Life Sciences Commons^™

Bio-Bust: Investigating Biotech Stock Factors Contributing To Abnormal Returns In The Wake Of Silicon Valley Bank's Failure, Spencer Kent

CMC Senior Theses

Following the unprecedented collapse of Silicon Valley Bank (SVB) in March 2023, this study explores abnormal stock price reactions within the biotechnology sector. As the chosen financial institution for countless Silicon Valley-type technology and healthcare firms, SVB's failure had a profound impact on small to mid-sized biotech companies. Analyzing a dataset of 180 biotech firms during a two-day event window over SVB’s collapse, I investigate whether exposure to SVB, or other factors, was the primary contributor to negative abnormal stock price reactions, considering variables such as the percentage of cash held at SVB, whether a firm maintained an active SVB …

C. Compactum Acts As A Comprehensive Climate Archive And Ecological Foundation In The Labrador Sea, Sadie Heckman

CMC Senior Theses

Clathromorphum compactum, a species of crustose coralline algae (CCA), is incredibly valuable for the future of high latitude ocean health, both as a comprehensive archive of changing ocean conditions, and ecologically as a foundational species for promoting biodiversity. Previous work establishes C. compactum as an effective climate proxy, and its life history provides several advantages for this use. C. compactum grow in nongeniculate, generally radial formations on hard substrates, over a wide distribution in mid-to-high latitude oceans and at subtidal depth ranges. Indeterminate growth leads to extreme longevity in C. compactum (Halfar et al., 2008), and growth rates are relatively …

Gut Dysbiosis Correlates With Covid-19 Severity, Ednita Escobar

CMC Senior Theses

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) impacts not only respiratory but also gut and oral microbiomes, influencing the manifestations of COVID-19. Each person’s unique microbiome consists of microorganisms such as bacteria, fungi, and viruses, some of which are symbiotic and others potentially harmful. Alterations in the gut microbiome, specifically, can affect the severity and symptoms of COVID-19. A review of studies indicate a pattern of gut dysbiosis in COVID-19 patients characterized by a decrease in beneficial microbiota and/or an increase in opportunistic pathogens. This gut imbalance correlates with disease severity, suggesting that the gut microbiome plays a significant role …

Beauty Of Life In Dynamical Systems: Philosophical Musings And Resources For Students, Soumya Banerjee, Joyeeta Ghose, Tarakeswar Banerjee, Kalyani Banerjee

Journal of Humanistic Mathematics

Information plays a key role in life and in complex biological systems, and dynamical systems underlie and can be used to represent many complex systems. Indeed, dynamical systems and information processing capabilities may be the hallmarks of life-like systems. In this paper we combine dynamical systems with a computational framework to generate art. The framework can be used to generate aesthetically appealing forms of life-like systems. Our work suggests that we may need an ``aesthetic sense'' to recognize life that we have not seen before. We also provide teaching resources for students in schools and undergraduate institutions.

Embracing Ai/Ml In Genetic Counseling: A Nationwide Survey On Program Leaderships’ Perspectives And Curriculum Integration, Kyla Holmes

KGI Theses and Dissertations

This study aimed to examine the attitudes and preparedness of genetic counseling program directors and faculty leadership in incorporating artificial intelligence and machine learning (AI/ML) into their curricula and its effect on core competency proficiency. AI/ML has been instrumental in creating and maintaining vital analytical tools and models employed by genetic counselors (GCs). However, research on the attitudes of faculty leadership in charge of training future GCs is limited. A nationwide survey conducted between November 2022 and February 2023 gathered 15 respondents holding diverse academic positions in genetic counseling program curriculum development. The majority of respondents had encountered AI/ML in …

The Development Of A Primer Payload With Microparticles For Uti Pathogen Identification Using Polythymidine- Modified Lamp Primers In Droplet Lamp, Jonas Otoo

KGI Theses and Dissertations

Nucleic acid amplification tests (NAATs) are among the diagnostic tests with the highest sensitivity and specificity. However, they are more complex to develop than other diagnostic tests such as biochemical tests and lateral flow immunoassay tests. Polymerase chain reaction (PCR) is the gold standard for NAATs. PCR requires thermal cycling to achieve clonal amplification of the target pathogen DNA for diagnosis. Thermal cycling poses a challenge in the development of PCR diagnostics for point-of-care (POC) settings. Loop-mediated isothermal amplification (LAMP) offers an isothermal method for NAATs diagnostics. The advancement of the microfluidics field significantly enhances the development of LAMP diagnostics …

Integrating Theatre And Biology: How Embodied Performance Can Enhance Empathy Among College Science Students, Annika C. Speer, Begona Echeverria

The STEAM Journal

In these field notes, we examine the integration of the arts into a 20-person honors biology seminar at UC Riverside “Beyond Science: Being Humane Amid Human Rights Crises.” We held a four-hour workshop to examine the ways in which performance and theatrical storytelling can enhance science learning. The workshop provided a unique avenue for exploring how human activities result in downward consequences including refugee displacement, one of the course objectives. In addition to the workshop, we conducted surveys and a focus group with the students to better understand their experience incorporating the arts into their science class. A key concept …

Dear Duck-Billed Platypus, Michael J. Leach Dr

The STEAM Journal

This piece is a concrete poem that both shows and describes the platypus (Ornithorhynchus anatinus).

