Life Sciences Commons^™

Krill Watching, Michael J. Leach

The STEAM Journal

This is a concrete, or visual, found poem about the scientific activity of observing krill in the deep sea. I discovered this concrete found poem in prose that Nicol (2019, p. 200) quoted from Ommanney (1938).

• Nicol, S 2019 ‘Oceans of krill’, in B Nogrady (ed) The best Australian science writing 2019, Sydney: NewSouth Publishing.
• Ommanney, FD 1938 South latitude, London: Longmans, Green & Co.

The Finch Effect: Evolutionary Metaphors And Illiberal Democracy In Central And Eastern Europe, Abigail Woodfield

Claremont-UC Undergraduate Research Conference on the European Union

In recent years, several states in Central and Eastern Europe have seen democratic digression. Such illiberal resurgences came as a surprise to the many political scientists who assumed that the future of these states was democratic. Indeed, after the fall of the Soviet Union, the world largely regarded liberal democracy as the predominant system of government. The future seemed bright, and it was tempting to understand that future in evolutionary terms—just as humans evolved under natural selection to become the dominant species, democracy had survived a similar competition and defeated all other systems of government to become the dominant regime. …

Development Of Novel Zika And Anthrax Viral Nanoparticle Vaccines, Elizabeth Henderson

KGI Theses and Dissertations

Vaccines protect against numerous infectious diseases and prevent millions of deaths annually, but there are still many infectious diseases for which no licensed vaccine exists. Developing a new vaccine requires balancing safety and efficacy, and viral nanoparticle (VNP) vaccines possess both of these characteristics. The work herein demonstrates how tobacco mosaic virus (TMV) nanoparticles can serve as a platform to create candidate vaccines for Zika virus (ZIKV) and anthrax. In the first study, a ZIKV-specific epitope was genetically fused to TMV to create a safe and inexpensive vaccine that proved highly immunogenic in mice and led to the discovery of …

Third Voices Conference On Teaching Stem With Music, September 22-23, 2019, Lawrence M. Lesser

Journal of Humanistic Mathematics

The third annual VOICES (Virtual Ongoing Interdisciplinary Collaborations on Educating with Song; https://www.causeweb.org/voices/) conference will be held online September 22-23, 2019. Chaired by Tiffany Getty, this conference will explore the use of song to teach STEM (science, technology, engineering, and mathematics) at the postsecondary (or secondary) level.

Applied Scientific Demiurgy I – Entrance Examination Information Sheet, Mario Daniel Martín

Journal of Humanistic Mathematics

This document provides all the required information needed by aspiring demiurges to sit the entrance examination for the foundation course Applied Scientific Demiurgy I in the scientific stream of the Bachelor of Applied Demiurgy at the Topological Hyper-university of Technological Cosmology.

Differential Equations Of Love And Love Of Differential Equations, Isaac Elishakoff

Journal of Humanistic Mathematics

In this paper, simple ordinary differential equations are discussed against the background of William Shakespeare’s Romeo and Juliet. In addition, a version of this relationship in a somewhat opposite setting is considered. It is proposed that engineering mathematics courses include this topic in order to promote additional interest in differential equations. In the final section it is shown that vibration of a single-degree-of-freedom mechanical system can be cast as a love-hate relationship between its displacement and velocity, and dynamic instability identified as a transition from trigonometric love to hyperbolic.

Using Hidden Markov Modeling For Biogeographical Ancestry Analysis, Melvin R. Currie

Journal of Humanistic Mathematics

This paper describes a methodology for analyzing X-chromosome data to establish biogeographical contributions to the author’s X chromosome. We present an exposition of how Hidden Markov Modeling (HMM) can be used as a black box for ancestry analysis and focus on a set of conditions that are not universal but fairly common. The first condition is that the ancestral populations are drawn from regions that have had very little or no contact with each other since prehistoric times. The second condition is that the number of possible ancestral populations is small. In this analysis, we assume that the ancestral populations …

Microrna Profiling And Engineering Of Cho Cell Lines Stably Expressing Difficult-To-Express Lysosomal Protein, Ifeanyi Amadi

KGI Theses and Dissertations

Difficult-to-express (DTE) recombinant proteins like multi-specific proteins, DTE monoclonal antibodies and lysosomal enzymes, have seen difficulties in manufacturability using Chinese hamster ovary (CHO) cells and other mammalian cells as production platforms. CHO cells are preferably used for protein production because of their innate ability to secrete human-like recombinant proteins with post-translational modification, resistance to viral infection and familiarity with drug regulators. However, despite huge progress made in engineering CHO cells for high volumetric productivity, expression of DTE proteins like recombinant lysosomal sulfatase represent one of the poorly understood proteins. Furthermore, there are growing interest in the use of microRNAs (miRNAs) …

