Epidemiology Commons^™

Genetics Of Smoking Behaviors In American Indians, Jeffrey A Henderson, Dedra S Buchwald, Barbara V Howard, Patricia Nez Henderson, Yafang Li, Rachel F Tyndale, Christopher I Amos, Olga Y Gorlova, Collaborative To Improve Native Cancer Outcomes (Cinco), A P50 Center For Population Health And Health Disparities Program Project Sponsored By The National Cancer Institute

Faculty, Staff and Students Publications

BACKGROUND: The smoking behavior of American Indians (AI) differs from that of non-Hispanic whites (NHW). Typically light smokers, cessation interventions in AIs are generally less effective. To develop more effective cessation programs for AIs, clinicians, researchers, and public health workers need a better understanding of the genetic factors involved in their smoking behavior. Our aim was to assess whether SNPs associated with smoking behavior in NHWs are also associated with smoking in AIs.

METHODS: We collected questionnaire data on smoking behaviors and analyzed blood and saliva samples from two Tribal populations with dramatically different cultures and smoking prevalence, one in …

Gender And Racial Disparity For Hospital Emergency Service Usage In Usa: A Quantitative Analysis For Various Age Groups During 2010–2017., Subhendra N. Sarkar, Anthony F. Devito, Evans Lespinasse, Faisal Khosa

Publications and Research

Background: Annually emergency department (ED) services are utilized by more than 100 million Americans making ED usage trends important determinants of healthcare quality, outcomes and cost. Previous workers have demonstrated the existence of disparity in various healthcare services in USA although a comprehensive analysis has not been undertaken. Dahlgren and Whitehead rainbow model has offered insights for multiple factors of influence on an individual’s health and focuses on the relationships among these factors. The Commission on Social Determinants of Health (CSDH; WHO initiatives) suggests that the social and environmental factors are at the root of most of the inequalities responsible …

Donor And Transplant Candidate Selection For Solid Organ Transplantation During The Covid-19 Pandemic, N Thao N Galvan, Nicolas F Moreno, Jay E Garza, Susan Bourgeois, Marion Hemmersbach-Miller, Bhamidipati Murthy, Katherine Timmins, Christine A O'Mahony, James Anton, Andrew Civitello, Puneet Garcha, Gabe Loor, Kenneth Liao, Alexis Shaffi, John Vierling, Rise Stribling, Abbas Rana, John A Goss

Faculty, Staff and Students Publications

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a novel coronavirus responsible for a worldwide pandemic has forced drastic changes in medical practice in an alarmingly short period of time. Caregivers must modify their strategies as well as optimize the utilization of resources to ensure public and patient safety. For organ transplantation, in particular, the loss of lifesaving organs for transplantation could lead to increased waitlist mortality. The priority is to select uninfected donors to transplant uninfected recipients while maintaining safety for health care systems in the backdrop of a virulent pandemic. We do not yet have a standard approach to evaluating …

The Use Of Penalized Regression Analysis To Identify County-Level Demographic And Socioeconomic Variables Predictive Of Increased Covid-19 Cumulative Case Rates In The State Of Georgia, Holly L. Richmond, Joana Tome, Haresh Rochani, Isaac Chun-Hai Fung, Gulzar H. Shah, Jessica S. Schwind

Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications

Systemic inequity concerning the social determinants of health has been known to affect morbidity and mortality for decades. Significant attention has focused on the individual-level demographic and co-morbid factors associated with rates and mortality of COVID-19. However, less attention has been given to the county-level social determinants of health that are the main drivers of health inequities. To identify the degree to which social determinants of health predict COVID-19 cumulative case rates at the county-level in Georgia, we performed a sequential, cross-sectional ecologic analysis using a diverse set of socioeconomic and demographic variables. Lasso regression was used to identify variables …

