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Biomedical Engineering and Bioengineering Commons

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City University of New York (CUNY)

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Articles 91 - 105 of 105

Full-Text Articles in Biomedical Engineering and Bioengineering

Characterization Of Rheological Properties And Degradation Of Genipin Crosslinked Fibrin Hydrogel For Annulus Repair, Dave Khyati Jan 2012

Characterization Of Rheological Properties And Degradation Of Genipin Crosslinked Fibrin Hydrogel For Annulus Repair, Dave Khyati

Dissertations and Theses

No abstract provided.


Technologya Nd Protocolsf Or Translational Researchin Electricals Timulation, Asif Rahman Jan 2012

Technologya Nd Protocolsf Or Translational Researchin Electricals Timulation, Asif Rahman

Dissertations and Theses

"Noninvasive electrical stimulation techniques like transcranial direct currents stimulation (tDCS) have been demonstrated to modulate neural function. Weak constant current is applied via scalp electrodes leading to subthreshold changes in neuron membrane potentials. Neuromodulation of the cortex using direct current (DC) stimulation may be a viable treatment for neurological disorders, enhancing cognitive function as well as facilitating neural plasticity. Theoretically, tDCS can employ many electrodes montages to emphasize directionality, focality, or intensity (Datta 2008, 2009, Dmochowski 2011) but what remains unclear is how these parameters influence cortical neurons considering their orientation and the local synaptic circuit in the region of ...


Effects Of Mild Heating On The Osteogenic Differentiation Of Human Mesenchymal Stem Cells During Inflammation, Kristifor Sunderic Jan 2012

Effects Of Mild Heating On The Osteogenic Differentiation Of Human Mesenchymal Stem Cells During Inflammation, Kristifor Sunderic

Dissertations and Theses

"Current surgical procedures to treat osteoarthritis have varying degrees of success, but carry inherent risks and a finite life expectancy. A more permanent solution is a treatment that regenerates biologically viable tissue that integrates with the patient and retains functionality. For maximal effectiveness, such a treatment should also repair bone loss known to occur in osteoarthritis and attenuate chronic inflammation that can obstruct healing. Mesenchymal stem cells have great potential to be used as part of a novel therapy for bone and cartilage regeneration. They are a highly regulated, self-renewing population of cells with potent mechanisms to avoid allogeneic rejection ...


Life-Cycle Optimization And Flow Control In A Nickel-Zinc Flow Assisted Battery, Steve Lever Jan 2012

Life-Cycle Optimization And Flow Control In A Nickel-Zinc Flow Assisted Battery, Steve Lever

Dissertations and Theses

Nickel-Zinc flow-assisted rechargeable batteries are currently being explored as a potential new generation of large-scale, low-cost energy storage devices. The viability of a commercial nickel-zinc battery has been hindered by the well-known phenomena of dendrite formation and zinc morphology variation over time. Applying electrolyte flow to traditional nickel-zinc battery systems has demonstrated significant life cycle performance improvements by reducing both dendrite formation and morphological variation. It has also been demonstrated that periodic low-current reconditioning discharge further improves cycle life. This thesis examines the effect of eliminating electrolyte flow during discharge of nickel-zinc flow assisted batteries, which would allow a much ...


Migration And Invasion Of Brain Tumors, Richard A. Able, Jr., Veronica Dudu, Maribel Vazquez Nov 2011

Migration And Invasion Of Brain Tumors, Richard A. Able, Jr., Veronica Dudu, Maribel Vazquez

Publications and Research

Recent advances in molecular biology have led to new insights in the development, growth and infiltrative behaviors of primary brain tumors (Demuth and Berens, 2004; Huse and Holland, 2010; Johnson et al., 2009; Kanu et al., 2009). These tumors are derived from various brain cell lineages and have been historically classified on the basis of morphological and, more recently, immunohistochemical features with less emphasis on their underlying molecular pathogenesis (Huse and Holland, 2010). The detailed molecular characterization of brain tumors has laid the groundwork for augmentation of standard treatment with patient-specific designed targeted therapies (Johnson et al., 2009; Kanu et ...


