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Theses/Dissertations

2021

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Full-Text Articles in Life Sciences

Impact Of Xenobiotics On Neuronal Outcomes, Gabriela Henriquez Dec 2021

Impact Of Xenobiotics On Neuronal Outcomes, Gabriela Henriquez

Open Access Theses & Dissertations

Neurodegenerative diseases are a common affliction of the Central Nervous System. They are caused by age, genetics, and environmental factors. Alzheimer's disease, Parkinson's disease, Huntington's disease, and Amyotrophic Lateral Sclerosis are well-known among the host of neurodegenerative disorders, with Alzheimer's disease and Parkinson's disease being the leading pathologies across this canvas. It is known that the pathogenesis of neurodegenerative diseases is multifactorial due to the involvement of genetic mutations, radical-induced protein damage, abnormal aggregation of misfolded proteins, and the formation of amyloid deposits. The amyloid proteins in neurodegenerative disease include Tau and Amyloid (Aβ) in Alzheimer's disease and α-Synuclein in …

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An Investigation Of Upper Extremity Motor Impairments In Children Diagnosed With Autism Spectrum Disorder: Motor Planning Vs Motor Execution, Patrick Anthony Cereceres Dec 2021

An Investigation Of Upper Extremity Motor Impairments In Children Diagnosed With Autism Spectrum Disorder: Motor Planning Vs Motor Execution, Patrick Anthony Cereceres

Open Access Theses & Dissertations

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder typically diagnosedwhen a child displays social and communication impairments, repetitive behaviors, and rhythmic movements like hand flapping. This disorder is unique because of the high variability of symptoms displayed between each individual who is diagnosed. Because of this, no neurological or physiological test exists to diagnose a child with ASD. Current diagnostic tests are various forms of interviews or observations which an experienced clinician must administer. While these tests have been instrumental in diagnosing children with ASD, many go undiagnosed, which can be detrimental as they transition into adulthood. Current literature indicates …

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The Study Of The Phytopathogen Dickeya Dadantii 3937 Cpx Signaling On The Regulation Of Virulence And Antimicrobial Resistance, Daqing Jiang Dec 2021

The Study Of The Phytopathogen Dickeya Dadantii 3937 Cpx Signaling On The Regulation Of Virulence And Antimicrobial Resistance, Daqing Jiang

Theses and Dissertations

Bacteria respond to environmental cues through a variety of mechanisms. Two-component systems (TCSs) are a conserved mechanism used by bacteria to accurately respond and sense environmental changes. The monitoring of envelope perturbance is linked to TCS CpxA/CpxR in animal-infecting pathogens. The study of the TCS response regulator (RR) CpxR is largely unexplored in phytopathogens. This work focuses on the genetic linkage between cpxR and T3SS expression regulation. We identified the multiple roles of CpxR on several T3SS regulators and its participation in the bacterial second messenger (c-di-GMP) signaling cascade. Moreover, a compound library screening revealed a novel Cpx inducer CHIR-090, …

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Deciphering Chemomechanical Couplings In Proteins Using Microsecond-Level Molecular Dynamics Simulations, Vivek Govind Kumar Dec 2021

Deciphering Chemomechanical Couplings In Proteins Using Microsecond-Level Molecular Dynamics Simulations, Vivek Govind Kumar

Graduate Theses and Dissertations

All-atom molecular dynamics (MD) simulations combine the high temporal resolution of experimental methods like smFRET and spatial resolution of methods like x-ray crystallography, to provide a detailed dynamic picture of biomolecular processes. Here, microsecond-level atomistic MD simulations have been used to characterize chemomechanical couplings in human fibroblast growth factor 1 (hFGF1) and the spike proteins of SARS CoV-1 and SARS-CoV-2. hFGF1 is a globular signaling protein that is involved in several physiological processes ranging from cell proliferation to wound healing. Experimental studies have previously described the low proteolytic and thermal stability of hFGF1, in addition to the stabilizing role of …

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Integrated Weed Management Strategies For Palmer Amaranth (Amaranthus Palmeri) In Cotton And Soybean Production Systems, Rodger Bruce Farr Dec 2021

