Lung-Delivered Il-10 Mitigates Lung Inflammation Induced By Repeated Endotoxin Exposures In Male Mice, Aaron Schwab, Todd A. Wyatt, Oliver Schanze, Amy J. Nelson, Angela Gleason, Michael J. Duryee, Deanna Mosley, Geoffrey M. Thiele, Ted R. Mikuls, Jill A. Poole

Journal Articles: Environmental, Agricultural & Occupational Health

Therapies capable of resolving inflammatory lung disease resulting from high-consequence occupational/environmental hazards are lacking. This study seeks to determine the therapeutic potential of direct lung-delivered interleukin (IL)-10 following repeated lipopolysaccharide exposures. C57BL/6 mice were intratracheally instilled with LPS (10 μg) and treated with IL-10 (1 μg) or vehicle control for 3 days. Lung cell infiltrates were enumerated by flow cytometry. Lung sections were stained for myeloperoxidase (MPO), CCR2, vimentin, and post-translational protein citrullination (CIT) and malondialdehyde-acetaldehyde (MAA) modifications. Lung function testing and longitudinal in vivo micro-CT imaging were performed. Whole lungs were profiled using bulk RNA sequencing. IL-10 treatment reduced …

Lung Disease In Relation To Unique Monocyte-Macrophage Subpopulations Induced By Combined Inhalant Endotoxin And Collagen-Induced Arthritis, Jill A. Poole, Aaron Schwab, Geoffrey M. Thiele, Todd A. Wyatt, Amy J. Nelson, Oliver Schanze, Angela Gleason, Michael J. Duryee, Bryant England, Ted R. Mikuls

Journal Articles: Environmental, Agricultural & Occupational Health

BACKGROUND: Lung disease is the most overrepresented cause of death in rheumatoid arthritis (RA). Animal studies have demonstrated potentiated autoimmunity, arthritis, and profibrotic/inflammatory lung disease with a combination of airborne exposures and collagen-induced arthritis (CIA), a model that recapitulates features of RA-associated interstitial lung disease (RA-ILD). As patients with RA-ILD demonstrate unique circulating monocyte subpopulations, this study aims to characterize lung infiltrating monocytes/macrophages in a mouse model of RA-ILD and determine whether reducing these cells mitigates the development of lung disease.

METHODS: Autoimmune-prone DBA/1J mice received intranasal inhalation of lipopolysaccharide (LPS) daily for up to 5 weeks and CIA induction. …

A Survey-Based Quantitative Analysis Of Stress Factors And Their Impacts Among Cybersecurity Professionals, Sunil Arora, John D. Hastings

Research & Publications

This study investigates the prevalence and underlying causes of work-related stress and burnout among cybersecurity professionals using a quantitative survey approach guided by the Job Demands-Resources model. Analysis of responses from 50 cybersecurity practitioners reveals an alarming reality: 44% report experiencing severe work-related stress and burnout, while an additional 28% are uncertain about their condition. The demanding nature of cybersecurity roles, unrealistic expectations, and unsupportive organizational cultures emerge as primary factors fueling this crisis. Notably, 66% of respondents perceive cybersecurity jobs as more stressful than other IT positions, with 84% facing additional challenges due to the pandemic and recent high-profile …

Neurosurgical Praxis Guidelines During The Covid-19 Outbreak. Consensus-Based On Currently Available Literature., José Antonio Soriano Sánchez, Bárbara Nettel Rueda, José Alberto Israel Romero Rangel, Armando Alpizar Aguirre, Miguel Ángel Andrade-Ramos, Ulises García Dr., Diego Mendez Rosito, Jorge A. Santos, Sara Patricia Pérez Reyes, Julian Eduardo Soto Abraham, Jose E. Valerio Pascua, Marco Antonio Barajas Romero, Eduardo Díaz Juárez, Alma Griselda Ramírez Reyes, Maria Elena Gonzalez, Claudia Katiutska González Valdez, Félix Domínguez Cortinas, Noé Santiago Ramírez, Tenoch Herrada Pineda, Manuel Eduardo Soto García, Edgar Nathal Vera, Gustavo Melo Guzmán

Archives of Neurosurgery

INTRODUCTION: The World Health Organization recommended several strategies to contain the COVID-19 pandemic, including optimization of care for all patients, especially the seriously ill. Given the strain, the pandemic has posed on healthcare systems around the world, many neurosurgical associations have provided triage recommendations for patients to save resources for the pandemic. We aimed to provide practical recommendations based on specific illnesses requiring surgical procedures commonly performed by neurosurgeons on a life-threatening basis of patient illness. We consider this guideline will help neurosurgeons for the appropriate triage of patients on a daily-situation basis during this pandemic.

