Occupational Health and Industrial Hygiene Commons^™

Zip8-Mediated Intestinal Dysbiosis Impairs Pulmonary Host Defense Against Bacterial Pneumonia, Derrick R. Samuelson, Deandra R. Smith, Kelly C. Cunningham, Todd A. Wyatt, Sannette C. Hall, Daryl J. Murry, Yashpal S. Chhonker, Daren L. Knoell

Journal Articles: Environmental, Agricultural & Occupational Health

Pneumococcal pneumonia is a leading cause of morbidity and mortality worldwide. An increased susceptibility is due, in part, to compromised immune function. Zinc is required for proper immune function, and an insufficient dietary intake increases the risk of pneumonia. Our group was the first to reveal that the Zn transporter, ZIP8, is required for host defense. Furthermore, the gut microbiota that is essential for lung immunity is adversely impacted by a commonly occurring defective ZIP8 allele in humans. Taken together, we hypothesized that loss of the ZIP8 function would lead to intestinal dysbiosis and impaired host defense against pneumonia. To …

Sars-Cov-2 Dysregulates Neutrophil Degranulation And Reduces Lymphocyte Counts, Abenaya Muralidharan, Todd A. Wyatt, St. Patrick Reid

Journal Articles: Environmental, Agricultural & Occupational Health

SARS-CoV-2, the virus that causes COVID-19, has given rise to one of the largest pandemics, affecting millions worldwide. High neutrophil-to-lymphocyte ratios have been identified as an important correlate to poor recovery rates in severe COVID-19 patients. However, the mechanisms underlying this clinical outcome and the reasons for its correlation to poor prognosis are unclear. Furthermore, the mechanisms involved in healthy neutrophils acquiring a SARS-CoV-2-mediated detrimental role are yet to be fully understood. In this study, we isolated circulating neutrophils from healthy donors for treatment with supernates from infected epithelial cells and direct infection with SARS-CoV-2 in vitro. Infected epithelial cells …

Aldehyde Trapping By Adx-102 Is Protective Against Cigarette Smoke And Alcohol Mediated Lung Cell Injury, Carmen A. Ochoa, Claire Nissen, Deanna Mosley, Christopher Bauer, Destiny Jordan, Kristina L. Bailey, Todd A. Wyatt

Journal Articles: Environmental, Agricultural & Occupational Health

Most individuals diagnosed with alcohol use disorders smoke cigarettes. Large concentrations of malondialdehyde and acetaldehyde are found in lungs co-exposed to cigarette smoke and alcohol. Aldehydes directly injure lungs and form aldehyde protein adducts, impacting epithelial functions. Recently, 2-(3-Amino-6-chloroquinolin-2-yl)propan-2-ol (ADX-102) was developed as an aldehyde-trapping drug. We hypothesized that aldehyde-trapping compounds are protective against lung injury derived from cigarette smoke and alcohol co-exposure. To test this hypothesis, we pretreated mouse ciliated tracheal epithelial cells with 0–100 µM of ADX-102 followed by co-exposure to 5% cigarette smoke extract and 50 mM of ethanol. Pretreatment with ADX-102 dose-dependently protected against smoke and …

Surface Modification Of Biodegradable Microparticles With The Novel Host-Derived Immunostimulant Cpdi-02 Significantly Increases Short-Term And Long-Term Mucosal And Systemic Antibodies Against Encapsulated Protein Antigen In Young Naïve Mice After Respiratory Immunization, Jacob E. Parriott, Jason P. Stewart, D. David Smith, Stephen M. Curran, Christopher D. Bauer, Todd A. Wyatt, Joy A. Phillips, Elizabeth Lyden, Geoffrey M. Thiele, Joseph A. Vetro Phd

Journal Articles: Environmental, Agricultural & Occupational Health

Generating long-lived mucosal and systemic antibodies through respiratory immunization with protective antigens encapsulated in nanoscale biodegradable particles could potentially decrease or eliminate the incidence of many infectious diseases, but requires the incorporation of a suitable mucosal immunostimulant. We previously found that respiratory immunization with a model protein antigen (LPS-free OVA) encapsulated in PLGA 50:50 nanoparticles (~380 nm diameter) surface-modified with complement peptide-derived immunostimulant 02 (CPDI-02; formerly EP67) through 2 kDa PEG linkers increases mucosal and systemic OVA-specific memory T-cells with long-lived surface phenotypes in young, naïve female C57BL/6 mice. Here, we determined if respiratory immunization with LPS-free OVA encapsulated in …

