Perception Of Illness And Its Association With Willingness To Adhere To Treatment In Chronic Hepatitis C Patients With New Diagnosis Of Nonalcoholic Fatty Liver Disease,
2022
University of Arkansas, Fayetteville
Perception Of Illness And Its Association With Willingness To Adhere To Treatment In Chronic Hepatitis C Patients With New Diagnosis Of Nonalcoholic Fatty Liver Disease, Carmel Kruse
The Eleanor Mann School of Nursing DNP Capstone Projects
Chronic liver disease is becoming the most common cause of mortality, morbidity, and utilization of healthcare services globally. Both nonalcoholic fatty liver disease (NAFLD) and chronic hepatitis C (CHC) are frequent causes of chronic liver disease. Recently, there have been significant findings on the relationship between NAFLD and CHC; patients with CHC have a higher incidence of NAFLD. The introduction of direct-acting antivirals has cured more CHC patients than ever before. Unfortunately, the current interventions for NAFLD requiring behavioral change remain ineffective. Patient’s ability to follow advice depends largely on their health beliefs; therefore, understanding their illness perception is an …
Validation Of Non-Invasive Co2 Tolerance Field Test,
2022
Boise State University
Validation Of Non-Invasive Co2 Tolerance Field Test, Joshua T. Murphey
Boise State University Theses and Dissertations
INTRODUCTION: Breathwork, or the specific act of controlling breathing to elicit a desired outcome, is not only a potential way to improve one’s mental well-being but also to alter adaptative responses through gas exchange at the capillary level. Increasing tolerance to carbon dioxide (CO2) has been positively correlated with improvement in athletic performance and reduction of stress and anxiety. However, there does not exist a validated non-invasive test to accurately measure one’s tolerance to CO2. PURPOSE: The purpose of this study was to validate the only currently known CO2 tolerance (CO2T) field test …
Unraveling The Effects Of Aerobic Exercise And Erk5 Signaling In The Solid Tumor Microenvironment Using Murine Models,
2022
University of Texas MD Anderson Cancer Center
Unraveling The Effects Of Aerobic Exercise And Erk5 Signaling In The Solid Tumor Microenvironment Using Murine Models, Hannah Savage
Dissertations and Theses (Open Access)
Solid tumors are comprised of multiple cell types which communicate and work together to promote tumor progression. Advances in the treatment of solid tumors have armed clinicians with more efficacious pharmacologic agents and combinations. However, a focus on drug adjuvants in the treatment of solid cancer has left gaps in knowledge regarding non-pharmacologic treatment adjuvants, like aerobic exercise. The current dissertation investigates pharmacologic and non-pharmacologic based approaches to remodel the solid tumor microenvironment landscape and alter therapeutic efficacy. We disassemble compartments of the tumor microenvironment, including tumor vasculature and immune infiltrate, using mouse models and single cell techniques, to elucidate …
Body Temperature And Diet As Drivers Of Obesity Development,
2022
The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences
Body Temperature And Diet As Drivers Of Obesity Development, Jessie Morrill
Dissertations and Theses (Open Access)
Metabolic disease and obesity affect millions of individuals worldwide and the prevalence of obesity is expected to continue to rise. Mechanisms underlying diet-induced metabolic disease and obesity are complex and are largely unknown. In this dissertation research, we aimed to make advances toward understanding how body temperature and high-fat diet consumption contribute to the development of obesity. Herein, we describe the progress that was made toward three research projects. In the first project, we develop novel animal models to determine the impact of reduced body temperature on obesity development and also demonstrate that severe obesity can be reversed through increased …
The Role Of The Hypoxia-Inducible Factor 2 In Pancreatic Cancer: Mechanisms Of Tumor Immunosuppression And Intestinal Radioprotection,
2022
The Texas Medical Center Library
