Factors Affecting The Reduction Rate Of Odontogenic Cyst After Decompression Based On Three-Dimensional Volumetric Analysis,
2022
Faculty of Dentistry
Factors Affecting The Reduction Rate Of Odontogenic Cyst After Decompression Based On Three-Dimensional Volumetric Analysis, Sarawut Wongrattanakarn
Chulalongkorn University Theses and Dissertations (Chula ETD)
The purpose of this study is to investigate factors that affect the reduction rate of odontogenic cysts after decompression based on three-dimensional volumetric analysis. The sample consisted of 30 patients who underwent decompression of odontogenic cysts at the Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chulalongkorn University, from 2010-2022. Preoperative and postoperative cone beam computed tomography results were collected. Volumetric analysis was performed to evaluate any differences in the reduction rate and percentage reduction in the volume (PRV) of the cystic lesion according to the sex, age, initial volume of the lesion, duration of decompression, location of the …
Comparison Of Volumetric Changes At Implant Connector Among Three Different Types Of Abutment After Cyclic Loading,
2022
Faculty of Dentistry
Comparison Of Volumetric Changes At Implant Connector Among Three Different Types Of Abutment After Cyclic Loading, Piyawan Jirayusakamol
Chulalongkorn University Theses and Dissertations (Chula ETD)
The aim of this study was to compare the volumetric change of dental implant among three different types of abutments after cyclic loading.Thirty dental implants (4.1x10 mm., Straumann®) were used .All of them were inserted in acrylic resin block with usual surgical protocol to gain primary stability and be able to retrieve for volumetric measurement later. Ten of each dental implant connected with Titanium abutment (Group1: Variobase abutment Straumann®), Gold abutment (Group2: UCLA abutment Straumann®) and Zirconia abutment (Group 3: Care abutment Straumann®) consecutively. Then all specimen was submitted to cyclic loading (1x106 cycles, axial load, 100N, 15 Hz) at …
Association Among Anterior Maxillary Dental Arch Form, Alveolar Bone Thickness And Sagittal Root Position Of Maxillary Central Incisor : A Cone Beam Computed Tomography Analysis,
2022
Faculty of Dentistry
Association Among Anterior Maxillary Dental Arch Form, Alveolar Bone Thickness And Sagittal Root Position Of Maxillary Central Incisor : A Cone Beam Computed Tomography Analysis, Suttikiat Somvasoontra
Chulalongkorn University Theses and Dissertations (Chula ETD)
Purpose: This study evaluated the association among the dental arch form, age-sex groups, and sagittal root position regarding alveolar bone thickness in the maxillary central incisor using cone-beam computed tomography (CBCT) images. Materials and Methods: CBCT images of 280 patients were categorized based on the dental arch form and age-sex groups. Five hundred and sixty sagittal CBCT images of the maxillary central incisors were examined to measure the labial and palatal bone thickness at the root apex level, at the mid-root level and 3 mm apically from cemento-enamel junction, with SRP classification. Chi-square, Kruskal-Wallis test, and multiple linear regression were …
Study Of Saliva Transcriptome And Proteome In Thai Patients With Dental Fluorosis,
2022
Faculty of Dentistry
Study Of Saliva Transcriptome And Proteome In Thai Patients With Dental Fluorosis, Patcharaporn Gavila
Chulalongkorn University Theses and Dissertations (Chula ETD)
The purpose of this study was to examine the expression profiles of RNA and protein in Thai individuals with dental fluorosis and compare them with those without fluorosis. Additionally, the study aimed to establish a correlation between the severity of dental fluorosis, urinary fluoride levels, and water fluoride levels. Methods: Schoolchildren in areas endemic for fluoride in Lamphun and Ratchaburi provinces of Thailand were screened for dental fluorosis severity and then enrolled in the study. Fluoride concentration in 24-hour urine and drinking water samples was measured using an ion-selective fluoride electrode. Saliva samples were collected in sterile tubes and stored …
