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Articles 1 - 24 of 24
Full-Text Articles in Life Sciences
Cortical Stimulation Mapping Of Heschl’S Gyrus In The Auditory Cortex For Tinnitus Treatment, Austin Huang
Cortical Stimulation Mapping Of Heschl’S Gyrus In The Auditory Cortex For Tinnitus Treatment, Austin Huang
CMC Senior Theses
Tinnitus is the perception of sound in the absence of an actual sound stimulus. Recent developments have shifted the focus to the central nervous system and the neural correlate of tinnitus. Broadly, tinnitus involves cortical map rearrangement, pathological neural synchrony, and increased spontaneous firing rates. Various cortical regions, such as Heschl’s gyrus in the auditory cortex, have been found to be associated with different aspects of tinnitus, such as perception and loudness. I propose a cortical stimulation mapping study of Heschl’s gyrus using a depth and subdural electrode montage to conduct electrocorticography. This study would provide high-resolution data on abnormal …
Computational Analysis Of Genomic Variants Affecting Predicted Microrna:Target Interactions In Prostate Cancer., Angélica Paola Hernández Pérez
Computational Analysis Of Genomic Variants Affecting Predicted Microrna:Target Interactions In Prostate Cancer., Angélica Paola Hernández Pérez
KGI Theses and Dissertations
Prostate cancer (PCa) is the most common cancer of men in the United States and is third only to lung and colon as a cause of cancer death. Clinical behavior of the disease is variable and the combination of prostate-specific antigen (PSA) screening and Gleason score staging are currently the best available molecular and pathology tools to predict outcomes. Cancer biology research establishes microRNAs (miRNAs) as key molecular components in both normal and pathological states. Thus, elucidating miRNAs perturbed by genomic alterations will expand our understanding of the molecular taxonomy of PCa with the aim to complement current practices in …
Optimization Of Recombinant Adeno-Associated Virus (Aav) Vector Production In Saccharomyces Cerevisiae, Juan Aponte
Optimization Of Recombinant Adeno-Associated Virus (Aav) Vector Production In Saccharomyces Cerevisiae, Juan Aponte
KGI Theses and Dissertations
Recombinant adeno-associated viral vectors (rAAV) are emerging drugs for gene therapy applications. Their non-pathogenic status, low inflammatory potential, availability of viral serotypes with different tissue tropisms, and prospective long-lasting gene expression are important attributes that make rAAVs safe and efficient therapeutic options. One of the main limitations for bringing rAAV gene therapy to the market is the difficulty in supplying enough rAAV vector product. The high vector doses suggested by early clinical data infer the need to scale up production at high volumes in order to satisfy patient demand. Current production platforms such as HEK293 or Sf9 cells are very …
“Primitive” Wood Characters Are Adaptive: Examples From Paracryphiaceae, Sherwin Carlquist
“Primitive” Wood Characters Are Adaptive: Examples From Paracryphiaceae, Sherwin Carlquist
Aliso: A Journal of Systematic and Floristic Botany
Why plants rich in plesiomorphic (“primitive”) features are alive today is a question that receives little comment. Apomorphies in angiosperms are often interpreted as valuable adaptations. However, both apomorphies and plesiomorphies can be keyed to ecological and physiological features. If a particular habitat remains little modified for long periods of geological time, plesiomorphic features should theoretically persist. The Bailey-Frost-Kribs correlations (usually between tracheary element length and character states in other wood features), deemed useful in their day, did not include adaptation to ecology, nor did they have the advantages that molecular-based phylogenies bring to us today. Montane cloud forests or …
New Additions To The Flora Of San Nicolas Island, Ventura County, California, Benjamin E. Carter, William F. Hoyer Iii, Jonathan Dunn, C. Matt Guilliams
New Additions To The Flora Of San Nicolas Island, Ventura County, California, Benjamin E. Carter, William F. Hoyer Iii, Jonathan Dunn, C. Matt Guilliams
Aliso: A Journal of Systematic and Floristic Botany
Ongoing collecting efforts on San Nicolas Island have substantially increased the number of plant species documented from the island. Here we report thirty-one plants previously unrecorded from the island. The list includes six eudicots, one monocot, four liverworts and twenty mosses. Five of these species are understood to be introduced on San Nicolas and the remainder are believed to be native. The native vascular plants are Logfia filaginoides, Cistanthe maritima and Muhlenbergia microsperma. Of the twenty-four new bryophytes, one—Asterella bolanderi—is the first record from the Channel Islands. Specific ecological and locality information are provided for the …
Contents 36(2)
Aliso: A Journal of Systematic and Floristic Botany
No abstract provided.