Integrated Weed Management Strategies For Palmer Amaranth (Amaranthus Palmeri) In Cotton And Soybean Production Systems, Rodger Bruce Farr

Graduate Theses and Dissertations

Management of Palmer amaranth [Amaranthus palmeri (S.) Wats.] in the Midsouth in soybean [Glycine max (L.)] and cotton (Gossypium hirsutum L.) production systems has become increasingly troublesome due to resistance to many of the commonly utilized herbicides in these systems. Developments have been made to utilize new chemistries as well as incorporate integrated weed management strategies to control Palmer amaranth, but questions have risen given the economic feasibility or effectiveness of these new strategies. Additionally, regulation has limited producers’ abilities to utilize some herbicide chemistries. As a result, experiments were conducted to 1) understand the utility of isoxaflutole in isoxaflutole-tolerant …

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Habitat Assessment Of Ozark Glades Using Selected Epigeal Predatory Arthropods, Austin Key Jones Dec 2021

Habitat Assessment Of Ozark Glades Using Selected Epigeal Predatory Arthropods, Austin Key Jones

Graduate Theses and Dissertations

Epigeal predatory arthropods were collected with pitfall-style traps in nine sandstone glades of varying ecological stages, and management histories, in the Ozarks of Northern Arkansas over three years. These sites were categorized into three Site Types; Intact, high quality glades; Degraded, forest-encroached glades, and Restored glades which had received woody vegetation removal and burning. Collections of ground spiders (Gnaphosidae), predatory ground beetles (Carabidae), and the sole species of scorpion present in the Ozarks, Centruroides vittatus, were reported on as well as the applicability of arthropod collection methods for glade habitat assessment. Habitat characteristics were recorded for each site and analyzed …

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Longitudinal Monitoring Of Tumor Response To Immune Checkpoint Inhibitors Using Diffuse Optical Spectroscopy, Joel Isaac Rodriguez Troncoso Dec 2021

Longitudinal Monitoring Of Tumor Response To Immune Checkpoint Inhibitors Using Diffuse Optical Spectroscopy, Joel Isaac Rodriguez Troncoso

Graduate Theses and Dissertations

Immune checkpoint drugs have completely changed the way people treat metastatic melanoma and non-small-cell lung cancer. While the impacts of these immunological checkpoints and their suppression on T cell function are well characterized, their consequences on the tumor microenvironment are not. In a CT26 mouse colorectal cancer model, we employed diffuse reflectance spectroscopy to track in vivo tumor microenvironmental alterations in response to immune checkpoint inhibitors. On three separate days, animals bearing CT26 tumor xenografts were given anti-PD-L1, anti-CTLA-4, a combination of both inhibitors, and isotype control. Within the first 6 days, monotherapy with either anti-PD-L1 or anti-CTLA-4 resulted in …

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Evaluation Of Two Neonatal Challenge Models For Broiler Chickens And Their Effects On Early Performance Parameters, Callie Selby Dec 2021

Evaluation Of Two Neonatal Challenge Models For Broiler Chickens And Their Effects On Early Performance Parameters, Callie Selby

Graduate Theses and Dissertations

Formaldehyde fumigation in poultry hatch cabinets has been utilized for sanitation of hatching eggs for over a century. Formaldehyde is utilized to minimize pathogenic microbes on the surface of the egg as well as the microbial bloom during the hatching process. While formaldehyde is effective, its use is regulated in the United States and Europe due to its carcinogenic nature. Formaldehyde has been shown to damage the cuticle of the egg, cause embryonic death, and damage the epithelial lining of the respiratory tract of freshly hatched chicks, predisposing them for respiratory infection. Alternatives for formaldehyde fumigation must be identified and …

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Investigating Effects Of Microenvironmental Stress On Cell Metabolism Using Multiphoton Imaging, Lisa Rebello Dec 2021

Investigating Effects Of Microenvironmental Stress On Cell Metabolism Using Multiphoton Imaging, Lisa Rebello

