Pharmacy and Pharmaceutical Sciences Commons^™

Characterizing The Public Sector Contribution To Drug Discovery And Development: The Role Of Government As A First Investor, Ekaterina Galkina Cleary, Matthew Jackson, Andrew Acevedo, Fred D. Ledley

CISI Publication

This research is focused on examining the role of the public sector as an early investor in biopharmaceutical discovery and development. In the United States, the National Institutes of Health (NIH) is the primary source of funding for basic biomedical research designed to elucidate fundamental mechanisms of biology, health, and disease. This research is expected to establish the scientific foundation for the discovery and development of new biopharmaceutical products. This interim report reviews the linear model of innovation underlying these expectations, and evidence for the effectiveness of this pathway. We also describe new data demonstrating that every new drug approved …

Serum Amyloid A Is Not Incorporated Into Hdl During Hdl Biogenesis, Ailing Ji, Xuebing Wang, Victoria P. Noffsinger, Drew Jennings, Maria C. De Beer, Frederick C. De Beer, Lisa R. Tannock, Nancy R. Webb

Saha Cardiovascular Research Center Faculty Publications

Liver-derived serum amyloid A (SAA) is present in plasma where it is mainly associated with HDL and from which it is cleared more rapidly than are the other major HDL-associated apolipoproteins. Although evidence suggests that lipid-free and HDL-associated forms of SAA have different activities, the pathways by which SAA associates and disassociates with HDL are poorly understood. In this study, we investigated SAA lipidation by hepatocytes and how this lipidation relates to the formation of nascent HDL particles. We also examined hepatocyte-mediated clearance of lipid-free and HDL-associated SAA. We prepared hepatocytes from mice injected with lipopolysaccharide or an SAA-expressing adenoviral …

Over-The-Counter Availability Of Levonorgestrel Emergency Contraception In Pharmacies On Oahu, Jennifer Chin, Jennifer Salcedo, Shandhini Raidoo

School of Medicine Publications

Since the United States Food and Drug Administration’s approval of over-the-counter levonorgestrel emergency contraception, access to this time-sensitive medication has improved. However, multiple barriers, including the cost of the medication and pharmacy availability, still exist. The objective of this study was to determine the over-the-counter availability of levonorgestrel emergency contraception in pharmacies on Oahu, Hawaii. We conducted a cross-sectional population-based study using in-person simulated patient encounters at all pharmacies on Oahu. Out of 109 chain pharmacies and 13 independent pharmacies, 102 (84%) pharmacies had levonorgestrel emergency contraception available over the counter. Of pharmacies in which it was available, 12.7% required …

Bone Marrow Concentrate (Bmc) Therapy In Musculoskeletal Disorders: Evidence-Based Policy Position Statement Of American Society Of Interventional Pain Physicians (Asipp), Laxmaiah Manchikanti, Christopher J. Centeno, Sairam Atluri, Sheri L. Albers, Shane Shapiro, Gerard A. Malanga, Alaa Abd-Elsayed, Mairin Jerome, Joshua A. Hirsch, Alan David Kaye, Steve M. Aydin, Douglas Beall, Don Buford, Joanne Borg-Stein, Ricardo M. Buenaventura, Joseph A. Cabaret, Aaron K. Calodney, Kenneth D. Candido, Cameron Cartier, Richard Latchaw, Sudhir Diwan, Ehren Dodson, Zachary Fausel, Michael Fredericson, Christopher G. Gharibo, Mayank Gupta, Adam M. Kaye, Nebojsa Nick Knezevic, Radomir Kosanovic, Matthew Lucas, Maanasa V. Manchikanti, R. Amadeus Mason, Kenneth Mautner, Samuel Murala, Annu Navani, Vidyasagar Pampati, Sarah Pastoriza, Ramarao Pasupuleti, Cyril Philip, Mahendra R Sanapati, Theodore Sand, Rinoo V Shah, Amol Soin, Ian Stemper, Bradley W Wargo, Philippe Hernigou

School of Pharmacy Faculty Articles

BACKGROUND: The use of bone marrow concentrate (BMC) for treatment of musculoskeletal disorders has become increasingly popular over the last several years, as technology has improved along with the need for better solutions for these pathologies. The use of cellular tissue raises a number of issues regarding the US Food and Drug Administration's (FDA) regulation in classifying these treatments as a drug versus just autologous tissue transplantation. In the case of BMC in musculoskeletal and spine care, this determination will likely hinge on whether BMC is homologous to the musculoskeletal system and spine.