METHODS: The Mexican Society …

Occupational Exposures To Chemicals In Dentistry: A Scoping Review, Geneviève Picard, Tisha Prakash, France Labrèche, Sabrina Gravel

Revues de littérature, synthèses de connaissances

The dental workforce comprises a variety of professions, most of which are predominantly occupied by women. Dental workers can be exposed to numerous toxic chemicals such as mercury, methacrylate polymers, and silica. This scoping review aims to synthesize the scientific literature on quantified chemical exposures and to identify research gaps in occupational chemical hazards faced by dental professionals. This review followed the Joanna Briggs Institute approach and PRISMA-ScR guidelines, using three concepts to search PubMed, Embase, and Web of Science: workers, dental care, and chemicals. Studies from high-income countries, published in French or English between 2000 and 2024 and reporting …

Strategies To Enhance Gme Program Coordinator Job Satisfaction And Well-Being, Stuart Slavin, Julie Beckerdale, April L. Mcguire, Linda Ortiz Morrison, Melanie Pigott, Carrie L. Racsumberger, Evangelina Rangel, Bret Stevens, Ramona Tirado, Cynthia D. Thompson, Latoya Wright

Department Dermatology Faculty Publications

[Introduction] Program and institutional coordinators in graduate medical education (GME) have very complex jobs that are often highly pressured and demanding, requiring a diverse skill set to manage effectively. While these positions can be immensely gratifying, the demands and pressures inherent in the roles pose threats to job satisfaction as well as risks to mental health and well-being. A national survey of 6372 coordinators found that 20.4% reported being dissatisfied or very dissatisfied with work, and 27.9% reported being likely or very likely to leave their job in the next year. ¹ Of the coordinators surveyed 36.3% screened positive for …

Resilience And Reality: Exploring The Lived Experiences Of People Living With Hiv In Texas During The Covid-19 Pandemic – A Qualitative Study., Ahmed F. Alanazi

Social Work Dissertations - Archive

This study investigated the lived experiences of individuals living with HIV (PLWH) in the Dallas-Fort Worth (DFW) area of Texas during the COVID-19 pandemic, using an Interpretative Phenomenological Analysis (IPA) framework. The research examined the intersection of health, social dynamics, and psychological resilience among PLWH, who faced compounded vulnerabilities due to systemic inequities and the dual public health crises of HIV and COVID-19. Through semi-structured interviews with ten participants from diverse backgrounds, the study captured the profound impacts of disrupted healthcare systems, heightened stigma, and social isolation on this marginalized population. The findings reveal that the pandemic exacerbated existing inequities …

Targeted Deletion Of Cxcl1 In Mscs Regulates Osteogenesis And Suppresses Bone-Metastatic Prostate Cancer, Catherine S. Johnson, Diane L. Costanzo-Garvey, Julio C. Valencia, Sanjana Rajgopal, Theodore Reed, Emma R. Brannon, Jeremy S. Frieling, Deanna Mosley, Todd A. Wyatt, Elijah F. Edmondson, Kabhilan Mohan, Grinu Mathew, Leah M. Cook

Journal Articles: Environmental, Agricultural & Occupational Health

Bone metastasis continues to be the greatest challenge in treating patients with prostate cancer despite ongoing research. In bone, prostate cancer tumors hijack normal bone remodeling processes to drive cancer progression. However, it is unclear how these interactions drive bone-metastatic prostate cancer growth in the bone environment. To understand the mechanisms associated with bone-metastatic prostate cancer regulation of mesenchymal stem cells (MSC), we previously identified that bone-metastatic prostate cancer induces MSC expression of the pro-inflammatory chemokine CXCL8 and its mouse functional homologue Cxcl1. To date, there has been little to no information about the role of CXCL1/8 in MSC biology …

Mistrust Among Injured Immigrant Workers: A Conceptual Framework, Maude Arsenault, Daniel Côté, Jessica Dubé

Revues de littérature, synthèses de connaissances

Background

In Quebec, injured workers have access to medical assistance, wage replacement indemnities, and rehabilitation measures, with most injuries resolved easily. However, a small percentage of cases require a lengthy rehabilitation process, which is particularly complex when involving immigrants. The therapeutic alliance is at the heart of the process, involving mutual trust and confidence and a degree of consensus about the therapeutic interventions to be used and, ultimately, the return to work.