Multi-Ancestry Genome-Wide Association Study Accounting For Gene-Psychosocial Factor Interactions Identifies Novel Loci For Blood Pressure Traits, Daokun Sun, Melissa A. Richard, Soloman K. Musani, Yun Ju Sung, Thomas W. Winkler, Karen Schwander, Jin Fang Chai, Xiuqing Guo, Tuomas O. Kilpeläinen, Dina Vojinovic, Hugues Aschard, Traci M. Bartz, Lawrence F. Bielak, Michael R. Brown, Kumaraswamy Chitrala, Fernando P. Hartwig, Andrea R. V. R. Horimoto, Yongmei Liu, Alisa K. Manning, Raymond Noordam, Donna K. Arnett

Epidemiology and Environmental Health Faculty Publications

Psychological and social factors are known to influence blood pressure (BP) and risk of hypertension and associated cardiovascular diseases. To identify novel BP loci, we carried out genome-wide association meta-analyses of systolic, diastolic, pulse, and mean arterial BP, taking into account the interaction effects of genetic variants with three psychosocial factors: depressive symptoms, anxiety symptoms, and social support. Analyses were performed using a two-stage design in a sample of up to 128,894 adults from five ancestry groups. In the combined meta-analyses of stages 1 and 2, we identified 59 loci (p value < 5e−8), including nine novel BP loci. The novel associations were observed mostly with pulse pressure, with fewer observed with mean arterial pressure. Five novel loci were identified in African ancestry, and all but one showed patterns of interaction with at least one psychosocial factor. Functional annotation of the novel loci supports a major role for genes implicated in the immune response (PLCL2), synaptic function and neurotransmission (LIN7A …

Effects Of Β-Carotene Intake On The Risk Of Fracture: A Bayesian Meta-Analysis, Tesfaye Getachew Charkos, Yawen Liu, Kemal Sherefa Oumer, Ann M. Vuong, Shuman Yang

School of Public Health Faculty Research

Background: Epidemiological studies examining the association between β-carotene intake and risk of fracture have reported inconsistent findings. We conducted a meta-analysis to investigate the association between β-carotene intake and risk of fracture. Methods: We systematically searched PubMed, EMBASE and Cochrane library databases for relevant articles that were published until December 2019. We also identified studies from reference lists of articles identified from the clinical databases. The frequentist and Bayesian random-effects model was used to synthesize data. Results: Nine studies with a total of 190,545 men and women, with an average age of 59.8 years, were included in this meta-analysis. For …

A Hybrid Agent-Based And Equation Based Model For The Spread Of Infectious Diseases, Elizabeth Hunter, Brian Mac Namee, John D. Kelleher

Articles

Both agent-based models and equation-based models can be used to model the spread of an infectious disease. Equation-based models have been shown to capture the overall dynamics of a disease outbreak while agent-based models are able to capture heterogeneous characteristics of agents that drive the spread of an outbreak. However, agent-based models are computationally intensive. To capture the advantages of both the equation-based and agent-based models, we create a hybrid model where the disease component of the hybrid model switches between agent-based and equation-based. The switch is determined using the number of agents infected. We first test the model at …

A Review Of American College Campus Tobacco Or Smoke Free Policies: A Case Study Of A Large Urban University, Sarah E. Powell

USF Tampa Graduate Theses and Dissertations

Objective: A year after a tobacco free policy was passed, the University of South Florida (USF) was interested in the overall policy opinions and efficacy. To assess this a project was completed that included a survey and geospatial data. The survey measured tobacco policy enforcement behavior and a geographic information system (GIS) mapped tobacco policy violation. This project introduces an evaluation process that can efficiently assess an institutions tobacco-free policy. Methods: Using a cross-sectional survey sent to students, faculty, and staff, understanding of policy and resources, tobacco use observations, stage of change regarding policy enforcement, self-efficacy to enforce, and perceived …

Genetic-Based Hypertension Subtype Identification Using Informative Snps, Yuanjing Ma, Hongmei Jiang, Sanjiv J. Shah, Donna K. Arnett, Marguerite R. Irvin, Yuan Luo

