Characteristics Of Patients Experiencing Extrapyramidal Symptoms Or Other Movement Disorders Related To Dopamine Receptor Blocking Agent Therapy,
2019
Butler University
Characteristics Of Patients Experiencing Extrapyramidal Symptoms Or Other Movement Disorders Related To Dopamine Receptor Blocking Agent Therapy, Shaina Musco, Laura Ruekert, Jaclyn Myers, Dennis Anderson, Michael Welling, Elizabeth Ann Cunningham
Scholarship and Professional Work – COPHS
Purpose/background: Dopamine receptor blocking agents (DRBAs), also known as antipsychotics, are medications widely used to treat a growing number of mental health diagnoses. However, their utility is limited by the potential to cause serious adverse movement reactions. Akathisia, dystonia, parkinsonism, and tardive dyskinesia (collectively known as extrapyramidal symptoms or EPSs) are associated with reduced social and occupational functioning, negative patient attitudes toward treatment, and nonadherence to pharmacotherapy. Neuroleptic malignant syndrome is a life-threatening reaction that can result from DRBA use and cause musculoskeletal dysfunction. The aim of this study is to profile patients who have developed DRBA-related movement adverse effects …
Enhancing The Sublingual Permeability Of Atropine Sulfate: Effect Of Ph And Penetration Enhancers,
2019
Nova Southeastern University
Enhancing The Sublingual Permeability Of Atropine Sulfate: Effect Of Ph And Penetration Enhancers, Rawan Saeed Bafail
Student Theses, Dissertations and Capstones
Atropine Sulfate (AS) auto-injector (AtroPen®) is being used as an effective and safe antidote for the treatment of organophosphate (OP) pesticides or nerve gas poisoning. The use of AtroPen® is associated with several drawbacks including: bulky size, availability, affordability, invasiveness, and administration errors. Previously, AS fast disintegrating sublingual tablets (FDSTs) were developed and the feasibility of AS sublingual permeability were demonstrated. However, AS permeability was delayed due to the negative impact of higher doses of AS on FDST’s physical characteristics. Therefore, the aim in this research project was to optimize the previously developed AS FDSTs. It was hypothesized that optimizing …
Bill Gatton College Of Pharmacy Interview Day Booklet - 2019,
2019
East Tennessee State University
Bill Gatton College Of Pharmacy Interview Day Booklet - 2019, Bill Gatton College Of Pharmacy, East Tennessee State University
Bill Gatton College of Pharmacy Miscellaneous Publications
No abstract provided.
The Value Of Universally Available Raw Nmr Data For Transparency, Reproducibility, And Integrity In Natural Product Research.,
2019
Center for Natural Product Technologies, University of Illinois at Chicago
The Value Of Universally Available Raw Nmr Data For Transparency, Reproducibility, And Integrity In Natural Product Research., James B. Mcalpine, Shao-Nong Chen, Andrei Kutateladze, John B. Macmillan, Giovanni Appendino, Andersson Barison, Mehdi A. Beniddir, Maique W. Biavatti, Stefan Bluml, Asmaa Boufridi, Mark S. Butler, Robert J. Capon, Young H. Choi, David Coppage, Phillip Crews, Michael T. Crimmins, Marie Csete, Pradeep Dewapriya, Joseph M. Egan, Mary J. Garson, Grégory Genta-Jouve, William H Gerwick, Harald Gross, Mary Kay Harper, Precilia Hermanto, James M. Hook, Luke Hunter, Damien Jeannerat, Nai-Yun Ji, Tyler A. Johnson, David G. I. Kingston, Hiroyuki Koshino, Hsiau-Wei Lee, Guy Lewin, Jie Li, Roger G Linington, Miaomiao Liu, Kerry L Mcphail, Tadeusz F Molinski, Bradley S Moore, Joo-Won Nam, Ram P Neupane, Matthias Niemitz, Jean-Marc Nuzillard, Nicholas H Oberlies, Fernanda M M Ocampos, Guohui Pan, Ronald J Quinn, D Sai Reddy, Jean-Hugues Renault, José Rivera-Chávez, Wolfgang Robien, Carla M Saunders, Thomas J Schmidt, Christoph Seger, Ben Shen, Christoph Steinbeck, Hermann Stuppner, Sonja Sturm, Orazio Taglialatela-Scafati, Dean J Tantillo, Robert Verpoorte, Bin-Gui Wang, Craig M Williams, Philip G Williams, Julien Wist, Jian-Min Yue, Chen Zhang, Zhengren Xu, Charlotte Simmler, David C Lankin, Jonathan Bisson, Guido F Pauli
Natural Sciences and Mathematics | Faculty Scholarship
With contributions from the global natural product (NP) research community, and continuing the Raw Data Initiative, this review collects a comprehensive demonstration of the immense scientific value of disseminating raw nuclear magnetic resonance (NMR) data, independently of, and in parallel with, classical publishing outlets. A comprehensive compilation of historic to present-day cases as well as contemporary and future applications show that addressing the urgent need for a repository of publicly accessible raw NMR data has the potential to transform natural products (NPs) and associated fields of chemical and biomedical research. The call for advancing open sharing mechanisms for raw data …
The Effects Of Methylphenidate (Ritalin) On The Neurophysiology Of The Monkey Caudal Prefrontal Cortex,
2019
Institut-Hôpital Neurologique de Montréal
The Effects Of Methylphenidate (Ritalin) On The Neurophysiology Of The Monkey Caudal Prefrontal Cortex, Sébastien Tremblay, Florian Pieper, Adam Sachs, Ridha Joober, Julio Martinez-Trujillo
