Developing Methods To Detect And Diagnose Chronic Traumatic Encephalopathy During Life: Rationale, Design, And Methodology For The Diagnose Cte Research Project,
2021
University of Nevada, Las Vegas
Developing Methods To Detect And Diagnose Chronic Traumatic Encephalopathy During Life: Rationale, Design, And Methodology For The Diagnose Cte Research Project, Jeffrey Cummings, Numerous Authors, See Full List Below
School of Medicine Faculty Research
Background: Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease that has been neuropathologically diagnosed in brain donors exposed to repetitive head impacts, including boxers and American football, soccer, ice hockey, and rugby players. CTE cannot yet be diagnosed during life. In December 2015, the National Institute of Neurological Disorders and Stroke awarded a seven-year grant (U01NS093334) to fund the “Diagnostics, Imaging, and Genetics Network for the Objective Study and Evaluation of Chronic Traumatic Encephalopathy (DIAGNOSE CTE) Research Project.” The objectives of this multicenter project are to: develop in vivo fluid and neuroimaging biomarkers for CTE; characterize its clinical presentation; refine …
An Empirical Comparative Study On The Two Methods Of Eliciting Singers’ Emotions In Singing: Self-Imagination And Vr Training,
2021
Nanjing University of Aeronautics and Astronautics
An Empirical Comparative Study On The Two Methods Of Eliciting Singers’ Emotions In Singing: Self-Imagination And Vr Training, Jin Zhang, Ziming Xu, Yueying Zhou, Pengpai Wang, Ping Fu, Xijia Xu, Daoqiang Zhang
Library Scholarship
Emotional singing can affect vocal performance and the audience’s engagement. Chinese universities use traditional training techniques for teaching theoretical and applied knowledge. Self-imagination is the predominant training method for emotional singing. Recently, virtual reality (VR) technologies have been applied in several fields for training purposes. In this empirical comparative study, a VR training task was implemented to elicit emotions from singers and further assist them with improving their emotional singing performance. The VR training method was compared against the traditional self-imagination method. By conducting a two-stage experiment, the two methods were compared in terms of emotions’ elicitation and emotional singing …
Facing Fears When Fearing Faces: Binocular Rivalry Perceptual Alternation And Approach-Avoidance In College-Aged Women With Autistic Traits And A History Of Adverse Experiences,
2021
Brigham Young University
Facing Fears When Fearing Faces: Binocular Rivalry Perceptual Alternation And Approach-Avoidance In College-Aged Women With Autistic Traits And A History Of Adverse Experiences, Sarah Kamhout
Undergraduate Honors Theses
Women with Autism Spectrum Conditions (ASCs) may be more likely to experience symptoms of trauma exposure due to greater likelihood of facing adverse childhood experiences (ACEs). In order to gain a better understanding of the neural mechanisms involved with ASC and PTSD in women who experience difficulty with social interactions, I examined the ability of two vision tasks-- Binocular Rivalry Perceptual Alternation (BR) and Visual Approach/Avoidance by the Self Task (VAAST)-- to predict symptoms of both conditions as well as differentiate between them. I also examined differences in response to neutral or emotional (angry or fearful) faces under both paradigms. …
Having A High-Activity Catechol-O-Methyltransferase Allele Is Associated With Elevated Anxiety And Lower Salivary Dehydroepiandrosterone But Also Lower Alpha Amylase In Children With Chromosome 22q11.2 Deletion Syndrome.,
2021
University Of New Orleans
Having A High-Activity Catechol-O-Methyltransferase Allele Is Associated With Elevated Anxiety And Lower Salivary Dehydroepiandrosterone But Also Lower Alpha Amylase In Children With Chromosome 22q11.2 Deletion Syndrome., Jessie Beebe
LSU New Orleans Theses and Dissertations
Chromosome 22q11.2 deletion syndrome (22q11.2DS) results from a hemizygous deletion located on the long arm of chromosome 22. The most common deletion sizes affect between 30 and 90 genes. Individuals with 22q11.2DS may develop serious developmental and psychiatric disorders. The phenotype is highly variable, however, and may be influenced by allelic variation of the retained copies of genes covered by the deletion. I set out to examine the effects of two genes, catechol-O-methyltransferase (COMT) and proline dehydrogenase (PRODH), in relation to anxiety in children and adolescents with 22q11.2DS. Individuals with the major COMT allele (higher activity) have significantly higher anxiety …
An End-To-End Cnn With Attentional Mechanism Applied To Raw Eeg In A Bci Classification Task,