Graduate Theses and Dissertations

Resistance to therapy in cancer is a major cause of poor prognosis in patients. Tumor hypoxia plays an active role in mediating treatment resistance and has been linked to metastases and metastatic potential in cancer. Our research focused on three objectives: i) To understand metabolic effects of chronic and intermittent hypoxia in murine breast cancer cells and its affiliation with metastatic potential ii) To identify the metabolic changes associated with radiation therapy in a panel of radiosensitive and radioresistant human head and neck cancer cells and iii) to monitor the changes in cell metabolism associated with gain of treatment resistance. …

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Assessing Plant And Lichen Diversity Using Reflectance Spectra, Lance Stasinski Dec 2021

Assessing Plant And Lichen Diversity Using Reflectance Spectra, Lance Stasinski

Electronic Theses and Dissertations

Biodiversity is changing and it is imperative that we continually assess it in order to preserve ecological services that we rely on. Spectral platforms are increasingly being used to assess biodiversity due to the fact that light reflected from an organism’s surface carries much of information about that organism. Despite the promise spectroscopy shows, two gaps in our knowledge remain. First, we do not know how well reflectance spectra can be used to estimate fine-scale diversity – intraspecific genetic and phenotypic diversity – that is fundamental to ecological and evolutionary processes. Second, spectral libraries, used to construct models to estimate …

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Relative Soybean Response To Aminocyclopyrachlor, 2,4-D, Dicamba, And Aminopyralid, Trey I. Clark Dec 2021

Relative Soybean Response To Aminocyclopyrachlor, 2,4-D, Dicamba, And Aminopyralid, Trey I. Clark

Masters Theses

This research compared the visual symptomology of four auxin herbicides applied at three rates to simulate tank contamination on non-auxin tolerant soybeans. The herbicides examined were aminocyclopyrachlor (ACP), 2,4-D, dicamba, and aminopyralid. The standard labeled rates (SLR) used to base the application rates were 0.12 kg ae ha-1 for ACP and aminopyralid while dicamba and 2,4-D used 1.12 kg ae ha-1. These four herbicides exhibit similar symptoms on soybeans which is problematic when diagnosing soybean response. One goal of this project was to obtain high-quality images of the four herbicide’s effect on soybeans, with the hope of …

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Physiological And Mechanical Comparisons Between Clipless And Flat Pedals, Katelyn Conroy Dec 2021

Physiological And Mechanical Comparisons Between Clipless And Flat Pedals, Katelyn Conroy

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of this study was to investigate the physiological and mechanical comparisons between clipless and flat pedals. Participants (n=4) completed two at-home 20-minute FTP tests: using clipless and flat pedals using Zwift. The order of conditions were randomized for each participant. Participants used their personal Smart Trainers, clipless pedals, and cycling shoes while flat pedals were provided (Syun-LP, Road Bike Platform Pedals). Power, heart rate and cadence were recorded and used for analysis. All dependent variables were compared using paired t-tests. Power was significantly greater for clipless (226.7 ± 46.2 W) vs. flat (215.2 ± 41.8 W) pedals (p …

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Designs And Outcomes Of Transcranial Magnetic Stimulation (Tms) And Repetitive Transcranial Magnetic Stimulation (Rtms) Circuits, Daniel Senda Dec 2021

Designs And Outcomes Of Transcranial Magnetic Stimulation (Tms) And Repetitive Transcranial Magnetic Stimulation (Rtms) Circuits, Daniel Senda

UNLV Theses, Dissertations, Professional Papers, and Capstones

This thesis reports the design and outcomes of several circuits intended for transcranial magnetic stimulation (TMS) and repetitive transcranial magnetic stimulation (rTMS) research. In simple terms, TMS circuits are composed of four main blocks: high voltage power source, energy storage bank, control switch, and coil. Each one of these blocks has characteristics that influence how well the circuit will perform for TMS procedures. A successful TMS research circuit must have the ability to emit controlled electromagnetic pulses through a coil connected to it. For the first block, voltages ranging from 50 V to 2 kV were used. In the second …