Epidemiology and Environmental Health Faculty Publications

In this work, we proposed a process to select informative genetic variants for identifying clinically meaningful subtypes of hypertensive patients. We studied 575 African American (AA) and 612 Caucasian hypertensive participants enrolled in the Hypertension Genetic Epidemiology Network (HyperGEN) study and analyzed each race-based group separately. All study participants underwent GWAS (Genome-Wide Association Studies) and echocardiography. We applied a variety of statistical methods and filtering criteria, including generalized linear models, F statistics, burden tests, deleterious variant filtering, and others to select the most informative hypertension-related genetic variants. We performed an unsupervised learning algorithm non-negative matrix factorization (NMF) to identify hypertension …

Association Between Dietary Inflammatory Index And Type 2 Diabetes Mellitus In Xinjiang Uyghur Autonomous Region, China, Wenhui Fu, Hualian Pei, Nitin Shivaooa, James R. Hébert, Tao Luo, Tian Tian, Dilibaier Alimu, Zewen Zhang, Jianghong Dai

Faculty Publications

Background Diet and inflammation have both been studied in relation to type 2 diabetes mellitus (T2DM). The aim of this cross-sectional study was to examine the association between the Dietary Inflammatory Index (DII®) and T2DM. Methods Subjects were adults enrolled in the baseline study of the Xinjiang multi-ethnic natural population cohort and health follow-up study from January to May 2019. The study involved 5,105 subjects (58.7% men) between 35 and 74 years of age. The DII score was calculated from a data obtained via a food frequency questionnaire consisting of 127 food items. Results Logistic regression analyses were used to …

Covid-19 And Quantitative Literacy: Focusing On Probability, Michael A. Lewis

Numeracy

The COVID-19 pandemic is arguably the worst crisis the world has faced, so far, in this new century. We haven’t seen a pandemic like this since the 1918 Flu at the beginning of the last century, and, as of this writing, there appears to be no end in sight. What those of us who’re focused on quantitative methods have noticed, in addition to the many people dying, becoming ill, and losing their livelihoods, is the importance of quantitative literacy to an understanding of what’s going on. That’s what this article is about. Specifically, it’s about how the COVID-19 pandemic is …

Geographic And Intra-Racial Disparities In Early-Onset Colorectal Cancer In The Seer 18 Registries Of The United States, Wesal H. Abualkhair, Meijiao Zhou, Carolina O. Ochoa, Leonel Lacayo, Caitlin Murphy, Xiao Cheng Wu, Jordan J. Karlitz

School of Medicine Faculty Publications

Background: Although early-onset colorectal cancer (EOCRC) incidence rates (IRs) are increasing, geographic and intra-racial IR disparities are not well defined. Methods: 2000-2015 Surveillance, Epidemiology, and End Results (SEER) program CRC IR Analysis (170,434 cases) was performed from ages 30 to 60 in four US regions, 18 individual registries, metropolitan and nonmetropolitan locations and stratified by race. Analyses were conducted in 1-year and 5-year age increments. Results: Wide US regional EOCRC IR variations exist: For example, age 45 IRs in the south are 26.8/100,000, 36.0% higher than the West, 19.7/100,000 (p < 0.0001). Disparities magnify between individual registries: EOCRC IRs in highest risk registries were 177-348% (Alaska Natives), 75-200% (Hawaii), 76-128% (Louisiana), and 61-125% (Kentucky) higher than lowest risk registries depending on age. EOCRC IRs are 18.2%-25.6% higher in nonmetropolitan versus metropolitan settings. Wide geographic intra-racial disparities exist. Within the White population, the greatest IR difference (78.8%) was between Kentucky (5.9/100,000) and Los Angeles (3.3/100,000) in 30- to 34-year-olds (p <.0001). Within the Black population, the greatest difference (136.2%) was between rural Georgia (30.7/100,000) and California excluding San Francisco-Oakland/San Jose-Monterey/Los Angeles (13/100,000) in 40- to 44-year-olds (p = 0003). Conclusion: Marked geographic EOCRC disparities exist with disproportionately high IRs in Alaska Natives, Hawaii, and southern registries. Geographic intra-racial disparities are present within White and Black populations. In Blacks, there are disproportionately high EOCRC IRs in rural Georgia. Although vigilance is required in all populations, attention must be paid to these higher risk populations. Potential interventions include assuring early investigation of symptoms, targeting modifiable risk factors and utilizing earlier age 45 screening options supported by some guidelines.

