Pharmacy and Pharmaceutical Sciences Commons^™

Impact Of Clinical Pharmacist Medication Review Upon Enrollment In A Program For All-Inclusive Care Of The Elderly (Pace), Adam Olesen, Kristen Wendell

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2020

Impact of clinical pharmacist medication review upon enrollment in a Program of All-Inclusive Care for the Elderly (PACE)

Adam Olesen, PharmD, PGY1 Resident
Kristen Wendell, PharmD, BCGP

Providence Elderplace Oregon

Learning Objective:

Describe the interventions and recommendations made by a pharmacist upon enrollment of a new participant at a PACE facility.

Abstract:

Pharmacists have been proven to be beneficial in the transitions of care for high-risk patients with multiple morbidities, such as the reduction of both polypharmacy and thirty-day readmission rates. The objective of this study is to quantify and characterize the total number and type of interventions and recommendations …

Evaluation Of Surgical Antibiotic Prophylaxis At A Large, Tertiary Medical Center, Emily Fox, Brent Footer, Angel Mendez

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2020

Emily Fox, PharmD, PGY-1 Pharmacy Resident

Brent Footer, PharmD, BCPS; Angel Mendez, Pharmacy Student

Providence Portland Medical Center, Portland, Oregon

Evaluation of surgical antibiotic prophylaxis at a large, tertiary medical center

Surgical site infections (SSI) are a significant cause of morbidity, prolonged hospitalization, and mortality. The cost of a single SSI is estimated to be upward of $25,000 and increases a patient’s length of hospital stay by ~10 days. Our institution has identified inappropriate or less than optimal antimicrobial prophylaxis as a potential contributor in several recent SSI cases. Current literature on this topic has found that there may be …

Implementing A Simplified Targeted Feedback Method To Reduce Fluoroquinolone Prescriptions In Emergency Departments, Minh Le, Alyssa Christensen, Brent Footer

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2020

Minh Le, PharmD

Alyssa Christensen, PharmD, BCIDP, Brent Footer, PharmD, BCPS

Providence Health System, Oregon

Implementing a simplified targeted feedback method to reduce fluoroquinolone prescriptions in emergency departments

Background: The CDC has proclaimed antibiotic resistance to be one of the biggest public health challenges of our time. Although fluoroquinolones (FQs) are among the most widely prescribed antibiotics in the ambulatory setting, there have been recent efforts to reduce their usage due to mounting concerns regarding their safety profile and resistance patterns. Provider audit-and-feedback has been shown to be among the most effective antimicrobial stewardship interventions, but the auditing process …

Evaluation Of Guideline-Directed Medication Therapy For Heart Failure With Reduced Ejection Fraction Patients At Discharge On 30-Day Readmission Rates At Two Tertiary Healthcare Centers, Jacqueline Hesse, Yan Xu, Meri Slavica, James E. Watkins, Alan Rankin, Joshua Remick

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2020

Evaluation of Guideline-Directed Medication Therapy for Heart Failure with Reduced Ejection Fraction Patients at Discharge on 30-Day Readmission Rates at Two Tertiary Healthcare Centers

Principal Investigator: Jacqueline Hesse, Pharm.D.

Preceptors: Yan Xu, Pharm.D., BCPS, BCCP; Meri Slavica, Ph.D., BCPS

Pharmacy Student: James Watkins, 2020 Pharm.D. Candidate

Sub-Investigators: Alan Rankin, MD; Joshua Remick, MD

Background:

Heart failure with reduced ejection fraction (HFrEF) is a chronic, progressive disease leading to symptoms such as dyspnea, cough, edema, fatigue, and exercise intolerance. The use of anangiotensin converting enzyme inhibitor (ACEi), angiotensin II receptor blocker (ARB), or angiotensin receptor-neprilysin inhibitor (ARNI) in combination with an …

Evaluating The Utility Of Cyp2c19 Genetic Testing For P2y12 Inhibitor Prescribing Within An Inpatient Setting, Thomas E. Maslo, Carolynn Null