Oral Health Service Of Older Adults In Long-Term Care Facilities,
2022
Faculty of Dentistry
Oral Health Service Of Older Adults In Long-Term Care Facilities, Puntawee Barameepipat
Chulalongkorn University Theses and Dissertations (Chula ETD)
To assess oral health service in long-term care facilities in Bangkok Methods: A cross-sectional study was conducted in 50 licensed long-term care facilities in Bangkok. Informed consent was obtained from all participants before conducting phone interviews and administering the questionnaire. The questionnaire covered various aspects, including demographics, health services, and oral health services provided within the long-term care facilities. Results: The study revealed variations in terms of operational years, service capacity, service expense per month, and provision of health services, including oral health services. It was found that the differences in service expenses impacted the provision of denture care for …
Intention To Obtain Silver Diamine Fluoride Treatment For Dental Caries Among Elderly,
2022
Faculty of Dentistry
Intention To Obtain Silver Diamine Fluoride Treatment For Dental Caries Among Elderly, Ratchawipa Nakphu
Chulalongkorn University Theses and Dissertations (Chula ETD)
Aims: To evaluate the intention of the elders to use the Silver Diamine Fluoride (SDF) treatment for stopping dental caries progression after being informed Materials and Methods: The elders aged 60-90 years old who are independent and can read Thai were recruited. A questionnaire-guided interview was performed to the elders after introduction of the SDF treatment. The questionnaire-guided interview was guided by the Theory of Reason Action (TRA) composed of 23 questions of 7 constructs including behavioral belief, evaluation of behavioral outcome, normative belief, motivation to comply, attitude towards behavior, subjective norm and intention. The intention to do the SDf …
Cranio-Oro-Facial Features And Masticatory Function In Patients With Craniosynostosis,
2022
Faculty of Dentistry
Cranio-Oro-Facial Features And Masticatory Function In Patients With Craniosynostosis, Yanisa Wongbanthit
Chulalongkorn University Theses and Dissertations (Chula ETD)
Objectives: The aim of this study was to evaluate cranio-oro-facial features and masticatory function in Thai subjects with craniosynostosis. Methods: Thirteen craniosynostosis (CS) patients aged between 6 - 17 years old who had treatment at the Princess Sirindhorn Craniofacial (PSC) Center, King Chulalongkorn memorial hospital and thirty age-matched non-CS subjects were recruited. Inform consents were obtained. Medical records were retrieved. Craniofacial and oral examination, radiographic evaluation, photograph, and masticatory function were recorded and compared with data of control subjects and that of Thai norms. Results: Among thirteen CS patients, four cases had cleft palate (30.8%), five had anterior openbite (38.5%), …
Factors Associated With Oral Health Status Among The Healthy Elderly In Phon Thong District, Roi Et Province, Thailand,
2022
Faculty of Dentistry
Factors Associated With Oral Health Status Among The Healthy Elderly In Phon Thong District, Roi Et Province, Thailand, Yaowapa Chantaraboot
Chulalongkorn University Theses and Dissertations (Chula ETD)
Objective: This study aimed to identify factors related to the oral health status of healthy elderly people in Phon Thong District, Roi Et Province, Thailand. Materials and methods: This cross-sectional study was conducted between 1 May and 25 December 2020 in Phon Thong District, Roi Et Province. A total of 249 male and female elderly people participated in the study. Oral health information was collected by trained dental hygienists using the Thai version of the oral health assessment tool [OHAT]. Data analysis used Mann–Whitney U tests, Chi-Square tests, and Binary logistic regression. Results: There were statistically significant associations between oral …
Awareness Of Medical Doctor On Medication-Related Osteonecrosis Of The Jaw In Osteoporosis Patients,
