Pharmacy and Pharmaceutical Sciences Commons^™

Less Common Bacterial, Fungal And Viral Infections: Review Of Management In The Pregnant Patient, Alyssa P. Gould, Hana R. Winders, Kayla R. Stover, P Brandon Bookstaver, Brooke Griffin, Christopher M. Bland, Lea S. Eiland, Milena Murray

Faculty Publications

This review is a comprehensive summary of treatment options for pregnant patients with less common bacterial, fungal, and viral infections. It offers guidance to clinicians based on the most recently published evidence-based research and expert recommendations. A search of MEDLINE (inception to March 2021) and the CDC website was performed. Liposomal amphotericin B is the preferred therapy for cryptococcosis, histoplasmosis, oesophageal candidiasis, and coccidioidomycosis, especially during the first trimester due to teratogenic concerns with azole antifungals. For oral candidiasis, clotrimazole troches or miconazole mucoadhesive buccal tablets are recommended. A β-lactam antimicrobial is preferred over doxycycline for various manifestations of Lyme …

Development Of Ibuprofen Tablet With Polyethylene Oxide Using Fused Deposition Modeling (Fdm) 3d Printing Coupled With Hot-Melt Extrusion, Sooyeon Chung

Electronic Theses and Dissertations

Ibuprofen is known to plasticize several polymers used in the pharmaceutical field, and it is considered challenging to achieve an immediate release by fused deposition modeling (FDM). Therefore, this study aimed to print ibuprofen tablet with a focus on achieving immediate release. Polyethylene oxide (Polyox WSR N80) was used as a main matrix to form the ibuprofen filament due to its water-soluble property and manifesting suitable mechanical property even with the high drug loading (40% w/w). Several release modifiers such as Kollidon VA64, Kollidon 12PF, Kollicoat IR, Kollidon CL, and Mannitol were added separately to the formulation to enhance the …

Rap1a Overlaps The Age/Rage Signaling Cascade In Type 2 Diabetes Mellitus, Stephanie Burr

Electronic Theses and Dissertations

Diabetic individuals have an increased risk for developing cardiovascular disease due to stiffening of the left ventricle, which is thought to occur, in part, by increased AGE/RAGE signaling. Advanced glycation end products (AGEs) accumulate within the body over time, and under hyperglycemic conditions, the formation and accumulation of AGEs is accelerated. AGEs exert their effect by binding to their receptor (RAGE) and can induce myofibroblast differentiation, oxidative stress, cell-extracellular matrix contraction, and cell migration. Previous findings from our lab have demonstrated that preventing the production of Rap1a, a Ras-like GTPase signaling protein, in cardiac fibroblasts will decrease type 2 diabetes …

Methylene Blue As Light And Reactive Oxygen Species Sensitive Ligand: Appicability In Hybrid Drug And Material Synthesis, Huy Dao

Electronic Theses and Dissertations

Methylene blue (MB) with a 10-N-carbamoyl linkage was discovered and developed as a multifunctional far-red (660 nm) photocleavable ligand capable of rendering a series of MB conjugated compounds with off-to-on fluorescence switch properties through the controlled release of MB. The released MB was successfully demonstrated to be an effective photosensitizer, imaging probe, and therapeutic agent. The complete release of MB was achieved with a cumulative light dose of 15 J/cm2. The photosensitivity was demonstrated to be dependent on the type of chemical bond at 10-N of the phenothiazine ring which links MB to a side group. Specifically, the urea bond-based …

Hot-Melt Extrusion Based Fused Deposition Modeling 3d Printing Of Atorvastatin Calcium Tablets: Impact Of Shape And Infill Density On Printability And Performance, Preethi Mandati

Electronic Theses and Dissertations

The main objective of the current research is to investigate the effect of shapes (heart and round shape tablets) and infill densities (50% and 100%) on drug release profiles of tablets prepared by hot melt extrusion (HME) coupled fused deposition modeling (FDM) technique. Two different commercial FDM 3D printers with different filament feeding mechanisms were evaluated for suitability of printing. Drug-loaded filaments of 1.5 mm and 2.5 mm diameters were extruded using Process 11 mm HME, using atorvastatin as a model drug and Kollicoat® IR, Kollidon® VA64, Kollidon®12PF, and Kolliphor® P407 as hydrophilic polymers. Filaments of Kollicoat® IR in combination …

Subcutaneous Delivery Of Albumin, Vy Nguyen

Electronic Theses and Dissertations

An increasing number of protein drugs are used in the clinic to treat a broad range of diseases. However, because of their large molecular sizes and high hydrophilicity, protein drugs are not orally bioavailable, which commonly require intravenous, intramuscular or subcutaneous injection. Thermosensitive polymers have been widely investigated as in situ depots for sustained drug release delivered through subcutaneous route.Albumin is the most abundant proteins in bloodstream. It has long half-life (19 days in human) and plays important roles such as acting as carrier for fatty acids, amino acids, waste products and medical compounds. Albumin has been studied for decades …

Guidelines On Prescriptive Authority For Nurses 2021, David Stewart, Madrean Schober, Lisa Nissen, Elissa Ladd, Kimberley Lamarche, Marie-Lyne Bournival, Deborah Gray, Sonia Sevilla, Marieke Kroezen, Frances Wong

Ellmer School of Nursing Faculty Publications

[First paragraph] Nurse prescribing has existed for over 50 years in some regions of the world. The diverse global nurse prescriptive authority landscape will be highlighted in this important publication. A framework embedding core components for safe and competent prescribers necessitates appropriate education, aligned regulatory authority and continuing professional development to uphold competencies. Evidence-informed models of nurse prescribing will weave in organisational and team support considerations required.