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2020

Thomas Maslo, PharmD, PGY-1 Pharmacy Resident

Carolynn Null, PharmD

Providence Portland Medical Center, Portland, Oregon

Evaluating the utility of CYP2C19 genetic testing for P2Y12 inhibitor prescribing within an inpatient setting

The emergence of pharmacogenomics offers the opportunity to practice precision medicine across health care. In patients presenting with acute coronary syndrome (ACS) and undergoing percutaneous coronary intervention (PCI), dual antiplatelet therapy (DAPT) is routinely prescribed for 12 months. DAPT consists of a P2Y12 inhibitor (clopidogrel, ticagrelor, or prasugrel) plus aspirin. Of the P2Y12 inhibitors, clopidogrel is uniquely impacted by CYP2C19 status. About 30% of the North American population carry at …

Education Of Heparin Per Pharmacy Guidelines To Increase Compliance, Safety, And Pharmacists’ Management Of Heparin Infusions, Christopher Truong, Braxton Mehl

Providence Pharmacy PGY1 Program at Providence Medford 2020

Presentation Title: Education of heparin per pharmacy guidelines to increase compliance, safety, and pharmacists’ management of heparin infusions

Authors: Christopher Truong, PharmD and Braxton Mehl, PharmD, BCCCP

Facility: Providence Medford Medical Center

Background: Element of Performance 4 of The Joint Commission’s National Patient Safety Goal 03.05.01 requires that hospitals have a written policy that addresses the need for baseline and ongoing laboratory tests to monitor and adjust anticoagulant therapy. Our hospital has a written Anticoagulation Management General Operating Policy for heparin orders managed through nursing or pharmacy. Currently, most heparin orders are nurse-managed and have resulted in lab and dosing …

Antinéoplasiques En Milieu Hospitalier : Étude Pilote Sur L’Exposition Potentielle Du Personnel D’Hygiène Et De Salubrité, France Labrèche, Capucine Ouellet, Brigitte Roberge, Ahmed Yennek, Nicolas Caron

Rapports de recherche scientifique

Certains antinéoplasiques (ANP), utilisés pour le traitement du cancer, sont eux-mêmes classés cancérogènes et peuvent avoir d’autres effets toxiques chez des travailleurs qui les manipulent. L’incidence du cancer et le nombre de personnes vivant avec le cancer ne cessent d’augmenter, ce qui permet d’envisager une augmentation des quantités d’ANP utilisées et du nombre de travailleurs potentiellement exposés. Une étude menée par l’Unité de recherche en pratique pharmaceutique du Centre hospitalier universitaire Ste-Justine a montré que plusieurs prélèvements effectués sur des surfaces touchées par le personnel infirmier et par celui de la pharmacie montraient des résidus d’ANP. Il n’y a cependant …

Demographics Of Opioid Prescriptions, Isaac Linton, Simon Condliffe

Economics & Finance Student Work

The author ran Linear Probability Model and Logistic Model regressions on data from the 2017 Medical Expenditures Panel Survey to determine demographics of opioid prescriptions. The dependent variable was opioid prescription received (Y/N) and independent variables included age, education level, relative income, race, insurance status, etc. Results of the regressions showed that people with public or private insurance are more likely to be prescribed an opioid, that the problem mainly affects white people, and that as educational attainment increases, likelihood of opioid prescription decreases.

Development And Characterization Of Selective Cb2r Inverse Agonists As A Novel Anti-Inflammatory Therapy For Neuroinflammation – Mechanisms Of Action In Murine And Human Microglia Models Provide Valuable Insights Into Their Therapeutic Potential, Sahar Saleh Alghamdi

Theses and Dissertations (ETD)

Introduction: Recently, research has revealed the presence of cannabinoid receptor 2 (CB2R) in the central nervous system (CNS); since then, the receptor has emerged as a promising therapeutic target for treating multiple neurodegenerative diseases (NDD) such as Alzheimer’s (AD), Parkinson’s (PD), Human Immunodeficiency Virus (HIV) and Multiple Sclerosis (MS). The restricted and upregulated expression of CB2R in activated microglia and lack of psychotropic activity make this receptor an attractive target for discovering novel therapy to treat neuroinflammatory diseases for which there is currently no curative treatment. Methodology: A library of compounds were synthesized and evaluated in ACTOne and TANGO-bla functional …

Annual Evaluation Of The Student's Perception Of The Value Of Writing Goals, Renee Kuess

ONU Student Research Colloquium

Focus: This study focused on pharmacy students’ perception of the value of writing goals and how this perception changes as students progress in the program.

