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Patient-Specific Quantification Of The Relationship Between The Left Atrium Pressure And The Ostial Diameter Of The Left Atrial Appendage, Sky Tianqi Gao 2018 University of Denver

Patient-Specific Quantification Of The Relationship Between The Left Atrium Pressure And The Ostial Diameter Of The Left Atrial Appendage, Sky Tianqi Gao

Electronic Theses and Dissertations

The left atrial appendage has been a historically understudied region of the heart until fairly recently with the new understanding of its role in the stroke pathway of patients with atrial fibrillation. The goal of this study is to take a look at the biomechanical behavior of the left atrium and left atrial appendage under normal physiological loading conditions using material properties taken from biaxial stretch tests. Several different options for material properties models were tested and biaxial stretch test data of cadaveric human tissue samples for the left atrium and appendage were fit to a Fung-type strain-energy function for …


Incidence Of Second Malignancy In Patients With Papillary Thyroid Cancer From Surveillance, Epidemiology, And End Results 13 Dataset, Mayumi Endo, Jessica Liu, Marcelle Dougan, Jennifer Lee 2018 Ohio State University - Main Campus

Incidence Of Second Malignancy In Patients With Papillary Thyroid Cancer From Surveillance, Epidemiology, And End Results 13 Dataset, Mayumi Endo, Jessica Liu, Marcelle Dougan, Jennifer Lee

Faculty Publications

Increased risk of second primary malignancy (SPM) in papillary thyroid cancer (PTC) has been reported. Here, we present the most updated incidence rates of second primary malignancy from original diagnosis of PTC by using the data from the Surveillance, Epidemiology, and End Results. In this cohort, 3,200 patients developed SPM, a substantially higher number than in the reference population of 2,749 with observed to expected ratio (O/E) of 1.16 (95% CI; 1.12–1.21). Bone and joint cancer had the highest O/E ratio of 4.26 (95% confidence interval [CI] 2.33–7.15) followed by salivary gland (O/E 4.15; 95% CI 2.76–6.0) and acute lymphocytic …


Environmental Effects On Drosophila Brain Development And Learning, Xia Wang, Amei Amei, J. Steven De Belle, Stephen P. Roberts 2018 Missouri University of Science and Technology

Environmental Effects On Drosophila Brain Development And Learning, Xia Wang, Amei Amei, J. Steven De Belle, Stephen P. Roberts

Biological Sciences Faculty Research & Creative Works

Brain development and behavior are sensitive to a variety of environmental influences including social interactions and physicochemical stressors. Sensory input in situ is a mosaic of both enrichment and stress, yet little is known about how multiple environmental factors interact to affect brain anatomical structures, circuits and cognitive function. In this study, we addressed these issues by testing the individual and combined effects of sub-adult thermal stress, larval density and early-adult living spatial enrichment on brain anatomy and olfactory associative learning in adult Drosophila melanogaster. In response to heat stress, the mushroom bodies (MBs) were the most volumetrically impaired among …


Tissue Expression Patterns Identify Mouse Cilia Genes, Timothy S. McClintock 2018 University of Kentucky

Tissue Expression Patterns Identify Mouse Cilia Genes, Timothy S. Mcclintock

Physiology Research Data

A summary of 2,127 mouse genes linked to cilia by previous high-throughput approaches (reviewed in Inglis et al., 2006), published studies of individual gene products, or by McClintock et al. 2008. Each gene was viewed at Entrez Gene to verify and update the Gene ID and Gene Symbol. Each was also searched against PubMed (Gene Symbol AND (cili* OR flagel*)) for published evidence linking the mouse gene or putative orthologs to cilia or flagella. This searchable file lists identifying information about each gene, functional information about the encoded protein, the number of high-throughput studies linking the gene to cilia, and …


Early Contributions To Infants’ Mental Rotation Abilities, Mihaela Constantinescu, David S. Moore, Scott P. Johnson, Melissa Hines 2018 University of East London

Early Contributions To Infants’ Mental Rotation Abilities, Mihaela Constantinescu, David S. Moore, Scott P. Johnson, Melissa Hines

Pitzer Faculty Publications and Research

Some cognitive abilities exhibit reliable gender differences, with females outperforming males in specific aspects of verbal ability, and males showing an advantage on certain spatial tasks. Among these cognitive gender differences, differences in mental rotation are the most robust, and appear to be present even in infants. A large body of animal research suggests that gonadal hormones, particularly testosterone, during early development could contribute to this gender difference in mental rotation. Also, substantial evidence supports an influence of socialization on mental rotation performance. The present study investigated the relationship of two types of factors, early postnatal testosterone exposure and parental …