Targeted Genome-Scale Gene Activation And Gene Editing In Human Cells To Understand Disease Models, Michael De La Cruz

KGI Theses and Dissertations

Since the discovery of sequence directed DNA editing reagents such as CRISPR-Cas9 RNA-guided and TALEN DNA endonucleases, there has been a snowball of advances in the life sciences due to the ability to efficiently edit and control genomes within living cells. CRISPR-Cas9 based genomic tools, which facilitate the high-throughput precise manipulation of genes, allow for unbiased functional genomic screens. We used a human CRISPR-Cas9 Synergistic Activation Mediator pooled library which utilizes an engineered protein complex for transcriptional activation of 23,430 endogenous genes to investigate the development of novel resistance mechanisms to lung cancer targeted therapy, Erlotinib. We set out to …

Novel Low Shear 3d Bioreactor For The Scaled Production Of High Purity Human Mesenchymal Stem Cells, Andrew Burns

KGI Theses and Dissertations

Human mesenchymal stem cells are an ideal candidate for stem cell therapies. They have been researched since the 1960’s and can differentiate into many desired functional cell types without undergoing teratogenesis. However, higher yields are needed for a marketable, successful stem cell therapy. To accomplish this, cells will have to be cultured to expand them to therapeutically relevant dosages for multiple patients. Bioreactor production is an ideal method to solve this problem.

The aim of this thesis is to test and validate a novel bioreactor for the cultivation of human mesenchymal stem cells. In this work, we investigate a novel …

Food – Eating With My Eyes, Nadia Arévalo

The STEAM Journal

Whole foods are visually stunning while being scientifically proven to be healthy. Here I share some images and notes of my colorful preparations that embrace the knowledge of the ever-expanding Nutritional Sciences.

Mass Caffeination, Michael J. Leach

The STEAM Journal

This poem reflects on caffeine intake in modern society from the perspective of a pharmacologist. It is a free verse, concrete poem that communicates the science of caffeine through both words and visual images.

Spot-On! Exploring Comprehension Of Ecological Concepts With Abstract Art Analogies, Jane Huggins

The STEAM Journal

Students enrolled in an online general studies course [GNM 2190: Extinct and Threatened Life] at Stockton University were presented with two different pieces of abstract art. They were asked to draw analogies from each piece of art to the ecological concepts studied in the course. Students provided written responses which were submitted as assignments in the learning management software, Blackboard [Bb]. This exercise was described as ‘open-ended’ by the instructor; no grading rubrics were used. Responses to each piece of art were collected from 47 students and were subsequently uploaded into Quirkosä software for qualitative analysis. Codes representing major concepts …

Spaces Between, Sara Kapadia

The STEAM Journal

No abstract provided.

Plantae Coulterianae: Thomas Coulter’S Californian Exsiccata, Gary D. Wallace

Aliso: A Journal of Systematic and Floristic Botany

An account of the extent, diversity, and importance of the Californian collections of Thomas Coulter in the herbarium (TCD) of Trinity College, Dublin, Ireland, is presented here. It is based on examination of collections in TCD, several other collections available online, and referenced literature. Additional information on historical context, content of herbarium labels and annotations is included. Coulter’s collections in TCD are less well known than partial duplicate sets at other herbaria. He was the first botanist to cross the desert of southern California to the Colorado River. Coulter’s collections in TCD include not only 60 vascular plant specimens previously …

Remembering Lee W. Lenz (1915–2019)

Aliso: A Journal of Systematic and Floristic Botany

Known primarily for his systematic work on Iris, Dr. Lee Lenz was also known for his taxonomic revision in other monocotyledonous groups such as Yucca, leading to his recognition of Yucca jaegeriana as distinct from the Joshua tree, Y. brevifolia. He was also involved in breeding horticultural forms from California native plants, such as xChiranthofremontia lenzii, and was credited with developing the first red-flowering iris within the Pacific Coast hybrids. Dr. Lenz was Director of Rancho Santa Ana Botanic Garden (now California Botanic Garden) in Claremont, California, from 1960 to 1983. A table lists his …

Shizen Nōhō: Restoring The Relationship Between Food, Nature, And People In Japan, Katharine Graham

Scripps Senior Theses

In Japan’s postwar era, agriculture has become highly industrialized, involving heavy machinery, chemical fertilizers, and pesticides, all in the name of “progress.” Through employing such practices, humans have attempted to improve upon nature’s way of doing things, and in turn have degraded the soil’s fertility, natural ecosystems, and human health. In response to this, Shizen Nōhō has emerged in Japan as an alternative way of cultivating food. Shizen Nōhō practitioners challenge the notion that we need chemical fertilizers, pesticides, and machinery to farm successfully. Rather, they advocate for a way of growing food that functions seamlessly with natural ecosystems. This …