Post-Endotoxin Exposure-Induced Lung Inflammation And Resolution Consequences Beneficially Impacted By Lung-Delivered Il-10 Therapy, Jill A. Poole, Rohit Gaurav, Aaron Schwab, Amy J. Nelson, Angela Gleason, Debra J. Romberger, Todd A. Wyatt

Journal Articles: Environmental, Agricultural & Occupational Health

Although lung diseases typically result from long-term exposures, even a robust, one-time exposure can result in long-lasting consequences. Endotoxin is a ubiquitous environmental/occupational inflammatory agent often used to model airway inflammation. Using a murine model, the return to lung homeostasis following high dose inhalant lipopolysaccharide (LPS, 10-100 μg) exposure were delineated over 2 weeks. LPS-induced rapid weight loss, release of proinflammatory mediators, and inflammatory cell influx with prolonged persistence of activated macrophages CD11c⁺CD11b⁺ and recruited/transitioning CD11c^intCD11b⁺ monocyte-macrophages out to 2 weeks. Next, lung-delivered recombinant (r) interleukin (IL)-10 was intratracheally administered for 3 doses initiated …

Early-Life Farm Exposures And Eczema Among Adults In The Agricultural Lung Health Study, Annah B. Wyss, Thanh T. Hoang, Hilde K. Vindenes, Julie D. White, Sinjini Sikdar, Marie Richards, Laura E. Beane-Freeman, Christine G. Parks, Mikyeong Lee, David M. Umbach, Stephanie J. London

Mathematics & Statistics Faculty Publications

Background

Several studies conducted in Europe have suggested a protective association between early-life farming exposure and childhood eczema or atopic dermatitis; however, few studies have examined associations in adults.

Objectives

We investigated associations between early-life exposures and eczema among 3217 adult farmers and farm spouses (mean age, 62.8 years) in a case–control study nested within an US agricultural cohort.

Methods

We used sampling-weighted logistic regression to estimate odds ratios and 95% confidence intervals for associations between early-life exposures and self-reported doctor-diagnosed eczema (273 cases) and polytomous logistic regression to estimate odds ratios (95% confidence intervals) for a 4-level outcome combining …

Understanding Parents' Experiences With Children With Type 1 Diabetes: A Qualitative Inquiry, Justin A. Haegele, Steven K. Holland, Eddie Hill

Human Movement Studies & Special Education Faculty Publications

Parenting is often described as a stress-inducing experience, which can be further complicated or made more stressful and anxiety-inducing when parenting children with chronic conditions such as type 1 diabetes (T1D). The incidence of T1D among children has risen and continues to rise globally, resulting in a need to understand the experiences of parenting children with T1D. The purpose of this qualitative inquiry was to explore the lived experiences, and the meaning ascribed to those experiences, of being a parent of a child with T1D. This qualitative study was conducted through an interpretivist paradigm and includes the experiences of 29 …

Réduction Des Risques Lors Des Interventions En Espace Clos : Développement D’Une Base De Connaissances Sur La Prévention Intrinsèque Et La Protection Collective, Damien Burlet-Vienney, Yuvin Chinniah, Ali Bahloul, Andrés Felipe González Cortés, Capucine Ouellet, Abdallah Ben Mosbah

Rapports de recherche scientifique

Les espaces clos parmi les plus courants dans les milieux de travail au Québec sont les réservoirs, les cuves, les puits d’accès, les égouts, les tuyaux et les citernes. Les entrées en espace clos sont effectuées, entre autres, pour des raisons de maintenance (p. ex. : réparation, inspection, nettoyage, déblocage). Les risques pour la santé et la sécurité des travailleurs impliqués sont variés : atmosphérique, chimique, biologique, mécanique, physique ou liés à une chute ou au non-respect des principes ergonomiques. Dans le cadre de ce projet, une moyenne de 2,6 décès par an en espace clos au Québec sur la …

Contrôle Des Énergies Dangereuses Par Cadenassage Et Par D’Autres Méthodes Chez Les Électriciens, Les Tuyauteurs, Les Frigoristes Et Les Mécaniciens Du Secteur De La Construction : Étude Exploratoire, Damien Burlet-Vienney, Yuvin Chinniah, Ayoub Nokra

Rapports de recherche scientifique

À la différence des études précédentes de l’Institut de recherche Robert-Sauvé en santé et en sécurité du travail (IRSST) sur le contrôle des énergies dangereuses et sur le cadenassage, cette étude est spécifique au secteur de la construction.

