Epidemiology Commons^™

An Epidemiological Synthesis Of Emerging And Re-Emerging Zoonotic Disease Threats In Cameroon, 2000-2022: A Systematic Review, Nancy B. Tahmo, Frankline Sevidzem Wirsiy, Dum-Buo Nnamdi, Marcel Tongo, James V. Lawler, M. Jana Broadhurst, Charles S. Wondji, David Brett-Major

Journal Articles: Epidemiology

INTRODUCTION: Population factors such as urbanization, socio-economic, and environmental factors are driving forces for emerging/re-emerging zoonotic diseases in Cameroon. To inform preparedness and prioritization efforts, this study mapped out epidemiological data (including prevalence) of zoonotic diseases occurring in Cameroon between 2000 and 2022 by demographic factors.

METHODS: Following the PRISMA guidelines, a protocol was registered in the PROSPERO database (CRD42022333059). Independent reviewers searched the PubMed, Embase, CINAHL, Cochrane, and Scopus databases on May 30, 2022 for relevant articles; duplicates were removed, and the titles, abstracts, and full texts were screened to identify eligible articles.

RESULTS: Out of 4142 articles identified, …

The Association Between Mediated Deprivation And Ovarian Cancer Survival Among African American Women, Andrew B. Lawson, Joanne Kim, Courtney Johnson, Kendra Ratnapradipa, Anthony J. Alberg, Maxwell Akonde, Theresa Hastert, Elisa V. Bandera, Paul Terry, Hannah Mandle, Michele L. Cote, Melissa Bondy, Jeffrey Marks, Lauren C. Peres, Joellen Schildkraut, Edward S. Peters

Journal Articles: Epidemiology

BACKGROUND: Deprivation indices are often used to adjust for socio-economic disparities in health studies. Their role has been partially evaluated for certain population-level cancer outcomes, but examination of their role in ovarian cancer is limited. In this study, we evaluated a range of well-recognized deprivation indices in relation to cancer survival in a cohort of self-identified Black women diagnosed with ovarian cancer. This study aimed to determine if clinical or diagnostic characteristics lie on a mediating pathway between socioeconomic status (SES) and deprivation and ovarian cancer survival in a minority population that experiences worse survival from ovarian cancer.

METHODS: We …

Identification Of Novel Biosynthetic Gene Clusters Encoding For Polyketide/Nrps-Producing Chemotherapeutic Compounds From Marine-Derived Streptomyces Hygroscopicus From A Marine Sanctuary, Hannah Ruth Flaherty

Honors Theses and Capstones

Nearly one out of six deaths in 2020, around ten million people, were caused by cancer, making it a leading cause of death worldwide (WHO, 2022). This major public health issue, in addition to the rise of multidrug-resistant (MDR) pathogens, provides a high demand for the discovery of new pharmaceutical drugs to be used clinically to treat these conditions. The Streptomyces genus accounts to produce 39% of all microbial metabolites currently approved for human health, indicating its potential as an important species to study for antimicrobial and anticancer agents. The long linear genome of Streptomyces contains specialized sequences known as …

The Geographic Pattern And Socioecological Factors Of Helicobacter Pylori Infections In The United States, Judith Ann Merryweather

Walden Dissertations and Doctoral Studies

AbstractHelicobacter pylori (H. pylori) is one of the most common human pathogens and may play a role in the development of several distinct diseases, which include gastric ulcer, duodenal ulcer, and gastric cancer. Studying geographic territories of the United States may reveal clusters with high rates of H. pylori infection and perhaps the prevalence of gastric cancer; however, geographic mapping of patterns in the United States is scarce. The purpose of this study was to investigate changes in H pylori infection patterns in the United States between two different time points (2000–2002 and 2016–2018). The primary hypotheses of this study …

Sleep Aid Use During Early Pregnancy And The Risk Of Birth Defects, Meredith M. Howley

