The Classification Of Basket Neural Cells In The Mammalian Neocortex,
2021
University of South Carolina
The Classification Of Basket Neural Cells In The Mammalian Neocortex, Sreya Pudi
Senior Theses
Basket neuronal cells of the mammalian neocortex have been classically categorized into two or more groups. Originally, it was thought that the large and small types are the naturally occurring groups that emerge from reasons that relate to neurobiological function and anatomical position. Later, a study based on anatomical and physiological features of these neurons introduced a third type, the net basket cell which is intermediate in size as compared to the large and small types. In this study, multivariate analysis was used to test the hypothesis that the large and small types are morphologically distinct groups. The results of …
The Costs Of Developing Treatments For Alzheimer’S Disease: A Retrospective Exploration,
2021
University of Nevada, Las Vegas
The Costs Of Developing Treatments For Alzheimer’S Disease: A Retrospective Exploration, Jeffrey L. Cummings, Dana P. Goldman, Nicholas R. Simmons-Stern, Eric Ponton
School of Medicine Faculty Research
Introduction: With the exception of the recent accelerated approval of aducanumab, in over 26 years of research and development (R&D) investment in Alzheimer's disease (AD), only five novel drugs—all for symptomatic treatment only—have reached FDA approval. Here, we estimate the costs of AD drug development during this period in the private sector. Methods: To estimate private R&D funding, we collected information on AD clinical trials (n = 1099; phases 1–4) conducted between January 1, 1995 and June 21, 2021 from various databases. Costs were derived using previously published methodologies and adjusted for inflation. Results: Since 1995, cumulative private expenditures on …
Microglia Polarize In Response To Transactive Response Dna-Binding Protein-43 (Tdp-43) And Display Partial Recovery After Removal Of The Stimulus,
2021
Harding University
Microglia Polarize In Response To Transactive Response Dna-Binding Protein-43 (Tdp-43) And Display Partial Recovery After Removal Of The Stimulus, Alicen Wilcox
Honors Theses
The proper response to protein signals is necessary for a healthy central nervous system (CNS), and protein dysregulation is a feature of neurodegenerative diseases. Transactive response DNA-binding protein-43 (TDP-43) is an intranuclear protein, but mislocalization is associated with amyotrophic lateral sclerosis (ALS). TDP-43 is released into the extracellular space where it is sensed by microglia, the CNS-resident immune cells. Our data and the literature suggest that microglia respond to TDP-43 dysregulation by increasing CNS inflammation. The goal of this study was to determine the impact of TDP-43 on microglial function and the extent to which microglia recovery. To study the …
The Effects Of Alcohol On The Developing Drosophila Nervous System,
2021
University of Louisville
The Effects Of Alcohol On The Developing Drosophila Nervous System, Erica E. Hassoun
The Cardinal Edge
Ethanol is the most common human teratogen, contributing to fetal alcohol syndrome (FAS) when effects are the most severe. Key effects of fetal alcohol syndrome are observed in the nervous system. The high prevalence of prenatal alcohol exposure necessitates novel treatment and prevention methods. However, ethical issues prevent researching humans in utero. For this reason, the fruit fly Drosophila melanogaster has emerged as a model organism for studying FAS. Because Drosophila is a small and non-placental organism, its environment can be easily controlled, allowing for specific doses and time periods of ethanol exposure to be studied. This review discusses findings …
The Motion Aftereffect: Mechanisms And Variants,
2021
University of Louisville
The Motion Aftereffect: Mechanisms And Variants, Erica E. Hassoun
The Cardinal Edge
The motion aftereffect causes a visual stimulus to undergo apparent motion. An adapting stimulus, which moves in a specific direction, adapts motion-responsive neurons in the middle temporal area (V5) to that direction of motion. Viewing a second stimulus, a test stimulus, produces apparent motion in the direction opposite that of the initial stimulus. Neural networks involved in attention and working memory are also implicated in the motion aftereffect. There is still little known regarding the mechanisms of the motion aftereffect, despite extensive documentation in the literature. This review discusses established knowledge of the motion aftereffect, focusing primarily on the middle …
During Natural Viewing, Neural Processing Of Visual Targets Continues Throughout Saccades,
2021
CUNY City College
During Natural Viewing, Neural Processing Of Visual Targets Continues Throughout Saccades, Atanas D. Stankov, Jonathan Touryan, Stephen Gordon, Anthony J. Ries, Jason Ki, Lucas C. Parra
Publications and Research
Relatively little is known about visual processing during free-viewing visual search in realistic dynamic environments. Free-viewing is characterized by frequent saccades. During saccades, visual processing is thought to be suppressed, yet we know that the presaccadic visual content can modulate postsaccadic processing. To better understand these processes in a realistic setting, we study here saccades and neural responses elicited by the appearance of visual targets in a realistic virtual environment. While subjects were being driven through a 3D virtual town, they were asked to discriminate between targets that appear on the road. Using a system identification approach, we separated overlapping …
Editorial: Roles Of Sleep Disruption And Circadian Rhythm Alterations On Neurodegeneration And Alzheimer's Disease,
2021
University of Kentucky
Editorial: Roles Of Sleep Disruption And Circadian Rhythm Alterations On Neurodegeneration And Alzheimer's Disease, Marilyn J. Duncan, Sigrid C. Veasey, Phyllis Zee
Neuroscience Faculty Publications
No abstract provided.
