Chemicals and Drugs Commons^™

Phytochemical And In-Vitro Cytotoxic Analyses Of Flavonoid Species Isolated From Chromolaena Leivensis, Luke A. Bryant

Electronic Theses and Dissertations

As a leading cause of death worldwide, cancer and its treatments remain a primary source of interest among researchers. Modern studies are looking into bioselective cytotoxicity to create new chemotherapies that do not have the same harsh side effects as those we use today. Natural product research has a promising future for the development of such treatments. Specifically, polar flavonoids may be the key to a bioselective treatment. Such flavonoid species are native to plants, often within flower petals or within the body. A natural antioxidant, they are designed not to harm healthy cells. This study focuses on the plant …

Exploring The Potential Benefits Of Combining Cannabidiol And Beta-Caryophyllene For Neuropathic And Inflammatory Pain: A Systematic Review, Khalid Benamar

School of Medicine Publications

Purpose: In this review, we examined the analgesic effect of the combination of cannabidiol (CBD) and beta-caryophyllene (BCP) in different pain conditions.

Methods: A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Literature searches were performed across major academic databases (Google Scholar, Web of Science, and PubMed) from 2009 to 2026 to identify studies investigating the analgesic effect of the combination of CBD and BCP.

Results: The search identified 31 records. Ten reports were screened and assessed for eligibility, and five studies met the inclusion and exclusion criteria. Findings consistently demonstrate …

Development Of A Protein Mass Spectrometric Assay For The Characterization Of Colorectal Cancer Exosomes, Frank J. Reed Iv

Science University Research Symposium (SURS)

Exosomes (sEV) carry proteins involved in intracellular communication and colorectal cancer (CRC) biology, but their morphologic overlap with non-vesicular extracellular particles (NVEPs), and other extracellular vesicles (EVs), including exomeres and supermeres, complicates proteomic characterization. This aim of this study is to develop mass spectrometric assays that evaluate sEV enrichment, purity, and distinguish sEV CRC-associated protein cargo from EV and NVEP CRC-associated protein cargo to better classify the role of sEVs in CRC biology.

Our lab previously analyzed conditioned media from DiFi, cystic clone (CC), and spikey clone (SC) CRC cell lines purified using dialysis, concentration, and electrophoresis enrichment (DCE) by …

November 2026, Swosu Rural Health Center

RURAL ROCKS

Welcome to the Hilltop, Raina Wrather!

Adverse Events Linked to Injectable Glutathione Compounded with Dietary Supplement Grade Ingredient: Current Situation | HAIs | CDC

CMS Releases Guidance and Technical Specifications on the Medicaid Direct Care Worker Compensation Reporting Requirement

Immunize - October 21, 2026

Epic launches Connectors to link its AI tools with third-party apps,,,

FDA Approves New Nonprescription Eye Drop for Relief of Eye Redness

FDA Issues Final Guidance on Prescription Drug Apps and Software

Release Of Bound Steroid From The Androgen And Estrogen Receptors Is Induced By Ddt And Its Analogs, Matthew D. Rosales, Tahyra Soto, Jacqueline I. Goodship, Ahyssa R. Cruz, Isaac A. Rodriguez, Ventura Cuba Flores, Amanda Chavez, Monica P. Solis, Esmeralda Lopez, Frank B. Dean, Evangelia Kotsikorou

School of Integrative Biological & Chemical Sciences Faculty Publications

The pesticide p,p'-DDT (DDT) and its analogs (p,p'-DDD, o,p'-DDD, and p,p'-DDE) inhibit the binding of dihydrotestosterone (DHT) to the androgen receptor (AR) and estradiol (E2) to the estrogen receptor (ERα) ligand-binding domains (LBDs), as previously reported. In this study, we introduce assays to measure the release of receptor-bound steroids. These compounds induced the release of DHT from the AR LBD and E2 from the ERα LBD. These findings suggest that DDT and its analogs may interact with a surface site on the LBD, thereby allosterically disrupting steroid binding. One potential site is binding function 3 (BF3). To explore this possibility, …