Legacy Theses & Dissertations (2009 - 2024)

This dissertation examines the validity of maternal self-reported medication exposures and then explores the associations between self-reported sleep aid use, including zolpidem specifically, and birth defects using data from three population-based case-control studies conducted within the United States. The first aim of this dissertation was to explore agreement between two sources of prescription medication use in early pregnancy: medical records and self-reported interview data from the Birth Defects Study To Evaluate Pregnancy exposureS (BD-STEPS). We observed that agreement of prescription data between self-report and medical records varies by whether the medication is used chronically or episodically. While self-reported medication information …

Maternal Exposure Of Perfluoroalkyl Substances (Pfas) During Pregnancy And Wheeze In Children : The Upstate Kids Study, Faria Sharmin

Legacy Theses & Dissertations (2009 - 2024)

Background: Prenatal exposure to perfluoroalkyl substances (PFASs), a group of persistent environmental chemicals with endocrine disrupting abilities, has been associated with immunomodulation and may contribute to the etiology of asthma in young children. The need for research and additional prospective analysis clearly exists to measure the impact of the chemicals (PFAS) on child wheeze or asthma. We used newborn dried blood spots to quantify two PFAS and their associations with infant wheeze in the Upstate KIDS population.Methods: We measured, perfluoro octane - sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) in 2071 singleton and 1040 twin infants born to mothers in …

Association Of Prenatal Exposure To Air Pollutants With Select Birth Defects Using The Case-Cohort Approach, Abigail Jeanne Stamm

Legacy Theses & Dissertations (2009 - 2024)

Background: Annually, 3-5% of infants are born with birth defects in the United States. In New York State (NYS), air pollution, specifically ozone (O3) and fine particulate matter (PM2.5), is detectable at levels that affect human health. Air pollution is associated with poor birth outcomes and contains components that are suspected to cause oxidative stress, which is one mechanism by which birth defects are formed.Methods: This study investigated the relationship between the development of select birth defects (oral clefts, craniosynostosis, and clubfoot) in singleton live births in NYS between 2002 and 2015 and weekly peak and average concentrations of O3 …

Trajectories Of Maternal Parenting Stress And Adolescent Behavioral Symptoms In Unmarried Families : The Roles Of Family Immigration Status, Harsh Parenting, And Father’S Early Involvement, Fei Tang

Legacy Theses & Dissertations (2009 - 2024)

BackgroundAdolescence is a critical period for developing social and emotional wellbeing. Adolescents experience many physical and social changes, making them vulnerable to adaptive and behavioral problems. Compared to their peers in married families, adolescents in unmarried families may be at particularly elevated risk of developing internalizing and externalizing behavioral problems, identifying key risk factors in a family context could provide insights on the development of family-based interventions. Mothers are often seen as the center of the environmental context of children development, their responsiveness to children may be impacted by their economic and psychological resources, which could crucially affect the wellbeing …

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Step Towards Unfolding The Mystery, Aditi Kamlesh Bhanushali

Legacy Theses & Dissertations (2009 - 2024)

AbstractBackground: Myalgic Encephalomyelitis, also known as chronic fatigue syndrome (CFS), is a complex disease that includes the dysregulation of the Central Nervous system. There is no exact known etiology or pathophysiology which leads to the development of ME/CFS. To understand the possible causes behind this mysterious disease, I conducted this project under the guidance of Dr. Moslehi to evaluate a range of demographic, lifestyle, and epidemiological factors and their risk in the development of ME/CFS. Methods: My project is part of a case-control study conducted by Dr. Roxana Moslehi. ME/CFS is a rare disease, so a case-control study design was …

Evaluating Spatial Relationships Between Environmental Factors And Contextual Sociodemographic Burden And Associations With Respiratory Morbidity Among Young Children: An Indicator-Based Approach, Neil Anthony Muscatiello

Legacy Theses & Dissertations (2009 - 2024)