Identification Of Antibiotic Ge37468a From Pseudonocardia Symbionts Of Trachymyrmex Septentrionalis Ants, Krithika Rao

Scripps Senior Theses

In response to the growing rates of antibiotic resistance in human bacterial pathogens, this study explores the natural products involved in the defensive symbiosis between actinobacteria and fungus-growing ants to uncover new potential antibiotics. This study also seeks to understand the function of natural antibiotics in their ecological contexts, especially those involved in defensive symbioses. Defensive symbiosis can be a beneficial platform for discovering useful antibiotics, because antibiotics in these relationships must be able to selectively inhibit enemies without harming hosts, and are therefore likely more specific and less toxic. Pseudonocardia sp. associated with Trachymyrmex septentrionalis ants demonstrated antibiotic activity …

Written In Bone: Damage Patterns In Agonopsis Vulsa Armor, Morgan Stewart

Scripps Senior Theses

Naturally occurring armor has evolved in many different classes of organisms, often in response to predation, although other factors may play a part. In this study, the scales of the benthic armored fish Agonopsis vulsa were examined for damage patterns in order to illuminate the life history and environmental interactions of the fish. Scales from the fish were systematically destroyed in the lab, and observations made from the damaged scales were used to create a categorical damage rating, which was applied to 34 specimens ranging in trunk length from 2.3 cm to 14.2 cm. The specimens were rendered as three-dimensional …

The Role Of Serum Histones In Canine Heat Stroke, Jenna Acutt

Scripps Senior Theses

Rising temperatures all over the world has correlated with more frequent heat stroke related injuries and death. This statistic not only applies to humans, but to canines as well, who have similar body temperature thresholds. Recent studies have demonstrated that serum histones, released after cell death from heat stroke, play a role in heat stroke related injuries and death. This proposal aims to determine the severity of the effects caused by serum histone release after heat stroke by exposing selected canine cell lines to cell lysate and purified histones H2A, H2B, H3, and H4, which have been found to be …

Changing Oceanic Conditions On The Foraging Patterns Of Cassin’S Auklets, Ptychoramphus Aleuticuschanging Oceanic Conditions On The Foraging Patterns Of Cassin’S Auklets, Ptychoramphus Aleuticus, Clare Flynn

Pomona Senior Theses

Cassin’s auklet (Ptychoramphus aleuticus) reproductive success has been monitored on Southeast Farallon Island (SEFI) for the past 45 years. Their productivity has varied with oceanic conditions. The purpose of this study is to connect how oceanic conditions affect Cassin’s auklet foraging behaviors. The California Current System (CCS) can normally maintain high plankton productivity, and thus high seabird productivity, because of coastal upwelling. I hypothesized that lower upwelling and/or higher sea surface temperatures (SSTs) lead Cassin’s auklets to spend more time on intensive foraging behaviors such as flying and diving, and have less time to spend resting. I also hypothesized that …

Farm To Label: A Critique Of Consumer Activism In The Sustainable Food Movement, Olivia Whitener

Pomona Senior Theses

“Local,” “organic,” “natural,” and “Fairtrade” are just several of the many claims adorning the food products that line grocery store shelves. These promises of environmental sustainability and social responsibility are pillars of the “good food revolution” sweeping the nation as consumers demand alternatives to the products of the industrial food system. Green consumerism, the premise that consumer demand for environmentally sustainable goods will bring about ecologically beneficial outcomes, is at the heart of the sustainable food movement. This thesis takes a critical look at the operation of green consumerism in the food system. It explores the ideology and shortcomings of …

In The Eye Of The Storm: Houston After Hurricane Harvey, Brandon Tolentino-Serrano

Pomona Senior Theses

Situated in one of the wettest climates in America, Houston, TX has had a long history of heavy rains and unprecedented floods. Unfortunately, floods have become more common over the last few decades as climate change increases the frequency and intensity of hurricanes around the globe. To complicate matters further, Houston has quickly sprawled to accommodate over 2.5 billion people. Rapid urbanization has rendered the landscape even more susceptible to floods through excess concretization and watershed disturbance. This thesis traces the history of the Bayou City in relation to the damages caused by Hurricane Harvey. By mapping out the original …

Fragile Oceans, Synthetic Flotsam And Microbial Collaboration – Explorations In The Visual Communication Of The Plastic Crisis, Ivan Langesfeld