En 2016, la section 2.20 « Cadenassage et autres méthodes de contrôle des énergies » a été ajoutée au Code de sécurité pour les travaux de construction (CSTC) qui régit la santé et la sécurité sur les chantiers de construction au Québec. Cette section du CSTC fait notamment référence à la notion de maître d’œuvre (MO) pour l’encadrement du contrôle des énergies …

Recyclage Primaire Des Matières Résiduelles Électroniques Au Québec : Portrait De La Santé Et De La Sécurité Du Travail Et Appréciation Du Risque Sanitaire, Sabrina Gravel, Bouchra Bakhiyi, Joseph Zayed, Sylvie Gravel, Daniel Côté, Brigitte Roberge, Jacques Lavoie, Loïc Wingert, France Labrèche

Rapports de recherche scientifique

En raison de l’utilisation croissante de composants et d’appareils électriques et électroniques, de même que de leur durée de vie relativement courte, la quantité de matières résiduelles électroniques ne cesse d’augmenter. Conséquemment, le nombre d’entreprises spécialisées dans le recyclage électronique (e-recyclage) est en nette croissance au Québec, comme ailleurs dans le monde. Ces entreprises emploient des travailleurs qui ont pour tâche de démonter les appareils afin d’en trier les composants qui seront subséquemment valorisés ou éliminés de manière sécuritaire. Ces tâches peuvent cependant entraîner l’exposition des travailleurs à un mélange de substances potentiellement toxiques, comprenant entre autres des poussières, des …

Analyse Du Concept De Marge De Manœuvre En Ergonomie Du Point De Vue Du Contrôle De La Motricité Humaine, Philippe Corbeil, André Plamondon, Denys Denis

Rapports de recherche scientifique

Le concept de marge de manœuvre se définit comme la liberté dont dispose un travailleur pour élaborer différentes façons de travailler afin de répondre aux exigences de production, et ce, sans effet défavorable sur sa santé (Coutarel, Caroly, Vézina et Daniellou, 2015; St-Vincent et al., 2011). Une forte charge de travail jumelée à une faible latitude décisionnelle restreint l’élaboration des gestes et pourrait pénaliser ainsi la santé des opérateurs. Les connaissances actuelles des façons de faire des manutentionnaires, qu’ils soient experts ou non, ne nous permettent pas d’apprécier dans sa totalité l’ampleur de cette liberté lorsqu’un individu doit répéter …

Accident De La Route Au Travail : Qu’En Est-Il Des Travailleurs Piétons?, Marie-Soleil Cloutier, Sylvanie Godillon, Daniel Lafond, Alexandre Marois, Nicolas Saunier, François Vachon

Rapports de recherche scientifique

Les travailleurs piétons (comme les signaleurs, les brigadiers scolaires, les facteurs) occupent des emplois qui s’effectuent à pied sur le réseau routier. Ils sont à pied pour de courts moments, par exemple pour faciliter la circulation ou encore effectuer des réparations (comme les travailleurs de la construction, les policiers, les employés de voiries), ou ils passent fréquemment de leur véhicule à la rue (comme les livreurs ou les éboueurs). L’ensemble de ces travailleurs a la caractéristique commune d’être en interaction avec plusieurs usagers de la route lorsque sur la route en tant que piéton, mais aussi avec des riverains et …

Analyse Prospective De L’Adaptation Des Travailleurs En Centre De Protection De L’Enfance Et De La Jeunesse Exposés À Un Évènement Potentiellement Traumatique : Effets D’Une Intervention De Soutien Par Des Pairs, Stéphane Guay, Alexandre Lemyre, Josianne Lamothe, Steve Geoffrion

Rapports de recherche scientifique

Problématique. Les travailleurs des services de protection de l’enfance sont exposés de manière répétée à des événements potentiellement traumatiques (EPT) dans le cadre de leur travail, notamment des actes de violence. Ils sont ainsi susceptibles de développer des problèmes de santé mentale tels que l’anxiété, l’insomnie, la dépression et des symptômes de stress post- traumatiques. Sur le plan professionnel, les EPT engendrent des coûts élevés pour l’individu et l’organisation : baisse de la satisfaction au travail, absentéisme, changement d’emploi, baisse de productivité, etc. Dans ce contexte, le Centre de la protection de l’enfance et de la jeunesse (CPEJ) du Centre-Sud-de-l’Île …

Maternal Occupational Exposure To Organic Solvents And Noise: Maternal Effects And Infant Outcomes, Kristen Van Buren

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Introduction: Several maternal occupational exposures have not yet been studied for potential reproductive harm or have inconsistent findings in the literature. Despite the challenges, identification of potential risk factors, specifically reproductive toxicants, is necessary to mitigate and prevent adverse health outcomes for working mothers and their infants. The purpose of this study was to examine maternal occupational exposure to organic solvents and noise to small-for-gestational age (SGA) and preterm birth (PTB) among infants. Additionally, the study sought to examine maternal occupational exposure to noise and presence of gestational diabetes (GDM) and pregnancy-related hypertension among participant mothers.

