Pharmacy and Pharmaceutical Sciences Commons^™

Development Of Ethanolic Extract Of Pinang Masak Jambi (Areca Catechu L.) As A Modulator Of Doxorubicin Cytotoxic Effect In Breast Cancer Therapy, Fitrianingsih Fitrianingsih, Indri Maharini, Diah Tri Utami

Pharmaceutical Sciences and Research

Doxorubicin is one of the chemotherapy agents that is often used in breast cancer therapy. Phenomenon of breast cancer cell resistance to chemotherapy agents has been traced to the molecular level. The development of compounds that can overcome drug resistance chemotherapy needs to be continuously developed, especially agents with specific molecular targets, namely P-glycoprotein (Pgp), NFkB, cyclin, and cyclin-dependent kinase (CDK). Another alternative is the combination of chemotherapy agents with chemopreventive agents (co-chemotherapy) to reduce side effects and increase sensitivity of cancer cells. Doxorubicin is often used in breast cancer therapy. This study was performed to determine the effect of …

Encapsulation Of Temulawak Extract By Using Nanocrystalline Cassava And Sago Starches And Maltodextrin, Titi Candra Sunarti, Fatimah J. Pasaribu, Christina Winarti

Pharmaceutical Sciences and Research

This study was conducted to evaluate the performance of Curcuma zanthorrhiza crude extract after encapsulated in nanocrystalline starch, and to investigate the effect of the ratio of nanocrystalline starches and maltodextrin; and the effect of concentration of temulawak extract on nanocapsule characteristics, as well as encapsulation effect on the stability of antioxidant activity. Preparation of nanocrystalline starch was conducted by using lintnerization and ethanol precipitation of cassava and sago starches. Nanocrystalline starch and maltodextrin were used as matrices with the ratio varied from 25:75, 50:50, and 75:25. The mixture of temulawak extract and matrices were homogenized and spray dried. Nanocapsules …

Incorporating A Clinical Pharmacist In An Outpatient Palliative Care Team, Crystal Rim, Sharon Leigh, Linda Desitter, Mary Grant, Dana Nguyen

Providence Pharmacy PGY1 Program at Providence Milwaukie and Providence Newberg Medical Centers 2020

Title: Incorporating a clinical pharmacist in an outpatient palliative care team

Crystal Rim, PharmD; Sharon Leigh, PharmD, BCPS; Linda De Sitter MD, MPH; Mary Grant, ANP; Dana Nguyen, PharmD

Palliative care is a growing field in medicine that focuses on delivering care that improves quality of life for patients with serious illnesses. Often, the goals of palliative care differ from traditional goals of medicine. Currently, there is limited data demonstrating the integration of pharmacists in the palliative care setting. The purpose of this quality improvement is to evaluate the clinical pharmacist’s role within an outpatient palliative care team when performing …

Impact Of Academic Detailing On Clinical Pharmacy Specialist Involvement In Medication Assisted, Lindsey M. Bartos, Kristin A. Tallman, Dara L. Johnson

Providence Pharmacy PGY2 Program at Providence Medical Group 2020

Title: Impact of academic detailing on clinical pharmacy specialist involvement in medication assisted treatment for opioid use disorder in a primary care setting

Lindsey Bartos, PharmD; Kristin Tallman, PharmD, BCPS, BCACP; Dara Johnson, PharmD, BCPP, BCACP

Introduction: Opioid prescribing and opioid overdose deaths have increased steadily since the 1990s, reaching a 6-fold increase between 1999 and 2017. The opioid crisis, as it became known, was declared a public health emergency in 2017. In 2018 alone, an estimated two million people had a diagnosed opioid use disorder (OUD). The use of medication-assisted treatment (MAT) for OUD reduces the use …

Impact Of Pharmacist-Led Appointments For Hypertension Management In A Primary Care Setting: A Retrospective Analysis, Anne Marie Thibodeaux, Christine Doran, Ben Rosati

Providence Pharmacy PGY2 Program at Providence Medical Group 2020

Impact of pharmacist-led appointments for hypertension management in a primary care setting: a retrospective analysis

Introduction: High blood pressure is a major risk factor for heart disease and stroke, two of the leading causes of death for Americans.1 Evidence supports the idea that pharmacist-led hypertension management can result in overall blood pressure reduction; however, it remains unclear whether pharmacist-led initiatives can also improve performance metrics.2-5

Research question: Can pharmacist-led appointments for blood pressure management positively impact hypertension metrics?