Sex, Ethnicity, And Socioeconomic Status On Attitudes Toward Women As Managers And Perceived Career Impediment: A Study Of Young Adults In Malaysia, Li teng Voon 2018 Cleveland State University

Sex, Ethnicity, And Socioeconomic Status On Attitudes Toward Women As Managers And Perceived Career Impediment: A Study Of Young Adults In Malaysia, Li Teng Voon

ETD Archive

The current study aims at examining the effects of sex, race, and socioeconomic status on young Malaysians; attitudes toward women as managers and the perceived barriers to their own careers. This paper also examined a moderated mediation, with the moderator being the working status of an individual's mother and the mediator being gender role attitudes. A great wealth of research in this area has been conducted in the Western culture, but much less is known about Malaysia and its young adults. This study provides a historical and sociocultural overview of Malaysia, and how its unique sociopolitical and societal structure impacts …


Rumination In Borderline Personality Disorder: An Examination Of Interpersonal Contexts In Experimental And Daily Life Settings, Skye C. Napolitano 2018 Cleveland State University

Rumination In Borderline Personality Disorder: An Examination Of Interpersonal Contexts In Experimental And Daily Life Settings, Skye C. Napolitano

ETD Archive

This study examined whether Borderline Personality Disorder (BPD) features predict increased rumination in response to interpersonal contexts, leading to increased negative affect (NA) outcomes across self-report, experimental, and daily life settings. As BPD is characterized by sustained NA, emotion dysregulation, and pervasive difficulties in interpersonal relationships, interpersonal contexts may present a specific liability for individuals with BPD to ruminate, and subsequently, experience enduring NA. Undergraduate participants (N=119) completed measures of BPD features, dispositional rumination, emotion dysregulation, and both 1) a laboratory protocol that measured spontaneous rumination and affective reactivity to non-interpersonal (sad film clip) and interpersonal (Cyberball) stimuli and 2) …


The Effect Of Taboo Words And Reprimands In An Audio-Visual Modified Stroop Task, Rachel B. Fernandes 2018 Cleveland State University

The Effect Of Taboo Words And Reprimands In An Audio-Visual Modified Stroop Task, Rachel B. Fernandes

ETD Archive

Previous research has found that participants respond less efficiently to taboo words in a modified emotional Stroop task than to neutral words because of the emotional nature of taboo words. Additionally, there is some evidence that the extent to which these words impact performance depends on whether the words appear in a participant’s native language. More specifically, the taboo effect has been found to be more pronounced in a person’s native language. One purpose of the current study was to determine whether previous results in a taboo Stroop task would be replicated. Another purpose of this study was to determine …


Examining Effects Of Arousal And Valence Across The Adult Lifespan In An Emotional Stroop Task, Samantha E. Tuft 2018 Cleveland State University

Examining Effects Of Arousal And Valence Across The Adult Lifespan In An Emotional Stroop Task, Samantha E. Tuft

ETD Archive

As age increases, there is evidence that people tend to pay less attention to negative information, pay more attention to positive information, or both. There are many theoretical accounts that attempt to explain this positivity bias. In the current study, I examined positivity effects across the adult lifespan by evaluating competing predictions of two theories: Socioemotional Selectivity Theory, which is based in motivation, and Dynamic Integration Theory, which is based in capacity. Computer mouse tracking was used to examine effects across levels of Valence (negative, neutral, and positive) and Arousal (low, medium, and high) in an emotional Stroop task. Participants …


Rhythm: An Open Source Imaging Toolkit For Cardiac Panoramic Optical Mapping, Christopher Gloschat, Kedar Aras, Shubnam Gupta, N. Rokhana Faye, Hanyu Zhang, Matthew W. Kay, Igor R Efimov, +several additional authors 2018 George Washington University

Rhythm: An Open Source Imaging Toolkit For Cardiac Panoramic Optical Mapping, Christopher Gloschat, Kedar Aras, Shubnam Gupta, N. Rokhana Faye, Hanyu Zhang, Matthew W. Kay, Igor R Efimov, +Several Additional Authors

Pharmacology and Physiology Faculty Publications

Fluorescence optical imaging techniques have revolutionized the field of cardiac electrophysiology and advanced our understanding of complex electrical activities such as arrhythmias. However, traditional monocular optical mapping systems, despite having high spatial resolution, are restricted to a two-dimensional (2D) field of view. Consequently, tracking complex three-dimensional (3D) electrical waves such as during ventricular fibrillation is challenging as the waves rapidly move in and out of the field of view. This problem has been solved by panoramic imaging which uses multiple cameras to measure the electrical activity from the entire epicardial surface. However, the diverse engineering skill set and substantial resource …