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Machine Learning Analysis Of Single Nucleotide Polymorphism (Snp) Data To Predict Bone Mineral Density In African American Women, Erick Githua Wakayu Dec 2021

Machine Learning Analysis Of Single Nucleotide Polymorphism (Snp) Data To Predict Bone Mineral Density In African American Women, Erick Githua Wakayu

UNLV Theses, Dissertations, Professional Papers, and Capstones

Osteoporosis is a debilitating disease in which an individual’s bones weaken, making bones fragile and more susceptible to fracture. While commonly found amongst postmenopausal Caucasian and Asian women based on previous studies, those of African descent (African American/Black) have largely been ignored when it comes to osteoporotic studies, especially when it comes to Genome Wide Association Studies (GWAS). From GWA studies, we gain access to single nucleotide poly-morphisms (SNPs) that may contribute to certain illnesses, such as osteoporosis. With low Bone Mineral Density (BMD) being one of the primary markers of potential osteoporosis, it is prudent that proper research is …

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Molecular Mechanisms Underlying The Suppression Of Cardiomyocyte Necroptosis By The Cop9 Signalosome In Mice, Megan T. Lewno Dec 2021

Molecular Mechanisms Underlying The Suppression Of Cardiomyocyte Necroptosis By The Cop9 Signalosome In Mice, Megan T. Lewno

Dissertations and Theses

Background: Within a large subset of heart failure, cardiac ubiquitin-proteasome system (UPS) inadequacy is causative. A vital UPS regulator is the COP9 signalosome (CSN). The CSN holocomplex is formed by 8 unique protein subunits (COPS1~COPS8) and regulates Cullin-RING ligases via Cullin deneddylation. Cardiomyocyte-restricted knockout (cko) of Cops8 causes massive cardiomyocyte necroptosis via the RIPK1-RIPK3-MLKL pathway, resulting in dilated cardiomyopathy (DCM) and shortened lifespan in mice. CSN’s deneddylase resides in COPS5 and Cops5-cko has not been explored. It is important to investigate how the necroptotic pathway within cardiomyocytes is activated in Cops8-cko mice as cardiomyocyte necroptosis has been shown to play …

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Impacts Of Environmental And Anthropogenic Stressors On Amphibian Welfare, Diversity, And Distribution In The Upper Missouri River Basin, Kaitlyn Campbell Dec 2021

Impacts Of Environmental And Anthropogenic Stressors On Amphibian Welfare, Diversity, And Distribution In The Upper Missouri River Basin, Kaitlyn Campbell

Dissertations and Theses

Climate change and anthropogenic stressors have contributed to rapid declines among various taxonomic groups; however, amphibian declines have been particularly intense and primarily stemmed from warming temperatures, habitat loss, exposure to contaminants, disease, and their subsequent interactions. Several climate mitigation strategies, like Bioenergy with Carbon Capture and Storage, have been proposed to alleviate the impact of rising temperatures; however, these proposals often fail to recognize and quantify the true impact on fauna, including changes in species distributions. To address this critical gap in knowledge, this research identified current amphibian distributions in the Upper Missouri River Basin and projected distribution changes …

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Impacts Of Anthropogenic Change On Plant Reproduction And Fitness, Alexandra S. Faidiga Dec 2021

Impacts Of Anthropogenic Change On Plant Reproduction And Fitness, Alexandra S. Faidiga

Masters Theses

Humans are altering natural systems around the globe in myriad ways. For plant species, such anthropogenic changes have resulted in increasingly fragmented populations, desynchronized interactions with mutualists, and shifted geographic ranges, among other effects. However, despite numerous examples of human impacts on plant populations, the consequences of these changes on plant reproduction remain poorly understood. In my thesis, I investigate the impacts of two forms of anthropogenic change–habitat disturbance and climate warming–on plant reproduction and fitness. I take two distinct approaches to address questions posed at local and regional scales. In Chapter I, I ask how inbreeding depression varies across …

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Growth, Browsing And Mortality In Mixed Oak And Pine Plantings, Heather Slayton Dec 2021