2022
Faculty of Dentistry
Awareness Of Medical Doctor On Medication-Related Osteonecrosis Of The Jaw In Osteoporosis Patients, Nachapol Supanumpar
Chulalongkorn University Theses and Dissertations (Chula ETD)
Antiresorptive drugs are widely used to treat osteoporosis. A serious adverse effect of these drugs is medication-related osteonecrosis of the jaw (MRONJ). By informing and educating patients about MRONJ, providing proper dental referral, and monitoring the oral health of patients who receive antiresorptive agents, physicians can reduce the risk of MRONJ. We investigated the awareness and clinical practices of physicians in Thailand with regard to MRONJ. Physicians who prescribed antiresorptive drugs for osteoporosis filled out an online self-administered questionnaire about demographic characteristics, awareness, and practices related to MRONJ. Most respondents agreed that antiresorptive drugs may cause MRONJ (92.3%), that poor …
Knowledge, Attitudes, Behavior, And Expectation Of Thai Patients Toward Dental Treatment During Covid-19 Pandemic: An Online Survey,
2022
Faculty of Dentistry
Knowledge, Attitudes, Behavior, And Expectation Of Thai Patients Toward Dental Treatment During Covid-19 Pandemic: An Online Survey, Paratcha Pingsuthiwong
Chulalongkorn University Theses and Dissertations (Chula ETD)
Aerosol-generating procedures with contaminated saliva may pose a risk of disease transmission during the COVID-19 pandemic. COVID-19 preventive measures in dental clinics have evolved in response to the pandemic situation. This research investigated the effect of this pandemic on Thai patients' knowledge, attitudes, and behavior toward dental treatment. The online survey was distributed in June 2022. There were 978 participants in the study. The results showed that most participants had accurate knowledge about the COVID-19 transmission route in dentistry. The mean and median level of concern in the following issues were: contracting COVID-19 in daily life (3.06 and 3.03), contracting …
Effect Of Normal Saline In Different Concentration On Soft Tissue Healing Of Extraction Wound: A Clinical Study,
2022
Faculty of Dentistry
Effect Of Normal Saline In Different Concentration On Soft Tissue Healing Of Extraction Wound: A Clinical Study, Walailuk Kunthikarn
Chulalongkorn University Theses and Dissertations (Chula ETD)
Sodium chloride solution (NaCl) is regarded as the most suitable and recommended medical irrigation, because of the nontoxic and isotonic properties. The previous in vitro study showed that NaCl solution induced migration and extracellular matrix excretion from human gingival fibroblast. However, there is no report concerning the effect of rinsing extraction wound with NaCl solution in clinical trial study. This research study is split mouth single-blind randomized controlled clinical trial to investigate if rinsing with 0.9% and 1.8% NaCl solution on extraction wound can promote soft tissue healing. The operation was performed in 60 socket sites. The patients, who had …
The Effects Of Decellularized Extracellular Matrix Derived From Jagged1-Treated Human Dental Pulp Stem Cells On Biological Responses Of Stem Cells Isolated From Apical Papilla,
2022
Faculty of Dentistry
The Effects Of Decellularized Extracellular Matrix Derived From Jagged1-Treated Human Dental Pulp Stem Cells On Biological Responses Of Stem Cells Isolated From Apical Papilla, Suphalak Phothichailert
Chulalongkorn University Theses and Dissertations (Chula ETD)
Objective: Indirect Jagged1 immobilization efficiently activates canonical Notch signaling in hDPSCs. This study aimed to investigate the characteristic of the Jagged1-treated hDPSCs-derived dECM and its biological activity on odonto/osteogenic differentiation SCAPs. Methods: Bioinformatic database of Jagged1-treated hDPSCs was analyzed by NetworkAnalyst. hDPSCs seeded on Jagged1 immobilized surface were maintained with N or OM followed by decellularization procedure, dECM-N or dECM-OM, respectively. SCAPs were reseeded on each dECM with either normal medium or OM. Cell viability was determined by MTT assay. Characteristics of dECMs and SCAPs were evaluated by SEM, EDX, immunofluorescent staining and alcian blue staining. A Multipotential differentiation assay. …