Study design: Retrospective chart review

Methods: Primary outcome data was measured via metric inventory, defined as percentage of …

Evaluation Of Transitional Care Interventions From A Decentralized Clinical Pharmacist In A Small Inpatient Geriatric Psychiatry Unit, Nathan Wong, Michael Brown

Providence Pharmacy PGY1 Program at Providence Milwaukie and Providence Newberg Medical Centers 2020

Evaluation of Transitional Care Interventions from a Decentralized Clinical Pharmacist in a Small Inpatient Geriatric Psychiatry Unit

Nathan Wong, PharmD; Michael Brown, RPh, BCPS, BCPP

Background: Transitioning between healthcare settings increases the risk for medication errors. A systematic review of 26 studies comparing various medication reconciliation interventions demonstrated consistent reductions in adverse drug events. Intensive pharmacist involvement and focus on high risk populations were the most successful. ¹ Geriatric and behavioral health populations are especially vulnerable with polypharmacy and cognitive impairment often complicating the picture. Providence Milwaukie Hospital (PMH) houses a small unit tailored to provide mental health care …

Empowering Caregivers To Recognize, Support, And Treat Opioid Use Disorder: An Interdisciplinary Assessment Of Knowledge, Attitudes, And Comfort Level Pre And Post-Education, Annette Sprankle, Mika Michaels

Providence Pharmacy PGY1 Program at Providence Medford 2020

Author: Annette Sprankle, PGY1 Pharmacy Resident, PMMC

Title: Empowering caregivers to recognize, support, and treat opioid use disorder: an interdisciplinary assessment of knowledge, attitudes, and comfort level pre and post-education

Background: Substance use disorder affects approximately one in every four hospitalized patients. These patients are often treated for the admitting medical issue without addressing their substance use disorder. A hospital admission provides an opportunity to connect patients to the medical system. Evidence demonstrates that starting medication-assisted treatment in the hospital reduces the risk of overdose upon discharge, rate of hospital readmission, length of stay, and hospital expenditures.

Purpose: The purpose …

Clinical Pharmacist-Led Intervention To Improve Statin Metric For Secondary Prevention At Providence Medical Group – Southern Oregon Region, Chloe Nguyen, Judy Wong, Karen White

Providence Pharmacy PGY2 Program at Providence Medical Group 2020

Clinical Pharmacist-Led Intervention to Improve Statin Metric for Secondary Prevention at Providence Medical Group – Southern Oregon Region

Chloe Nguyen, PharmD, Judy Wong, PharmD, BCACP, and Karen White, PharmD, BCACP

Background: Currently, there is a gap in meeting the statin metric at Providence Medical Group in Southern Oregon Region. The purpose of this project is to identify intervention strategies to improve statin metric for secondary prevention among patients with clinical atherosclerotic cardiovascular disease (ASCVD).

Methods: This quality improvement project was approved by the system’s Institutional Review Board. Patients at least 18 years of age with diagnosis of clinical ASCVD not …

Effect Of A Pharmacist-Led Antimicrobial Stewardship (Ams) Program On Outpatient Fluoroquinolone Prescribing In The Elderly, Katie Larue, Chelsea Mannebach, Bonnie Jiron

Providence Pharmacy PGY2 Program at Providence Medical Group 2020

Title: Effect of a pharmacist-led antimicrobial stewardship (AMS) program on outpatient fluoroquinolone prescribing in the elderly

Authors: LaRue, Katie PharmD; Mannebach, Chelsea PharmD, BCPS, BCACP; Jiron, Bonnie, PharmD, BCACP

Introduction: The Center for Disease Control and Prevention, the Society of Infectious Diseases Pharmacists, and American Pharmacists Association recognize the need for outpatient AMS programs and the important role pharmacists play in appropriate prescribing. Fluoroquinolones (FQ) pose many risks, highlighted by U.S Food and Drug Administration safety warnings, including aortic dissection, hypoglycemia, mental health side effects, and tendonitis, along with the risk of Clostridium difficile infections, particularly in …

Implementation And Evaluation Of Pulmonary Arterial Hypertension Clinical Program And Pharmacist Education At A Health-System Specialty Pharmacy, Timothy Cao, Adam Saulles, Tara Berkson

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2020

Timothy Cao, PharmD, PGY-1 Pharmacy Resident

Preceptors: Adam Saulles, PharmD, CSP, BCACP and Tara Berkson, PharmD, BCACP

Providence Health and Services, Portland, Oregon

Implementation and evaluation of pulmonary arterial hypertension clinical program and pharmacist education at a health-system specialty pharmacy

Pulmonary Arterial Hypertension (PAH) is a progressive, debilitating, and costly disease, often resulting in poor prognosis when treatment is inadequate. With an exponential growth of specialty therapies, clinical pharmacists in specialty pharmacies are well-equipped to play an integral role in improving patient care outcomes and reducing overall healthcare costs. By incorporating a PAH-specific clinical program as part of the specialty …