Contraception Or Complication: A Review Of Depo-Provera’S Pharmacology And Public Health Implication, Phylicia Carpenter

Best Integrated Writing

This review article explores the link between progestogens and meningioma risk and outlines the biological mechanisms that may contribute to tumorigenesis. Two progestogens are emphasized through the paper: cyproterone acetate and medroxyprogesterone acetate (Depo-Provera). An important French study examining the relationship between progestogens use and meningioma risk is discussed, along with the health risks associated with long-term use. Additionally, this review advocates for increased routine prescriber-patient consultations and stronger drug regulation to educate and protect patients, particularly those experiencing socioeconomic disadvantages. It is important to note that the FDA recently updated the label for injectable medroxyprogesterone acetate in December 2025 …

Best Integrated Writing Fall 2026 - Complete Edition, Wright State University School Of Humanities And Cultural Studies, Kristie Mckiernan

Best Integrated Writing

Best Integrated Writing includes excellent student writing from Integrated Writing courses taught at Wright State University.

Systematic Profiling Of Encoder Architectures And Multimodal Embeddings In Protein Foundation Models Reveals Data Set-Driven Separability Regimes In Prediction Of Allosteric And Orthosteric Binding Sites, Alina Bazarova, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

Allosteric regulation represents a fundamental mechanism of protein function, yet distinguishing allosteric from orthosteric protein-binding sites remains a persistent computational challenge. While multimodal protein foundation models offer the potential to integrate complementary biological signals, including sequence, structure, functional annotations, and conformational dynamics, their performance determinants in allosteric binding site detection remain poorly understood. We introduce a unified computational framework for profiling multimodal protein foundation models across distinct binding site separability regimes. Rather than evaluating models solely by predictive accuracy, the framework combines systematic modality embedding ablations, encoder architecture comparisons, and variance decomposition to characterize how evolutionary, structural, functional, and dynamical …

Innovative Development Of Synthetic Biology Industry From Perspective Of Deep Integration Of Four Chains, Qin Guo, Chao Zhang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Future industries represent the development direction of technological innovation and emerging industries, and are the main path to accelerate the formation of new quality productivity. As an important subsector of the future industry, synthetic biology industry is becoming a new track and new format for new quality productivity, and various regions are making cutting-edge directions such as synthetic biology industry a hot topic for future industrial layout. Based on the analysis of typical cities such as Shenzhen, Beijing, Tianjin, Shanghai, Hangzhou, and Changzhou, the current integration of the Four Chains in the synthetic biology industry is facing a four-dimensional dilemma …

Ai-Driven Drug Innovation Research: Trends, Challenges, And Countermeasures, Tian Miao, Qi Zhou, Lianzheng Zhou, Weijun Xu, Siyuan Liu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Artificial intelligence (AI) is profoundly transforming the innovation paradigm, industrial ecosystem, and business model of drug research and development. In recent years, the global AI-driven pharmaceutical market has grown rapidly. Major economies, multinational pharmaceutical enterprises, and technology giants are accelerating their strategic deployment. AI pharmaceutical industry has entered a critical stage of transitioning from proof-of-concept to commercial-application. China attaches great importance to the integrated development of AI and the biopharmaceutical industry, but it still faces challenges, including data scarcity, talent shortages, algorithmic black-boxes, regulatory lag, and weak foundations. This study proposes measures from the aspects of data supply, talent cultivation, …

Time-Varying Spatial Ventricular Gradient Orientation Is Associated With Anthracycline Heart Failure, Andrea N. Rosas Diaz, Hans F. Stabenau, Patricia Tung, Jason Nelson, Gabriel Pajares Hurtado, Sarah Warack, Sanam Alilou, Arunashis Sau, Daniel B. Kramer, Aarti Asnani, Jonathan W. Waks

Division of Cardiology Faculty Papers

BACKGROUND

Anthracycline use is limited by cardiotoxicity resulting in heart failure (HF). The spatial ventricular gradient(SVG) is a vectorcardiographic measurement of myocardial electrical heterogeneity associated with sudden death and incident HF. It is unclear if serial measurement of SVG after anthracycline initiation can help predict subsequent HF.