Opioid Use Disorder: The Timeline For Medication Assisted Therapy, Alexander Cristofori

Capstone Showcase

Opioid Use Disorder is patterns of opioid use leading to withdrawal, giving up important life events in order to use opioids, and excessive time spent using opioids, to name a few diagnostic criteria. The clinical progression of the disorder involves periods of acute exacerbation and remission that are cyclic in nature. Treatment is most effective when it includes both pharmacological and psychosocial modalities, referred to as medication assisted therapy (MAT). Three drugs used commonly in MAT-based treatment for OUD from oldest to newest include Methadone, Buprenorphine-naloxone, and Naltrexone. Treatment program models that prioritize total abstinence from the addictive substance attached …

The Characterization Of Purified Citrate-Coated Cerium Oxide Nanoparticles Prepared Via Hydrothermal Synthesis, Matthew L. Hancock, Robert A. Yokel, Matthew J. Beck, Julie L. Calahan, Travis W. Jarrells, Eric J. Munson, George A. Olaniyan, Eric A. Grulke

Chemical and Materials Engineering Faculty Publications

Hypothesis

Cerium oxide nanoparticles were synthesized using a hydrothermal approach with citric acid as a stabilizing agent. Citric acid adsorption onto the nanoceria particle surface can cease particle formation and create a stable dispersion for an extended shelf life. The product was dialyzed immediately following the synthesis to remove unreacted cerium that could contribute to biological effects. Nanoparticle characterization results are expected to help identify the surface citrate bonding structure.

Experiments

Many characterization techniques were utilized to determine size, morphology, surface properties, and citrate complexation on the nanoceria particle surface. These included transmission electron microscopy, electron energy loss spectroscopy, dynamic …

Research News, Publications, 2021, Volume 4, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period of October 1 through December 31, 2021

Research News, Grants, 2021, Volume 4, Soumyajit Majumdar

Grants (2015-)

Grants and contracts awarded during October - December 2021.

Computational Modeling Of Non-Active Functional States Of The Cannabinoid Receptor 1 And Its Ligands, Ayooluwa Olufunmi Aderibigbe

Electronic Theses and Dissertations

The cannabinoid receptor 1 (CB1) is a class A G-protein coupled receptor that is implicated in a variety of physiological processes, such as energy homeostasis, appetite regulation, cognition and motor control, and mood regulation. CB1 is widely distributed throughout the body, but is mainly expressed in the brain. Molecules that reduce CB1 signaling exhibit anti-obesity properties due to their effect in reducing appetite and body weight gain. However, the consequence of reducing CB1 signaling in the CNS includes adverse neuropsychiatric effects such as depression and suicidal ideation. Two methods of scientific interest for developing CB1 antagonists as anti-obesity drugs are …

Positive Deviants For Medication Therapy Management: A Mixed-Methods Comparative Case Study Of Community Pharmacy Practices, Omolola A. Adeoye-Olatunde, Leslie M. Lake, Celena Strohmier, Amanda K. Gourley, Ashli R. Ray, Alan J. Zillich, Margie E. Snyder

Department of Pharmacy Practice Faculty Publications

Background

To optimize medication use in older adults, the Centers for Medicare & Medicaid Services (CMS) launched Medication Therapy Management (MTM) services as part of Medicare Part D policy; however, strategies for achieving high quality MTM outcomes are not well understood.

Objective

The objective of this study was to generate hypotheses for strategies contributing to community pharmacies’ high performance on policy-relevant MTM quality measures.

Methods

This mixed-methods comparative case study was guided by the Positive Deviance approach and Chronic Care Model. The study population consisted of pharmacy staff employed by a Midwestern division of a national supermarket-community pharmacy chain. Data …

A User-Centered Evaluation Of Medication Therapy Management Alerts For Community Pharmacists: Recommendations To Improve Usability And Usefulness, Margie Snyder, Omolola A. Adeoye-Olatunde, Stephanie A. Gernant, Julie Diiulio, Heather A. Jaynes, William R. Doucette, Alissa L. Russ-Jara

Department of Pharmacy Practice Faculty Publications

Background

Community pharmacists provide comprehensive medication reviews (CMRs) through pharmacy contracts with medication therapy management (MTM) vendors. These CMRs are documented in the vendors' web-based MTM software platforms, which often integrate alerts to assist pharmacists in the detection of medication therapy problems. Understanding pharmacists’ experiences with MTM alerts is critical to optimizing alert design for patient care.

Objectives

The objectives of this study were to 1) assess the usability and usefulness of MTM alerts for MTM vendor-contracted community pharmacists and 2) generate recommendations for improving MTM alerts for use by community pharmacists.

