food and Drug Administration
Development Of Two Reference Materials For All Trans-Retinol, Retinyl Palmitate, Α- And Γ-Tocopherol In Milk Powder And Infant Formula, A.B. Shehata, M.S. Rizk, A.M. Farag, I.F. Tahoun
Journal of Food and Drug Analysis
Vitamins are important food constituents that can be present in almost every foodstuff. Food quality and safety depends on food surveillance by reliable quantitative analysis enabled by appropriate quality control. Certified matrix reference materials are versatile tools to support quality assurance and control. However, in the case of vitamins, which are important in various foods, there is a lack of matrix reference materials. Two certified reference materials for the determination of all-trans-retinol, retinyl palmitate, and α- and γ-tocopherol in milk powder and infant formula have been developed by the National Institute of Standards, Egypt. This article presents the preparation, characterization, …
Safety Assessment Of Menaquinone-7 For Use In Human Nutrition,
2020
Taiwan Food and Drug Administration
Safety Assessment Of Menaquinone-7 For Use In Human Nutrition, B. Ravishankar, Y.A. Dound, D.S. Mehta, B.K. Ashok, Souza A. De, M.-H. Pan, C.-T. Ho, V. Badmaev, A.D.B. Vaidya
Journal of Food and Drug Analysis
Vitamin K occurs widely in foods and has been shown to have a beneficial effect on the cardiovascular system, as well as anticancer, anti-inflammatory, and antiosteoporosis properties. A previous study indicates that long-chain menaquinone-7 may be more bioavailable than vitamin K and short-chain menaquinones. In the present study, acute, subacute toxicity and genotoxicity assays were carried out to evaluate the safety of oral menaquinone-7 in albino Wistar rats. Oral administration of menaquinone-7, at a concentration of 2000 mg/kg, did not cause toxic symptoms in either male or female rats. A subacute toxicity study also proved the safety and tolerance of …
Major Flavonoid Constituents And Short-Term Effects Of Chun Mee Tea In Rats,
2020
Taiwan Food and Drug Administration
Major Flavonoid Constituents And Short-Term Effects Of Chun Mee Tea In Rats, Y. Wang, W. Li, J. Ning, R. Hong, H. Wu
Journal of Food and Drug Analysis
Chun Mee tea is a kind of green tea produced in China mainly for export purposes. Foam quantity is usually used as an index for evaluating the quality of Chun Mee tea. In the current study, we compared the concentrations of total saponin and flavonoids between foamy and low-foam Chun Mee tea. Our research confirmed that the total saponin and O-glycosylated flavonoid concentrations were related to the foam quantity of Chun Mee teas. We also studied the short-term safety effects of extract supplementation with foamy and low-foam Chun Mee tea in rats by routine blood tests and analysis of liver …
Characterization And Determination Of Antioxidant Components In The Leaves Of Camellia Chrysantha (Hu) Tuyama Based On Composition-Activity Relationship Approach,
2020
Taiwan Food and Drug Administration
Characterization And Determination Of Antioxidant Components In The Leaves Of Camellia Chrysantha (Hu) Tuyama Based On Composition-Activity Relationship Approach, J.-B. Wei, X. Li, H. Song, Y.-H. Liang, Y.-Z. Pan, J.-X. Ruan, X. Qin, Y.-X. Chen, C.-L. Nong, Z.-H. Su
Journal of Food and Drug Analysis
Camellia chrysantha (Hu) Tuyama (CCT), an ornamental plant possessing antioxidant activity, has been infused as tea and drank for its health benefits. The antioxidant components in CCT, however, had not been clearly characterized. To quickly identify the antioxidant constituents of CCT, a composition-activity relationship strategy based on ultra high-pressure liquid chromatography coupled with linear ion trap hybrid orbitrap mass spectrometry and orthogonal partial least-squares method has been applied. As a result, 16 variables were found to make significant contributions to the 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity. Six of them were identified as catechin (1), epicatechin (5), vitexin (8), isovitexin (10), quercetin-7-O-β-D-glucopyranoside …
In Vitro Anti-Diabetic Effect And Chemical Component Analysis Of 29 Essential Oils Products,
2020
Taiwan Food and Drug Administration
In Vitro Anti-Diabetic Effect And Chemical Component Analysis Of 29 Essential Oils Products, H.-F. Yen, C.-T. Hsieh, T.-J. Hsieh, F.-R. Chang, C.-K. Wang
Journal of Food and Drug Analysis
Twenty-nine commercial essential oil (EO) products that were purchased from the Taiwan market, including three different company-made Melissa officinalis essential oils, were assayed on their glucose consumption activity and lipid accumulation activity on 3T3-L1 adipocytes. The EOs of M. officinalis were significantly active in both model assays. By contrast, EOs of peppermint, lavender, bergamot, cypress, niaouli nerolidol, geranium-rose, and revensara did not increase glucose consumption activity from media, but displayed inhibited lipid accumulation activity (65-90% of lipid accumulation vs. the control 100%). Because of the promising activity of M. officinalis EOs, three different products were collected and compared for their …
Border Inspections Of Imported Food And Related Products In Taiwan From 2011 To 2013,
2020
Taiwan Food and Drug Administration
Border Inspections Of Imported Food And Related Products In Taiwan From 2011 To 2013, H.-C. Chen, H.-L. Huang, S.-C. Chen, W.-L. Lu, C.-H. Tung, H.-W. Shiau, J.-Y. Wang, H.-W. Huang, J.-F. Shyu, R.-L. Feng, Y.-M. Chiang