The Role Of The Hypoxia-Inducible Factor 2 In Pancreatic Cancer: Mechanisms Of Tumor Immunosuppression And Intestinal Radioprotection, Carolina Garcia Garcia
Dissertations and Theses (Open Access)
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with dismal prognosis. The only curative option for patients is surgery, but over 80% of patients are not surgical candidates. Unfortunately, PDAC is resistant to the three remaining options. PDAC is characterized by a profoundly hypoxic and immunosuppressive stroma, which contributes to its therapeutic recalcitrance. Alpha-smooth muscle actin+ (αSMA+) cancer-associated fibroblasts (CAFs) are the most abundant stromal component, as well as mediators of stromal deposition. The hypoxia-inducible factors (HIF1 and HIF2) coordinate responses to hypoxia, yet, despite their known association to poor patient outcomes, their functions within the PDAC tumor microenvironment (TME) …
Expression Of Claudins In Gill And Opercular Membranes In Relation To Osmoregulation In Euryhaline Atlantic Killifish, Fundulus Heteroclitus,
2022
University of Arkansas, Fayetteville
Expression Of Claudins In Gill And Opercular Membranes In Relation To Osmoregulation In Euryhaline Atlantic Killifish, Fundulus Heteroclitus, Allison Mcfarland
Graduate Theses and Dissertations
Atlantic killifish (Fundulus heteroclitus) are euryhaline teleosts, which means they can thrive in environments with varying salinities, ranging from concentrated seawater (SW) to dilute fresh water (FW) and thus survive in estuaries. To be able to maintain ionic and osmotic homeostasis in these diverse salinities, osmoregulatory organs like gill and opercular membrane must be able to adjust the permeability and transport of water and ions. The surface epithelia in these organs need to prevent the passive flux of ions and water in a drastically changing environment, while being able to switch between active ion secretion or uptake dependent upon environmental …
Engineering Of Ideal Systems For The Study And Direction Of Stem Cell Asymmetrical Division And Fate Determination,
2022
Old Dominion University
Engineering Of Ideal Systems For The Study And Direction Of Stem Cell Asymmetrical Division And Fate Determination, Martina Zamponi
Biomedical Engineering Theses & Dissertations
The cellular microenvironment varies significantly across tissues, and it is constituted by both resident cells and the macromolecules they are exposed to. Cues that the cells receive from the microenvironment, as well as the signaling transmitted to it, affect their physiology and behavior. This notion is valid in the context of stem cells, which are susceptible to biochemical and biomechanical signaling exchanged with the microenvironment, and which plays a fundamental role in establishing fate determination and cell differentiation events. The definition of the molecular mechanisms that drive stem cell asymmetrical division, and how these are modulated by microenvironmental signaling, is …
Identifying A Glucocorticoid-Activated Gpcr That Rapidly And Non-Genomically Increases Camp Levels In Mammalian Cells,
2022
Chapman University
Identifying A Glucocorticoid-Activated Gpcr That Rapidly And Non-Genomically Increases Camp Levels In Mammalian Cells, Francisco Nunez
Pharmaceutical Sciences (PhD) Dissertations
Glucocorticoids (GCs) are steroid hormones that regulate diverse physiological processes. Synthetic versions of GCs are commonly used to treat inflammatory diseases such as asthma by modulating gene expression to suppressing several inflammatory activities. However, it is estimated that 5-10% of asthmatics are unresponsive to GCs, which may be explained by receptor desensitization and/or the presence of a neutrophilic endotype. One understudied phenomenon of GCs is their ability to induce rapid, non-genomic actions. For example, GCs can acutely modulate calcium concentrations levels, induce smooth muscle relaxation and modulate nitric oxide synthase activity, within minutes and sometimes seconds, which is too rapid …
Advanced Age And Neurotrauma Diminish Glutathione And Impair Antioxidant Defense After Spinal Cord Injury,
2022
University of Kentucky
