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Trends In Osteoporosis And Mean Bone Density Among Type 2 Diabetes Patients In The Us From 2005 To 2014, Yingke Xu, Qing Wu 2021 University of Nevada, Las Vegas

Trends In Osteoporosis And Mean Bone Density Among Type 2 Diabetes Patients In The Us From 2005 To 2014, Yingke Xu, Qing Wu

Public Health Faculty Publications

© 2021, The Author(s). This study aimed to examine how bone health changed among T2DM patients in the past decade. Continuous National Health and Nutrition Examination Survey (NHANES) data from 2005–2006 to 2013–2014 were analyzed to examine the trends of bone mineral density (BMD) and the prevalence trends of osteoporosis osteopenia among T2DM patients and non-diabetic people aged 40 years and older. The age- and BMI-adjusted mean BMD of the femur neck for the four NHANES cycles decreased linearly in both T2DM patients and non-diabetic people (both Plinear trend ≤ 0.009). Among women with T2DM, the mean BMD ...


The Temporal Nature Of Social Context: Insights From The Daily Lives Of Patients With Hiv, Gemmae M. Fix, Eileen M. Dryden, Jacqueline Boudreau, Nancy R. Kressin, Allen L. Gifford, Barbara G. Bokhour 2021 Boston University

The Temporal Nature Of Social Context: Insights From The Daily Lives Of Patients With Hiv, Gemmae M. Fix, Eileen M. Dryden, Jacqueline Boudreau, Nancy R. Kressin, Allen L. Gifford, Barbara G. Bokhour

Open Access Publications by UMMS Authors

BACKGROUND: Patients' life contexts are increasingly recognized as important, as evidenced by growing attention to the Social Determinants of Health (SDoH). This attention may be particularly valuable for patients with complex needs, like those with HIV, who are more likely to experience age-related comorbidities, mental health or substance use issues. Understanding patient perceptions of their life context can advance SDoH approaches.

OBJECTIVES: We sought to understand how aging patients with HIV think about their life context and explored if and how their reported context was documented in their electronic medical records (EMRs).

DESIGN: We combined life story interviews and EMR ...


Long-Term Dynamics Of The Kidney Disease Epidemic Among Hiv-Infected Individuals, Heather Gudaz, Henry A. Ogu, Elissa J. Schwartz 2021 Washington State University

Long-Term Dynamics Of The Kidney Disease Epidemic Among Hiv-Infected Individuals, Heather Gudaz, Henry A. Ogu, Elissa J. Schwartz

Spora: A Journal of Biomathematics

One of many risks facing HIV+ individuals is the development of kidney dysfunction and end stage kidney disease (ESKD). A differential equation-based mathematical model was developed to assess the impact of antiretroviral therapy on the progression to kidney disease and on reducing mortality due to kidney failure. Analytical and numerical predictions of long-term HIV+ ESKD prevalence show that therapy can lead to either extremely low levels of disease prevalence or increased prevalence, depending on drug efficacy levels and mechanisms of action. Maintenance of HIV+ ESKD prevalence below one individual is possible with sufficient efficacy (e.g., 99%) against the progression ...


Covid Town Hall And Commencement Regalia, Cedarville University 2021 Cedarville University

Covid Town Hall And Commencement Regalia, Cedarville University

COVID-19 Updates

No abstract provided.


Associations Of Cereal Grains Intake With Cardiovascular Disease And Mortality Across 21 Countries In Prospective Urban And Rural Epidemiology Study: Prospective Cohort Study, Sumathi Swaminathan, Mahshid Dehghan, John Michael Raj, Tinku Thomas, Sumathy Rangarajan, David Jenkins, Prem Mony, Viswanathan Mohan, Scott A. Lear, Romaina Iqbal 2021 St John's Research Institute, Bangalore, India

Associations Of Cereal Grains Intake With Cardiovascular Disease And Mortality Across 21 Countries In Prospective Urban And Rural Epidemiology Study: Prospective Cohort Study, Sumathi Swaminathan, Mahshid Dehghan, John Michael Raj, Tinku Thomas, Sumathy Rangarajan, David Jenkins, Prem Mony, Viswanathan Mohan, Scott A. Lear, Romaina Iqbal

Community Health Sciences

Objective: To evaluate the association between intakes of refined grains, whole grains, and white rice with cardiovascular disease, total mortality, blood lipids, and blood pressure in the Prospective Urban and Rural Epidemiology (PURE) study.
Design: Prospective cohort study.
Setting: PURE study in 21 countries.
Participants: 148 858 participants with median follow-up of 9.5 years.
Exposures: Country specific validated food frequency questionnaires were used to assess intakes of refined grains, whole grains, and white rice.
Main outcome measure: Composite of mortality or major cardiovascular events (defined as death from cardiovascular causes, non-fatal myocardial infarction, stroke, or heart failure). Hazard ratios ...


