Life Sciences Commons^™

Literary Digest: Cannibal Poetry And Biology, Alicia Anzaldo, Claire Boeck, Sara Schupack

The STEAM Journal

A humanities professor and a biology professor at Wilbur Wright College collaborated to create a lesson on human digestion and poetry, enriching the humanities course theme on cannibalism. This article describes the lesson plan, examples of student work, and faculty reflections.

Nature In Deconstruction, Russell Chowdhury

The STEAM Journal

This 'desconstructive photography' shows how humans interact with nature.

Justin's Save The Frogs Project, Justin Sather

The STEAM Journal

Justin’s Save the Frog Project goals are 1) to spread the awareness about the rapid decline in frog population 2) inspire others to make the environment a better place for people and animals 3) make an impact by building wetlands in California specifically for the CA Red-Legged Frogs and Foothill Yellow Legged.

Science And Sentiment: Affecting Change In Environmental Awareness, Attitudes, And Actions Through The Daily Nature Project, Elizabeth D. Haynes Poronsky

The STEAM Journal

Knowledge about what motivates pro-environmental behavior is important to organizations that seek to encourage environmental stewardship. Research suggests that targeting emotions and beliefs about nature can be more effective in changing environmental actions than increasing knowledge. Daily Nature, a site on the social media platform Facebook, features a daily nature photograph, a quote from a notable historical person and a related lyrical written passage. The popularity of this site lends credence to the appeal of interdisciplinary formats, and underscores the benefits of encouraging emotional and aesthetic ties to nature.

Creativity, Laterality And Critical State Balance In Learning, Jenny Rock, Asher Flatt

The STEAM Journal

Understanding the intersecting cognitive pathways that are integral to ways of thinking, creating and functioning in both art and science is an important grounding for a STEAM educational approach. We combine three divergent concepts, including creativity, hemisphere laterality, and critical state theory, to argue for a more balanced approach to learning as part of a modern meaning-centered education in STEAM. Reviewing the concept of hemisphere laterality, or how the two hemispheres of our brain have different (though not disconnected) ways of processing sensory information, we note how these two means of interpreting the world have become unbalanced in traditional modes …

Understanding Huntington's Disease Using Machine Learning Approaches, Sonali Lokhande

KGI Theses and Dissertations

Huntington’s disease (HD) is a debilitating neurodegenerative disorder with a complex pathophysiology. Despite extensive studies to study the disease, the sequence of events through which mutant Huntingtin (mHtt) protein executes its action still remains elusive. The phenotype of HD is an outcome of numerous processes initiated by the mHtt protein along with other proteins that act as either suppressors or enhancers of the effects of mHtt protein and PolyQ aggregates. Utilizing an integrative systems biology approach, I construct and analyze a Huntington’s disease integrome using human orthologs of protein interactors of wild type and mHtt protein. Analysis of this integrome …

Voices: Conference On Teaching Stem With Music, September 27-28, 2017, Gregory J. Crowther

Journal of Humanistic Mathematics

This first-of-its-kind, online-only conference will explore the use of music to teach STEM (science, technology, engineering, and mathematics) at the college level (including AP courses). Presentations will be live-streamed from the conference website, https://www.causeweb.org/voices. Online registrations (for only $10 apiece!) will be accepted at the conference website until the conclusion of the conference on September 28, 2017.

One = Zero, Eric John Gofen

Journal of Humanistic Mathematics

In this paper, I use Mathematics in addition to the three most pure sciences --- Physics, Chemistry, and Rap --- to prove that 1=0. The argument uses The Ideal Gas Law, Ohm's Law, the Definitions of Power and Velocity in addition to indefinite integrals, simple mathematical operations, and the 99 Problems Law. The intuition-crushing result can be applied to all branches of mathematics and sciences and will likely go down as one of the greatest discoveries of all time.

The Maine Chance: Private-Public Partnership And The Katahdin Woods And Waters National Monument, Char Miller

Pomona Faculty Publications and Research

The claim of a federal “land grab” in response to the creation of Katahdin Woods and Waters National Monument in Maine revealed a lack of historical awareness by critics of how two other cherished parks were established there: through private-public partnerships and the donation of land by private citizens.