Growth, Browsing And Mortality In Mixed Oak And Pine Plantings, Heather Slayton

Masters Theses

The purpose of this project was to determine if different oak/pine arrangements elicited potential beneficial interactions that affected seedling growth, mortality and overall protection from deer browsing. Northern red oak (Quercus rubra L.) and shortleaf pine (Pinus echinata Mill.) were planted together and alone in six different planting patterns and spacings, replicated over three blocks in recent clearcuts in east Tennessee, USA. Each block consisted of two monocultures planted at a 3.0 by 3.0 meter (m) spacing and four multi-cropped treatments planted at varying spatial arrangements (0.3 m, 1.0 m, 1.5 m, and 3.0 m) from neighboring shortleaf …

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The Factors Influencing The Leader’S Perceptions Of Success Of Dairy Cooperatives: The Case Of Cumbal Nariño’S Dairy Associations, Omar Efren Aza Fuelantala Dec 2021

The Factors Influencing The Leader’S Perceptions Of Success Of Dairy Cooperatives: The Case Of Cumbal Nariño’S Dairy Associations, Omar Efren Aza Fuelantala

Masters Theses

During the last few decades, Colombia’s dairy sector has been affected by economic, social, and political conditions, not only endangering it but also putting at risk the long-term sustainability of the dairy industry. To mitigate these conditions, the dairy farmers have joined cooperatives, which enabled them to gain some strategic advantages and reduce the adverse effects of the economic, political, and social conditions. This study evaluates the influence of economic, financial, membership, management and operational characteristics on the presidents’ perceptions of success of the dairy associations in Cumbal-Nariño. To accomplish this objective, we surveyed the presidents of dairy associations in …

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The Effect Of Bovine Endometrial Cell Conditioned Media On In Vitro Produced Bovine Embryo Development And Gene Expression, Mary A. Oliver Dec 2021

The Effect Of Bovine Endometrial Cell Conditioned Media On In Vitro Produced Bovine Embryo Development And Gene Expression, Mary A. Oliver

Masters Theses

In vitro produced (IVP) bovine embryos provide enhanced genetic value and a means for studying early embryonic development. However, IVP embryos are developmentally compromised and are lower quality compared to in vivo derived (IVD) embryos. Consequently, after transfer pregnancy rates from IVP embryos are consistently lower, as they exhibit the highest amounts of pregnancy failure during the early embryonic phase (prior to day 28). Progesterone (P4) has been shown to influence bovine endometrial epithelial (EPI) and stromal fibroblast (SF) cells to secrete developmentally important molecules that promote early embryo development and conceptus elongation. However, IVP embryos are not exposed to …

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Feeding Behavior And Influence Of Hemp Varieties And Fertilization Rates On Damage Caused By Corn Earworm, Helicoverpa Zea, Julian Cosner Dec 2021

Feeding Behavior And Influence Of Hemp Varieties And Fertilization Rates On Damage Caused By Corn Earworm, Helicoverpa Zea, Julian Cosner

Masters Theses

Production of industrial hemp, Cannabis sativa L., has increased tremendously in the U.S. after its legalization through the Agricultural Improvement Act of 2018, known as the 2018 Farm Bill, which allowed commercial hemp production. By grower number, in 2020, Tennessee was the nation’s largest hemp program with over 1,800 producers licensed to grow up to 6,500 hectares (16,000 acres) according to the Tennessee Department of Agriculture. Though fiber and seed have a role in the industry, most growers (ca. 98%) concentrate on cannabidiol production because of the expected higher cash value potential per hectare. Introducing hemp as a monocrop system …

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Seasonality, Distribution, And Biological Control Of Crapemyrtle Bark Scale, A New Invasive Threat In Tennessee, Amira Cornish Dec 2021

Seasonality, Distribution, And Biological Control Of Crapemyrtle Bark Scale, A New Invasive Threat In Tennessee, Amira Cornish