2021
Chapman University
An End-To-End Cnn With Attentional Mechanism Applied To Raw Eeg In A Bci Classification Task, Elnaz Lashgari, Jordan Ott, Akima Connelly, Pierre Baldi, Uri Maoz
Psychology Faculty Articles and Research
Objective. Motor-imagery (MI) classification base on electroencephalography (EEG) has been long studied in neuroscience and more recently widely used in healthcare applications such as mobile assistive robots and neurorehabilitation. In particular, EEG-based motor-imagery classification methods that rely on convolutional neural networks (CNNs) have achieved relatively high classification accuracy. However, naively training CNNs to classify raw EEG data from all channels, especially for high-density EEG, is computationally demanding and requires huge training sets. It often also introduces many irrelevant input features, making it difficult for the CNN to extract the informative ones. This problem is compounded by a dearth of training …
Neuronal Migration In Developmental Hyperserotonmia: Assessment Of Vesicular Glutamate In The Raphe Nuclei,
2021
Missouri State University
Neuronal Migration In Developmental Hyperserotonmia: Assessment Of Vesicular Glutamate In The Raphe Nuclei, Trey M. Shupp
Graduate Theses/Dissertations
The neurotransmitter serotonin is involved in the early development of the central nervous system and the organization of neurons throughout the cerebral cortex and cerebellum. It is proposed that serotonin indirectly interacts with cells in the marginal zone of the cerebral cortex known as Cajal-Retizus (CR) cells. These cells secrete the extracellular matrix protein reelin, which is known for its role in neuronal organization and migration during early neural development. It has been observed that low levels of serotonin are associated with similarly low levels of reelin during development and have been reported to result in disorganization of neurons in …
Gpr37 Modulates Progenitor Cell Dynamics In A Mouse Model Of Ischemic Stroke,
2021
Emory University School of Medicine
Gpr37 Modulates Progenitor Cell Dynamics In A Mouse Model Of Ischemic Stroke, Sharon Owino, Michelle M. Giddens, Jessie G. Jiang, Trang Kimberly T. Nguyen, Fu Hung Shiu, Trisha Lala, Marla Gearing, Myles R. Mccrary, Xiaohuan Gu, Ling Wei, Shan P. Yu, Randy A. Hall
Neuroscience: Faculty Publications
The generation of neural stem and progenitor cells following injury is critical for the function of the central nervous system, but the molecular mechanisms modulating this response remain largely unknown. We have previously identified the G protein-coupled receptor 37 (GPR37) as a modulator of ischemic damage in a mouse model of stroke. Here we demonstrate that GPR37 functions as a critical negative regulator of progenitor cell dynamics and gliosis following ischemic injury. In the central nervous system, GPR37 is enriched in mature oligodendrocytes, but following injury we have found that its expression is dramatically increased within a population of Sox2-positive …
Exercise Training Rescues Increased Brain Isf Aβ Caused By Chronic Isolation Stress In App/Ps1 Transgenic Mice,
2021
Missouri State University
Exercise Training Rescues Increased Brain Isf Aβ Caused By Chronic Isolation Stress In App/Ps1 Transgenic Mice, Lydia M. Holtmann
Graduate Theses/Dissertations
Alzheimer’s Disease (AD) is a progressive brain disorder that destroys memory and cognition thought to be initiated through the build-up of the amyloid-beta (A) peptide. The A peptide aggregates, slowly forming into insoluble plaque substances that destroy the brain and worsen patient’s symptoms over time. Studies have shown that chronic isolation stress (CIS) increases the A peptide soluble and insoluble levels in the brain and that exercise training decreases these levels in transgenic mouse models of AD. We sought to determine if an exercise training regimen would rescue the increase in Aβ levels caused by CIS in the APP/PS1 transgenic …
Promoting Youth Mental Health During The Covid-19 Pandemic: A Longitudinal Study,
2021
Harvard Faculty of Arts and Sciences
Promoting Youth Mental Health During The Covid-19 Pandemic: A Longitudinal Study, Maya L. Rosen, Alexandra M. Rodman, Steven W. Kasparek, Makeda Mayes, Malila M. Freeman, Liliana J. Lengua, Andrew N. Meltzoff, Katie A. Mclaughlin
Neuroscience: Faculty Publications