A Vascular Flora Of The Kiavah Wilderness, Scodie Mountains, Kern County, California, Erika M. Gardner

Aliso: A Journal of Systematic and Floristic Botany

Congress designated the Kiavah Wilderness in 1994 under the California Desert Protection Act. It is located in the Scodie Mountains in Kern County, ca. 24 km (15 mi) east of Lake Isabella and 24 km (15 mi) west of Ridgecrest, and encompasses a total of 137 mi² (354 km²) with elevations ranging from 1000 to 2200 m (3500–7294 ft). The Wilderness is ecologically important because it occurs in a transition zone between two floristic provinces, the Sierra Nevada of the California Floristic Province and the Mojave Desert of the Desert Province. It is of cultural significance because …

Phylogenetics Of The Borage Family: Delimiting Boraginales And Assessing Closest Relatives, Kristen E. Hasenstab-Lehman

Aliso: A Journal of Systematic and Floristic Botany

The placement of Boraginales, and relationships within the family have remained elusive in modern, broad phylogenetic studies. In order to assess the phylogeny of Boraginales, and specifically to test the sister lineage of the order, a data matrix of the chloroplast markers rbcL, ndhF, and trnL-trnF was assembled from GenBank and de novo sequences (representing 132 new GenBank accessions). Phylogenies inferred using Maximum Likelihood and Bayesian frameworks resulted in identical topologies. Tests for alternative topologies were used to assess whether any of the candidates for sister (Solanales, Gentianales, Lamiales, or Vahlia) to Boraginales could …

Vestured Pits In Echium (Boraginaceae): Island Woodiness Revisited, Sherwin Carlquist

Aliso: A Journal of Systematic and Floristic Botany

Vestured pits are present on pits of secondary xylem vessels of all studied Echium species, roots as well as stems. Variations in vesturing presence do occur in the genus (across wide circular pit cavities; along margins of elliptical pit apertures; aggregated to various degrees; variously abundant), but these are difficult to define precisely and are related primarily to organography and ecology rather than to the taxonomic system. The Macaronesian species have been reported to form a single clade. Wood anatomical features other than vesturing are also closely keyed to species ecology and, in particular subclades, growth forms. Woodiness, exemplified by …

Impact Of Ground Water Depletion On The Mesquite Community At Edwards Air Force Base, Western Mojave Desert, California, Jonathan E. Campbell, M. Rasoul Sharifi, Philip W. Rundel

Aliso: A Journal of Systematic and Floristic Botany

Edwards Air Force Base (EAFB) provides a habitat refugium for mesquite woodlands in the western Mojave Desert of the Antelope Valley. Although many mesquite communities in the arid southwest are considered invasive as they reduce the extent of grazing lands, the community at EAFB is composed primarily of large, widely spaced trees that provide food and shelter for local wildlife species and recreational opportunities for base personnel. Unfortunately, the range of these mesquite trees appears to be contracting as mature and old individuals dominate the community. Although anecdotal evidence suggests that the fall in the local groundwater table is responsible …

The Vegetation And Flora Of Edwards Air Force Base, Western Mojave Desert, California, David Charlton, Philip W. Rundel

Aliso: A Journal of Systematic and Floristic Botany

Edwards Air Force Base extends over 121,000 ha in the Antelope Valley of the western Mojave Desert, with much of the area part of a closed endorheic basin that held the Pleistocene Lake Thompson. Notable topographic features are Rogers, Rosamond and Buckhorn dry lakes, while rounded domes and scattered hills are present to the north and east. Elevation gradients are limited, ranging from a low of 690 m to 1044 m near the eastern margin. Diverse communities of saltbush scrub dominate the lower plains, while creosote bush scrub and Joshua tree woodlands are present away from the old lake basin. …

Richness And Current Status Of Gymnosperm Communities In Aguascalientes, Mexico, María Elena Siqueiros-Delgado, Rebecca S. Miguel, José A. Rodríguez-Avalos, Julio Martínez-Ramírez, José C. Sierra-Muñoz

Aliso: A Journal of Systematic and Floristic Botany

The gymnosperm diversity of Aguascalientes, Mexico, is presented. Fifteen species from five genera and three families are reported, two of Coniferales (Cupressaceae and Pinaceae) and one of Gnetales (Ephedraceae). Pinus is the most diverse and abundant genus with seven species. The most abundant species is P. teocote, while P. strobiformis is the scarcest. Juniperus is the next most diverse genus, represented by four species, with J. deppeana the most abundant and J. durangensis the scarcest. Cupressus lusitanica, Taxodium mucronatum and Ephedra compacta are each the sole representatives of their genera. Most conifers occupy the mountainous part of the …

Plant Phenology And Water Relations In A Saline Pan-Dune Mosaic In The Western Mojave Desert, M. Rasoul Sharifi, William N. Brostoff, Philip W. Rundel

Aliso: A Journal of Systematic and Floristic Botany

An extensive mosaic of small clay pans and low stable dunes exists within Edwards Air Force Base in the western Mojave Desert of California. This pan-dune ecosystem, positioned between the large Rosamond and Rogers dry lakes on the old Pleistocene lakebed of Lake Thompson, provides an opportunity to study the seasonal patterns in growth and flowering phenology and water relations in a saltbush scrub community dominated by a mix of C₃ and C₄ species. C₃ shrubs initiated vegetative growth in February, with current shoot and leaf production largely ceasing in most species by mid-April. The deeply rooted …

Index To Volume 35

Aliso: A Journal of Systematic and Floristic Botany

No abstract provided.