The body of public health literature related to air pollution epidemiology is extensive. Similarly, the body of literature related to social epidemiology has also expanded greatly in recent years. While studies in these sub-disciplines of epidemiology sometimes seek to control for variables more commonly studied in one or the other, fewer studies report on their combined effects. Studies which do attempt to summarize how the combined air pollution burden and contextual sociodemographic burden differentially effect health outcomes beyond their individual effects could be beneficial in understanding links between the environment and certain health outcomes such as childhood asthma. The proposed …

Gestational Epigenetic Aging : Prenatal Influences And Early Life Associations, Emilia Pawlowski

Legacy Theses & Dissertations (2009 - 2024)

Development Origins of Health (DOHaD) evidence suggests that prenatal exposures have an important impact on offspring health throughout the life course. Environmental and psychosocial exposures during fetal development are associated with a range of health outcomes for offspring, and effects are often sex specific. One of the mechanisms which may explain differences in health outcomes is epigenetic alterations, which are the molecular mechanisms that regulate gene expression and can be modified during fetal development. Many studies have shown that psychosocial stress and social adversity can modulate epigenetic mechanisms and affect health. While there are several methods for measuring epigenetic alterations, …

Examining The Association Between Childhood Adversity And Later Life Cardiometabolic Diseases, Shreya Shrinivas

Legacy Theses & Dissertations (2009 - 2024)

ACEs stands for Adverse Childhood Experiences, which are traumatic or stressful events that occur in childhood before the age of 18 (Wisner, 2022). These experiences can include physical, emotional, or sexual abuse; neglect; household dysfunction, such as parental separation, domestic violence, substance abuse, or incarceration; or exposure to community violence, racism, or discrimination. Research has shown that individuals who experience ACEs are at a higher risk for developing chronic diseases such as heart disease, diabetes, cancer, and mental health disorders later in life (Felitti, 2002). This is because ACEs can cause toxic stress, which is chronic activation of the stress …

Effect Of Treatment, Stage Of Lung Cancer, And Socioeconomic Status On Life Expectancy Within Marginalized Communities, Elsadig Ahmed Elsharif

Walden Dissertations and Doctoral Studies

Lung cancer is one of the most common cancers in the United States, and it accounts for 25% of cancer deaths. About 70% of cancer cases are diagnosed during late stages, leading to poor outcomes. An estimated 60% of cancer cases involve underserved and disadvantaged communities. However, there are limited studies had addressed effects of treatment, stage of lung cancer, and socioeconomic status on life expectancy within marginalized communities. Research questions examined effect of treatment, stage of lung cancer, and socioeconomic status on life expectancy of lung cancer patients between 2009 and 2019. This study was grounded in the deductive …

Public Health Interventions Guided By Houston’S Wastewater Surveillance Program During The Covid-19 Pandemic, Loren Hopkins, Katherine B Ensor, Lauren Stadler, Catherine D Johnson, Rebecca Schneider, Kaavya Domakonda, James J Mccarthy, Edward J Septimus, David Persse, Stephen L Williams

Faculty, Staff and Student Publications

Since the start of the COVID-19 pandemic, wastewater surveillance has emerged as a powerful tool used by public health authorities to track SARS-CoV-2 infections in communities. In May 2020, the Houston Health Department began working with a coalition of municipal and academic partners to develop a wastewater monitoring and reporting system for the city of Houston, Texas. Data collected from the system are integrated with other COVID-19 surveillance data and communicated through different channels to local authorities and the general public. This information is used to shape policies and inform actions to mitigate and prevent the spread of COVID-19 at …

Maternal Folate Status And Risk Factors For Autism Spectrum Disorders, Michael M. Haniff