The COVID-19 pandemic has introduced novel stressors into the lives of youth. Identifying factors that protect against the onset of psychopathology in the face of these stressors is critical. We examine a wide range of factors that may protect youth from developing psychopathology during the pandemic. We assessed pandemic-related stressors, internalizing and externalizing psychopathology, and potential protective factors by combining two longitudinal samples of children and adolescents (N = 224, 7-10 and 13-15 years) assessed prior to the pandemic, during the stay-at-home orders, and six months later. We evaluated how family behaviors during the stay-at-home orders were related to changes …
Elucidating The Modulatory Role Of Dopamine In The C. Elegans Chemosensory Ash Neuron,
2021
California State University, San Bernardino
Elucidating The Modulatory Role Of Dopamine In The C. Elegans Chemosensory Ash Neuron, Cory Kunkel
Electronic Theses, Projects, and Dissertations
The neurotransmitter dopamine regulates chemosensory avoidance behavior in the model organism Caenorhabditis elegans. Avoidance behaviors are mediated by the polymodal ASH nociceptive sensory neurons, and behavioral avoidance of stimuli detected by ASH is less robust when dopamine signaling is impaired. We are investigating the neural response of the ASH neurons to various stimuli; our investigation includes the behavioral and physiological responses from the ASH neurons as dopamine signaling is manipulated to better understand the effects of dopamine on these sensory neurons. We hypothesize that dopamine plays a regulatory role on the ASH neurons, lessening the response of the ASH …
Gabaergic-Related Pathology In The Anterior Cingulate Cortex Of Postmortem Human Brain Tissue In Autism Spectrum Disorder,
2021
East Tennessee State University
Gabaergic-Related Pathology In The Anterior Cingulate Cortex Of Postmortem Human Brain Tissue In Autism Spectrum Disorder, Gethien Andrew
Electronic Theses and Dissertations
The anterior cingulate cortex (ACC) is part of the cognitive and emotional brain circuitry that mediates social interaction. Imbalances between inhibitory, GABAergic neurons, and excitatory, glutamatergic neurons, in this region are essential to brain circuity during social responses and are thought to be involved with behaviors associated with autism spectrum disorder (ASD). Enriched cell populations of glutamatergic neurons, obtained through laser capture microdissection, were used for gene expression studies of GABAergic receptors (GABRA1, GABRA4, and GABBR1). Additionally, proteins that impact GABAergic synapses (Spinophilin, CPLX1, mTOR, IGF1R, PSD95, PARP1) were investigated using Western Blotting with punchdissected homogenate brain tissue from ACC …
Neurotranscriptomic Changes Associated With Chick-Directed Parental Care In Adult Non-Reproductive Japanese Quail,
2021
Chapman University
Neurotranscriptomic Changes Associated With Chick-Directed Parental Care In Adult Non-Reproductive Japanese Quail, Patricia C. Lopes, Robert De Brujin
Biology, Chemistry, and Environmental Sciences Faculty Articles and Research
For many species, parental care critically affects offspring survival. But what drives animals to display parental behaviours towards young? In mammals, pregnancy-induced physiological transformations seem key in preparing the neural circuits that lead towards attraction (and reduced-aggression) to young. Beyond mammalian maternal behaviour, knowledge of the neural mechanisms that underlie young-directed parental care is severely lacking. We took advantage of a domesticated bird species, the Japanese quail, for which parental behaviour towards chicks can be induced in virgin non-reproductive adults through a sensitization procedure, a process that is not effective in all animals. We used the variation in parental responses …
Aducanumab: Appropriate Use Recommendations,
2021
University of Nevada, Las Vegas
Aducanumab: Appropriate Use Recommendations, Jeffrey Cummings, Steve Salloway
School of Medicine Faculty Research
Aducanumab recently received accelerated approval by the FDA. An Expert Panel was comprised to provide recommendations on appropriate use of aducanumab in real world practices. Patient selection, aducanumab administration and monitoring, management of ARIA, and best practices in patient care in the context of aducanumab therapy are described. The paper was published in the Journal of Prevention of Alzheimer's Disease.
Classical Conditioning Of Cognitive States,
2021
Ursinus College
Classical Conditioning Of Cognitive States, Arthur Burns
Neuroscience Presentations
This research sought out to do preliminary testing to prepare for honors research in the 2021 academic year. This research focuses on attempting to classically condition cognitive states. Learning tasks were designed to elicit relaxation or arousal in partisans and a combination of EEG data, pupil dilation data, performance on cognitive tasks, and self-report were used to evaluate the level of cognitive states in participants.