Genome-Wide Association Study Of Smoking Trajectory And Meta-Analysis Of Smoking Status In 842,000 Individuals, Ke Xu, Boyang Li, Kathleen A. Mcginnis, Rachel Vickers-Smith, Cecilia Dao, Ning Sun, Rachel L. Kember, Hang Zhou, William C. Becker, Joel Gelernter, Henry R. Kranzler, Hongyu Zhao, Amy C. Justice, Va Million Veteran Program

Epidemiology and Environmental Health Faculty Publications

Here we report a large genome-wide association study (GWAS) for longitudinal smoking phenotypes in 286,118 individuals from the Million Veteran Program (MVP) where we identified 18 loci for smoking trajectory of current versus never in European Americans, one locus in African Americans, and one in Hispanic Americans. Functional annotations prioritized several dozen genes where significant loci co-localized with either expression quantitative trait loci or chromatin interactions. The smoking trajectories were genetically correlated with 209 complex traits, for 33 of which smoking was either a causal or a consequential factor. We also performed European-ancestry meta-analyses for smoking status in the MVP …

Analisis Risiko Kesehatan Pajanan Particulate Matter (Pm2.5) Pada Pekerja Pengrajin Batu Bata Di Kecamatan Taktakan, Kota Serang, Banten, Tahun 2018, Nadiya Nurul Huda, Haryoto Kusnoputranto

Jurnal Nasional Kesehatan Lingkungan Global

Clay brick industry worker are at risk for the health effect to exposure PM2,5, resulting from combustion and forming process. This study aimed to estimate the risk of PM2,5 exposure in ambient air to clay brick industry worker in Kecamatan Taktakan Serang Banten. This study used primary data of 73 worker and environment sampel was measured from 9 site with Haz dust EPAM 5000. Univariate data were present and health risk was calculated using environmental health risk assessment method that generates value of individual exposure intake per day. Exposure intake was calculated based on PM2,5 concentration, individual exposure patterns, and …

Analisis Risiko Kesehatan Pemulung Akibat Pajanan Gas No2 Dan So2 Di Tpa Cipayung, Depok Tahun 2018, Rezha Pratiwi Eka Gharini, Ema Hermawati

Jurnal Nasional Kesehatan Lingkungan Global

Background. Gases NO2 and SO2 are air pollutants that cause odor and pollute the air around the landfill. The gases will emerge at every stage of landfilling and compaction operations in the landfill. This study aims to analyze the level of exposure risk of NO2 and SO2 gas, in ambient air to health disturbance on scavengers who move and settle around TPA Cipayung, Depok. Methods. This research was conducted in March-June of 2018 using the method of writing Environmental Health Risk Analysis (ARKL). Results. The result of measurement of NO2 has the average of measurement result is 31,794 µg/m3 , …

Analisis Hubungan Tingkat Kebisingan Dengan Kejadian Hipertensi Pada Pekerja Bagian Refining Di Pt X Tahun 2019, Shabrina Khairani, Umar Fahmi Achmadi