Objective

This article delves into the concept of mistrust as more than the absence of trust, and sheds light on its role in the rehabilitation process of immigrant …

A Comprehensive Review And Bibliometric Analysis On Collaborative Robotics For Industry: Safety Emerging As A Core Focus, Aida Haghighi, Morteza Cheraghi, Jérôme Pocachard, Valérie Botta-Genoulaz, Sabrina Jocelyn, Hamidreza Pourzarei

Revues de littérature, synthèses de connaissances

Research organizations and academics often seek to map the development of scientific fields, identify research gaps, and guide the direction of future research. In cobot-related research, the scientific literature consulted does not propose any comprehensive research agenda. Moreover, cobots, industrial robots inherently designed to collaborate with humans, bring with them emerging issues. To solve them, interdisciplinary research is often essential (e.g., combination of engineering, ergonomics and biomechanics expertise to handle safety challenges). This paper proposes an exhaustive study that employs a scoping review and bibliometric analysis to provide a structured macro perspective on the developments, key topics, and trends in …

Laryngeal Hypersensitivity From The Perspective Of Pain Science: An Integrative Review Of Empirical Studies On Associated Factors And Processes, William Saint-Jules, Hugo Massé-Alarie, Nicole Y. K. Li-Jessen, Maude Desjardins

Revues de littérature, synthèses de connaissances

Objective

Laryngeal hypersensitivity (LHS) is a state of heightened sensorimotor response to stimuli in the upper airway. Although its clinical picture is becoming progressively clearer with recent research progress, specificities about its associated factors and processes remain to be clarified. The aim of this integrative review was to synthesize published empirical data from human studies on LHS, focusing on related factors and pathophysiology.

Study Design and Data Sources

Integrative review of the literature; Pubmed, EMBASE, and Web of Science.

Methods

Keywords associated with the following three main concepts were used to query databases: (1) manifestations potentially associated with an irritable …

Supports For Mental Well-Being Valued By Healthcare Workers: Qualitative Analysis Of Data From A Canadian Cohort Of Healthcare Workers During The Covid-19 Pandemic, Shannon Marie Ruzycki, Anil Adisesh, Quentin Durand-Moreau, France Labrèche, Tanis Zadunayski, Erica Stroud, Nicola Cherry

Études primaires

A prospective cohort of 4964 HCWs from four Canadian provinces was established early in the COVID-19 pandemic. Participants were invited to comment about workplace mental health supports at three time points. We performed a thematic content analysis of responses from 1738 participants using the Social Support Behaviour Code framework to categorize barriers to support as informational, tangible, emotional, social, or expressing esteem. Themes were synthesized into suggestions for healthcare organizations to prepare for future crises. Formal and informal peer support, workplace mental health supports, and one-on-one counseling were most often mentioned as valued. Analysis suggested that workplace social networks as …

The Incidence Of Postmenopausal Breast Cancer In Relation To Occupational Exposure To Textile Fibers And Dusts In Montreal, Canada, 2008-2011, Maymouna Myriam Ka, France Labrèche, Mark S. Goldberg, Vikki Ho

Études primaires

Objective To estimate the associations between occupational exposure to textile fibers/dusts, and incidence of postmenopausal invasive breast cancer.

Methods

A population-based case-control study conducted in Montreal (2008 − 2011) identified hospital cases (N = 695) and population controls (N = 608) from the electoral list. Occupational hygienists examined participants’ occupations and tasks, and attributed exposures to several textile fibers. For all tumors and according to biomolecular subtypes, odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using logistic regression models with different exposure indices, adjusting for potential confounders.

Results

Ever exposure to cotton dust was associated with an increased …

Vocational Training And Occupational Health: An Ergonomics Approach To Gender And Disabilities For Social Sustainability, Myriam Bérubé, Céline Chatigny, Marie Laberge

Études primaires

The Work-Oriented Training Path (WOTP) in Quebec, Canada, is a dual vocational training program that offers students with learning difficulties supervised traineeships. Teachers play a pivotal role in managing students' occupational health and safety (OHS), yet must do so under tight time constraints, limited institutional guidance and highly diverse student profiles. Building on an activity-centered ergonomics and capabilities framework, this multiple-case study explores how gender, disabilities, and work determinants shape OHS management within the WOTP, emphasizing their implications for social sustainability. Twenty-seven semi-structured interviews were conducted with 15 WOTP teachers; 497 narrated anecdotes, which are units of speech when teachers' …

Characterization Of Airborne Bacterial Diversity In Conventional Hen Houses, Enriched Colonies And Aviaries, And Link Between Possible Bioaerosol Sources, M.-W. St-Germain, M. Veillette, V. Létourneau, A. D. Larios Martínez, S. Godbout, M. Boulianne, C. Duchaine

Études primaires

Background

Canada’s transition toward alternative housing systems for laying hens may have an impact on bioaerosol content and concentrations in those environments. This project aimed to characterize the airborne bacterial diversity in six conventional hen houses, six enriched colonies and six aviaries. The bacterial diversity found in bioaerosols was also compared to the diversity found in feces or litter samples from each corresponding housing type to investigate similarities between possible bioaerosol sources and bioaerosols.