Classical Conditioning Of Cognitive States,
2021
Ursinus College
Classical Conditioning Of Cognitive States, Arthur Burns
Neuroscience Summer Fellows
This research sought out to do preliminary testing to prepare for honors research in the 2021 academic year. This research focuses on attempting to classically condition cognitive states. Learning tasks were designed to elicit relaxation or arousal in partisans and a combination of EEG data, pupil dilation data, performance on cognitive tasks, and self-report were used to evaluate the level of cognitive states in participants.
Exploring The Relationship Between Cellular Senescence, Apolipoprotein E, And Alzheimer’S Disease,
2021
Dominican University of California
Exploring The Relationship Between Cellular Senescence, Apolipoprotein E, And Alzheimer’S Disease, Buay Deng
Natural Sciences and Mathematics | Biological Sciences Master's Theses
Alzheimer’s disease (AD) is the most common form of dementia in the world and currently affects more than 50 million people and has no cure to date. One of its major neuropathological hallmarks is the presence of senile plaques—formed from Amyloid-β (Aβ) oligomers. Aβ has also been associated with the development of cellular senescence in preclinical AD models, suggesting that cellular senescence may be mechanistically involved in disease progression. Cellular senescence is a stress response that occurs when cells are exposed to degenerative factors that puts them into permanent cell cycle arrest, this process increases with age. Apolipoprotein E (ApoE) …
Mechanisms Of How Diet And Light Interact To Influence Drosophila Longevity Through The Eye,
2021
Dominican University of California
Mechanisms Of How Diet And Light Interact To Influence Drosophila Longevity Through The Eye, Charles H. Lau
Natural Sciences and Mathematics | Biological Sciences Master's Theses
Previous studies in Drosophila melanogaster have established that overexposure to light damages photoreceptors and that photoreceptor degeneration contributes to shortened lifespans. However, the role of diet and circadian rhythms in the eye has not yet been elucidated. Many vital processes in the eye are regulated by circadian rhythms, and circadian misalignment has been proven as a driver of aging. In the eye, one of the most enriched circadian functions is phototransduction. Phototransduction plays a major role in the organism’s ability to detect light. Our lab has previously proven that Dietary Restrictions (DR) can play a role in amplifying circadian rhythms …
Neuromuscular Control Strategy During Object Transport While Walking: Adaptive Integration Of Upper And Lower Limb Movements,
2021
Louisiana State University
Neuromuscular Control Strategy During Object Transport While Walking: Adaptive Integration Of Upper And Lower Limb Movements, Ahyoung Song
LSU Doctoral Dissertations
When carrying an object while walking, a significant challenge for the central nervous system (CNS) is to preserve the object’s stability against the inter-segmental interaction torques and ground reaction forces. Studies documented several strategies used by the CNS: modulation of grip force (GF), alterations in upper limb kinematics, and gait adaptations. However, the question of how the CNS organizes the multi-segmental joint and muscle coordination patterns to deal with gait-induced perturbations remains poorly understood. This dissertation aimed to explore the neuromuscular control strategy utilized by the CNS to transport an object during walking successfully. Study 1 examined the inter-limb coordination …
Eeg Features Of Explore-Exploit Decision-Making In Alcohol Use Disorder,
2021
University of New Mexico
Eeg Features Of Explore-Exploit Decision-Making In Alcohol Use Disorder, Ethan Campbell
Psychology ETDs
Little research has assessed explore-exploit behavior in addiction using drug cues and even fewer studies have measured the neural activity underlying these behaviors. The present study aims to explore brain mechanisms of disordered decision-making in alcohol use disorder (AUD) through electroencephalography (EEG) during performance of a novelty bandit task with alcohol imagery and using a validated computational model of explore-exploit dynamics. Individuals with AUD (n = 28) and age and sex-matched controls (n = 27) showed differences in choice behavior and showed differences in EEG activity as a function of exploratory behavior, chosen stimulus type, and explore-exploit computational …
Editorial: Invertebrate Neuroscience: Contributions From Model And Non-Model Species,
2021
Barnard College
Editorial: Invertebrate Neuroscience: Contributions From Model And Non-Model Species, Maria P. Fernandez, Clare C. Rittschof, Jimena A. Sierralta
Entomology Faculty Publications
No abstract provided.