Jurnal Nasional Kesehatan Lingkungan Global

Background. The level of noise exposed to workers in industry that exceeds the threshold value can cause a stress mechanism that will increase heart rate and blood pressure. The purpose of this study is to find out the association between noise exposure and hypertension on workers in Refining section at PT X. Methods. This research method used a quantitative approach and a cross-sectional design on the 51 workers at Refining. This research used chi-square and regression logistics test as statistical analysis. Results. The result showed, there is a significant relationship between noise exposure and hypertension with p-value = 0,029 (OR …

Efektivitas Penyuluhan Individual Dan Kelompok Dalam Meningkatkan Pengetahuan, Sikap, Dan Perilaku Pengelolaan Sampah Rumah Tangga Berkonsep 3r (Studi Kasus Di Kelurahan Abadijaya Kota Depok Tahun 2018), Erin Firliana, Zakianis Zakianis

Jurnal Nasional Kesehatan Lingkungan Global

Background. The problem of increasing amount of waste is due to the lack of understanding and public awareness about household waste management using the 3R concept. Counseling is a health education activity carried out by disseminating information and instilling confidence to improve the knowledge, attitude, and behavior concerning household waste management using the 3R concept. The goal of this study is to find out which of the following counseling methods between individual counseling or group counseling is more effective at improving the value of average knowledge, attitude, and behavior towards household waste management using the 3R concept in Kelurahan Abadijaya, …

Hubungan Konsentrasi Kadar Debu Pm10 Dengan Kejadian Gejala Ispa (Infeksi Saluran Pernapasan Akut) Pada Pekerja Proyek Konstruksi X Di Depok Tahun 2018, Andi Putri Fildzana Dwi Annisa F, Umar Fahmi Achmadi

Jurnal Nasional Kesehatan Lingkungan Global

Background. The condition of a construction project which full of workers, with their 8 hours of working time and the number of vehicles carrying building materials in and out to the site causing the workers to be susceptible to affected Acute Respiratory Infection Symptom due to exposure to PM10 continuously. Based on this research, the author raised the issue of the association between PM10 dust level concentration with the case of Acute Respiratory Infection symptom in construction project workers in Depok. Methods. This research uses Cross Sectional study by taking samples from 100 respondents. Results. The average PM10 measurement result …

Hubungan Higiene Sanitasi Makanan Jajanan Dengan Kontaminasi Escherichia Coli Pada Makanan Jajanan Anak Sekolah Dasar Di Kecamatan Medan Satria Dan Kecamatan Jati Asih, Kota Bekasi Tahun 2018, Alifah Syafriyani, I Made Djaja

Jurnal Nasional Kesehatan Lingkungan Global

Background. Snack is a source of nutrition for children in school. However, special snack foods sold in elementary schools are not always safe, and are also susceptible to contamination with Escherichia coli. Methods. Therefore, this study was conducted to understand the relationship of primary school children's snacks sanitation in Medan Satria and Jati Asih Subdistricts, Bekasi City with E.coli contamination in snacks using Cross Sectional design. Results. The results showed that 16.4% (10 samples) snack were contaminated with E. coli. Based on the chi square test, there was significant association between hygiene sanitation of raw materials (OR = 6,150), hygiene …

Hubungan Pengetahuan, Sikap, Dan Perilaku Penggunaan Pestisida Dan Nilai Risiko (Rq) Pada Petani Cabai, Kubis, Dan Kentang Di Kecamatan Cikajang, Rizqy Fauzi, Suyud Warno Utomo

Jurnal Nasional Kesehatan Lingkungan Global

Background. Pesticides used by farmers to protect crops from pests. The use of pesticides is influenced by the knowledge, attitudes, and behavior of farmers. Residues of pesticide active ingredient can survive on objects plant and agricultural environments. Exposure to pesticides to farmers and consumers raises the risk of health problems. Forecast risk of health problems can be detected by RQ value. This study aimed to analyze the relationship between knowledge, attitudes, and behavior of pesticide use and risk of health problems in farmers. The research was conducted in the Cikajang, Garut. Field sampling and interviews conducted pesticide use in gardens …