Physiology and Pharmacology Publications
© 2019 Tremblay et al. Methylphenidate (MPH), commonly known as Ritalin, is the most widely prescribed drug worldwide to treat patients with attention deficit disorders. Although MPH is thought to modulate catecholamine neurotransmission in the brain, it remains unclear how these neurochemical effects influence neuronal activity and lead to attentional enhancements. Studies in rodents overwhelmingly point to the lateral prefrontal cortex (LPFC) as a main site of action of MPH. To understand the mechanism of action of MPH in a primate brain, we recorded the responses of neuronal populations using chronic multielectrode arrays implanted in the caudal LPFC of two …
Maternal Protein Restriction During Perinatal Life Affects Lung Mechanics And The Surfactant System During Early Postnatal Life In Female Rats.,
2019
Western University
Maternal Protein Restriction During Perinatal Life Affects Lung Mechanics And The Surfactant System During Early Postnatal Life In Female Rats., Reza Khazaee, Lynda A Mccaig, Cory Yamashita, Daniel B Hardy, Ruud A W Veldhuizen
Physiology and Pharmacology Publications
Limited information is available on how fetal growth retardation (FGR) affects the lung in the neonatal period in males and females. This led us to test the hypothesis that FGR alters lung mechanics and the surfactant system during the neonatal period. To test this hypothesis a model of FGR was utilized in which pregnant rat dams were fed a low protein diet during both the gestation and lactation period. We subsequently analyzed lung mechanics using a FlexiVent ventilator in male and female pups at postnatal day 7 and 21. Lung lavage material was obtained at postnatal day 1, 7 and …
Pharmaceutical Industry's Effect On Socioeconomic Development In Sub-Saharan Africa In Relation To Family Planning Accessibility,
2019
Virginia Commonwealth University
Pharmaceutical Industry's Effect On Socioeconomic Development In Sub-Saharan Africa In Relation To Family Planning Accessibility, Tessa Demarest
AUCTUS: The Journal of Undergraduate Research and Creative Scholarship
There is a large unmet need for family planning services in sub-Saharan Africa (Goodkind et al, 2018). Pharmaceutical companies contribute to the accessibility of medications in developing countries (Cottingham & Berer, 2011). If the pharmaceutical industry strongly affects access to contraceptives in sub-Saharan Africa, then it is possible that adjustments made to the industry would increase access to contraceptives. I explored how contraceptives change the economic and social development of subSaharan Africa to determine if contraception benefits Africans enough for their shortage to be a serious injustice. This is followed by how the pharmaceutical industry affects access to and types …
Optimization And Characterization Of Hot-Melt Extruded Anti-Inflammatory And Local Anesthetic Bio-Adhesive Semisolid Formulation Using Design Of Experiments (Doe),
2019
University of Mississippi
Optimization And Characterization Of Hot-Melt Extruded Anti-Inflammatory And Local Anesthetic Bio-Adhesive Semisolid Formulation Using Design Of Experiments (Doe), Rishi Chinmay Thakkar
Electronic Theses and Dissertations
Hot melt extrusion is a versatile continuous manufacturing process extensively investigated for its applications with production of oral solid dosage forms, the aim of this study was to venture the applicability of HME in continuous manufacturing of topical semi-solid ointment formulations. Novel combination of a topical corticosteroid (Triamcinolone Acetonide) and local anesthetic (Lidocaine hydrochloride) were selected to be formulated with a water-soluble ointment base consisting of PEG 4000, PEG 1500 and Propylene glycol after performing appropriate drug-excipient compatibility studies. To determine the ratios of the solid to liquid components of the macrogol base, ‘quality by design’ approach was employed by …
Insight Into The Dynamics Of Apobec3g Protein In Complexes With Dna Assessed By High Speed Afm,
2019
University of Nebraska Medical Center
Insight Into The Dynamics Of Apobec3g Protein In Complexes With Dna Assessed By High Speed Afm, Yangang Pan, Luda S. Shlyakhtenko, Yuri L. Lyubchenko
Journal Articles: Pharmaceutical Sciences
APOBEC3G (A3G) is a single-stranded DNA (ssDNA) binding protein that restricts the HIV virus by deamination of dC to dU during reverse transcription of the viral genome. A3G has two zinc-binding domains: the N-terminal domain (NTD), which efficiently binds ssDNA, and the C-terminal catalytic domain (CTD), which supports deaminase activity of A3G. Until now, structural information on A3G has been lacking, preventing elucidation of the molecular mechanisms underlying its interaction with ssDNA and deaminase activity. We have recently built a computational model for the full-length A3G monomer and validated its structure using data obtained by time-lapse High-Speed Atomic Force Microscopy …
Snake Bite,
2019
JSS AHER
Snake Bite, Meghna Arora, Rajendra Prasad
Digital Journal of Clinical Medicine
No abstract provided.