Evaluation Of A Two-Way, Hipaa-Compliant Text-Messaging Platform In A Health System Specialty Pharmacy, Dj Clark, Adam Saulles, Tara Berkson

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2020

PDJ Clark, PharmD, PGY1 Pharmacy Practice Resident
Adam Saulles, PharmD, CSP, BCACP; Tara Berkson, PharmD, BCACP

Providence Health and Services, Portland, Oregon

Evaluation of a two-way, HIPAA-compliant text-messaging platform in a health system specialty pharmacy

Specialty medications, including those used to treat Multiple Sclerosis (MS), represent a growing proportion of prescription drug expenditures in the United States. MS is a chronic, progressive condition that requires maintenance therapy with disease-modifying medications. Many patients with MS rely on specialty pharmacies to obtain, dispense, and perform the necessary monitoring for these complex medication regimens. A study performed in 2017 by Munsell et al, …

Clinical Impact Of An Hiv Specialist Pharmacist Collaborative Practice Agreement: A 1-Year Retrospective Review Of Interventions, Rebekah Bartholomew, Geoffrey L'Heureux, Brent Footer

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2020

Title: Clinical Impact of an HIV Specialist Pharmacist Collaborative Practice Agreement: a 1-year Retrospective Review of Interventions

Purpose/Background:

HIV continues to be one of the most complex disease states for patients and providers to manage. With new medications and guidelines being routinely updated, ensuring that patients are on optimal anti-retroviral therapy (ART) throughout their lives can be difficult. Previous studies on pharmacist-led HIV services have shown that utilizing a pharmacist to manage ART is beneficial. The purpose of this study is to add to that body of evidence by analyzing the clinical impact of a nascent collaborative practice agreement for …

Pd-1 And Pd-L1 Inhibitors: A Single Center Medication Assistance Program (Map) Experience, Sarah Tu, Shuntao Cai

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2020

PD-1 and PD-L1 Inhibitors: A Single Center Medication Assistance Program (MAP) Experience

Sarah Tu, PharmD and Shuntao Cai, PharmD, BCOP

Robert W. Franz Cancer Center, Providence Cancer Institute, Portland, OR, USA

Background: PD-1 and PD-LI inhibitors are a large component of the growing immuno-oncology field and every year there are increasing studies investigating potential indications for these agents. This IRB approved retrospective chart review examines patients in the Medication Assistance Program (MAP) within a large tertiary medical center who are on PD-1 and PD-L1 medications due to financial barriers and/or non-FDA approved regimens (unlabeled indications). This study seeks to evaluate …

Safe Opioid Prescribing At Discharge, Taylor Goodman, Elva Van Devender, Luetta Jones, Courtney Barber

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2020

Safe Opioid Prescribing at Discharge Taylor Goodman, PharmD; Elva Van Devender, PharmD; Luetta Jones, PharmD; Courtney Barber

Background/Purpose: The opioid epidemic has led to devastating consequences, especially in Oregon, with an average of five Oregonians dying each week from opioid overdose. Opioid prescriptions at discharge are correlated with future continued opioid use. United States providers prescribe more opioids both inpatient and at discharge than other countries, and Oregon providers wrote more opioid prescriptions per person than the national average. Oversupplying prescription opioids can lead to reservoirs of unused medication, creating opportunities for non-medical use and overdose. Pharmacy interventions have …

Development And Implementation Of Take-Home Naloxone Kit For Patients Admitted To The Emergency Department Of A Large Tertiary Care Hospital, Myung Seon (Amy) Song, Pamela Levine, Katharine F. Marshall, Chelsea Harmon

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2020

Title: Development and implementation of take-home naloxone kit for patients admitted to the emergency department of a large tertiary care hospital

Authors: Myung Seon (Amy) Song, PharmD; Pamela Levine, PharmD, BCPS; Katharine F. Marshall, MD; Chelsea Harmon, PharmD Candidate 2020

Background/Purpose: In 2017, the United States Department of Health and Human Services (HHS) declared the opioid epidemic as a public health emergency as more than 70,000 people died from drug overdoses. Approximately 75% percent of unintentional opioid-overdose deaths occurred outside of a medical setting. In order to combat the opioid crisis, the US Surgeon General urged prescribers and pharmacists …

Impact Of Real-Time Antimicrobial Stewardship Team Intervention Versus Conventional Microbiology Reporting On Time To Appropriate Antimicrobial Therapy In Patients With Enterobacterales Bacteremia, Scott C. King, Alyssa B Christensen, Brent Footer, Timothy G. Shan, Kim Health, Ivor Thomas, Margaret Oethinger

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2020

Scott C. King

Alyssa B. Christensen, Brent W. Footer, Timothy G. Shan, Kim Health, Ivor Thomas, and Margret Oethinger

Impact of real-time antimicrobial stewardship team intervention versus conventional microbiology reporting on time to appropriate antimicrobial therapy in patients with Enterobacterales bacteremia.