Methods: Annually, all students in the pharmacy program are required to reflect on the previous year’s goals and develop new goals. Following this assignment, a survey was sent out to a random sample (n=162) of students. Based on the feedback, the response was classified as indicating “value” or “no value”.

Results: Of the 162 surveys sent out, there were 78 completed responses. 56.25% of responses indicated the student found “value” in the assignment. The data …

Gauging Interest In An Elective Course To Further Careers In Healthcare Academia, Karielle Shaffery

ONU Student Research Colloquium

There has been continuous growth in the number of pharmacy schools, which has led to an expanded need for pharmacy faculty members. Although there is a recognized and unmet need for such faculty, the topic of pharmacy academia is sparsely addressed in pharmacy programs. Integrating students in an elective teaching course during their didactic education, prior to determination of their career path, could inspire more students to take on the role of an educator. Ideally, allowing students to have first-hand experience in academia focused activities and exposing them to the responsibilities of an academician could peak interest in this area. …

“Put Me In Coach!”: How Pharmacists Can Contribute To Elite Sports, Mel Sturgill

BU Well

Professional and amateur athletes alike often have teams of healthcare professionals that oversee the care of injuries. Among these healthcare professionals, pharmacists have not been included as a member of the care team. Pharmacists are medication experts that can help mitigate medication mistakes and adverse reactions. Additionally, the pharmacist can provide medication information and doping awareness to help athletes reach and maintain their top performance levels in a healthy and safe manner.

Stress: The Silent Sickness, Neethu George

BU Well

From cramming for a test to arguing with a friend, individuals experience stress every day. While stress can be beneficial in certain situations, letting stress get out of control can lead to a variety of mental and physical health issues. This article examines the different types of stress, ways to cope with stress, and the overall effect of stress on human health.

Pharmacist-Driven Culture And Sexually Transmitted Infection Testing Follow-Up Program In The Emergency Department, Stephanie C. Shealy, Christine Alexander, Tina Grof Hardison, Joseph Magagnoli, Julie Ann Justo, Caroline Derrick, Joseph Kohn, Hana Rac Winders, Troy Privette, Majdi N. Al-Hasan, P. Brandon Bookstaver

Faculty Publications

Expanding pharmacist-driven antimicrobial stewardship efforts in the emergency department (ED) can improve antibiotic management for both admitted and discharged patients. We piloted a pharmacist-driven culture and rapid diagnostic technology (RDT) follow-up program in patients discharged from the ED. This was a single-center, pre- and post-implementation, cohort study examining the impact of a pharmacist-driven culture/RDT follow-up program in the ED. Adult patients discharged from the ED with subsequent positive cultures and/or RDT during the pre- (21 August 2018–18 November 2018) and post-implementation (19 November 2018–15 February 2019) periods were screened for inclusion. The primary endpoints were time from ED discharge to …

The Urban/Rural Divide In Access To Medication-Assisted Treatment For Opioid Use Disorder In Utah, Debasree Dasgupta, Erin Fanning Madden, Sandra H. Sulzer, Timothy Light, Michelle Chapoose, Suzanne Prevedel

All Current Publications

Death by drug poisoning is the leading cause of death due to injury in the state of Utah (UDOH, 2014). From 2013-2015, Utah ranked seventh in the nation for drug overdose deaths, the majority of which were opioid-related (CDC, 2018a). In 2017, the age-adjusted mortality rate from drug overdose in Utah was 15.5 per 100,000, putting the state above the national average of 14.9 per 100,000 (CDC, 2018b). Opioid overdose death rates in most of rural Utah far exceeds rates across the urban counties of the state. The higher rates of deaths in rural Utah is indeed concerning. Evidence indicates …