Community Structure And Demography In A Saline Pan-Dune Mosaic In The Western Mojave Desert, M. Rasoul Sharifi, William N. Brostoff, Philip W. Rundel

Aliso: A Journal of Systematic and Floristic Botany

A unique saline ecological system formed by an extensive mosaic of small clay pans and low stable dunes exists within Edwards Air Force Base in the western Mojave Desert of California. This ecosystem lies between the large Rosamond and Rogers dry lakes on the old Pleistocene lakebed of Lake Thompson. Plant communities on the low and relatively stable dunes were broadly classed as saltbush scrub, with a total canopy cover of 30–36%. Atriplex confertifolia was the typical dominant, with Ericameria nauseosa as an important associate. Taller dunes of younger age and less saline soils had similar plant cover, but a …

The Effect Of The Chromoshadow Domains Of Hhp1, Hpl1, And Hpl2 On Heterochromatin Protein Localization In Tetrahymena Thermophila, Claire Bagnani

Scripps Senior Theses

In the nucleus, post-translational modifications on histone N-terminal tails can determine how local DNA is packaged. In one case, T. thermophila proteins Hhp1, Hpl1, and Hpl2, all related to the Heterochromatin Protein 1 (HP1) family, are associated with heterochromatin and thus gene silencing. They may do this by binding to trimethylated lysine 9 and lysine 27, located on the tail of histone H3. One distinct region of these proteins, the chromodomain (CD), may bind these marks, while another region, the chromoshadow domain (CSD) homodimerizes to interact with other proteins. This study explores what effect, if any, the CSD has on …

Menageries Multiple: An Introduction To Zoological Multiplicity In The Modern American Zoo, Emily D. Gratke

Scripps Senior Theses

American zoological parks have been sites of intense consumer and scholar interest since their origination in the 20th century. Today, zoos reside at a tenacious hub of ideologies, practices, and priorities contributed to by various stakeholder groups. I propose that the foundational cause of this tension is zoological multiplicity: the theory that through human practices and perceptions, animals can embody multiple identities. Via an exploration of zoological multiplicity in American zoos with specific focus on zoo management, zoogoer, and animal activist stakeholder groups, this project proposes the widespread acknowledgment and understanding of zoological multiplicity as a method to improve animal …

Toric Ideals, Polytopes, And Convex Neural Codes, Caitlin Lienkaemper

HMC Senior Theses

How does the brain encode the spatial structure of the external world?

A partial answer comes through place cells, hippocampal neurons which

become associated to approximately convex regions of the world known

as their place fields. When an organism is in the place field of some place

cell, that cell will fire at an increased rate. A neural code describes the set

of firing patterns observed in a set of neurons in terms of which subsets

fire together and which do not. If the neurons the code describes are place

cells, then the neural code gives some information about the …

Slowing The Evolution And Outbreak Of Antibiotic Resistance, Connie Okasaki

HMC Senior Theses

Antibiotic resistance is a problem of significant and growing international concern, in part due to the rapid evolution of new resistances. One potentially important factor in the emergence of resistance is concentrated antibiotic use in environments such as hospitals. Such high use creates a strong selective pressure for pathogens to evolve resistance. We analyze some strategies hospitals can use to slow the evolution of resistance, and estimate the length of the delay between evolution and outbreak of resistance.

Soil Erosion Risk Factors And The Impacts Of Diversification On Organic Strawberry Farms Along California’S Central Coast, Kay Sterner

Pomona Senior Theses

Soil erosion is a major issue that threatens to undermine our current system of agriculture. Due to the fact that this system is in turn the number one cause of erosion, agricultural practices in the United States need to be rethought. This study explores how traditional ideas of erosion risks are related to observed erosion on organic strawberry farms along California’s Central Coast. In addition, diversified farming systems are addressed as a possible solution for the current unsustainability of our farming practices. The data from this research suggest that diversity of crops on farms could be linked to less soil …

From Yosemite To A Global Market: How Patagonia, Inc. Has Created An Environmentally Sustainable And Socially Equitable Model Of Supply-Chain Management, Mary-Clare Bosco

Pomona Senior Theses

There is an urgent pressure of the time (2016) to re-evaluate our patterns of consumption to adapt to changing climates and reduce waste and pollution. Because an immediate restructuring of global production strategies is not likely any time soon, industrial innovators are finding new ways of redesigning supply-chain management in efforts to move towards environmentally sustainable business in which all manufacturing practices are transparent. Patagonia, Inc. is a testament to the often-debated question of economic value in green business practices, and this thesis acts as an outline as to how they arrived at such an impressive presence in the business …