Walden Dissertations and Doctoral Studies

Autism spectrum disorders (ASD) are thought to be influenced by environmental, genetic, and maternal factors, including potential links to periconceptional folic acid. This quantitative case-control study, guided by the life course theory, explored the association of maternal risk factors (age, race, education, income, folate status, gestational diabetes, gestational hypertension, and MTHFR mutation) on the precipitation of ASD in offspring. The sample comprised 96 mothers of children with ASD and 143 mothers of children without ASD. Logistic regression analysis indicated no significant association between maternal folate status and ASD (OR = 1.00, 95% CI [1.000, 0.001], p = .755). Mothers with …

Relationship Between Homelessness, Substance Use, Employment, Living On A Reservation And Tuberculosis Among Northern Plains Native Americans, Darla Mccloskey

Walden Dissertations and Doctoral Studies

Native Americans in the Northern Plains have a long history of tuberculosis (TB) infections. There is limited research on the causes of latent TB infections (LTBI) and TB in this population. The purpose of this quantitative study was to assess the relationship between latent TB and factors of homelessness, substance use, employment, living on a reservation, and active or latent TB among this population using the eco-social theory as the theoretical framework. Data from 146 TB cases of Native Americans living in the Northern Plains and diagnosed with TB from 1999 to 2019 were analyzed using chi-square tests that showed …

The Relationship Between Chlamydia, Gonorrhea, Syphilis And Race, Gender, And Age, Johnny James Mcgrew

Walden Dissertations and Doctoral Studies

The purpose of this quantitative correlational design using secondary data from Colorado Department of Public Health and Environment was to examine the relationship between different types of sexually transmitted infections (STIs), specifically, chlamydia, gonorrhea, and syphilis, and race, gender, and age in the United States. This study is significant because it could assist medical personnel to focus on more personally-based STI treatments. This study could also lead to a call for more research regarding sexual health programs across the nation, individuals’ willingness to share personal information regarding STIs, and how sexual health programs could increase testing for STIs. The study …

Pancreatic Cancer: Quantitative Study Investigating The Regional Risk Factors In North Carolina, Holly Marie Myers

Walden Dissertations and Doctoral Studies

Pancreatic cancer is the fourth-leading cause of cancer-related deaths in the United States, killing more than 90% of individuals diagnosed within 5 years. Due to the lack of signs and symptoms, 82% of all pancreatic cancer cases are diagnosed in terminal stages. As such, the most powerful method to reducing the morbidity and mortality of pancreatic cancer is to further investigate the risk factors. According to the theoretical framework of the ecosocial theory, long-term exposure to exposures to unfavorable socioecological and environmental factors serve as a “web of causation” for adverse health outcomes. Using data from the North Carolina Department …

Food Environment As A Moderator In The Relationship Between Ultra-Processed Food Intake And Mortality In The United States, Brandon Jerod Grandy

Walden Dissertations and Doctoral Studies

According to recent studies, the consumption of ultra-processed food is a major issue that leads to fatal outcomes within the United States, which is relevant because this type of food has become more accessible over the years. Using data from the National Health And Nutrition Examination Survey III (NHANES III), previous researchers found that frequent consumption of ultra-processed foods was associated with greater chances of all-cause mortality in U.S. adults, but little research has focused on factors that can impact ultra-processed food consumption, such as food environment. The purpose of this quantitative longitudinal study was to examine the effect of …

Hospitalizations And Mortality ​With Alzheimer’S Disease And Related Dementias Diagnosis In Georgia, 2020, Chloe Hale

Georgia Public Health Association Annual Meeting & Conference

More than 6 million Americans aged 65 and older are living with an Alzheimer’s disease or related dementia diagnosis (ADRD) in 2022. Data from the 2019 Behavioral Risk Factor Surveillance System report that in Georgia, 1 in 9 people aged 45 and older experienced confusion or memory problems that have been getting worse over the past year.

Georgia Department of Public Health Injury Prevention Program creates a healthy Georgia through conversations and collaborations for change using data driven program building. The programs utilize Georgia’s established infrastructure, clear priorities, and the dynamic network of partnerships guided by a robust network of …