Methods: The study population …

An Attempt To Bring Modern Workplace Realities To The Social Security Disability Adjudication System, Robert E. Rains

Dickinson Law Review (2017-Present)

No abstract provided.

An Ecological Study Of Glyphosate Use And Non-Hodgkin’S Lymphoma, Dexter Corlett, Steven R. Browning

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Glyphosate is currently the most widely used herbicide in the world. Initially thought to be non-carcinogenic in humans, in 2015 glyphosate was classified as a “probable carcinogen” by the International Agency for Research on Cancer due to several small epidemiological studies indicating a link between the pesticide and hematologic cancers, especially non-Hodgkin’s lymphoma (NHL). The current work is an ecological study using counties in Kentucky, Arkansas, and Iowa to compare glyphosate usage to NHL incidence using a multivariate Poisson regression. We found no significant correlation between glyphosate use and NHL incidence, though caution should be taken to draw significance from …

Covid-19 Patients With Documented Alcohol Use Disorder Or Alcohol-Related Complications Are More Likely To Be Hospitalized And Have Higher All-Cause Mortality, Kristina L. Bailey, Harlan Sayles, James Campbell, Neha Khalid, Madyson Anglim, Jana Ponce, Todd A. Wyatt, James C. Mcclay, Ellen L. Burnham, Alfred Anzalone, Corrine K. Hanson

Journal Articles: Environmental, Agricultural & Occupational Health

BACKGROUND: Coronavirus Disease 2019 (COVID-19) has affected every country globally, with hundreds of millions of people infected with the SARS-CoV-2 virus and over 6 million deaths to date. It is unknown how alcohol use disorder (AUD) affects the severity and mortality of COVID-19. AUD is known to increase the severity and mortality of bacterial pneumonia and the risk of developing acute respiratory distress syndrome. Our objective is to determine whether individuals with AUD have increased severity and mortality from COVID-19.

METHODS: We utilized a retrospective cohort study of inpatients and outpatients from 44 centers participating in the National COVID Cohort …

Interactions Of International Pilots' Stress, Fatigue, Symptoms Of Depression, Anxiety, Common Mental Disorders And Wellbeing, Marion Venus, Martin Grosse Holtforth

International Journal of Aviation, Aeronautics, and Aerospace

Objective

This study Investigates more dimensions than previous studies simultaneously: pilots’ duty rosters, stress, sleep difficulties, fatigue levels, wellbeing, symptoms of depression, anxiety, and common mental disorders (CMD), and how they are interrelated.

Background

Several scientific studies have confirmed that fatigue can pose a significant risk to flight safety. Other studies reported positive depression screening results for more pilots, compared with the general population.

Method

A cross-sectional online survey was completed by 406 international pilots, who reported their duty rosters of the last two months. Pilots also self-assessed their stress-levels, sleep problems, fatigue, wellbeing, and mental health.

Results

Although pilots …

Mise À Jour D’Un Outil D’Aide À La Décision Pour L’Estimation Du Risque Lié À Une Exposition À Un Mélange De Substances Chimiques Dans L’Air : Une Nouvelle Version De Mixie, Maude Pomerleau, Philippe Sarazin

Rapports de recherche scientifique

MiXie QC est un outil qui permet d’estimer les risques pour la santé lors d’exposition professionnelle à des mélanges de contaminants. L’utilitaire recense les cas potentiels d’additivité des effets toxiques en croisant des listes d’organes cibles des agents chimiques. Cette étude visait à documenter les modifications apportées dans la version française par l’INRS en 2017 (MiXie FR) en effectuant la comparaison des versions française et québécoise de l’outil. L’accès aux banques de données (BD) des agents et des effets sur la santé des deux versions de MiXie a été fourni par les experts toxicologues responsables de l’utilitaire au Québec et …

Exploring Agricultural Worker Self-Efficacy During A Covid-19 Delta Variant Surge And Adverse Environmental Conditions, Hannah Lascano

All Master's Theses

Yakima County is a rural county with an urban core located in central Washington State. With over 60% of its workforce dedicated to agriculture, food production, and other essential industries, the impact of the COVID-19 pandemic has been particularly compounded in Yakima County populations. Factors such as low decision-making power, limited ability to social distance, and occupational limitations such as fear of job loss, non-compliance with immigration regulations, and lack of representation have yet to be explored during the COVID-19 Delta variant (Delta) surge in conjunction with environmental conditions. This study utilized a novel, online survey of Yakima County residents, …