Masters Theses

Crapemyrtle bark scale, Acanthococcus (= Eriococcus) lagerstroemiae (Kuwana), an invasive pest from Asia, is a threat in the United States. to crape myrtles grown in ornamental nurseries and in landscapes. Although mortality to crape myrtles is rare, its negative effects on aesthetics is considerable. It should affect the sale (valued at >$66 million wholesale) and use of crape myrtle in landscapes. This pest species has been found in numerous states, including Tennessee, where little is known about its state-wide distribution, lifecycle, biology, natural enemies, and impact on crape myrtles. The purpose of this two-year study is to gain additional knowledge …

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Molecular Markers Within And Beyond Viburnum: A Single Set Of Ssrs For An Immense Genus, Trinity Paige Hamm Dec 2021

Molecular Markers Within And Beyond Viburnum: A Single Set Of Ssrs For An Immense Genus, Trinity Paige Hamm

Masters Theses

Comprised of more than 160 species, Viburnum is the largest genus in the Viburnaceae (formerly Adoxaceae) alongside Adoxa and Sambucus. The native range of Viburnum species spans much of the Northern Hemisphere and extends into the mountains of South America and Southeastern Asia. Their wide geographic range has made Viburnum particularly interesting to phylogeographers and phylogeneticists. This diverse genus is also horticulturally valuable with varying traits such as fragrance, fruit color, and bud and inflorescence form. There is sufficient morphological diversity in the genus for there to be more than 70 species and intraspecific hybrids in cultivation, and in …

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Influence Of Physical Variability Of Highly Weathered Sedimentary Rock On Nitrate In Area 3 Of The Enigma Field Research Site At Y-12, Erin Kelly Dec 2021

Influence Of Physical Variability Of Highly Weathered Sedimentary Rock On Nitrate In Area 3 Of The Enigma Field Research Site At Y-12, Erin Kelly

Masters Theses

Uranium processing and waste storage in unlined waste ponds leached contaminants into the groundwater at Y-12, Oak Ridge, Tennessee, from the 1950s to 1980s. Groundwater wells near the S-3 ponds have had the highest nitrate concentrations of groundwater anywhere in the world (>10,000 mg/L). For reference, the maximum contaminant level for nitrate in drinking water set by the U.S. Environmental Protection Agency is 10 mg/L. Since 2012, the ENIGMA (Ecosystems and Networks Integrated with Genes and Molecular Assemblies) group has been characterizing, monitoring, and conducting field experiments to understand the interactions between contaminants, microbes, and the subsurface. The goals …

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An Analysis Of Environmental Conditions Impacting Cyanobacterial Algal Blooms In Drinking Water Sources In Upstate South Carolina, Gregory Langlois Dec 2021

An Analysis Of Environmental Conditions Impacting Cyanobacterial Algal Blooms In Drinking Water Sources In Upstate South Carolina, Gregory Langlois

All Theses

Maintaining water quality in reservoirs used for drinking water has been an issue in recent years due to the presence of algal blooms. Algal blooms are a perennially recurring problem that can have negative impacts on tourism, recreation, and overall water quality. Additionally, algal blooms will often produce an assortment of chemicals, some of which are hazardous to the health of humans, and some of which that, while relatively innocuous, result in unpleasant tastes and odors in water. Geosmin and 2-methylisoborneol are two taste and odor compounds that are notoriously difficult to treat out of drinking water sources by traditional …

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Glycan Functionalization Of Iron Oxide Nanoparticles (Ionps) As A Method Of Inactivating Antibiotic Resistant Neisseria Gonorrhoeae Via A Magnetically Mediated Energy Delivery (Magmed) System, Cedric Taylor Dec 2021

Glycan Functionalization Of Iron Oxide Nanoparticles (Ionps) As A Method Of Inactivating Antibiotic Resistant Neisseria Gonorrhoeae Via A Magnetically Mediated Energy Delivery (Magmed) System, Cedric Taylor