Using Geospatial Analysis For High School Environmental Science Education: A Case Study Of The Jane Goodall Institute's Community-Centered Conservation Approach, Madison G. Vorva

Pomona Senior Theses

Given my experiences as a young conservation advocate, I saw a need to teach students the importance of interconnectedness, cultural awareness and systems-thinking skills through a spatial lens. I believe these skills are required for holistic, equitable and sustainable conservation decision-making in local and international contexts. This thesis uses geospatial tools to teach conservation ecology vocabulary and concepts from high school environmental science curriculum in two online resources. The purpose of my lesson plan is to show students how conservationists address complex conservation and land-use challenges using the Jane Goodall Institute’s community-centered conservation approach as a case-study. My hope is …

Engineering An Alkane-Hydroxylating Bacterial Monooxygenase: A Tale Of Two Chemistries, Arjun Nanda

Pomona Senior Theses

Toluene / o-xylene monooxyenase (ToMO) from Pseudomonas sp. OX1 is a multimeric metalloenzyme enzyme that efficiently catalyzes the hydroxylation of aromatic hydrocarbons with high specificity. Though included in a larger group of conserved bacterial multicomponent monooxygenases (BMMs) studied as potential biocatalysts for industrial hydrocarbon chemistry, the substrate specificity and oxygenated intermediates of ToMO differ greatly from its well-characterized, alkane-hydroxylating analog sMMO. Despite a shared global topology and near identical active sites, sMMO can cleave inert C-H bonds in alkanes while ToMO cannot - two seemingly similar structures give rise to vastly different chemistries. This work seeks to determine a structural …

Molecular Modeling Of Novel Tryptamine Analogs With Antibiotic Potential Through Their Inhibition Of Tryptophan Synthase, Jared Schattenkerk

CMC Senior Theses

The growing prevalence of antibiotic-resistant bacteria is a global health crisis that threatens the effectiveness of antibiotics in medical treatment. Increases in the number of antibiotic-resistant bacteria and a drop in the pharmaceutical development of novel antibiotics have combined to form a situation that is rapidly increasing the likelihood of a post-antibiotic era. The development of antibiotics with novel enzymatic targets is critical to stall this growing crisis. In silico methods of molecular modeling and drug design were utilized in the development of novel tryptamine analogs as potential antibiotics through their inhibition of the bacterial enzyme tryptophan synthase. Following the …

Phage Display To Identify Functional Resistance Mutations To Rigosertib, Nedim Filipovic

CMC Senior Theses

In vitro protein selection has had major impacts in the field of protein engineering. Traditional screens assay individual proteins for specific function. Selection, however, analyzes a pool of mutants and yields the best variants. Phage display, a successful selection technique, also provides a reliable link between variant phenotype and genotype. It can also be coupled with high throughput sequencing to map protein mutations; potentially highlighting vital mutations in variants. We propose to apply this technique to cancer therapy. RAF, a serine/threonine kinase, is critical for cell regulation in mammals. RAF can be activated by oncogenic RAS, found in over 30% …

Matrix Model Analysis Of A Coastal Northern California Subpopulation Of The Western Snowy Plover (Charadrius Alexandrinus Nivosus), Jaclyn Grace Stewart

CMC Senior Theses

Shorebirds are increasingly threatened by introduced predators, invasive grasses, and human disturbance. Matrix models can be used to predict population growth and assess management options. The Pacific coast population of the western snowy plover, Charadrius alexandrinus nivosus, is listed as threatened under the Endangered Species Act, largely due to high rates of nest predation. A matrix model for the entire Pacific coast metapopulation of western snowy plovers was published in 1999 by Nur et al., but population growth has not been comprehensively reassessed since, even after development of a recovery plan (USFWS 2007) and extensive management intervention. I built …

The Role Of The Dosage Compensation Complex As A Pathway For Spiroplasma To Induce Male Lethality In Drosophila Melanogaster, Becky Cheng

CMC Senior Theses

Drosophila melanogaster and many other insects harbor intracellular bacterial symbionts that are transmitted vertically from infected host mothers to their offspring. Many of these bacteria alter host reproductive developmental processes in order to increase their transmission success. For example, Spiroplasma, a spirochete that naturally infects D. melanogaster, selectively kills males during mid-embryogenesis while sparing females. Previous studies suggested that Spiroplasma interacts genetically with the male-specific dosage compensation pathway, which causes ~2-fold up-regulation of most genes located on the male’s single X chromosome so that their expression matches the levels found in females who have two Xs. To further …