OBJECTIVES: The aim of this review is …

Immunogenicity In Clinical Practice And Drug Development: When Is It Significant?, Valentina Shakhnovich, Bernd Meibohm, Amy Rosenberg, Andrzej M. Kierzek, Rachel Hasenkamp, Ryan S. Funk, Craig J. Thalhauser, Piet H. Van Der Graaf, Yow Ming C. Wang, Lora Hamuro

Manuscripts, Articles, Book Chapters and Other Papers

No abstract provided.

Evaluation Of Acute Myeloid Leukemia Induction Regimens In Elderly Patients With Unfavorable Risk Cytogenetics That Are Candidates For Intensive Remission Therapy, Monica Tadros, Guenther Koehne, Talia Zahra, Moe Shwin, Jessica Unzaga, Nicholas Chow

All Publications

No abstract provided.

School Of Pharmacy Intellectual Property Report Fy20, Second Quarter Report, Soumyajit Majumdar

U. S. Patents, School of Pharmacy

School of Pharmacy Intellectual Property Report FY20, Second Quarter Report (as of 12/31/2019)

Unexpected Cell Type-Dependent Effects Of Autophagy On Polyglutamine Aggregation Revealed By Natural Genetic Variation In C. Elegans., J Alexander-Floyd, S Haroon, M Ying, A A Entezari, C Jaeger, M Vermulst, T Gidalevitz

Department of Pharmacology and Experimental Therapeutics Faculty Papers

BACKGROUND: Monogenic protein aggregation diseases, in addition to cell selectivity, exhibit clinical variation in the age of onset and progression, driven in part by inter-individual genetic variation. While natural genetic variants may pinpoint plastic networks amenable to intervention, the mechanisms by which they impact individual susceptibility to proteotoxicity are still largely unknown.

RESULTS: We have previously shown that natural variation modifies polyglutamine (polyQ) aggregation phenotypes in C. elegans muscle cells. Here, we find that a genomic locus from C. elegans wild isolate DR1350 causes two genetically separable aggregation phenotypes, without changing the basal activity of muscle proteostasis pathways known to …

Molecular Basis For Activation And Biased Signaling At The Thrombin-Activated Gpcr Proteinase Activated Receptor-4 (Par4), Pierre E. Thibeault, Jordan C. Lesarge, D'Arcy Arends, Michaela Fernandes, Peter Chidiac, Peter B. Stathopulos, Leonard G. Luyt, Rithwik Ramachandran

Physiology and Pharmacology Publications

© 2020 Thibeault et al. Proteinase-activated receptor (PAR)-4 is a member of the proteolytically-activated PAR family of G-protein– coupled receptors (GPCR) that represents an important target in the development of anti-platelet therapeutics. PARs are activated by proteolytic cleavage of their receptor N terminus by enzymes such as thrombin, trypsin, and cathepsin-G. This reveals the receptor-activating motif, termed the tethered ligand that binds intramolecularly to the receptor and triggers signaling. However, PARs are also activated by exogenous application of synthetic peptides derived from the tethered-ligand sequence. To better understand the molecular basis for PAR4-dependent signaling, we examined PAR4-signaling responses to a …

An Interprofessional Approach To A Service-Learning Health Project For Area Homeless: A Case Study, Caroline Carpenter, Samuel T. Shannon, Jana P. Sutton, Theresa D. Thomas, John R. Webb, Ashley Wiltcher, Rhonda Hensley