Altered Theta Rhythm And Hippocampal-Cortical Interactions Underlie Working Memory Deficits In A Hyperglycemia Risk Factor Model Of Alzheimer’S Disease,
2021
University of Nevada, Las Vegas
Altered Theta Rhythm And Hippocampal-Cortical Interactions Underlie Working Memory Deficits In A Hyperglycemia Risk Factor Model Of Alzheimer’S Disease, Ryan A. Wirt, Lauren A. Crew, Andrew A. Ortiz, Adam M. Mcneela, Emmanuel Flores, Jefferson W. Kinney, James M. Hyman
Integrated Health Sciences Faculty Research
Diabetes mellitus is a metabolic disease associated with dysregulated glucose and insulin levels and an increased risk of developing Alzheimer’s disease (AD) later in life. It is thought that chronic hyperglycemia leads to neuroinflammation and tau hyperphosphorylation in the hippocampus leading to cognitive decline, but effects on hippocampal network activity are unknown. A sustained hyperglycemic state was induced in otherwise healthy animals and subjects were then tested on a spatial delayed alternation task while recording from the hippocampus and anterior cingulate cortex (ACC). Hyperglycemic animals performed worse on long delay trials and had multiple electrophysiological differences throughout the task. We …
Anti-Angiogenic Effects Of Chemotherapeutic Agents And Their Enhancement With Ot-515 And S-Nach,
2021
The American University in Cairo AUC
Anti-Angiogenic Effects Of Chemotherapeutic Agents And Their Enhancement With Ot-515 And S-Nach, Shimaa Adel Heikal
Theses and Dissertations
Chemotherapeutic agents have been used for the treatment of numerous types of tumors with great success. Cisplatin and Doxorubicin are among the well-known chemotherapeutic drugs that showed efficacy against various types of cancers. However, cell resistance and major side effects like chemotherapy-induced peripheral neuropathy (CIPN) are limiting factors in using these compounds. Using a combination or adjuvant compounds with anti-angiogenic effects is one of the strategies suggested to decrease resistance or ameliorate chemotherapeutic toxicity. The present study investigated the anti-angiogenic effects of Cisplatin and Doxorubicin alone and combined with Sulfated non-anticoagulant heparin (S-NACH), a low molecular weight heparin LMWH that …
Distress Tolerance As A Mechanism Linking Violence Exposure To Problematic Alcohol Use In Adolescence,
2021
Columbia University
Distress Tolerance As A Mechanism Linking Violence Exposure To Problematic Alcohol Use In Adolescence, Charlotte Heleniak, China R. Bolden, Connor J. Mccabe, Hilary K. Lambert, Maya L. Rosen, Kevin M. King, Kathryn C. Monahan, Katie A. Mclaughlin
Neuroscience: Faculty Publications
Adolescents exposed to violence are at elevated risk of developing most forms of psychopathology, including depression, anxiety, and alcohol abuse. Prior research has identified emotional reactivity and difficulties with emotion regulation as core mechanisms linking violence exposure with psychopathology. Scant research has examined behavioral responses to distress as a mechanism in this association. This study examined the association of violence exposure with distress tolerance—the ability to persist in the face of distress—and whether lower distress tolerance linked violence exposure with subsequent increases in depression, anxiety, and alcohol abuse problems during adolescence. Data were collected prospectively in a sample of 287 …
Validation Of A Single Channel Eeg For The Athlete: A Machine Learning Protocol To Accurately Detect Sleep Stages,
2021
Nova Southeastern University
Validation Of A Single Channel Eeg For The Athlete: A Machine Learning Protocol To Accurately Detect Sleep Stages, Kayla Thompson, Kamil Celoch, Frankie Pizzo, Ana I. Fins, Jaime Tartar
Journal for Sports Neuroscience
There is a large and growing movement towards the use of wearable technologies for sleep assessment. This trend is largely due to the desire for comfortable, burden free, and inexpensive technology. In tandem, given the competitive nature of professional athletes enduring high training load, sleep is often jeopardized which can result in adverse outcomes. Wearable devices hold the promise of increasing the ease of monitoring sleep in athletes which can inform health and recovery status, as well as aid performance optimization. However, wearable devices typically lack sufficient validity to assess sleep – and especially sleep stages. To address this concern, …
Odor-Evoked Increases In Olfactory Bulb Mitral Cell Spiking Variability,
2021
Virginia Commonwealth University
Odor-Evoked Increases In Olfactory Bulb Mitral Cell Spiking Variability, Cheng Ly, Andrea K. Barreiro, Shree Hari Gautam, Woodrow L. Shew
Physics Faculty Publications and Presentations