Advanced Age And Neurotrauma Diminish Glutathione And Impair Antioxidant Defense After Spinal Cord Injury, Andrew N. Stewart, Ethan P. Glaser, Caitlin A. Mott, William M. Bailey, Patrick G. Sullivan, Samir P. Patel, John C. Gensel
Physiology Faculty Publications
Advanced age at the time of spinal cord injury (SCI) exacerbates damage from reactive oxygen species (ROS). Mechanisms underlying this age-dependent response are not well understood and may arise from decreased antioxidant defense. We investigated how spinal cord levels of the antioxidant glutathione (GSH), and its regulation, change with age and SCI. GSH is used by GSH peroxidase to sequester ROS and is recycled by GSH reductase. Male and female, 4- and 14-month-old (MO) mice received a 60 kDyn contusion SCI, and the levels of GSH and its regulatory enzymes were evaluated at one and three days post-injury (dpi). The …
Physical Activity And Mindfulness Are Associated With Lower Anxiety In Different But Complementary Ways,
2022
McMaster University
Physical Activity And Mindfulness Are Associated With Lower Anxiety In Different But Complementary Ways, Allison L. Mizzi, Antony D. Karelis, Jennifer J. Heisz
International Journal of Exercise Science
International Journal of Exercise Science 15(7): 1075-1084, 2022. Introduction: Anxiety is the most prevalent mental illness worldwide. Physical activity and mindfulness both reduce anxiety. The two are highly related; however, the relative association of physical activity and mindfulness on anxiety has yet to be examined. The present study aimed to evaluate the unique variance accounted for by physical activity and mindfulness on anxiety. Methods: Fifty young adults from a student population (M ± SD = 19 ± 0.2 years old; 58% female) reported their physical activity, mindfulness, and anxiety symptoms at the start of the study and reported their change …
Impact Of An Acute Bout Of Submaximal Aerobic Exercise On Circulating Leukocytes In Individuals With Spinal Cord Injury,
2022
University of British Columbia, Okanagan
Impact Of An Acute Bout Of Submaximal Aerobic Exercise On Circulating Leukocytes In Individuals With Spinal Cord Injury, Garett S. Jackson, Kendra R. Todd, Jan W. Van Der Scheer, Jeremy J. Walsh, Gabriel U. Dix, Kathleen A. Martin Ginis, Jonathan P. Little
International Journal of Exercise Science
International Journal of Exercise Science 15(3): 1085-1104, 2022. Individuals with spinal cord injury (SCI) may experience cardiovascular, musculoskeletal and organ function dysregulation. Sequelae include reduced catecholamine secretion and attenuated immune responses which may impact exercise-induced leukocytosis. The purpose of this study was to characterize major leukocyte subtypes following 30 minutes of acute, submaximal aerobic exercise, in line with updated international SCI exercise guidelines for adults. It was hypothesized that exercise would increase major leukocyte subtypes when compared to fasted baseline. Eight participants with SCI (incomplete n = 6; complete n = 2) completed a 30-minute bout of aerobic exercise on …
Aerobic Performance Detriments While Wearing A Face Mask Diverge Among Males And Females,
2022
Baylor University
Aerobic Performance Detriments While Wearing A Face Mask Diverge Among Males And Females, Jose M. Moris, Yunsuk Koh
International Journal of Exercise Science
International Journal of Exercise Science 15(2): 1105-1116, 2022. The current study examined the impact of wearing a face mask (FM) at rest and while exercising on cardiorespiratory variables and aerobic performance between males and females. Nine males (21.4 ± 0.5 yr) and 9 females (21.8 ± 3.6 yr) performed a pulmonary function test and a graded maximal exercise test (GXT) on a treadmill with an FM and without an FM in random order. During the GXT, cardiorespiratory variables were measured at different exercise intensities (rest, 40%, 55%, 70%, 80%, 100% of VO2max) and during recovery. Regardless of sex, …
The Acute Effect Of In Natura Beetroot Juice Intake On Intra-Session Exercise Sequences During Concurrent Training,
2022
Camilo José Cela University