Rethinking Consumer Protection: Escaping Death By Regulation,
2019
Embry-Riddle Aeronautical University
Rethinking Consumer Protection: Escaping Death By Regulation, Thomas L. Tacker
Publications
This book is designed to appeal to anyone who is at all interested in topics related to making life better and safer—for all us consumers. Our current approach to consumer protection is extremely flawed; sometimes costing lives rather than saving them. There are better ways to protect ourselves and the people we love.
Are First Generation Immigrants More Inclined To Participate In Clinical Research?,
2019
Eastern Michigan University
Are First Generation Immigrants More Inclined To Participate In Clinical Research?, Aisha Farha
Master's Theses and Doctoral Dissertations
The number of immigrants entering the United States has increased dramatically in the past 30 years, but minorities and ethnic groups are underrepresented in research studies. This study examined first- and second-generation Arab American immigrants in Dearborn, Michigan, using a survey from 65 participants to determine the impact of generation on clinical research participation. Fifty-one (78%) of the respondents were first-generation immigrants, and 14 (22%) were second generation. There was no statistical difference between first- and second-generation immigrants in their willingness to participate in clinical research. Further research with a larger and more diverse population is needed to evaluate willingness …
Car T Cells As A Patentable Therapeutic,
2019
Rollins College
Car T Cells As A Patentable Therapeutic, Mckenzie List
Honors Program Theses
The development of a therapeutic to treat a particular disease is a complicated process that incorporates numerous components such as drug discovery, clinical trials, FDA approval and patentability. In the last two decades, cancer research and development has shifted from identifying small molecule therapeutic agents to focusing research on a novel approach designated as immunotherapy. Today, immunotherapy has progressed from a twentieth century scientific theory into an innovative treatment to cancer. In particular, CAR T cells have demonstrated therapeutic properties for certain types of cancers, but these living cells are not compatible with the traditional therapeutic model. First, the drug …
Addressing Drug Misuse On A College Campus: An Academic And Resource Driven Approach,
2019
Butler University
Addressing Drug Misuse On A College Campus: An Academic And Resource Driven Approach, Deborah Ebbinghaus
Undergraduate Honors Thesis Collection
In recent years, the United States has experienced an epidemic of drug misuse. Many studies have indicated those in the typical college age demographic of eighteen to twenty-five years of age are particularly at risk. This research examines prescription drug misuse on college campuses, with the aim of proposing additional resources for the University. It has three components: a literature analysis, a policy, procedure, and resource review, and new resource development. The literature review will examine journal articles published after January 1, 2010 related to prescription misuse in collegians. It also examines state and university specific data. The policy, procedure, …
Actionable Patient Safety Solutions (Apss) #3a: Medication Errors,
2019
Chapman University
Actionable Patient Safety Solutions (Apss) #3a: Medication Errors, Ron Jordan, Jerika Lam, Peter Antevy, Steven Barker, Linda Beneze, Michel Bennett, Laressa Bethishou, Jim Broselow, John Burnam, Mitchell Goldenstein, Kari Hamlin, Helen Haskell, Christopher Jerry, Edwin Loftin, Ariana Longley, Jacob Lopez, Anne Lyren, Brendan Miney, Sidney Morice, Steve Mullenix, Robert Nickell, Rochelle Sandell, David Shane Lowry, Robin Shannon, Deeba Siddiqui, Charles Simmons, Nat Sims, Robert Stein, Laura Townsend, Jason Yamaki, Sun Yang
Pharmacy Faculty Articles and Research
A medication error is a preventable event in any healthcare setting that may lead to inappropriate medication use while in the control of the healthcare professional or patient, ultimately leading to patient harm and/or death. Medication errors can be classified into five categories: 1) wrong drug, 2) wrong dose, 3) wrong route, 4) wrong frequency and/or 5) wrong patient.