Light Leaf: Observations Of Leaves In Light, Paul Kelley

The STEAM Journal

For me, spending time in isolation yielded some interesting findings, as I began to closely observe the various leaves that engulf my backyard. Every new day brought with it a new detail, a subtlety with every shift in light, revealing an endless array of abstractions, textures and colors. I was seeing the hidden life of leaves dancing in the sunlight. Naturally, I began documenting my observations.

Students Arts Participation Increases Stem Motivation Via Self-Efficacy, Stephen M. Dahlem

The STEAM Journal

This work found that there exists a correlation between student motivation in science, technology, engineering and mathematics (STEM) and student participation in the arts during high school with self-efficacy being a mediator. STEM is an important component of student success from a broad, national, perspective, as well as from a domain-specific point of view. The results of this work may provide aid to teachers, parents, administrators, and even students seeking to find ways to increase student motivation and performance in the STEM subjects. Additionally, this work may be of interest to advocates of the arts. This quantitative correlational study was …

Challenge-Based Learning & Steam Curriculum, Diana Lockwood

The STEAM Journal

STEAM education is being integrated into elementary schools as a way to engage more students in creativity, hands-on learning, and problem-based learning also referred to as Challenge-Based-Learning (CBL). This article focuses on elementary educators’ curriculum design for STEAM and presenting students with open-ended questions phrased as a challenge as a way to raise student interest and achievement (DeJarnette, 2018; Hunter-Doniger, 2018). When students received challenges to solve, they felt more open to sharing their ideas since there was more than one potential right answer (DeJarnette, 2018; Drake, 2012). When implementing CBL, teachers act as facilitators using a constructivist approach as …

Contents 41(1–2)

Aliso: A Journal of Systematic and Floristic Botany

No abstract provided.

Dedication

Aliso: A Journal of Systematic and Floristic Botany

No abstract provided.

Comparative Leaf Water Absorption Between Chaparral Island And Mainland Taxa: A Common Garden Experiment, Humera S. Mirza, Lauren M. Tucker, Rodrigo Méndez-Alonzo, Edward G. Bobich, Frank W. Ewers

Aliso: A Journal of Systematic and Floristic Botany

In California and other Mediterranean-type ecosystems, island species are typically exposed to more fog but less rain than mainland species. Because adaptations to absorb water from fog may conflict with those to minimize water loss, we hypothesized that island species should have greater fog absorption than their mainland congeners due to foliar uptake but at the cost of modifying other leaf structural and functional traits. To determine whether foliar water absorption is an adaptation to insularity, we compared seven physiological and anatomical leaf traits between congeneric island and mainland species of two genera, Ceanothus and Arctostaphylos, in a common …

A Tribute To Gary D. Wallace

Aliso: A Journal of Systematic and Floristic Botany

No abstract provided.

A Vascular Flora Of The South Fork Tule River, Southern Sierra Nevada, Tulare County, California, Jessica M. Orozco

Aliso: A Journal of Systematic and Floristic Botany

I conducted a floristic study of the South Fork Tule River watershed, located in the southern Sierra Nevada in Tulare County, California. The primary objectives of this floristic study were to document and catalogue all vascular plant taxa that occur in the watershed, describe the plant communities, analyze the flora and its affinities with other areas, and establish a herbarium for the Tule River Indian Reservation. The upper reaches of the South Fork Tule River originate on the western slope of Slate Mountain in the Sequoia National Forest and drain west through the Tule River Indian Reservation into Lake Success. …

Forty Years Of Change In Piute Cypress (Hesperocyparis Nevadensis), A Rare California Tree, After Frequent Fire And Drought, Amarina Wuenschel, Jim A. Bartel, Alexis Bernal

Aliso: A Journal of Systematic and Floristic Botany

Piute cypress (Hesperocyparis nevadensis) is a rare cypress species endemic to the Lake Isabella region in the southern Sierra Nevada in California. Piute cypress groves have not been quantitatively studied in the last 40 years and with recent fires (some in short succession) and observed mortality, we had questions surrounding conditions in groves recovering from fire compared to other groves with no recorded fire histories. Piute cypress rarely survive fire and are obligate seeders with serotinous cones and, as such, require sufficient time after fire to grow to reproductive maturity to be able to withstand future fire. We …