Effects Of The Orthodontic Miniscrew Geometric Design On The Bone Microdamage And Primary Stability,
2022
Faculty of Dentistry
Effects Of The Orthodontic Miniscrew Geometric Design On The Bone Microdamage And Primary Stability, Panida Methawit
Chulalongkorn University Theses and Dissertations (Chula ETD)
This study investigated the effects of the pitch (P) and thread shape on orthodontic miniscrew cortical bone microdamage. The relationship between microdamage and primary stability was examined. Ti6Al4V orthodontic miniscrews had custom-made thread heights (H) and pitch sizes and were classified into the following groups: HCPC (control); HCPN (with a narrower pitch); and HTPC (with a taller thread height) (HC = 0.12 mm; HT = 0.36 mm; PC = 0.60 mm; PN = 0.30 mm). The orthodontic miniscrews were inserted in the pilot hole of prepared 1.0-mm-thick tibia cortical bone, and the maximum insertion torque (MIT) and Periotest value (PTV) …
Prediction Of Future Caries In Toddlers Via Salivary Microbiome: A 1-Year Longitudinal Study,
2022
Faculty of Dentistry
Prediction Of Future Caries In Toddlers Via Salivary Microbiome: A 1-Year Longitudinal Study, Ratcha Raksakmanut
Chulalongkorn University Theses and Dissertations (Chula ETD)
Dental caries in children is the most common chronic oral disease that could disturb their quality of life including their development. Early prevention is a key approach to reducing the prevalence of early childhood caries. However, a reliable caries predictor, as an essential tool for targeted prevention that is important to this approach, is still lacking for infants before caries onset. Therefore, we aimed to develop the caries risk prediction model based on the salivary microbiome of caries-free 1-year-old children to predict caries onset at 1-year follow-up. Using a nested case-control design within a prospective cohort study, 30 saliva samples, …
Expression Of Superoxide Dismutase 3 (Sod3) During Orthodontic Tooth Movement In Rats,
2022
Faculty of Dentistry
Expression Of Superoxide Dismutase 3 (Sod3) During Orthodontic Tooth Movement In Rats, Phanchanit Jindarojanakul
Chulalongkorn University Theses and Dissertations (Chula ETD)
Hypoxia induces reactive oxygen species (ROS) production in periodontal tissues. Superoxide dismutase 3 (SOD3) is an enzyme protecting cells from ROS. This study investigated SOD3 expression and function during rat orthodontic tooth movement (OTM) and in hypoxia-exposed rat PDL cells. OTM of right maxillary first molars were performed in Sprague-Dawley rats for 1 and 14 days (n = 6 per group). SOD3 and HIF-1α expression were evaluated by immunohistochemistry. SOD3 effects on cell viability and proliferation, ROS production, and mRNA expression of Hif-1α, Rankl, and Opg in PDL cells and osteoclast differentiation were investigated under normoxia and hypoxia. SOD3 expression …
The Effect Of Nano-Silver Fluoride In Remineralization On Artificial Dentine Caries: An In Vitro Study,
2022
Faculty of Dentistry
The Effect Of Nano-Silver Fluoride In Remineralization On Artificial Dentine Caries: An In Vitro Study, Peeraya Punpeng
Chulalongkorn University Theses and Dissertations (Chula ETD)
The aim of this in vitro study was to compare the remineralization efficiency among Nano-silver fluoride 400 ppm (NSF400), 38% Silver diamine fluoride (38% SDF) and 5% Sodium fluoride (5% NaF) on artificial dentine caries in permanent molar or premolar teeth. The teeth were sectioned to obtain 120 specimens (3 x 3 x 2 mm3). After artificial caries were created, the lesion depth (LD) was measured using Micro-computed tomography (Micro-CT) (n=15 specimens/group), and the surface microhardness (SMH) was measured using a Knoop microhardness tester (n=15 specimens/group). Subsequently, all specimens were randomly assigned to four groups: Group 1) NSF400, Group 2) …
Evaluation Of Different Scaffolds For Bone Regeneration In Rat Calvarial Bone Defects,