The Acute Effect Of In Natura Beetroot Juice Intake On Intra-Session Exercise Sequences During Concurrent Training, Diego Souza, Julio Ribeiro, Andrea Simão, Millán Aguilar-Navarro, Marcos Polito
International Journal of Exercise Science
International Journal of Exercise Science 15(2): 1075-1085, 2022. The purpose of this study was to analyze the acute effects of in natura beetroot juice intake on intra-session exercise sequences during concurrent training. Following a randomized double-blind placebo-controlled crossover design, 20 well-trained men (21.4 ± 2.9 years; 74.8 ± 6.3 kg; 175.7 ± 5.0 cm) performed two concurrent training sessions with different intra-session exercise sequences: CT1 (aerobic exercise + resistance exercises) and CT2 (resistance exercises + aerobic exercise). The resistance exercises were bench-press, lat-pull down, and shoulder-press (three sets to failure; 2 s cadence for the concentric and eccentric phases; 90 …
Investigating The Psychophysiological Response To Grade One Muscular Injury In Professional Australian Football Athletes,
2022
La Trobe University
Investigating The Psychophysiological Response To Grade One Muscular Injury In Professional Australian Football Athletes, Billymo Rist, Alan J. Pearce, Anthea C. Clarke
International Journal of Exercise Science
International Journal of Exercise Science 15(5): 1052-1063, 2022. The purpose of this study was to examine Australian Football athletes’ responses to a grade one muscular injury from a psychophysiological perspective to understand the strength of the association between stress, optimism, and cortisol. Forty-five players listed with one professional Australian Football club volunteered for this study. Inclusion criteria consisted of sustaining a muscular injury during the course of the season with four-weeks predicted recovery time (as diagnosed by club medical staff, n=9). The control group were age, position, and career history matched players from the same sample. Players were also matched …
Living Situation And Physical Activity In The Covid-19 Pandemic Among American Private University Students,
2022
Rice University
Living Situation And Physical Activity In The Covid-19 Pandemic Among American Private University Students, Eduardo Gonzalez Villarreal, Laura S. Kabiri, Cassandra S. Diep, Hedi Y. Perkins, Amanda M. Perkins-Ball, Augusto X. Rodriguez
International Journal of Exercise Science
International Journal of Exercise Science 15(4): 1064-1074, 2022. Many university students experienced changes during the COVID-19 pandemic, including potential changes in physical activity (PA) levels and living situation. As PA behaviors in young adulthood help establish life-long habits and future health outcomes, the purpose of this study was to investigate overall change in PA, as well as change in PA due to living situation, among private university students during the COVID-19 pandemic. Private university students (n = 109) between 18 and 25 years of age completed an online survey that included the International Physical Activity Questionnaire – Short Form. T-tests …
Short-Term Effects Of Repeated-Sprint Training On Vertical Jump Ability And Aerobic Fitness In Collegiate Volleyball Players During Pre-Season,
2022
Federal University of Paraiba
Short-Term Effects Of Repeated-Sprint Training On Vertical Jump Ability And Aerobic Fitness In Collegiate Volleyball Players During Pre-Season, Petrus Gantois, Gilmário Ricarte Batista, Leonardo Sousa Fortes, Arnaldo Luís Mortatti, Matheus Dantas, Daniel Gomes Da Silva Machado, Breno Guilherme De Araújo Ticoco Cabral
International Journal of Exercise Science
International Journal of Exercise Science 15(6): 1040-1051, 2022. The aim of this study was to assess the effect of repeated-sprint training (RST) on vertical jump ability and aerobic power in college volleyball players. Nineteen male volleyball players, aged between 18-24 years, were randomized into the RST group (RST; n = 10) and control group (CG; n = 9). The RST included 2-3 sets of 6x30m all-out sprints, twice per week, in addition to the regular training routine. The control group performed only the regular volleyball training sessions (i.e. mainly of technical-tactical drills). All players performed a maximal graded treadmill test, …