Spectators At Athletic Events, Library Reminder, And Reduced Pricing For Rapid Covid Tests, Cedarville University 2021 Cedarville University

Spectators At Athletic Events, Library Reminder, And Reduced Pricing For Rapid Covid Tests, Cedarville University

COVID-19 Updates

No abstract provided.


Sex, Diabetes Status And Cognition: Findings From The Study Of Longevity In Diabetes, Chris Moran, Paola Gilsanz, Michal S. Beeri, Rachel A. Whitmer, Mary E. Lacy 2021 Monash University, Australia

Sex, Diabetes Status And Cognition: Findings From The Study Of Longevity In Diabetes, Chris Moran, Paola Gilsanz, Michal S. Beeri, Rachel A. Whitmer, Mary E. Lacy

Epidemiology Faculty Publications

INTRODUCTION: Women comprise two-thirds of people with dementia, making female sex a significant dementia risk factor. Both type 1 diabetes (T1D) and type 2 diabetes (T2D) are known dementia risk factors with an increasing global incidence. Understanding whether subtle sex differences persist in cognitive function prior to dementia in the context of diabetes may help elucidate the magnitude of sex effects on dementia risk.

RESEARCH DESIGN AND METHODS: We examined cross-sectional data from the Study of Longevity in Diabetes (SOLID), a prospective cohort study of members of Kaiser Permanente Northern California aged 60 years and older with T1D (n=758 ...


Association Between Incarceration And Incident Cardiovascular Disease Events: Results From The Cardia Cohort Study, Jordan Coleman, Donald M. Lloyd-Jones, Hongyan Ning, Norrina B. Allen, Catarina I. Kiefe, Emily A. Wang, Mark D. Huffman 2021 Northwestern University

Association Between Incarceration And Incident Cardiovascular Disease Events: Results From The Cardia Cohort Study, Jordan Coleman, Donald M. Lloyd-Jones, Hongyan Ning, Norrina B. Allen, Catarina I. Kiefe, Emily A. Wang, Mark D. Huffman

Population and Quantitative Health Sciences Publications

BACKGROUND: Incarceration has been associated with higher cardiovascular risk, yet data evaluating its association with cardiovascular disease events are limited. The study objective was to evaluate the association between incarceration and incident fatal and non-fatal cardiovascular disease (CVD) events.

METHODS: Black and white adults from the community-based Coronary Artery Risk Development in Young Adult (CARDIA) study (baseline 1985-86, n = 5105) were followed through August 2017. Self-reported incarceration was measured at baseline (1985-1986) and Year 2 (1987-1988), and fatal and non-fatal cardiovascular disease events, including coronary heart disease, stroke, and heart failure, and all-cause mortality, were captured through 2017. Analyses were ...


The National Covid Cohort Collaborative: Clinical Characterization And Early Severity Prediction [Preprint], Tellen D. Bennett, Christopher G. Chute, N3C Consortium 2021 University of Colorado

The National Covid Cohort Collaborative: Clinical Characterization And Early Severity Prediction [Preprint], Tellen D. Bennett, Christopher G. Chute, N3c Consortium

UMass Center for Clinical and Translational Science Supported Publications

Background: The majority of U.S. reports of COVID-19 clinical characteristics, disease course, and treatments are from single health systems or focused on one domain. Here we report the creation of the National COVID Cohort Collaborative (N3C), a centralized, harmonized, high-granularity electronic health record repository that is the largest, most representative U.S. cohort of COVID-19 cases and controls to date. This multi-center dataset supports robust evidence-based development of predictive and diagnostic tools and informs critical care and policy.

Methods and Findings: In a retrospective cohort study of 1,926,526 patients from 34 medical centers nationwide, we stratified patients ...


One Spark Can Light A Fire: How To Become A Mental Health Advocate, Marquinta Harvey, Shannon Jackson 2021 The Fearless Campaign and Belmont University

One Spark Can Light A Fire: How To Become A Mental Health Advocate, Marquinta Harvey, Shannon Jackson

Black Issues Conference

One Spark Can Light a Fire: How to Become a Mental Health Advocate

There is increasing awareness surrounding mental health and conversations are beginning to make their way to the forefront of issues that demand significant attention. However, the path from awareness to advocacy remains poorly understood. Mental Illness is an important issue that affects 1 in 4 individuals and unlike most chronic illnesses the onset occurs early in the life spectrum, usually in adolescence and young adulthood.

The issue of mental health is not limited to individual genetic predisposition and/or behaviors but involves many layers related to individual ...