Journal of Interprofessional Practice and Collaboration

Providing health care services for the homeless community requires multiple health care disciplines to meet the varying needs of the community. The needs of the homeless are multifaceted and thus require expertise of an interprofessional team to help break down barriers and achieve positive outcomes for the clients served. This case study shares the work done by a team of faculty and students from a local university in Marriage and Family Therapy, Counseling, and graduate nursing. The focus of the group was to provide physical and mental health screenings and make appropriate community referrals as needed. The work was sponsored …

A Patient-Centered Right Care Approach To Sudden Infant Death Syndrome Prevention In A Rural Clinic, Caroline Carpenter

Journal of Interprofessional Practice and Collaboration

Background: Nationally, sudden infant death syndrome (SIDS) is the leading cause of death among babies 1 to 12 months of age, and many of these deaths are a result of sleep-related accidental suffocation while in an unsafe sleeping environment.

Local Problem: Baseline data from a chart audit at a rural clinic showed that only 80% of parents were placing infants on their backs for sleep, and there was no standardization among providers for teaching safe sleep practices. The aim of this project was to implement right care for SIDS prevention at newborn wellness visits 80% of the time within 90 …

Ethical Considerations When Conducting Research With Older Adults, Karen Arrant

Journal of Interprofessional Practice and Collaboration

The ethical issue exists between the researcher’s passion for the study focus and the human rights of the participant. This manuscript provides a case study, an actual illustration, but names were changed to protect anonymity. Objectives include examining the researcher’s perspective and personal beliefs, identifying the process to recruit participants, the ethical manner to disseminate information, and identifying ethical principles during the study process.It is mandatory that minute attention is given to the details of caring for the safety and welfare of study participants.

Ethics In Research, Karen Arrant

Journal of Interprofessional Practice and Collaboration

Due to a history of unethical research studies, ethical codes were developed to address the treatment of humans during research. After World War II, the Nuremberg Code was developed to prevent research misconduct by establishing specific protective criteria for human subjects. The Belmont Report, developed in 1978 in the United States, regulates studies today. The Belmont Report contains three basic ethical principles: (1) respect for persons, (2) beneficence, and (3) justice. The Belmont Report provides research-based protective implementation for informed consent, risk/benefit assessment, and participant selection. This case study demonstrates how to implement ethical standards successfully during research with human …

The Lived Experience Of Pregnancy As A Black Woman In America: A Descriptive Phenomenological Case Study, Jodie C. Gary, Sharon L. Dormire, Jamil Norman, Idethia S. Harvey Drph

Journal of Interprofessional Practice and Collaboration

PURPOSE: Health disparities in childbearing black women in the United States have continued through multiple decades despite overall improvements in pregnancy-related outcomes for other ethnicities. Pregnancy outcomes for black women include greater risks of maternal mortality, severe morbidity, as well as preterm and low birthweight infants. From a person-centered perspective, the description of the lived experiences of adversity for pregnant black women is missing from the literature. This omission is believed to attribute to the continued health disparities in this population.

METHODS: While the study was originally designed using focus group methodology for data collection for a larger number of …

Parents Of Children With Physical Impairments And Their Relationship With Intervention Team Members: A Case Study, Patti Calk

Journal of Interprofessional Practice and Collaboration

Aim. Historically, parents of children with disabilities report mixed views of their relationship with their children’s intervention team. The author was interested in ascertaining reasons for positive and negative interactions and ways to improve collaboration and teamwork.

Methods. A qualitative study was conducted utilizing interviews with three mothers of children considered multi-handicapped. The subjects were chosen from a purposive, convenience sample. Data was coded into recurrent themes.