Using Computational Fluid Dynamics And Optical Sensor Technology To Scale Cell Culture Platforms, Mandar Makwana

KGI Theses and Dissertations

Different cell culture vessels ranging from micro scale to laboratory scale to commercial scale play critical role in upstream process development for biologics manufacturing. Based on the mode of operation, cell culture vessels have different hydrodynamic environments, making it challenging to scale. Integrated approaches using computational tools supported by experimental studies can overcome these challenges. Computational Fluid Dynamics (CFD) is one such tool that can simulate hydrodynamics within the cell culture vessels and can provide insights at macro and micro-scale. Accuracy of a CFD model significantly depends on the fluid model and assumptions. Traditionally, simple two-equation fluid models were developed …

Biogeography Of Special Metabolites Produced By Ant-Associated Bacteria, Katherine Hansen

Scripps Senior Theses

There is an urgent and growing need for novel antibiotics with the growing prevalence of antibiotic-resistant pathogens. Ecologically-guided discovery is a strategy that focuses on how and where specially evolved metabolites such as antibiotics are used in nature. This strategy reveals unique active molecules with potential for human use. An unexplored niche with great potential for antibiotic discovery exists with Southwestern fungus-farming Trachymyrmex ants and their Actinobacteria symbionts. In exchange for nutrients from the ant, the ants’ bacterial symbiont produces antifungal molecules that protect the ants’ fungal cultivar from invasion by pathogenic microorganisms. They also produce antibacterial molecules to protect …

Nitrogen Isotopes In Deep Sea Corals; A Potential Tracer Of Paleoceanographic Conditions, Sylvia Bergerud

Scripps Senior Theses

Abstract

In the face of anthropogenic climate change, increasing pressure is being mounted on contextualizing current climate altercations compared to those of the past. One key tracer of climate variation is the isotopic ratio of 15N compared to 14N, which tracks biological and chemical reactions throughout the N cycle. However, it is difficult to find accurate palaeoceanographic records of N isotope fractionation, as most sedimentary and organic samples are subject to extensive diagenesis, degradation, and erosive processes. Scleractinian corals present a potential solution to this lack of accurate data. Multiple studies indicate that, due to their protective aragonite skeletons and …

Analysis Of Biologically Effective Dose For Retroactive Yttrium-90 Trans-Arterial Radioembolization Treatment Optimization, Mj Lindsey

CMC Senior Theses

Trans-arterial radioembolization (TARE) is a protracted modality of radiation therapy where radionuclides labeled with Yttrium-90 (⁹⁰Y) are inserted inside a patient's hepatic artery to treat hepatocellular carcinoma (HCC). While TARE has been shown to be a clinically effective and safe treatment, there is little understanding of the radiobiological relationship between absorbed dose and tissue response, and thus there is no dosimetric standard for treatment planning. The Biologically Effective Dose (BED) formalism, derived from the Linear-Quadratic model of radiobiology, is used to weigh the absorbed dose by the time pattern of delivery. BED is a virtual dose that can …

The Relationship Between Parasite Infection, Body Condition, And Migration In White-Crowned Sparrows And California Towhees, Madeline Galbraith

CMC Senior Theses

Long-distance animal migration plays a large role in the spread of infectious disease, potentially causing an increase or a decrease in infection. These outcomes can be serious, as infection has the ability to induce a variety of effects on the host, all which may impact their overall health. The consequences of infection on a host can be measured using body condition. Changes to an individual’s body condition are central to the mechanisms involved in migration’s ability to both increase (ex: susceptibility) and decrease infection (ex: migratory culling). Therefore, when assessing potential migratory effects, it is important to consider relationships between …

Investigation Into The Potential For Acquired Cross Tolerances Of Amphetamines, Benjamin Weldon

CMC Senior Theses

In the United States, the treatment of ADHD through use of psychostimulants in adolescents is a growing reality that many people know today and many more will know in the coming years. Although the effectiveness of psychostimulants is a known asset, the benefits of these medications may not be a permanent solution, suggesting not only the presence of a tolerance build up, but as many stimulants are prescribed in a joint effort to combat ADHD, a possible cross tolerance between two prescribed medications. There are minimal studies published that have addressed the topic of cross stimulation tolerance buildup between prescription …

Treatment Of Anxiety By Transcutaneous Vagus Nerve Stimulation: A Retrospective Chart Review, Rhea Gandhi

CMC Senior Theses

Surgical vagus nerve stimulation (VNS) was FDA cleared for depression (2005) and epilepsy. (1997). In the surgical procedure, a pacemaker is implanted below the collarbone (clavicle) and connected to the vagus nerve in the neck. Transcutaneous vagus nerve stimulation (tVNS) is a non-surgical alternative to VNS and there is evidence supporting its effectiveness for several conditions. Advantages include lower cost and fewer adverse side effects.