Can A Comprehensive Transition Plan To Barefoot Running Be The Solution To The Injury Epidemic In American Endurance Runners?, Michael A. Scarlett 2018 Claremont McKenna College

Can A Comprehensive Transition Plan To Barefoot Running Be The Solution To The Injury Epidemic In American Endurance Runners?, Michael A. Scarlett

CMC Senior Theses

Fossils belonging to the genus Homo, dating as far back as two million years ago, exhibit uniquely efficient features suggesting that early humans had evolved to become exceptional endurance runners. Although they did not have the cushion or stability-control features provided in our modern day running shoes, our early human ancestors experienced far less of the running-related injuries we experience today. The injury rate has been estimated as high as 90% annually for Americans training for a marathon and as high as 79% annually for all American endurance runners. There is an injury epidemic in conventionally shod populations that …


Specialization In Athletic Training: A Natural Evolution, JJ Wetherington 2018 St. Luke's Sports Medicine

Specialization In Athletic Training: A Natural Evolution, Jj Wetherington

Clinical Practice in Athletic Training

No abstract provided.


Assessing Lower Extremity Injury Risk In A Mid-Atlantic Drum Corps Using The Weight Bearing Lunge Test, Nicolas C. Merritt, Cameron J. Powden 2018 Furman University

Assessing Lower Extremity Injury Risk In A Mid-Atlantic Drum Corps Using The Weight Bearing Lunge Test, Nicolas C. Merritt, Cameron J. Powden

Clinical Practice in Athletic Training

With athletic training’s expansion into non-traditional settings, it is important to assess if screening tools can provide value in range of settings. Currently, there is a dearth of information regarding specific models for injury risk assessment in drum corps patients. The Weight Bearing Lunge Test (WBLT) has been used to evaluate those at risk for suffering a lower extremity injury (LEI) in a traditional athletic population. This practice-based research is an attempt to apply current evidence of injury risk assessment use in the traditional settings to performing arts. The purpose of our investigation was to determine the effect of WBLT …


Short Term Effects Of A Pectoralis Minor Positional Release In Collegiate Swimmers: A Case Series, Jonathan Roman, Noelle M. Selkow 2018 Illinois State University

Short Term Effects Of A Pectoralis Minor Positional Release In Collegiate Swimmers: A Case Series, Jonathan Roman, Noelle M. Selkow

Clinical Practice in Athletic Training

A tight pectoralis minor correlates to abnormal scapular kinematics, which can cause pain, loss of range of motion and even loss of function, due to the change in scapular position. With these muscular imbalances causing forward scapular posture, the pectoralis minor is a key component to address in the prevention and treatment of shoulder impingement and scapular dyskinesis. This study investigated the effectiveness of a single positional release therapy (PRT) treatment of the pectoralis minor on scapular posture in collegiate swimmers immediately and 24 hours post intervention. Seventeen Division III collegiate swimmers (7 males and 10 females) volunteered to participate, …


Expanding Clinical Practice With Complementary And Integrative Health, Such As Tai Chi, As Therapeutic Interventions, Connor A. Burton 2018 Indiana State University

Expanding Clinical Practice With Complementary And Integrative Health, Such As Tai Chi, As Therapeutic Interventions, Connor A. Burton

Clinical Practice in Athletic Training

No abstract provided.


Novel Antioxidant Properties Of Doxycycline, Dahn L. Clemens, Michael J. Duryee, Cleofes Sarmiento, Andrew Chiou, Jacob D. McGowan, Carlos D. Hunter, Sarah L. Schlichte, Jun Tian, Lynell W. Klassen, James R. O'Dell, Geoffrey M. Thiele, Ted R. Mikuls, Matthew C. Zimmerman, Daniel R. Anderson 2018 University of Nebraska Medical Center

Novel Antioxidant Properties Of Doxycycline, Dahn L. Clemens, Michael J. Duryee, Cleofes Sarmiento, Andrew Chiou, Jacob D. Mcgowan, Carlos D. Hunter, Sarah L. Schlichte, Jun Tian, Lynell W. Klassen, James R. O'Dell, Geoffrey M. Thiele, Ted R. Mikuls, Matthew C. Zimmerman, Daniel R. Anderson