Bitten By The Science Bug (Nycsef 2011), Maribel Vazquez Mar 2011

Bitten By The Science Bug (Nycsef 2011), Maribel Vazquez

Publications and Research

The invited keynote address to the participants of the final round of the 2011 New York City Science and Engineering Fair (NYCSeF) at the American Museum of Natural History (AMNH).


Bone Tissue Quality Determination Of Mice Through A Novel Reference Point Indentation Technique, Matin Lendhey Jan 2011

Bone Tissue Quality Determination Of Mice Through A Novel Reference Point Indentation Technique, Matin Lendhey

Dissertations and Theses

"Bone strength deteriorates with age; which increases the susceptibility to fracture. Current clinical techniques for the estimation of bone strength are largely Bone Mineral Density (BMD) based. However, toughness, which is the ability to resist crack growth, plays a critical role in bones‟ fracture resistance. Traditionally, toughness measurements involve large samples, obviating their use clinically. Recent data suggest that a reference point indentation approach provides a novel, localized measure of toughness from whole bones. In the current research, we evaluated the sensitivity of this method to discriminate small known differences in fracture toughness that exist between inbred mouse strains with ...


Development Of An Approach To Increase Drug Uptake To Bone Tumors Using Non-Invasive Mechanical Loading, Paolo E. Palacio Jan 2011

Development Of An Approach To Increase Drug Uptake To Bone Tumors Using Non-Invasive Mechanical Loading, Paolo E. Palacio

Dissertations and Theses

This thesis develops an approach to enhance drug delivery to bone tumors by implementing a non-invasive mechanical loading technique. An imaging protocol that characterizes the load-enhanced drug uptake is also presented. The long-term goal of this work is to develop a clinical protocol that enhances the delivery of therapeutic agents to bone tumors by utilizing load-bearing activity. This easy-to-implement approach could help increase drug uptake into the tumor interstitial fluid space as well as into tumor cells, thereby enhancing a drug's clinical effect while decreasing systemic drug dosage and unwanted side effects. This thesis details the process used to ...


Proteomic Analysis Of Human Mesenchymal Stem Cell Aging During Serial Sub-Culture, Pawan Kc Jan 2011

Proteomic Analysis Of Human Mesenchymal Stem Cell Aging During Serial Sub-Culture, Pawan Kc

Dissertations and Theses

"Human mesenchymal stem cells (hMSCs) hold great potential for clinical applications in regenerative medicine. However, hMSCs occur at a very low frequency in bone marrow so the clinical use as cellular therapeutics requires suitable techniques for isolation and expansion. Furthermore, these cells can be expanded in vitro for only limited passage numbers before they reach a senescent state. Previous studies have shown that long term culture of hMSCs results in the decrease in proliferation rates, changes in genomic expressions, increase in cell sizes, and other morphological changes. Currently the mechanisms of hMSC aging and biomarkers associated with it have not ...


Effects Of Estrogen Loss On The Vascular Porosity In Rat Cortical Bone, Jessica D Levy Jan 2011

Effects Of Estrogen Loss On The Vascular Porosity In Rat Cortical Bone, Jessica D Levy

Dissertations and Theses

"Osteoporosis is a skeletal disease that currently affects 10 million Americans, and is characterized by low bone mass and increased skeletal fragility (National Osteoporosis Foundation, 2011). Estrogen loss, which begins during menopause, is the leading cause of osteoporosis in women. Recent research has focused on changes in cortical bone microporosity due to estrogen loss, which is important for bone health; load-induced interstitial fluid flow within the lacunar-canalicular porosity surrounding osteocytes is thought to play an important role in bone maintenance, while the vascular porosity provides a pressure relaxation mechanism for the fluid flow in the lacunar-canalicular porosity. Recent high-resolution micro-CT ...


Transport Of Antibodies And Nanoparticles Across An In Vitro Blood-Brain Barrier, Lin Zhang Jan 2011

Transport Of Antibodies And Nanoparticles Across An In Vitro Blood-Brain Barrier, Lin Zhang

Dissertations and Theses

"The blood-brain barrier (BBB) is a dynamic interface between the blood circulation and the central nervous system (CNS). While it serves as a selective barrier to water and solutes to prevent the blood-borne toxins from entering into the brain tissue, it hinders the drug delivery to the CNS for the treatment of brain diseases. Recently therapeutic antibodies and a variety of drug-loaded nanoparticles (NPs) have been widely used to treat CNS disorders such as brain tumors, Alzheimer's disease and Parkinson's disease. To improve brain delivery efficacy of antibodies and NPs, it is necessary to quantify their transport parameters ...