Safety Constraint Optimization Of Combination Drug Therapy In Hypertension Clinical Trials,
2019
Georgia Southern University
Safety Constraint Optimization Of Combination Drug Therapy In Hypertension Clinical Trials, Victor Chukwu
College of Graduate Studies: Theses & Dissertations
In Clinical Practice, combination drug therapy has become common in treating many disease conditions. The purpose of these combinations is often to ensure optimal efficacy and to reduce adverse effects that may arise from monotherapy. Clinical trials have also been conducted to ensure efficacy and safety of these combinations before they are introduced into the market. However, adverse effects still occur with combination therapies. The objective of this study is to (1) To determine a region of optimum doses of Drug A and Drug B in combination while focusing on efficacy alone (2) To determine a region of optimum doses …
Design, Synthesis, And Evaluation Of Gunw-3 As A Brain Targeting Agent,
2019
South Dakota State University
Design, Synthesis, And Evaluation Of Gunw-3 As A Brain Targeting Agent, Asim Najmi
Electronic Theses and Dissertations
The blood brain barrier (BBB) is a barrier in the brain that separates the peripheral blood circulation system from the central nerve system (CNS). The barrier effectively protects the brain from xenobiotics. The BBB serves as a physical barrier through the tight junction of endothelial cells that were found to be 50-100 times tighter than that of normal endothelial cells. Different drug efflux pumps such as P-glycoproteins and multidrug-resistance proteins are found to be overdistributed on the BBB. These drug efflux pumps help pump xenobiotics out if they enter the cells and serv as an additional mechanism to prevent xenobiotics …
Nutritional Transporter Mediated Drug Delivery For Cancer,
2019
South Dakota State University
Nutritional Transporter Mediated Drug Delivery For Cancer, Siddharth S. Kesharwani
Electronic Theses and Dissertations
Recent advancements in nanotechnology have unfolded novel opportunities in medicine, especially in targeted therapeutics and imaging for cancer. However, the majority of the existing nanotechnologies for cancer suffer from shortcomings such as (i) rapid elimination from the systemic circulation before reaching the cancer tissue. (ii) poor tumor accumulation, targeting, and penetration due to inadequate vasculature and extensive extracellular matrix in the tumor. Thus, overcoming these two limitations of nanotechnology is of considerable interests for cancer researchers. In this dissertation, we demonstrate the feasibility of glucose-modified nanoparticles (GLU-NPs) as an efficient cancer targeted-delivery system for enhancing the systemic circulation time and …
Development Of A Novel Nanotechnology-Based Vaccine Adjuvant And Delivery System For Systemic And Mucosal Immunity,
2019
South Dakota State University
Development Of A Novel Nanotechnology-Based Vaccine Adjuvant And Delivery System For Systemic And Mucosal Immunity, Mohammed Ali Bakkari
Electronic Theses and Dissertations
Many serious infections for which there are no existing vaccines, enter by a mucosal route such as HIV, influenza, and tuberculosis, etc. Therefore, designing safe and effective mucosal vaccines that elicit robust immune response at mucosal sites is still a major challenge without a safe mucosal adjuvant. Previously, our laboratory had discovered inulin acetate as a novel toll-like-receptor-4 agonist (adjuvant). The study in this dissertation explored the application of nanoparticles prepared with inulin acetate (InAc-NPs) as a vaccine adjuvant and delivery system for enhancing mucosal immunity. The rationale behind selecting InAc-NPs is their proven ability to activate strong systemic immunity …
Assessment And Analysis Of H.Pylori Infection Treatment Strategies Of St. Vincent Hospital's Family And Internal Medicine Clinics,
2019
Butler University
Assessment And Analysis Of H.Pylori Infection Treatment Strategies Of St. Vincent Hospital's Family And Internal Medicine Clinics, Rebecca Orr
Undergraduate Honors Thesis Collection
Helicobacter pylori is a gram-negative bacteria that is responsible for causing chronic gastritis, ulcers in the stomach and intestine, and eventually even gastric lymphoma or cancer. Multiple treatment options have been recommended for treating an H. pylori infection based on kidney function, previous antibiotic exposure, and whether or not the infection is recurrent. The most common regimens used at St. Vincent's primary care centers closely mimic the American College of Gastroenterology's clinical guidelines. However, these medications (clarithromycin and levofloxacin) have been associated with high rates of resistance in other countries. The United States has very limited data on H. pylori's …