Journal Articles: Cellular & Integrative Physiology

Doxycycline (DOX), a derivative of tetracycline, is a broad-spectrum antibiotic that exhibits a number of therapeutic activities in addition to its antibacterial properties. For example, DOX has been used in the management of a number of diseases characterized by chronic inflammation. One potential mechanism by which DOX inhibits the progression of these diseases is by reducing oxidative stress, thereby inhibiting subsequent lipid peroxidation and inflammatory responses. Herein, we tested the hypothesis that DOX directly scavenges reactive oxygen species (ROS) and inhibits the formation of redox-mediated malondialdehyde-acetaldehyde (MAA) protein adducts. Using a cell-free system, we demonstrated that DOX scavenged reactive oxygen …


Domestic Violence And Demographic Variables As Predictors Of Resiliency Among Young Adults, Sylvanus O. Abraham 2018 Walden University

Domestic Violence And Demographic Variables As Predictors Of Resiliency Among Young Adults, Sylvanus O. Abraham

Walden Dissertations and Doctoral Studies

An increased understanding of resilience may determine how human psychological development can result in positive outcomes despite adversarial situations. However, current studies have not provided a relevant predictive model that can adequately predict resilience, particularly among young adults exposed to domestic violence. Based on Bronfenbrenner's ecological systems theory, the purpose of this quantitative noncomparative study was to examine whether domestic violence, age, gender, ethnicity, individual emotional and physical abilities, types of domestic violence exposure, and frequency of domestic violence exposure could adequately predict resilience among young adults. Quantitative data were collected from 118 young adults in the Midsouth region of …


Asymmetric Patterns Of Small Molecule Transport After Nanosecond And Microsecond Electropermeabilization, Esin B. Sözer, C. Florencia Pocetti, P. Thomas Vernier 2018 Old Dominion University

Asymmetric Patterns Of Small Molecule Transport After Nanosecond And Microsecond Electropermeabilization, Esin B. Sözer, C. Florencia Pocetti, P. Thomas Vernier

Bioelectrics Publications

Imaging of fluorescent small molecule transport into electropermeabilized cells reveals polarized patterns of entry, which must reflect in some way the mechanisms of the migration of these molecules across the compromised membrane barrier. In some reports, transport occurs primarily across the areas of the membrane nearest the positive electrode (anode), but in others cathode-facing entry dominates. Here we compare YO-PRO-1, propidium, and calcein uptake into U-937 cells after nanosecond (6 ns) and microsecond (220 µs) electric pulse exposures. Each of the three dyes exhibits a different pattern. Calcein shows no preference for anode- or cathode-facing entry that is detectable with …


Bilateral Deficit: A Comparison Between Upper-Body And Lower-Body Maximal Strength, James Lee Ramsey 2018 Eastern Michigan University

Bilateral Deficit: A Comparison Between Upper-Body And Lower-Body Maximal Strength, James Lee Ramsey

Master's Theses and Doctoral Dissertations

Purpose: The study’s primary purpose was to determine if maximal unilateral strength is greater than maximal bilateral strength for the leg press and vertical dumbbell press exercises. The secondary purpose was to determine if blood glucose levels differ between the unilateral and bilateral conditions for the leg press exercise. Methods: Thirty college-aged volunteers reported on two separate occasions, 72 hours apart, for maximal strength testing. Blood glucose was obtained before and after strength testing for the leg press exercise. A paired samples t-test was conducted to determine significance (p < .05). Results: Participants were significantly stronger for the bilateral leg press; however, no significant differences were observed for the vertical dumbbell press exercise. No significant differences were observed in plasma blood glucose for the leg press exercise. Conclusion: Participants did not display a bilateral lateral deficit, which may have been a result of their resistance training prior to the study.


Quantifying Changes In Accelerations And Heart Rate Indicative Of Fatigue During Condensed Competitions In Elite Youth Ice Hockey Players, Kenneth L. Martel 2018 Eastern Michigan University

Quantifying Changes In Accelerations And Heart Rate Indicative Of Fatigue During Condensed Competitions In Elite Youth Ice Hockey Players, Kenneth L. Martel

Master's Theses and Doctoral Dissertations

Thirty-three elite youth ice hockey players wore Bioharness-3 (Zephyr, MD) sensors to compare accelerations (ACC) and heart rate (HR) over four games (G1–G4) in three days, in order to establish changes in cardiovascular stress and physical exertion associated with fatigue. Peak ACC and HR across multiple time frames were quantified and analyzed in conjunction to determine exertion profiles for each game. MANOVAs for peak ACC and HR, at each time point across G1–G4 and multiple games per day (M1, M2) for magnitude and time as main effects were performed. HR beats per minute decreased between G1 and G3/G4 in time …


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