Evaluation Of A Novel Self-Assembled Nanocoating In Promoting Bone On-Growth And Apposition On Metal, Hani Ghazi Jan 2011

Evaluation Of A Novel Self-Assembled Nanocoating In Promoting Bone On-Growth And Apposition On Metal, Hani Ghazi

Dissertations and Theses

"Loosening of metal is the leading cause of clinical failures of orthopedic surgeries. A novel coating of self-assembled monolayer of phosphonate molecules (SAMP) that chemically enhances metallic surfaces by covalently bonding to their naturally occurring oxidized surfaces has been developed.1 The SAMP coating is chemically stable, and its in-vitro results showed that it promotes cell proliferation, osteoblast adhesion and enhances biological attachment to metal surfaces.1 The purpose of this study is to establish the efficacy of this novel chemical surface treatment in improving the fixation of metallic implants in both cortical and cancellous bone over a conventional untreated ...


A Microfluidic Device To Establish Concentration Gradients Using Reagent Density Differences, Qingjun Kong, Richard A. Able, Jr., Veronica Dudu, Maribel Vazquez Dec 2010

A Microfluidic Device To Establish Concentration Gradients Using Reagent Density Differences, Qingjun Kong, Richard A. Able, Jr., Veronica Dudu, Maribel Vazquez

Publications and Research

Microfabrication has become widely utilized to generate controlled microenvironments that establish chemical concentration gradients for a variety of engineering and life science applications. To establish microfluidic flow, the majority of existing devices rely upon additional facilities, equipment, and excessive reagent supplies, which together limit device portability as well as constrain device usage to individuals trained in technological disciplines. The current work presents our laboratory-developed bridged microLane system, which is a stand-alone device that runs via conventional pipette loading and can operate for several days without need of external machinery or additional reagent volumes. The bridged microLane is a two-layer polydimethylsiloxane ...


Metallic Nanoparticle On Micro Ring Resonator For Bio Optical Detection And Sensing, Ali Haddadpour, Yasha Yi Aug 2010

Metallic Nanoparticle On Micro Ring Resonator For Bio Optical Detection And Sensing, Ali Haddadpour, Yasha Yi

Publications and Research

We have numerically investigated the unique effects of metallic nanoparticle on the ring resonator, especially multiple Au nanoparticles on the micro ring resonator with the 4-port configuration on chip. For the Au nanoparticle, because it has smaller real refractive index than air and large absorption refractive index, we found that there is a blue shift for the ring resonance wavelength, instead of red shift normally observed for dielectric nanoparticles. The drop port intensity is strongly dependent on both number and size of nanoparticles, while relatively independent on position of nanoparticles. The correlation between the penetration depth of Au and the ...


Low Concentration Microenvironments Enhance The Migration Of Neonatal Cells Of Glial Lineage, Richard A. Able, Jr., Celestin Ngnabeuye, Cade Beck, Eric C. Holland, Maribel Vazquez Jun 2002

Low Concentration Microenvironments Enhance The Migration Of Neonatal Cells Of Glial Lineage, Richard A. Able, Jr., Celestin Ngnabeuye, Cade Beck, Eric C. Holland, Maribel Vazquez

Publications and Research

Glial tumors have demonstrated abilities to sustain growth via recruitment of glial progenitor cells (GPCs), which is believed to be driven by chemotactic cues. Previous studies have illustrated that mouse GPCs of different genetic backgrounds are able to replicate the dispersion pattern seen in the human disease. How GPCs with genetic backgrounds transformed by tumor paracrine signaling respond to extracellular cues via migration is largely unexplored, and remains a limiting factor in utilizing GPCs as therapeutic targets. In this study, we utilized a microfluidic device to examine the chemotaxis of three genetically-altered mouse GPC populations towards tumor conditioned media, as ...