Methods

This was a convergent, parallel mixed-methods evaluation …

A Mixed-Methods Study Of Pharmacy Instructors' Early Experiences With A Teaching Electronic Medical Record, Omolola A. Adeoye-Olatunde, Olga O. Vlashyn, Kimberly Plake, Jamie L. Woodyard, Zachary A. Weber, Debra K. Litzelman, Alissa L. Russ-Jara

Department of Pharmacy Practice Faculty Publications

Introduction

As use of electronic medical records (EMRs) increases in healthcare, multiple accreditation organizations recommend training future clinicians on EMRs as part of the academic curriculum. Therefore, some pharmacy programs now utilize an academic EMR. Our objective was to examine pharmacy instructors' early experiences with a commercially available teaching EMR (tEMR) in order to identify current and future priorities along with benefits and barriers to academic EMR use in pharmacy education.

Methods

We conducted semi-structured interviews and a web-based survey with pharmacy instructors. Interview and survey data analyses consisted of hybrid inductive/deductive approaches to coding data and descriptive statistics, …

Research And Scholarly Methods: Semi-Structured Interviews, Omolola A. Adeoye-Olatunde, Nicole Olenik

Department of Pharmacy Practice Faculty Publications

The popularity and value of qualitative research has increasingly been recognized in health and pharmacy services research. Although there is certainly an appropriate place in qualitative research for other data collection methods, a primary benefit of the semi-structured interview is that it permits interviews to be focused while still giving the investigator the autonomy to explore pertinent ideas that may come up in the course of the interview, which can further enhance understanding of the pharmacy service being assessed. The purpose of this narrative review is to summarize methodological considerations and procedures for conducting semi-structured interviews in pharmacy services research. …

An Evaluation Of The Spread And Scale Of Patienttoc™ From Primary Care To Community Pharmacy Practice For The Collection Of Patient-Reported Outcomes: A Study Protocol, Margie Snyder, Betty Chewning, David Kreling, Susan M. Perkins, Lyndee M. Knox, Omolola A. Adeoye-Olatunde, Heather A. Jaynes, Jon C. Schommer, Matthew M. Murawski, Nisaratana Sangasubana, Lisa A. Hillman, Geoffrey M. Curran

Department of Pharmacy Practice Faculty Publications

Background

Medication non-adherence is a problem of critical importance, affecting approximately 50% of all persons taking at least one regularly scheduled prescription medication and costing the United States more than $100 billion annually. Traditional data sources for identifying and resolving medication non-adherence in community pharmacies include prescription fill histories. However, medication possession does not necessarily mean patients are taking their medications as prescribed. Patient-reported outcomes (PROs), measuring adherence challenges pertaining to both remembering and intention to take medication, offer a rich data source for pharmacists and prescribers to use to resolve medication non-adherence. PatientToc™ is a PROs collection software developed …

Development Of Site - Specific Drug Delivery Systems Using Hot Melt Extrusion And Fused Deposition Modeling 3d Printing, Nagireddy Reddy Dumpa

Electronic Theses and Dissertations

Due to preferential site of drug absorption and the need for increased concentration of medication at the required tissues, dosage forms should be designed or formulated in such a way that medication is released at a specific site or after a specific time in the gastrointestinal tract (GIT). Knowledge of transit times of dosage forms in each part of GIT, by use of particular polymers or employing specific delivery systems such as floating systems, delivery of medication to specific sites in the GIT can be achieved. HME coupled FDM 3D printing has the capability to create customized dosage forms for …

Nmr-Based Characterization Of A Glucan Isolated From Ganoderma Lucidum, Alysia Gonzales

Electronic Theses and Dissertations

Ganoderma lucidum is a polypore fungus commonly known as Lingzhi, Youngji or Reishi mushroom in East Asia. It is frequently marketed as an herbal supplement and often utilized as traditional Chinese medicine. Our research comprises the structural investigation of the principal polysaccharide from this fungus. After proper purification, the fungal glucan was subjected to multiple experiments of NMR spectroscopy, including 1D 1H and 13C, 2D; 1H-1H COSY, 1H-1H TOCSY, 1H-1H NOESY, 1H-13C HSQC, 1H-1H Phase Sensitive-TOCSY, and 1H-13C TOCSY-HSQC NMR spectra. Data has confirmed that this fungal polysaccharide contains residues of glucose (91.31%) as major, galactose (4.99%), and mannose (3.69%) …

Towards A New Method Of Determining Protein Structure, Niloofar Abolhasani Khaje

Electronic Theses and Dissertations

Hydroxyl radical protein footprinting (HRPF) by fast photochemical oxidation of proteins (FPOP) is a mass spectrometry-based technique that measures the apparent protein oxidation rate by freely diffusing hydroxyl radicals at different regions in a protein, and correlates changes in this apparent rate with changes in the solvent accessibility of the protein target based on quantifying the amount of oxidation of different regions of a protein. While there have been many advancements in HRPF-FPOP, oxidation measurement still suffers from high variability between measurements. High variability reduces the power statistical power this technique even in the presence of radical dosimetry measurements and …