Vaccines In Current Culture: The Hpv Vaccine Controversy, Alyssa Johnston

Senior Honors Theses

The use of vaccinations has drastically decreased mortality and morbidity rates related to infectious disease and has become an intrinsic part of modern health care. However, the fear of risks related to vaccines has been partially responsible for the decisions of many parents to delay or avoid vaccinating their children. The human papilloma virus (HPV) vaccine specifically is one of the most controversial vaccines in current culture due to reports of new onset or exacerbation of autoimmune diseases, infertility, and even death following its administration. This review synthesizes information regarding the relevance and safety of the HPV vaccine, as well …

The Pediatric Anti-Viral Immune Response Impairs Neural Stem/Progenitor Cell Activity, Yashika Kamte, Manisha N. Chandwani, Lauren A. O'Donnell

Graduate Student Research Symposium

The neuropathological outcomes of a viral infection in the brain are often age-dependent. Infection of the immature CNS can lead to impairment of neural/stem progenitor cell (NSPCs) activity. NSPCs are multi-potent progenitor cells of the CNS and are responsible for populating the brain with neurons, astrocytes, and oligodendrocytes during development. Viral infections may alter NSPC activity via two mechanisms; directly by infection of the NSPC or indirectly due to the anti-viral immune response. Here, we examined the impact of a neurotropic infection on NSPC activity in pediatric mice (postnatal day 10), where brain and immune system development is ongoing. In …

Maternal Exposure To Δ9-Tetrahydrocannabinol Impairs Female Offspring Glucose Homeostasis And Endocrine Pancreatic Development In The Rat., Ryan Gillies, Kendrick Lee, Sebastian Vanin, Steven R Laviolette, Alison C Holloway, Edith Arany, Daniel B Hardy

Physiology and Pharmacology Publications

Recent reports indicate that 7% of pregnant mothers in North America use cannabis. This is concerning given that in utero exposure to Δ9-tetrahydrocannabinol (Δ9-THC), the main psychoactive component in cannabis, causes fetal growth restriction and may alter replication and survival of pancreatic β-cells in the offspring. Accordingly, we hypothesized that maternal exposure to Δ9-THC during pregnancy would impair postnatal glucometabolic health of offspring. To test this hypothesis, pregnant Wistar rats were treated with daily intraperitoneal injections of either 3 mg/kg Δ9-THC or vehicle from gestational day 6 to birth. Offspring were subsequently challenged with glucose and insulin at 5 months …

Prevalence Of Syphilis Disease Throughout Some Expatriate Workers In Iraq, Israa Mamdooh Subhi, Abdul-Raheem Yahya Mahdi

Al-Esraa University College Journal for Medical Sciences

Syphilis is a sexually transmitted infection caused by the spirochete Treponema pallidum. Syphilis has been a major infection in man throughout recorded history and has challenged clinicians with its many clinical manifestations. It can also spread to other people by kissing or close body contact. The disease begins with sores and then could spread to other parts of the body through its stages (primary, secondary, tertiary and latent stages) and can also reach the heart and nervous system, and it may be fatal. The data on this disease in Iraq is limited and literature is scanty. A total of 70 …

Nefopam Versus Ketorolac For Post-Operative Pain Control In Cesarean Section, Shireen Kh Almuradi, Ali H. Mosleh, Ghison Ik Al-Adal

Al-Esraa University College Journal for Medical Sciences

More than 230 million people undergo surgery each year worldwide, and the number is increasing annually. Surgery commonly causes postoperative pain that should be alleviated as soon and as effectively as possible to reduce suffering, promote the healing process and rehabilitation, and prevent complications. However, clinical pain management after surgery remains far from successful despite the dramatically increased scientific evidence in this area. Many patients suffer from severe pain after surgery. Aim: The aim of this study is to compare between ketorolac and nefopam when administered intravenously as post-operative analgesia in cesarean section. Patients and methods: 60 patients, who were …