Dr. White's Covid Reminders, Cugo Days, And New Package Lockers, Cedarville University 2021 Cedarville University

Dr. White's Covid Reminders, Cugo Days, And New Package Lockers, Cedarville University

COVID-19 Updates

No abstract provided.


The Association Of Circulating Amylin With Β-Amyloid In Familial Alzheimer's Disease, Han Gia Ly, Nirmal Verma, Savita Sharma, Deepak Kotiya, Sanda Despa, Erin L. Abner, Peter T. Nelson, Gregory A. Jicha, Donna M. Wilcock, Larry B. Goldstein, Rita Guerreiro, José Brás, Angela J. Hanson, Suzanne Craft, Andrew J. Murray, Geert Jan Biessels, Claire Troakes, Henrik Zetterberg, John Hardy, Tammaryn Lashley, Alzheimer’s disease Exome Sequencing Group, Florin Despa 2021 University of Kentucky

The Association Of Circulating Amylin With Β-Amyloid In Familial Alzheimer's Disease, Han Gia Ly, Nirmal Verma, Savita Sharma, Deepak Kotiya, Sanda Despa, Erin L. Abner, Peter T. Nelson, Gregory A. Jicha, Donna M. Wilcock, Larry B. Goldstein, Rita Guerreiro, José Brás, Angela J. Hanson, Suzanne Craft, Andrew J. Murray, Geert Jan Biessels, Claire Troakes, Henrik Zetterberg, John Hardy, Tammaryn Lashley, Alzheimer’S Disease Exome Sequencing Group, Florin Despa

Pharmacology and Nutritional Sciences Faculty Publications

Introduction

This study assessed the hypothesis that circulating human amylin (amyloid‐forming) cross‐seeds with amyloid beta (Aβ) in early Alzheimer's disease (AD).

Methods

Evidence of amylin‐AD pathology interaction was tested in brains of 31 familial AD mutation carriers and 20 cognitively unaffected individuals, in cerebrospinal fluid (CSF) (98 diseased and 117 control samples) and in genetic databases. For functional testing, we genetically manipulated amylin secretion in APP/PS1 and non‐APP/PS1 rats.

Results

Amylin‐Aβ cross‐seeding was identified in AD brains. High CSF amylin levels were associated with decreased CSF Aβ42 concentrations. AD risk and ...


Meeting Minutes, WKU Council of Academic Deans 2021 Western Kentucky University

Meeting Minutes, Wku Council Of Academic Deans

Council of Academic Deans

Meeting regarding accreditation, Colonnade director, academic program review, pass grade numbers, provost search, micro-credentials, graduate admission standards, graduate-level prior learning assessment, travel policy and cross-listed courses merging on Blackboard.


Memory-Related Frontal Brainwaves Predict Transition To Mild Cognitive Impairment In Healthy Older Individuals Five Years Before Diagnosis, Yang Jiang, Juan Li, Frederick A. Schmitt, Gregory A. Jicha, Nancy B. Munro, Xiaopeng Zhao, Charles D. Smith, Richard J. Kryscio, Erin L. Abner 2021 University of Kentucky

Memory-Related Frontal Brainwaves Predict Transition To Mild Cognitive Impairment In Healthy Older Individuals Five Years Before Diagnosis, Yang Jiang, Juan Li, Frederick A. Schmitt, Gregory A. Jicha, Nancy B. Munro, Xiaopeng Zhao, Charles D. Smith, Richard J. Kryscio, Erin L. Abner

Behavioral Science Faculty Publications

BACKGROUND: Early prognosis of high-risk older adults for amnestic mild cognitive impairment (aMCI), using noninvasive and sensitive neuromarkers, is key for early prevention of Alzheimer's disease. We have developed individualized measures in electrophysiological brain signals during working memory that distinguish patients with aMCI from age-matched cognitively intact older individuals.

OBJECTIVE: Here we test longitudinally the prognosis of the baseline neuromarkers for aMCI risk. We hypothesized that the older individuals diagnosed with incident aMCI already have aMCI-like brain signatures years before diagnosis.

METHODS: Electroencephalogram (EEG) and memory performance were recorded during a working memory task at baseline. The individualized baseline ...


Influence Of A One-Time Web-Based Provider Intervention On Patient-Reported Outcomes After The Well-Child Visit: A Feasibility Study, Chad M. Coleman, Gwen L. Alexander, Charles Barone, Andrew S. Bossick, Zeinab Kassem, Mei Lu, Yueren Zhou, Andrea E. Cassidy-Bushrow 2021 Henry Ford Health System

Influence Of A One-Time Web-Based Provider Intervention On Patient-Reported Outcomes After The Well-Child Visit: A Feasibility Study, Chad M. Coleman, Gwen L. Alexander, Charles Barone, Andrew S. Bossick, Zeinab Kassem, Mei Lu, Yueren Zhou, Andrea E. Cassidy-Bushrow

Journal of Patient-Centered Research and Reviews

Purpose: Patient-centered care promotes positive health outcomes in pediatrics. We created a provider-focused intervention and implemented it in a pragmatic clustered randomized controlled trial to improve health-related quality of life (HRQOL) among pediatric patients.