Vascular Flora Of The Upper Rock Creek Watershed, Eastern Sierra Nevada, California, Joy D. England
Vascular Flora Of The Upper Rock Creek Watershed, Eastern Sierra Nevada, California, Joy D. England
Aliso: A Journal of Systematic and Floristic Botany
The upper Rock Creek watershed is located on the east slope of the Sierra Nevada in Inyo and Mono counties. It is ca. 36.5 square miles (94.5 square km) in area and varies in elevation from 7360 to 13,750 ft (2243 to 4191 m). Quaternary glacial erosion and deposition produced striking landscape features, including alpine fell fields and numerous small lakes. Previous floristic inventories in Rock Creek recorded a combined 396 minimum-rank taxa (species, subspecies, varieties, named hybrids) but were restricted to Little Lakes Valley and the surrounding high areas. An updated, annotated checklist of vascular plants is presented, based …
Reviewers Of Manuscripts, Volume 36
Reviewers Of Manuscripts, Volume 36
Aliso: A Journal of Systematic and Floristic Botany
No abstract provided.
Index To Volume 36
Aliso: A Journal of Systematic and Floristic Botany
No abstract provided.
New Species, New Combinations And New Synonymies Towards A Treatment Of Acanthaceae For The Manual De Plantas De Costa Rica, Lucinda A. Mcdade, Barry E. Hammel, Carrie A. Kiel
New Species, New Combinations And New Synonymies Towards A Treatment Of Acanthaceae For The Manual De Plantas De Costa Rica, Lucinda A. Mcdade, Barry E. Hammel, Carrie A. Kiel
Aliso: A Journal of Systematic and Floristic Botany
In preparation for the publication of the Manual de Plantas de Costa Rica, new species, names, combinations, and synonymies are provided in six genera of Acanthaceae: Anisacanthus, Chamaeranthemum, Dicliptera, Justicia, Ruellia and Stenostephanus. The new species are A. grace-woodiae, J. altior, J. lithophila and S. chavesii. A new name at the species level, R. leonardiana, is provided for R. tubiflora var. hirsuta. With Habracanthus, Hansteinia, Kalbreyeriella and Razisea being subsumed within Stenostephanus, the new combinations S. blepharorhachis, S. citrinus, S. leiorhachis (= Razisea spicata …
Potential For Climate Induced Methane Hydrate Dissociation, Graham Macwilliams
Potential For Climate Induced Methane Hydrate Dissociation, Graham Macwilliams
Pomona Senior Theses
Methane hydrates are frozen deposits of methane and water found in high pressure or low temperature sediments. When these deposits destabilize, large quantities of methane can be emitted into the atmosphere. This is significant to climate change because methane has 25 times more greenhouse gas potential than Carbon Dioxide. Worldwide, it is estimated there are between 2500 and 10000 gigatons of methane stored in hydrate deposits. This represents more carbon than all fossil fuels on Earth. It is estimated that between 200 and 2000 gigatons of methane are stored in hydrates in Arctic waters acutely vulnerable to greenhouse warming. Over …
Restoration Of Mauri (Life-Force) To Okahu Bay: Investigation Of The Cultural, Social, And Environmental Restoration, Emily Freilich
Restoration Of Mauri (Life-Force) To Okahu Bay: Investigation Of The Cultural, Social, And Environmental Restoration, Emily Freilich
Pomona Senior Theses
This thesis investigated the restoration of mauri (life-force) to Ōkahu Bay, Auckland New Zealand. Ōkahu Bay is part of the land and waters of Ngāti Whātua Ōrākei, a Māori hapū (sub-tribe). Ngāti Whātua Ōrākei has been driving the restoration, restoring Ōkahu Bay based on their worldview, visions, and concerns. This vision and control of the restoration process allows them to bring in the hapū in sustainable engagement and have the long-term vision and commitment necessary for self-determination. However, while there has been progress with projects and improved decision-making authority, hapū members are still not seeing their whānau (family) swimming in …
Pollinator Power: Supporting Bees Through Ecoregion Specific Planting Guides, Maya Thomas
Pollinator Power: Supporting Bees Through Ecoregion Specific Planting Guides, Maya Thomas
Scripps Senior Theses
The pollination of flowering crops by bees is an invaluable ecosystem service that supports biodiversity and much of the global agricultural system. Pollinators move pollen between the male structures of a plant to the female structures of a plant of the same species. This fertilizes the female plant, which then produces the next generation. This process also provides the pollinator with the nectar or pollen it needs to survive. While some plants transfer pollen through different means, the majority of plants need help from pollinators to reproduce. Depending on the means of pollination, pollination can be classified as abiotic or …
A Link Between Gut Microbes & Depression: Microbial Activation Of The Human Kynurenine Pathway, Christina Cobb
A Link Between Gut Microbes & Depression: Microbial Activation Of The Human Kynurenine Pathway, Christina Cobb
CMC Senior Theses