OBJECTIVES

The objective of the study was to determine if time-varying SVG measurements are associated with anthracycline HF.

METHODS

Retrospective, single-center study of adult patients with cancer treated with anthracyclines between 1992 to 2019. Standard 12-lead electrocardiograms obtained within 6 months before and up to 5 years after anthracycline initiation were analyzed. Patients …

Spriz (Ccdc127) Protein Conserved In Deuterostome Animals Is A Rigid Omm-Imm Tether That Locally Sets Mitochondrial Ims Volume, Raman Shulinski, Roman Loban, Danny Farhat, Benjamín Cartes-Saavedra, Matthew J. Magda, Pavel Kotchetkov, Victoria Caminiti, Linda David, Yuri I. Wolf, Conor O'Dwyer, Morgan Fullerton, Yan Burelle, Jyh-Yeuan E. Lee, Andrea Raimondi, Eugene V. Koonin, György Hajnóczky, Mary-Ellen Harper, Luca Pellegrini

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

The double-membrane nature of mitochondria generates an intermembrane volume through which ions, reactive oxygen species, and metabolites must flux to reach the matrix or cytosol, but whether this volume is a genetically specified structure remains unknown. We identify SPRIZ (spatial regulator of the intermembrane zone), the product of Ccdc127, a gene conserved across deuterostome animals. SPRIZ assembles into an ∼18-nanometer homodimeric tether anchored in the outer mitochondrial membrane (OMM) and inserted into the inner mitochondrial membrane (IMM) through vertebrate-specific hydrophobic loops, physically spacing the two membranes and setting local intermembrane volume. Cryo-electron tomography of native mitochondria revealed rod-like densities …

Analysis And Study Of The Content Of Chloride Salts In Oil, Natalia Evgenievna Sheina, Muborak Akramovna Mirshomilova

Technical science and innovation

The article addresses the critical issue of crude oil quality control, specifically focusing on the determination of chloride salts (sodium, calcium, and magnesium), which exert a destructive impact on processing equipment. The paper provides a detailed analysis of the adverse effects of salts, which lead to severe equipment corrosion, scaling, and a reduced yield of valuable oil fractions. The chemical principles and specific applications of two standardized methods for analyzing aqueous extracts according to GOST 21534-2021 and ASTM D3230 are described: indicator (argentometric and mercurimetric) and potentiometric titration. The experimental section presents the results of a comparative analysis of crude …

October 2026, Swosu Rural Health Center

RURAL ROCKS

SWOSU Rural Health Center Highlights Innovation at Oklahoma Rural Health Conference

Rural Health. Community Strength

Adverse Events Linked to Injectable Glutathione Compounded with Dietary Supplement Grade Ingredient: Current Situation | HAIs | CDC

Epic shifts focus to cybersecurity while AI, interoperability agenda still on track, company says

UnitedHealthcare, Cigna, Centene sign on to CertifyOS' new provider credentialing model

Hospitals' use of AI coding tools cost BCBSA plans $942M more for similar care: analysis

Why Prime Therapeutics is betting on bridging the gaps between medical, pharmacy benefits

HRSA names 10 drugmakers for revised 340B rebate pilot ahead of 2027 launch

HRSA …

Making Indole-Based Drug Ingredients Faster With A Simple Iron Catalyst, Samuel Voell, Eike B. Bauer

Undergraduate Research Symposium

Substituted indoles have significant pharmaceutical relevance and are common building blocks in medicinal chemistry. They are part of many approved drugs across various areas and are also widely explored as leads for antiviral and antibacterial activity. This includes treatment of MRSA, a bacterium type that is resistant to common antibiotics and responsible for complicated infections. Many reactions in pharmaceutical production are slow and inefficient; catalysis facilitates the synthesis of pharmaceutically relevant products. Catalysis provides an efficient, lower-energy pathway to form a product, thereby saving time and energy. Ferrocenium tetrafluoroborate (FcBF4), is a catalyst we are currently investigating. FcBF4 is an …