2022
Faculty of Dentistry
Evaluation Of Different Scaffolds For Bone Regeneration In Rat Calvarial Bone Defects, Jeerawit Sirakittiworapong
Chulalongkorn University Theses and Dissertations (Chula ETD)
Scaffold plays a key role in the context of tissue engineering. It not only provides a structural support for cells, but also creates an appropriate milieu for recruited cells, enhancing the therapeutic effects of cell-based treatments, and enabling the controlled release of biological cues such as growth factors. Collagen is widely used scaffold material in tissue engineering, particularly in periodontal and bone regeneration. Other natural polymers, however, have been developed and can be useful. Therefore, in this study, we aim to investigate the ability of four different natural polymers including collagen, chitosan, silk fibroin, and silk fibroin/gelatin hydrogel in promoting …
Protein Expression After Gingival Injection Of Messenger Rna Encoding Platelet-Derived Growth Factor-Bb In Ligature-Induced Rat Periodontitis,
2022
Faculty of Dentistry
Protein Expression After Gingival Injection Of Messenger Rna Encoding Platelet-Derived Growth Factor-Bb In Ligature-Induced Rat Periodontitis, Pimphorn Meekhantong
Chulalongkorn University Theses and Dissertations (Chula ETD)
As a new class of medicines, mRNA platform has proven to be safe and effective. The objective of this study was to investigate the effect of local inflammation on platelet derived growth factor-BB (PDGF-BB) expression after gingival injection of PDGF-BB mRNA in lipid nanoparticles (LNPs) in ligature-induced rat periodontitis and to examine the dose-dependent effect of gingival delivery of mRNA. 3-0 silk was placed around maxillary left second molar for two weeks and removed, while the corresponding molar on the right was non-ligated. Under stereomicroscope, a significant bone loss at ligature sites was observed as compared to the non-ligature sites, …
Hydroxyapatite Nanoparticle And Bone Scaffold To Deliver Microrna-302a-3p For Bone Healing In A Critical-Sized Bone Defect,
2022
Faculty of Dentistry
Hydroxyapatite Nanoparticle And Bone Scaffold To Deliver Microrna-302a-3p For Bone Healing In A Critical-Sized Bone Defect, Pirawish Limlawan
Chulalongkorn University Theses and Dissertations (Chula ETD)
Bone tissue engineering is a therapeutic approach for large bone defects. It is being studied to create efficient bone substitution material. However, the autograft with consequence of multiple morbid sites is still a gold standard. This study aimed to use surface modified hydroxyapatite nanoparticle on a 3D-printed tricalcium phosphate/hydroxyapatite (TCP/HA) scaffold to deliver miRNA-302a-3p to enhance bone regeneration as a novel approach for bone tissue engineering. Hydroxyapatite nanoparticles (HA-NPs) were created with hydrothermal method and surface modified with cationic molecule 3-aminopropyltriethoxysilane (APTES) or poly2-(dimethylamino)ethyl methacrylate (PDMAEMA) to enhance miRNA condensation and cellular uptake. The biocompatibility, miRNA condensation ability, cellular uptake …
Study Of Mutation And Pathomechanism Of Runx2 In Cleidocranial Dysplasia,
2022
Faculty of Dentistry
Study Of Mutation And Pathomechanism Of Runx2 In Cleidocranial Dysplasia, Sermporn Thaweesapphithak
Chulalongkorn University Theses and Dissertations (Chula ETD)
Cleidocranial dysplasia (CCD) is a skeletal disorder affecting the skull, teeth, and clavicles, and is associated with the RUNX2 variants. We identified the five variants from five families, three were novel, comprising c.739delA (p.(Ser247Valfs*)), c.901C>T (p.(Gln301*)), and c.1081C>T (p.(Gln361*)) and two were reported, comprising c.673C>T (p.Arg225Trp) and c.674G>A (p.Arg225Gln). All patients exhibited typical CCD features, but we observed the unreported phenotypes, left forth-ray brachymetatarsia. Moreover, we reviewed the C-terminus RUNX2 variants in the CCD patients and found 81 variants that have been reported. To determine, the pathomechanism of CCD caused by the variants in the C-terminus, …