Our gut microbiota is involved in human development, nutrition, and the pathogenesis of gut disorders, but has more recently been implicated as a possible mechanism in the pathophysiology of several brain disorders, including disorders of mood and affect, such as depression. Researchers have referred to this dynamic, bidirectional signaling pathway between the gut and the brain as the “gut-brain axis.” However, most research on this axis has been limited to rodent studies, and there has been little insight into the mechanism behind it. I propose that the kynurenine pathway, where tryptophan is converted to kynurenine, is a compelling mechanism mediating …
Ccl11 As A Biomarker For The In Vivo Diagnosis Of Chronic Traumatic Encephalopathy, Robert Weissenfels
Ccl11 As A Biomarker For The In Vivo Diagnosis Of Chronic Traumatic Encephalopathy, Robert Weissenfels
CMC Senior Theses
Chronic traumatic encephalopathy is the neurodegenerative disease that is ascribed to the long term development of cognitive, behavioral, emotional, and motor deficits as a result of the exposure to high amounts of sub concussive traumatic brain injuries. The disease has gained recent popularity in the media for its prevalence in American football as a response to recent research that has suggested the prominence of the disease in nearly every NFL player that is examined post mortem. This has produced a growing concern for the consequences of head impact and participation in contact sports. Despite media attention, little is currently known …
An Exploration Of The Adaptive Functions Of Dreams And Empirically-Based Methods Of Dream Interpretation, Isaac Roberts
An Exploration Of The Adaptive Functions Of Dreams And Empirically-Based Methods Of Dream Interpretation, Isaac Roberts
CMC Senior Theses
This paper presents a meta-analysis of dream theory within psychology and neuroscience. The questions it attempts to answer are: what is the neuroscientific basis of dreaming? Why do dreams exist (do they have an adaptive function)? Could dreams possibly have no function? And, what is the best way to interpret a dream? The current analysis presents various theories relevant to each of these questions and compares their viability. It also briefly examines the origins of psychological thought on dreams and, towards the end, outlines the steps and empirical support for a well-regarded method of dream interpretation known as the cognitive …
Can A Comprehensive Transition Plan To Barefoot Running Be The Solution To The Injury Epidemic In American Endurance Runners?, Michael A. Scarlett
Can A Comprehensive Transition Plan To Barefoot Running Be The Solution To The Injury Epidemic In American Endurance Runners?, Michael A. Scarlett
CMC Senior Theses
Fossils belonging to the genus Homo, dating as far back as two million years ago, exhibit uniquely efficient features suggesting that early humans had evolved to become exceptional endurance runners. Although they did not have the cushion or stability-control features provided in our modern day running shoes, our early human ancestors experienced far less of the running-related injuries we experience today. The injury rate has been estimated as high as 90% annually for Americans training for a marathon and as high as 79% annually for all American endurance runners. There is an injury epidemic in conventionally shod populations that …
Adapting To The Changing Tide: An Evaluation Of California’S Drought Policies And Future Mitigation Strategies, Lauren Dorsey
Adapting To The Changing Tide: An Evaluation Of California’S Drought Policies And Future Mitigation Strategies, Lauren Dorsey
CMC Senior Theses
California endured an extreme and prolonged drought from 2012 until the winter of 2017, offering a fascinating yet tragic example of how drought impacts lives. Despite this recent and stark phenomenon, there is surprisingly little information about its effects and implications. This thesis aims to lessen this knowledge gap by asking how severe the drought was, how well the state responded, and what policies would increase California’s water security. It answers these questions by exploring the Golden State’s long and complicated water management history, which is necessary to understand the current drought policy framework; then, it collects the emerging literature …
Using Renewable Energy To Increase Tribal Sovereignty: A Feasibility Study For A Biomass Energy Plant On The Cocopah Reservation, Lauren Katrina D'Souza
Using Renewable Energy To Increase Tribal Sovereignty: A Feasibility Study For A Biomass Energy Plant On The Cocopah Reservation, Lauren Katrina D'Souza
CMC Senior Theses
Native American reservations in the United States are often located on mineral-rich lands, making them a target for fossil fuel development in already socioeconomically disadvantaged areas. As environmentally damaging as they are, coal and oil industries can bring invaluable jobs and money to isolated reservations, causing tribes to rely on fossil fuels for mere economic survival. In these instances of corporations or the federal government exploiting Native American labor and land, tribes lose the most fundamental principle of tribal governance: tribal sovereignty. Replacing fossil fuels and securing energy independence with a stable, renewable energy source is key to reclaiming that …