Methods: A one-time (1–1.5-hour) webinar focusing on patient-centered care and motivational interviewing, using obesity screening as an example, was developed. Pediatric providers were recruited and randomized to either intervention (webinar) or control (usual care) arms. All well-child visits to these providers for a period of up to 5 months following webinar completion (or study enrollment for controls) were identified, and these family/patients were ...


Estimating The Population Attributable Fraction Of Asthma Due To Electronic Cigarette Use And Other Risk Factors Using Kentucky Behavioral Risk Factor Survey Data, 2016-2017, W. Jay Christian, Courtney J. Walker 2021 University of Kentucky

Estimating The Population Attributable Fraction Of Asthma Due To Electronic Cigarette Use And Other Risk Factors Using Kentucky Behavioral Risk Factor Survey Data, 2016-2017, W. Jay Christian, Courtney J. Walker

Epidemiology Faculty Publications

Introduction: Electronic nicotine delivery systems ENDS have become popular in the United States among both new users of nicotine and those seeking less harmful alternatives to traditional cigarettes. Users often perceive ENDS as being less harmful than traditional cigarettes. This study investigated the relationship between use of ENDS and asthma in a representative sample of adults. Methods: For this cross-sectional study, we used data from the Kentucky Behavioral Risk Factor Surveillance System telephone survey data from 2016-2017. Using a weighted multivariable logistic regression analysis, we identified important covariates to adjust for to calculate the population attributable fraction (PAF) of asthma ...


Chronic Pain And Mood Disorders In Asian Americans, Deborah L. Huang, Indraneil Bardhan, Joosun Shin, Jordan F. Karp, Mijung Park 2021 University of Washington

Chronic Pain And Mood Disorders In Asian Americans, Deborah L. Huang, Indraneil Bardhan, Joosun Shin, Jordan F. Karp, Mijung Park

Asian / Pacific Island Nursing Journal

Purpose: Pain and mood disorder frequently coexist. Yet, for Asian Americans (AAs), scant information about pain and mood disorder is available. Our aims were to compare (1) the rates of pain and mood disorders and (2) the magnitude of associations between pain and mood disorders between AAs and European Americans (EAs), and across different Asian subgroups.

Methods: An analytical data was constructed from the Collaborative Psychiatric Epidemiology Studies (CPES), a representative sample of community-residing U.S. adults (n=9,871). Pain morbidity were assessed by self-report. Mood disorders, including major depression and anxiety disorders, were assessed using the diagnostic interview ...


Next Week In Chapel, Quarantine & Testing, And Dining Changes For Spring, Cedarville University 2021 Cedarville University

Next Week In Chapel, Quarantine & Testing, And Dining Changes For Spring, Cedarville University

COVID-19 Updates

No abstract provided.


Innate Lymphoid Cells And Disease Tolerance In Sars-Cov-2 Infection [Preprint], Noah J. Silverstein, Yetao Wang, Zachary Manickas-Hill, Claudia C. Carbone, Ann Dauphin, MGH COVID-19 Collection & Processing Team, Jonathan Z. Li, Bruce D. Walker, Xu G. Yu, Jeremy Luban 2021 University of Massachusetts Medical School

Innate Lymphoid Cells And Disease Tolerance In Sars-Cov-2 Infection [Preprint], Noah J. Silverstein, Yetao Wang, Zachary Manickas-Hill, Claudia C. Carbone, Ann Dauphin, Mgh Covid-19 Collection & Processing Team, Jonathan Z. Li, Bruce D. Walker, Xu G. Yu, Jeremy Luban

University of Massachusetts Medical School Faculty Publications

BACKGROUND: Risk of severe coronavirus disease 2019 (COVID-19) increases with age, is greater in males, and is associated with decreased numbers of blood lymphoid cells. Though the reasons for these robust associations are unclear, effects of age and sex on innate and adaptive lymphoid subsets, including on homeostatic innate lymphoid cells (ILCs) implicated in disease tolerance, may underlie the effects of age and sex on COVID-19 morbidity and mortality.

METHODS: Flow cytometry was used to quantitate subsets of blood lymphoid cells from people infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), comparing those hospitalized with severe COVID-19 (n=40 ...


Personal Wellness Checks, Monday Contract Meals, Covid Testing, And More, Cedarville University 2021 Cedarville University

Personal Wellness Checks, Monday Contract Meals, Covid Testing, And More, Cedarville University

COVID-19 Updates

No abstract provided.


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