Anxiety is tied to excess or unopposed sympathetic nervous system activity, while the parasympathetic nervous system, especially the vagus nerve, is relatively underactive. This study aimed to investigate a potential impact of regular tVNS stimulation …

Revisiting The 2018 Corsica Oil Spill - A Preliminary Case Study Of Ecosystem Recovery From Pahs In Yelkouan Shearwater (Puffinus Yelkouan), Makenna Mahrer

CMC Senior Theses

Polycyclic aromatic hydrocarbons (PAHs) are a specific class of persistent organic pollutants (POPs) heavily associated with crude oil, and pose genotoxic and physiological threats to marine life when released into the aquatic environment during a petroleum spill. This study seeks to understand the residual impacts of the 2018 Corsica oil spill on Puffinus yelkouan (Yelkouan Shearwater), a seabird endemic to the Mediterranean basin, using the species as a bioindicator for contamination in the region. Though classified by the IUCN Red List as ‘vulnerable,’ this species remains grossly understudied in present monitoring literature. This study made use of blood samples and …

Effects Of Male Attractiveness On Prostaglandin E2 Production Levels, Kyra Cousins

CMC Senior Theses

Sexual conflict or sexual antagonism can encourage co-evolution between males and females of a given species. In house crickets (Acheta domesticus), unattractive (smaller) and attractive (larger) males seem to use differential allocation of prostaglandin E₂ in their spermatophore to pursue different propagation strategies in influencing female oviposition. This study aims to determine the means by which attractive and less attractive males press their reproductive advantage by focusing on prostaglandin E₂. To test the hypothesis that the difference in prostaglandin E₂ concentration is essential for female reproductive manipulation, spermatophores were retrieved from 21 pairs of mated …

Copy Number Alterations Of Aggressive Pituitary Neuroendocrine Tumors, Grace Zhang

Scripps Senior Theses

Pituitary neuroendocrine tumors (PitNETs) are tumors of the pituitary gland. Although most are benign, they can cause severe morbidity if compression of surrounding tissue and/or endocrinopathies occur.

Aggressive PitNETs are notably detrimental and difficult to predict, and their effects are further exacerbated by challenges in treatment. Although histological studies can detect certain markers of tumor aggressiveness, they are insufficient at wholly predicting PitNET aggressiveness, making the clinical behavior of PitNETs challenging to determine. Since treatment of aggressive tumors also remains suboptimal, this further results in negative impacts on health and quality of life.

Genetic markers, such as copy number variations …

Variation In Soil-Mediated Drought Response Traits Between Sympatric Species Of Mimulus, Anna Reitman

Scripps Senior Theses

The ‘time limitation hypothesis’ is an evolutionary theory regarding evolution in angiosperms. The theory attributes ephemeral drought stress to transitions from a perennial to annual life history and an animal- to self-pollinating mating style. The most influential edaphic parameter on water availability is soil texture (i.e. grain size) due to its controls on porosity. Adhesion weakens with coarseness allowing for expedited rates of water loss via evaporation and percolation. The potential implications of coarse soil textures on major transitions in angiosperms due to drought mediation as the ‘time-limitation hypothesis’ proposes has yet to be thoroughly examined. Here, we grew two …

Oral Contraceptives And Affective Disorders: Neurobiology And Informed Choice, Sophia Mae Drezner

Scripps Senior Theses

Pregnancy prevention and female reproductive freedom have been some of the most contested political issues for decades. Abortion, a fundamental part of women’s healthcare, divides liberals and conservatives on an international scale. The consequences of unintended pregnancy without safe and reliable contraception are widespread, disproportionately impacting women of color, trans and non-binary folks, and poorer communities. The birth control pill is the most common form of oral contraception (OC) globally. Many people with ovaries begin the pill or other hormonal contraceptive (HC) methods as young as 11 years old. Exogenous progesterone and estrogen are known to impact mood, affect, physiology, …

Cultivating Carrots, Community, And Health-Conscious Children: Investigating The Effects Of Community Garden Implementation On Nutrition Attitudes Of Elementary Students In The Los Angeles Unified School District, Hannah Michele Tiedemann

Scripps Senior Theses

Growing up in an urban food desert can significantly affect children's development, health, and well-being (Jencks et al., 1990; Leventhal et al., 2000). Compared to their more affluent peers, youth living in low-socioeconomic urban neighborhoods are at greater risk of experiencing poor-quality diets, food insecurity, unhealthy body weights, and mental health problems (Duncan et al., 1997; Sampson et al., 1997). Moreover, children living in food-insecure households are more likely to consume calorically dense diets high in trans fat and added sugar, putting them at risk for poor health, childhood obesity, and chronic, diet-related diseases as adults (Nielsen et al., 2002). …