Journal of Food and Drug Analysis
[No abstract available]
Antioxidant, Antimicrobial, Antitumor, And Cytotoxic Activities Of An Important Medicinal Plant (Euphorbia Royleana) From Pakistan,
2020
Taiwan Food and Drug Administration
Antioxidant, Antimicrobial, Antitumor, And Cytotoxic Activities Of An Important Medicinal Plant (Euphorbia Royleana) From Pakistan, A. Ashraf, R.A. Sarfraz, M.A. Rashid, M. Shahid
Journal of Food and Drug Analysis
The aim of present study was to evaluate antioxidant, antimicrobial, and antitumor activities of methanol, hexane, and aqueous extracts of fresh Euphorbia royleana. Total phenolic and flavonoid contents were estimated as gallic acid and querectin equivalents, respectively. Antioxidant activity was assessed by scavenging of free 2,2′- diphenyl-1-picrylhydrazyl radicals and reduction of ferric ions, and it was observed that inhibition values increase linearly with increase in concentration of extract. The results of ferric reducing antioxidant power assay showed that hexane extract has maximum ferric reducing power (12.70 ± 0.49 mg gallic acid equivalents/g of plant extract). Maximum phenolic (47.47 ± 0.71 …
High-Throughput Liquid Chromatography Tandem Mass Spectrometry Method For Simultaneous Determination Of Fampridine, Paroxetine, And Quinidine In Rat Plasma: Application To In Vivo Perfusion Study,
2020
Taiwan Food and Drug Administration
High-Throughput Liquid Chromatography Tandem Mass Spectrometry Method For Simultaneous Determination Of Fampridine, Paroxetine, And Quinidine In Rat Plasma: Application To In Vivo Perfusion Study, S. Achanti, R.R. Katta
Journal of Food and Drug Analysis
A selective and high-throughput liquid chromatography–mass spectrometry method has been developed and validated for the simultaneous quantification of paroxetine, fampridine, and quinidine in rat plasma using imipramine as an internal standard. Following protein precipitation extraction, the analytes and internal standard were run on XBridge C18 column (150 mm × 4.6 mm, 5 μm) using a gradient mobile phase consisting of 5mM ammonium formate in water (pH 9.0) and acetonitrile in a flow gradience program. The precursor and product ions of the drugs were monitored on a triple quadrupole instrument operated in the positive ionization mode. The method was validated over …
Nonenzymatic Glucose Sensor Based On Disposable Pencil Graphite Electrode Modified By Copper Nanoparticles,
2020
Taiwan Food and Drug Administration
Nonenzymatic Glucose Sensor Based On Disposable Pencil Graphite Electrode Modified By Copper Nanoparticles, S. Pourbeyram, K. Mehdizadeh
Journal of Food and Drug Analysis
A nonenzymatic glucose sensor based on a disposable pencil graphite electrode (PGE) modified by copper nanoparticles [Cu(NP)] was prepared for the first time. The prepared Cu(NP) exhibited an absorption peak centered at ∼562 nm using UV-visible spectrophotometry and an almost homogenous spherical shape by scanning electron microscopy. Cyclic voltammetry of Cu(NP)-PGE showed an adsorption controlled charge transfer process up to 90.0 mVs−1The sensor was applied for the determination of glucose using an amperometry technique with a detection limit of [0.44 (±0.01) μM] and concentration sensitivity of [1467.5 (±1.3) μA/mMcm−2]. The preparation of the Cu(NP)-PGE sensor was reproducible (relative standard deviation …
Antifatigue And Increasing Exercise Performance Of Actinidia Arguta Crude Alkaloids In Mice,
2020
Taiwan Food and Drug Administration
Antifatigue And Increasing Exercise Performance Of Actinidia Arguta Crude Alkaloids In Mice, Y. Liu, C. Liu
Journal of Food and Drug Analysis
Actinidia arguta (Siebold et Zucc.) Planch. ex. Miq. is one of the most recently domesticated fruit species with increasing commercial production worldwide. It is a well-known traditional Chinese medicine and is used to reduce blood glucose and treat atopic dermatitis. In addition, it possesses antioxidant, anticancer, and antiallergic properties. In this study, we investigated the physical antifatigue and exercise performance effects of A. arguta crude alkaloids (AACA) extracted with 70% ethanol. Four groups of male Kunming mice (n = 16) were orally administered AACA at doses of 0 mg/kg/d (vehicle), 50 mg/kg/d (AACA-50), 100 mg/kg/d (AACA-100), or 200 mg/kg/d (AACA-200) …
Production Of A Monoclonal Antibody Against Aflatoxin M1 And Its Application For Detection Of Aflatoxin M1 In Fortified Milk,
2020
Taiwan Food and Drug Administration
Production Of A Monoclonal Antibody Against Aflatoxin M1 And Its Application For Detection Of Aflatoxin M1 In Fortified Milk, U. Chadseesuwan, A. Sangdokmai, U. Pimpitak, S. Puthong, T. Palaga, K. Komolpis
Journal of Food and Drug Analysis
Aflatoxin M1 (AFM1) is a toxic metabolite of the fungal product aflatoxin found in milk. For food safety concern, maximum residual limits of AFM1 in milk and dairy products have been differently enforced in many countries. A suitable detection method is required to screen a large number of product samples for the AFM1 contamination. In this study, monoclonal antibodies (MAbs) against AFM1 were generated using a conventional somatic cell fusion technique. After screening, five MAbs (AFM1-1, AFM1-3, AFM1-9, AFM1-11, and AFM1-17) were obtained that showed cross-reactivity with aflatoxin B1 (AFB1) and aflatoxin G1 (AFG1) but with no other tested compounds. …