Results

Specific richness (S_obs) and CHAO1 indexes were higher in air samples from conventional hen houses and enriched colonies, compared to their corresponding fecal …

Occupational Exposure To Combustion By-Products And Breast Cancer Risk In Postmenopausal Women, Kahlila Paul-Cole, France Labrèche, Mark S. Goldberg, Sydney Westra, Vikki Ho

Études primaires

Objective

To estimate the association between lifetime occupational exposure to select combustion by-products and postmenopausal breast cancer (BC) risk.

Materials and Methods

Data from a population-based case-control study among postmenopausal women residing in Montréal, Quebec were used. Cases included 661 women aged between 47 and 75 yr, diagnosed with incident malignant BC between 2008 and 2011. Controls comprised 587 women randomly selected from the Quebec Electoral List, frequency-matched to cases by 5-year age groups. Information on risk factors and lifetime occupational histories was collected by interview. Two industrial hygienists used job histories to assign exposure to 293 agents, including 6 …

Évolution Des Troubles Mentaux Liés Au Travail Au Québec Entre 2012 Et 2021, Jaunathan Bilodeau, Martin Lebeau, Marc-Antoine Busque, Alain Marchand

Études primaires

Introduction : Plusieurs pays ont connu une augmentation du nombre de troubles mentaux acceptés au cours des dernières années, mais les variations possibles de cette évolution dans la main-d’œuvre demeurent à explorer.

But de l’étude : Cette étude examine la distribution dans le temps des troubles mentaux acceptés selon la profession, le secteur industriel, le sexe et l’âge au Québec.

Résultats : Les taux d’incidence des troubles mentaux et leur évolution varient selon la profession et le secteur industriel. Alors que le taux est généralement plus élevé dans les professions mixtes et le secteur tertiaire, l’augmentation de ces taux s’observe …

An Epidemiological Study Of Finger, Hand, And Wrist Injuries In The Department Of Air Force And Us Workers, Melody Kay Gwilliam

Graduate Theses, Dissertations, and Problem Reports (ETD)

ABSTRACT

An Epidemiological Study of Finger, Hand, and Wrist Injuries in the Department of Air Force and US workers

Melody Gwilliam

Background and Objectives: Fingers, hands, and wrists (FHW) are the leading injured body parts in work-related injuries in the United States (U.S.) and in the U.S. Department of the Air Force (DAF). There has been limited research on risk factors for FHW injuries. Workers across all industries are at risk for these injuries. The objectives of these studies are to 1) describe and compare FHW injuries among enlisted, officer, and civilian U.S. Department of the Air Force (DAF) …

Polymeric Nanocomposites-Based Advanced Coatings For Antimicrobial And Antiviral Applications: A Comprehensive Overview, Rachid Amrhar, Jaspal Singh, Mostafa Eesaee, Pascal Carrière, Alireza Saidi, Phuong Nguyen-Tri

Revues de littérature, synthèses de connaissances

The rise in microbial infections and viral outbreaks has accelerated the development of advanced antibacterial and antiviral coating that effectively minimize infection risks. Amidst rising global health concerns due to infectious diseases, these coatings have emerged as vital solutions for surface protection across various settings. This review focuses on the recent development and in-depth analysis includes synthesis process, inactivation mechanism in photoreactive antimicrobial and antiviral bio-coatings. This review comprehensively explores the development of different nanocomposite materials, including polymers based on metal oxide nanoparticles, metal nanoparticles, graphene-based materials, and organic-inorganic composites. Their practicality and compatibility with diverse surfaces such as ceramics, …

A Systematic Review And Evaluation Of The Tools Measuring Work-Related Psychosocial Factors In Prospective Research On Sickness Absence Of Health Care Workers, Laurent Corthésy-Blondin, Simona Margheritti, Samantha Vila Masse, Andrea Gragnano, Alessia Negrini

Revues de littérature, synthèses de connaissances

Purpose:

This systematic literature review aims to list the validated tools measuring work-related psychosocial factors (WRPFs) influence health care workers’ (HCWs) sickness absence (SA), and to evaluate their psychometric and practical properties.

Methods:

Using the PsycINFO, Medline, and Web of Science databases, the search targeted prospective studies on WRPFs and SA in HCWs published between 2012 and 2023. The validated, self-report tools that measured WRPFs and that yielded at least one significant predictor of SA in HCWs were identified. An evaluation of the psychometric and practical properties was performed.

Results:

Based on inclusion criteria, three prospective studies on HCWs were …