Optimize Your Fitness, Optimize Your Business: The Balanced Scorecard, Analysis And Application For The Crossfit Affiliate, Jordan G. Aronowitz
Optimize Your Fitness, Optimize Your Business: The Balanced Scorecard, Analysis And Application For The Crossfit Affiliate, Jordan G. Aronowitz
CMC Senior Theses
The Balanced Scorecard for the CrossFit Affiliate will provide unprepared or inexperienced managers with the necessary information to make informed operational decisions. The Balanced Scorecard incorporates financial data, customer satisfaction, internal operations, and future growth to create a series of cause-and-effect relationships that illustrate how decisions in one aspect of a business affect others. The Balanced Scorecard particularly benefits inexperienced managers leading small businesses. As overall small business growth increased, the boutique fitness industry expanded. The CrossFit brand rose in conjunction, but because corporate leaders insist on a hands-off licensing model, affiliate owners do not receive assistance from CrossFit corporate …
Do The Lifetime Prevalence And Prognosis Of Schizophrenia Differ Among World Regions?, Cheryl Lynn Smith
Do The Lifetime Prevalence And Prognosis Of Schizophrenia Differ Among World Regions?, Cheryl Lynn Smith
CMC Senior Theses
Much cross-cultural research has been done on the topic of schizophrenia, but few studies thus far have focused on lifetime prevalence and prognosis together, grouped by world region. Additionally, there has been severe bias in which countries and regions have been studied both historically and currently. Any study that had statistics on lifetime prevalence per 1000 people and/or DALYs, from a specified country or region, was included in this thesis. Results showed that lifetime prevalence of schizophrenia does not differ among WHO regions, but DALYs and thus prognosis do differ. Several major conclusions can be drawn from these results. One …
Crispr Genetic Editing: Paths For Christian Acceptance And Analysis Of In Vivo And In Vitro Efficiency, Mandeep Sandhu
Crispr Genetic Editing: Paths For Christian Acceptance And Analysis Of In Vivo And In Vitro Efficiency, Mandeep Sandhu
Scripps Senior Theses
With advancements in CRISPR-cas9 broadening the potential paths for clinical usage of genetic editing, conversations about genetic editing have grown to outside simply scientific communities and into mainstream conversations. This study focuses specifically on Christian discourse of genetic editing and locates four major tensions for many Christians when they think about genetic editing: beginning of life, Creator-human relationship, imago Dei, and stewardship. With these major concerns in mind, I identify epigenetics, somatic cell genetic editing, and in vivo genetic editing research as important research paths to pursue as they can potentially produce techniques that more Christian individuals would feel comfortable …
Restoration Of Mauri (Life-Force) To Ōkahu Bay: Investigation Of A Community Driven Restoration Process, Emily Freilich
Restoration Of Mauri (Life-Force) To Ōkahu Bay: Investigation Of A Community Driven Restoration Process, Emily Freilich
Pomona Senior Theses
This thesis investigated the restoration of mauri (life-force) to Ōkahu Bay, Auckland New Zealand. Ōkahu Bay is part of the land and waters of Ngāti Whātua Ōrākei, a Māori hapū (sub-tribe). Ngāti Whātua Ōrākei has been driving the restoration, restoring Ōkahu Bay based on their worldview, visions, and concerns. This vision and control of the restoration process allows them to bring in the hapū in sustainable engagement and have the long-term vision and commitment necessary for self-determination. However, while there has been progress with projects and improved decision-making authority, hapū members are still not seeing their whānau (family) swimming in …
Crispr-Cas9 Mediated Hmgcl Ko In 3xtg Ad Mice Reduces The Cognitive Deficit Improvement Seen In An Intermittent Metabolic Switching Regimen, Eric Joon Bum Kil
Crispr-Cas9 Mediated Hmgcl Ko In 3xtg Ad Mice Reduces The Cognitive Deficit Improvement Seen In An Intermittent Metabolic Switching Regimen, Eric Joon Bum Kil
CMC Senior Theses
Individuals in modern Western societies are experiencing increasing sedentary lifestyles, overindulgence of high fat, high-sugar diets, and extremely sterilized conditions, putting immense pressure on researchers and clinicians alike to come up with viable treatments for conditions implicated with an aging society. Emerging research have published the benefits of IMS and metabolic switching in a variety of neuroprotective, cellular stress resistance, and neuroplasticity pathways in animal models and clinical results from randomized trials of IMS regimens with susceptible human populations are soon to be published. The application of genome editing and next-generation sequencing (NGS) strategies to clinical and neurodegenerative research continues …