Heat Stress And The Control Of Skeletal Muscle Mass,
2022
University of New Mexico - Main Campus
Heat Stress And The Control Of Skeletal Muscle Mass, Zachary J. Fennel
Health, Exercise, and Sports Sciences ETDs
PURPOSE: 1) Compare the effects of whole-body heat stress (HS) and resistance exercise (RE) on thermoregulatory responses and skeletal muscle heat shock and hypertrophy related signaling. 2) Examine the effects of acute heat stress (HEAT) on myotube growth and fusion compared to controls (CON), hypertrophy (HYPER), and atrophy (RAPA) treatments in-vitro. METHODS: 1) Eight healthy, physically active and resistance trained individuals (18-45 years) completed RE and HS. 2) 48 hours following treatments, C2C12 myotubes were assessed for myotube area and nuclear fusion index. RESULTS: 1) RE and HS similarly increased muscle but not core temperatures. HS but not RE increased …
Health And Fitness Comparisons Among Middle-Aged And Older Adults With Long-Term Participation In Four Different Sports,
2022
The University of Alabama, Tuscaloosa, AL, USA
Health And Fitness Comparisons Among Middle-Aged And Older Adults With Long-Term Participation In Four Different Sports, Peixuan Zheng, Lei Zhang, Feng Shi, Kaiwen Man, Elroy J. Aguiar
International Journal of Exercise Science
International Journal of Exercise Science 15(6): 1028-1039, 2022. Physical activity is known to confer numerous health benefits. However, few studies have assessed the prolonged impact of participation in different sports on health and fitness. The purpose of this cross-sectional study was to compare the impact of long-term participation (i.e., ≥9 years) in four different sports, including two traditional Chinese (Tai Chi; diabolo) and two modern sports (aerobics; track and field [TF]) on health and fitness measures among middle-aged and older adults. Participants (n=252, 56.6±8.5y, 66% female) completed the following measures: height, weight, BMI, waist circumference, waist-hip ratio (WHR), body fat%, …
Individual Fluctuations In Blood Lactate Concentration During An Ice Hockey Game; Differences Between Player Positions,
2022
Mid Sweden University; University of Gävle
Individual Fluctuations In Blood Lactate Concentration During An Ice Hockey Game; Differences Between Player Positions, Nestor Lögdal, Marko S. Laaksonen, Erik P. Andersson
International Journal of Exercise Science
International Journal of Exercise Science 15(6): 985-993, 2022. The main purpose of the current study was to provide an in-depth description of individual player’s intra-game physiological responses during an ice hockey game. A secondary aim was to compare these responses between forwards and defensemen. Six elite junior ice hockey players, three forwards and three defensemen, median (interquartile range) 17 (17–17) years, 182 (180–185) cm, and 78 (74– 80) kg were recruited to participate in the study. Capillary blood samples were taken following each shift and analyzed for blood lactate concentration (BLC). Heart rate (HR) was registered continuously throughout the game. …
Relationships Between Lower-Body Power, Sprint And Change Of Direction Speed Among Collegiate Basketball Players By Sex,
2022
Oklahoma State University
Relationships Between Lower-Body Power, Sprint And Change Of Direction Speed Among Collegiate Basketball Players By Sex, Javier A. Zaragoza, Quincy R. Johson, Daniel J. Lawson, Elizabeth L. Alfaro, J. Jay Dawes, Doug B. Smith
International Journal of Exercise Science
International Journal of Exercise Science 15(6): 974-984, 2022. The purpose of this study was to determine if significant relationships exist between absolute and relative lower-body power and selected measures of speed among male and female collegiate basketball players. Archived performance testing data from 29 (male = 14; female = 15) NCAA division II collegiate basketball players were used for this analysis. These measures included lane agility, 10-yard sprint, and shuttle run time (sec). A Pearson’s correlation coefficient was used to determine if significant relationships existed between measures of lower-body power and linear sprint time, change of direction speed (CODS), and …