Introduction:

The benefit of rapid laboratory speciation combined with real time antimicrobial stewardship team (AMT) interventions has been shown to improve patient outcomes and decrease hospital costs. The Providence Oregon region conducts direct from blood culture matrix-assisted laser desorption/ionization time of flight (MALDI-TOF) identification, which results in decreased time to organism identification. The MALDI-TOF identification has allowed the AMT …

Evaluation Of Late-Onset Sepsis Antibiotic Utilization And Revision Of Empiric Late-Onset Sepsis Antibiotic Prescribing Guidelines, Alex Creevan, Sara Clark, Anavice Jimenez, Michael Garcia

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2020

Alex Creevan, PharmD

Michael Garcia, PharmD, Angela Roberti, PharmD, Sara Clark, PharmD, Anavice Jimenez, PharmD Candidate

Providence St. Joseph Health, Portland, OR

Evaluation of late-onset sepsis antibiotic utilization and revision of empiric late-onset sepsis antibiotic prescribing guidelines

Neonatal late-onset sepsis (LOS) is commonly defined as an infection occurring after the first 72 hours of life. Late onset sepsis is a common complication of prolonged admission to the neonatal intensive care unit (NICU) and is a major cause of morbidity and mortality. Due to risks associated with LOS, empiric antibiotics can be inappropriately prescribed, which may lead to multi-drug resistant bacteria, …

Standardizing Specialty Pharmacist Follow-Up Frequency In Patients Prescribed Inflammatory Disease-Modifying Therapies, Rochelle Castrillo, Linda Huynh, Tara Berkson, Adam Saulles

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2020

Submission Category Specialty Pharmacy

Purpose Specialty medications for inflammatory conditions have demonstrated decreased effectiveness, safety, and quality of life, largely attributable to inadequate medication adherence. Furthermore, with poorer health outcomes, patients face greater healthcare costs associated with exacerbations, flares, and hospitalizations. Monitoring for non-adherence, side effects, and health status changes is essential for patients diagnosed with inflammatory conditions. The benefit of a standardized pharmacist clinical follow-up assessment is currently lacking in specialty pharmacy literature. This study will implement a standardized pharmacist follow-up frequency guide and determine its clinical value and utility for patient safety and therapeutic goals in newly established …

Evaluating Outcomes Of Medication-Related Interventions From The “Seniors At Risk For Falls After Emergency Room Visit” (Safer) Pilot Project, Ling J. Zhan, Sharon Leigh, Mary E. Kuebrich, Clara Mikhaeil, Kevin Hom, Colleen M. Casey

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2020

Primary Author: Ling J. Zhan, PharmD

Co-Authors: Sharon Leigh, PharmD BCPS, Mary Beth Kuebrich, MS, AGPCNP-BC, Clara Mikhaeil, PharmD, BCPS, Colleen M. Casey, PhD, ANP-BC

Location: Providence Health & Services, Portland, Oregon

Title: Evaluating outcomes of medication-related interventions from the “Seniors At risk for Falls after Emergency Room visit” (SAFER) pilot project

Purpose: Falls are the leading cause of injury in older adults, resulting in decreased mobility, loss of independence, and increased health care costs. Even a single fall puts an older adult at higher risk for future falls. Despite numerous studies showing evidence that multifactorial fall risk interventions are …

Pharmacoeconomic Impact Of Patient-Centric Oncology Service Model, Kasey Rubin, Samuel Jacobson, Shannon Buxell

Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2020

Kasey Rubin PharmD.

Samuel Jacobson PharmD. BCOP, Shannon Buxell PharmD.

Providence Health & Services, Portland Oregon

Pharmacoeconomic impact of patient-centric oncology service model

Providence Health & Services recently embedded ambulatory oncology pharmacists into the ambulatory oncology clinic setting. The overall purpose of this retrospective study is to quantify the financial benefits of ambulatory oncology pharmacists as well as quantify patient-centric factors through utilization of an onsite specialty pharmacy. This study was submitted and approved by Institutional Review Board. Electronic health records of patients who visited the ambulatory oncology clinic will be retrospectively reviewed over two time periods: 12 months preceding …