Enantioselectivity Of The Photochemical Continuous-Flow Isomerization Of Humulones, Gregory M. Giovine, Trevor Smith, Bruce Hamper

Undergraduate Research Symposium

Humulones, the primary natural product present in the historically significant hop flower, represent a largely unexplored candidate for structure-based pharmaceutical design.  Showing promising biological activity as an anti-bacterial and anti-inflammatory agent, humulones are of interest both for their bioactive properties and for their long-established tolerability and natural abundance.  Humulones undergo a characteristic isomerization reaction, where the six-membered substituted phloroglucinol ring contracts to a five-membered ring isohumulone, under a variety of conditions, including those enabled by brewing conditions (thermal, metal-catalyzed) and by exposure to UV light.  Optimization of the photocatalyzed isomerization of n-humulone to n-isohumulone in flow conditions resulted in a …

Overview Of Glp-1ra Medications, Thomas A.F. Cordaro Pharmd, Sumaiya A. Difaa Pharmd, Amel J. Basil Pharmd

Transformative Medicine

GLP-1 is an incretin hormone that is naturally produced in the body that regulates blood glucose and appetite. The first GLP-1RA that was FDA approved, exenatide, in 2005, originated from the Gila monster and beaded lizard, via the discovery of the exendin-4 peptide. GLP-1RAs function by mimicking endogenous GLP-1 incretin hormone, leading to an increase in glucose-dependent insulin release from beta-cells of the pancreas, decrease in glucagon release, delayed gastric emptying, and satiety. Due to the benefits seen from initiating GLP-1RAs in the market, it sparked interest in numerous studies which proved that certain GLP-1RAs can provide cardiorenal protection. The …

Glp-1 Receptor Agonists And Wound Healing In Diabetic Foot Ulcers: A Scoping Review, Merlin Sajeev, Amanda L. Killeen

School of Podiatric Medicine - Student Research

Level of Evidence: Level 5

Poster Category: Non-sponsored

Introduction: Diabetic foot ulcers (DFUs) are a major complication of diabetes and are associated with delayed wound healing, infection, amputation, and substantial morbidity. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) improve glycemic control and may influence inflammation, vascular function, and tissue repair. However, clinical evidence evaluating their relationship with DFU healing remains limited.

Aim: To characterize available clinical evidence examining the association between GLP-1 RA use and wound-healing outcomes in patients with diabetic foot ulcers.

Methods: PubMed and Google Scholar were searched for English-language studies published from 2021–2026 using terms combining “GLP-1 receptor …

Drug Development And Promising Therapeutic Targets For Coronary Artery Disease: Current Landscape And Future Prospects: Cvia State-Of-The-Art Review, Shan Hu, Zhen Guo, Chenze Li, Xiang Nie, Jinjie Wang, Jianmei He, Cheng Zhuang, Limin Zhang, Depeng Li, Yutong Lin, Danan Wang, Duanbin Li, Fomin Zhang, Qiongjun Zhu, Xiaoyi Bao, Ning Zhang, Xiaolu Jiao, Wenbin Zhang, Beibei Du, Hongmei Zhao, Yongjian Zhu, Bing Xiao, Yupeng Liu, Haoyu Wu, Di Fan, Peng Li, Hongshan Chen, Xin-Liang Ma, Jun Pu

Department of Emergency Medicine Faculty Papers

Coronary artery disease (CAD) remains the leading cause of death globally, despite the limited efficacy of current pharmacological therapies. The need for safer and more effective treatment strategies has never been more urgent. This review provides a contemporary overview of advances in CAD drug development. Novel lipid-lowering agents such as proprotein convertase subtilisin/kexin type 9 (PCSK9) and angiopoietin-like protein 3 (ANGPTL3) inhibitors, anti-inflammatory therapies targeting interleukin pathways, and metabolic modulators have expanded the therapeutic landscape. Concurrently, precision medicine and drug repurposing approaches, informed by genomic profiling and biomarker-based stratification, are transforming the framework of CAD therapy. The integration of artificial …

Journal Ida 2023 102 4

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.