All Theses

With the increase of antibiotic resistant bacteria, current established therapeutic treatment methods are rapidly demonstrating decreasing efficacy. For this project, we are studying a novel alternate mechanism of treating antibiotic resistant bacteria by utilizing magnetic iron oxide nanoparticles (IONPs) coated with a heterobifunctional polyethylene glycol polymer (PEG) and functionalized with glycan structures that can interact with Neisseria gonorrhoeae FA1090. Interaction between the IONPs and bacteria is manipulated by an external alternating magnetic field (AMF) in a process known as magnetically mediated energy delivery (MagMED). Magnetic IONPs were synthesized and reacted with PEG (PEG-IONPs) and functionalized with glycans Gal(α1-3)Gal(β1-4)Glc(β1-1) (common name: …

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Effects Of Cashew Nut Shell Extract On Nutrient Digestibility And Ruminal Fermentation Under In Vitro Batch Culture And Continuous Culture Conditions, Chandler Compton Dec 2021

Effects Of Cashew Nut Shell Extract On Nutrient Digestibility And Ruminal Fermentation Under In Vitro Batch Culture And Continuous Culture Conditions, Chandler Compton

All Theses

The overall objective of this research was to determine the effects of cashew nut shell extract (CNSE; 59% anacardic acid and 18% cardol) on nutrient digestibility and rumen fermentation profile under in vitro batch culture (Chapter 2) and continuous culture conditions (Chapter 3). The second objective was to determine an optimal supplementation dosage for dairy cows. The batch culture study was organized as a randomized complete block design with 15 replicates per treatment incubated for 24 h during four incubation runs. Each incubation was inoculated with rumen contents collected from ruminally fistulated cows fed either a close-up ( …

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Sources Of Peanut Digging Losses And Strategies To Reduce Losses During Inversion, Loren Samenko Dec 2021

Sources Of Peanut Digging Losses And Strategies To Reduce Losses During Inversion, Loren Samenko

All Theses

Presented research was conducted at Clemson University’s Edisto Research and Education Center to quantify harvest related losses associated with the effects of peanut digger blade geometry, the effects of the peanut digger inversion assembly, and the effects of vine load on digging and strategies to address vine load. Three studies were performed to determine the potential losses incurred during the digging processes; various harvest metrics were analyzed to quantify the effects of the treatments. Five objectives guided the presented research. Objectives of the effects of peanut digger blade geometry study investigated the impact of blade geometry and blade aggression on …

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Fine Mapping Of Chilling Requirement And Bloom Date To Enable Marker-Assisted Breeding Of Climate Resilient Peach, Gizem Demirel Dec 2021

Fine Mapping Of Chilling Requirement And Bloom Date To Enable Marker-Assisted Breeding Of Climate Resilient Peach, Gizem Demirel

All Theses

Peach (Prunus persica (L.) Batsch) fruit is a delicious summer treat appreciated for its sweet, juicy, and aromatic taste all over the globe. With only 44 calories and zero fat per fruit, peach has a great popularity among consumers and producers for its nutritional and economic value. Peach production is threatened by unpredictable climate changes, rising temperatures that reduce winter chill, especially in the warmer growing areas, resulting in fruit and yield loss. Therefore, it is necessary to develop cultivars that are resilient to environmental changes. Peach breeding takes a long time, and this process can benefit from the …

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Differentiating The Mechanistic Role And Chemotherapeutic Potential Of Src And Podoplanin In Oncogenic Transformation, Edward P. Retzbach Dec 2021

Differentiating The Mechanistic Role And Chemotherapeutic Potential Of Src And Podoplanin In Oncogenic Transformation, Edward P. Retzbach

Graduate School of Biomedical Sciences Theses and Dissertations

There were an estimated 20 million new cancer cases worldwide in 2020, resulting in nearly 1000 deaths per hour [1]. Oral cancer exemplifies the difficulties of treating cancer patients. The first line for oral cancer treatment is surgery and radiation that can lead to patient disfigurement and decreased quality of life in cancer survivors [2-4]. Though there have been many developments in chemotherapy in the last 30 years, the 50% mortality rate associated with oral cancer has not changed [4, 5]. Longitudinal studies that track survival rates in oral cancer patients demonstrate a 3-fold reduction in patient deaths when patients …

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