Pomona Senior Theses

Scientific evidence that the ocean plastic crisis is larger in scale and more sinister than previously thought continues to mount, but the rate of plastic production is only rising. What will it take to decisively turn the tide against plastic? We need scientists, politicians, and industry changemakers to continue producing knowledge and positive change in the industry, but we need to go further still. This thesis explores art as an alternative visual communication strategy with the capacity to encourage curiosity, empathy, and positive engagement with the issue of ocean plastics. The series of work explores bacterial bioluminescence as an artistic …

Island Invasion: The Silent Crisis In Hawaii, Sophia Janssen

Pomona Senior Theses

Keeping out invasive species may, upon first review, seem like a trivial environmental cry from ecologists and deep environmentalists; a belated wish to return to an undeveloped world where nature was pristine. However invasive species create problems that impact all of us and can have far more severe consequences than changing a stunning landscape. These problems are heightened in islands like Hawaii, where the fragile ecosystems have developed over centuries of evolution and adaptation. The introduction of a disease-carrying mosquito can put the people of Hawaii at risk to many vector-born illnesses and create an epidemic, taking human life. The …

Put Your Money Where Your Mouth Is: Reforming Organized Dentistry To Address Persistent Oral Health Disparities In The U.S., Aparna Chintapalli

Pomona Senior Theses

The importance of oral health has been largely neglected from the conventional standards of healthcare in terms of public understanding & prioritization, the industrial infrastructure, and the scope of prevention & early-intervention services. Its adjunctive locus to the field of medicine has lead to the bifurcation of the oral cavity from the rest of the human body. As a result of this divide, there have been multiple factors that have allowed socially stratified oral health outcomes to manifest. This thesis examines the determinants of oral health disparities through a multidisciplinary lens (i.e. biology, public policy, infrastructure), and offers evidence of …

A Composite Review Of The Proposed Molecular Mechanisms And Genetic Components Underlying Parkinson’S Disease, Paige Brodrick

Scripps Senior Theses

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the progressive death of dopaminergic neurons present in the substantia nigra. The clinical presentation of PD includes tremors, slowed movement (bradykinesia), muscle and limb rigidity, and difficulty with walking and balancing. While many environmental factors can affect the onset and progression of the disease, genetic mutations have a large influence. Of the identified PD-linked genetic mutations, mutations in the leucine-rich repeat kinase 2 (LRRK2) are one of the most common genetic causes of PD. Located in endosomes, LRRK2 has been shown to play a role in the sorting and endocytosis …

Role Of Managed Marine Areas On The Diversity And Individual Responses Of Rocky Intertidal Shore Grazers In Central Chile, Kathy Liu

Scripps Senior Theses

Many different types of marine benthic herbivores or “grazers” inhabit coastal intertidal zones and play a crucial role in inter- and shallow subtidal ecosystems. Chile has one of the most diverse intertidal zones, but many intertidal grazers are exploited for human consumption. Marine protected areas (MPAs) and marine management and exploitation areas (MEAs) are promising tools for Chile to combat over exploitation of these grazer and other marine resources. This study surveyed the impact of sites with contrasting management on the diversity and abundance of all intertidal grazers and their impact on the size frequency and shell length-body weight allometry …

Relations Among Maternal And Paternal Behavior And Children's Stress Biology, S.K. Jiaming Lin, Stacey N. Doan, John Milton

Scripps Senior Theses

Parenting behavior has been shown to have a wide range of effects, influencing children’s psychological and biological stress outcomes. Most research focuses on maternal parenting behaviors, with few studies observing the effects of paternal behaviors or the influence of both parents on their children. In this study, the relationship between maternal and paternal parenting behaviors was examined in its association to predict children’s cortisol levels. Cultural differences in parenting styles was also observed. American (N=86) and Chinese (N=97) families participated in the study, with parents reporting their behaviors. Children’s cortisol was collected during a stressor task and correlational analysis was …

Investigating Neurogenesis As A Veritable Epigenetic Endophenotype For Alzheimer's Disease, Layne Wells

Scripps Senior Theses

Alzheimer's disease (AD) is the most common neurodegenerative disease, characterized by progressive amyloid plaque aggregation, neurofibrillary tangles, and cortical tissue death. As the prevalence of AD is projected to climb in coming years, there is a vested interest in identifying endophenotypes by which to improve diagnostics and direct clinical interventions. The risk for complex disorders, such as AD, is influenced by multiple genetic, environmental, and lifestyle factors. Significant strides have been made in identifying genetic variants linked to AD through the genome-wide association study (GWAS). It has been estimated in more recent years, however, that GWAS-identified variants account for limited …