Results. Mothers of children with disabilities indicated that the attitude of the professionals, communication among team members, and listening behaviors contribute to the formation of a positive or negative parent-professional …

Autocatalytic Tissue Polymerization Reaction Mechanism In Colorectal Cancer Development And Growth., Bruce M Boman, Arthur Guetter, Ryan M Boman, Olaf A Runquist

Department of Pharmacology and Experimental Therapeutics Faculty Papers

The goal of our study was to measure the kinetics of human colorectal cancer (CRC) development in order to identify aberrant mechanisms in tissue dynamics and processes that contribute to colon tumorigenesis. The kinetics of tumor development were investigated using age-at-tumor diagnosis (adenomas and CRCs) of familial adenomatous coli (FAP) patients and sporadic CRC patients. Plots of age-at-tumor diagnosis data as a function of age showed a distinct sigmoidal-shaped curve that is characteristic of an autocatalytic reaction. Consequently, we performed logistics function analysis and found an excellent fit (p < 0.05) of the logistic equation to the curves for age-at-tumor diagnoses. These findings indicate that the tissue mechanism that becomes altered in CRC development and growth involves an autocatalytic reaction. We conjecture that colonic epithelium normally functions as a polymer of cells which dynamically maintains itself in a steady state through an autocatalytic polymerization mechanism. Further, in FAP and sporadic CRC patients, mutation in the adenomatous polyposis coli (APC) gene increases autocatalytic tissue polymerization and induces tumor …

Effects Of Compaction Pressure, Speed And Punch Head Profile On The Ultrasonically-Extracted Physical Properties Of Pharmaceutical Compacts, Xiaochi Xu, Yigitcan Coskunturk, Vivek S. Dave, Justin V. Kuriyilel, Murray F. Wright, Rutesh H. Dave, Centin Cetinkaya

Pharmacy Faculty/Staff Publications

Despite a well-established manufacturing-process understanding, tablet quality issues are frequently encountered during various stages of drug-product development. Compact breaking force (tensile strength), capping and friability are among the commonly observed characteristics that determine the integrity, quality and manufacturability of tablets. In current study, a design space of the compaction pressure, compaction speed and head flat types is introduced for solid dosage compacts prepared from pure silicified microcrystalline cellulose, a popular tableting excipient. In the reported experiments, five types of head flat types at six compaction pressure levels and two compaction speeds were employed and their effects on compact mechanical properties …

Opioids In The Las Vegas Metro, Elia Del Carmen Solano-Patricio, Caitlin Saladino, William E. Brown

Health

In 2014, Nevada was one of 7 states selected to participate in a national policy coalition to reduce prescription drug abuse. As a result, the Nevada Department of Health and Human Services (DHHS) and the Southern Nevada Health District (SNHD) created a data dashboard to track opioid prescriptions and opioid-involved overdose incidents. This Fact Sheet synthesizes state-level data from the Nevada Opioid Overdose Surveillance Dashboard and focuses on the Las Vegas Metropolitan Statistical Area (MSA). The data track opioid prescription rates as they correlate to opioid-involved overdose deaths, emergency room visits, and hospitalizations.

Pcsk9 Inhibitors In Secondary Prevention – An Opportunity For Personalized Therapy, Chase Board, Michael S. Kelly, Michael D. Shapiro, Dave L. Dixon

Pharmacy Faculty Articles and Research

Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of death worldwide. Low-density lipoprotein cholesterol (LDL-C) is the primary cause of ASCVD and reducing LDL-C levels with statin therapy significantly reduces ASCVD risk; however, significant residual risk remains. Two monoclonal antibodies (mAbs), alirocumab and evolocumab, that target proprotein convertase subtilisin/kexin-type 9 (PCSK9), reduce LDL-C levels by up to 60% when used in combination with statins and significantly reduce the risk of recurrent ASCVD events in both stable secondary prevention and acute coronary syndrome populations. Pre-specified analyses of recent randomized controlled trials have shed light on how best to prioritize these therapies …

Opioids In Nevada, Peter Grema, Caitlin Saladino, William E. Brown

Health

This Fact Sheet presents data from the Washington Post’s Drug Enforcement Administration (DEA) database on opioid shipments in the United States and provides information pertaining to Nevada and each of its 17 regions (16 counties and one independent city). This Fact Sheet compares the Washington Post’s opioid shipment data with opioid prescription rates relative to Nevada’s population in 2010.