The spiking variability of neural networks has important implications for how information is encoded to higher brain regions. It has been well documented by numerous labs in many cortical and motor regions that spiking variability decreases with stimulus onset, yet whether this principle holds in the OB has not been tested. In stark contrast to this common view, we demonstrate that the onset of sensory input can cause an increase in the variability of neural activity in the mammalian OB. We show this in both anesthetized and awake rodents. Furthermore, we use computational models to describe the mechanisms of this …
Investigation Of Notch Signaling In Cone Fate Specification In Vertebrate Retina,
2021
CUNY Graduate Center
Investigation Of Notch Signaling In Cone Fate Specification In Vertebrate Retina, Xueqing Chen
Dissertations, Theses, and Capstone Projects
In the vertebrate retina, cone photoreceptors are crucial for high acuity color vision. Several retinal diseases lead to loss of cones and there is a need to identify the normal developmental genesis of these cells to inform the development of stem cell-based therapies. Cone genesis has previously been shown to be repressed by Notch signaling, however, the mechanism by which Notch signaling controls cone fate determination is still unclear. It has been identified that cone photoreceptors are formed from multipotent retinal progenitor cells (RPCs) that first generate genetically-defined, restricted RPCs with limited mitotic and fate potential to preferentially form cones …
A Randomized Controlled Trial Of Psychological Outcomes Of Mobile Guided Resonant Frequency Breathing In Young Adults With Elevated Stress During The Covid-19 Pandemic,
2021
CUNY Graduate Center
A Randomized Controlled Trial Of Psychological Outcomes Of Mobile Guided Resonant Frequency Breathing In Young Adults With Elevated Stress During The Covid-19 Pandemic, Al Amira Safa Shehab
Dissertations, Theses, and Capstone Projects
Deep breathing practices have shown promise in reducing stress, anxiety, and depression in different populations, including young adults. Specifically, resonant frequency breathing can exert an impact on stress response systems through the vagus nerve and the hypothalamo-pituitary-adrenal (HPA) axis. This may induce reductions in stress and improvement in emotion regulation. Young adults, including college students, tend to be at a higher risk for psychological distress, as they face several psychosocial challenges. The COVID-19 pandemic has imposed new and unique stressors that resulted in higher levels of stress and emotional symptoms and it has been shown that this may have placed …
Working Memory Task Performance In Children With Sli: A Behavioral And Erp Study,
2021
CUNY Graduate Center
Working Memory Task Performance In Children With Sli: A Behavioral And Erp Study, Megan V. Mcveety
Dissertations, Theses, and Capstone Projects
In addition to language deficits, children with Specific Language Impairment often show deficits in tests of various aspects of working memory, including capacity, updating, and selective attention. The purpose of the present study is to examine the specific drivers of differences in working memory processing in 8–11 year-old children with and without SLI using behavioral and electrophysiological measures. Participants completed an n-back task with three working memory load conditions (0-back, 1-back, 2-back), with the addition of distractor trials at the 1-back and 2-back levels. The SLI group performed significantly less accurately across all task conditions. The children with SLI also …
Contributions Of Reward Identity And Time Prediction Errors To Pavlovian Learning,
2021
CUNY Graduate Center
Contributions Of Reward Identity And Time Prediction Errors To Pavlovian Learning, Daniel B. Siegel
Dissertations, Theses, and Capstone Projects
Some models of associative learning attempt to explain effects such as blocking and unblocking as reflecting a prediction error (PE): Associative strength, and thereby learning, are said to be greater when the unconditioned stimulus (US) received following a cue deviates from one’s expectations. Some models of PE-motivated behavior and PE-relevant brain activity represent the US as a single quantitative variable for outcome value, and that learning therefore only occurs when outcome value differs from expectations. There is growing evidence to suggest that changes in other dimensions of reward, such as identity and timing, also contribute to learning. In Experiment 1, …
Estrogen Modulation Of Vta Dopamine Neuron Physiology And Behavioral Responsivity To Variable Social Stressors,
2021
CUNY Graduate Center
Estrogen Modulation Of Vta Dopamine Neuron Physiology And Behavioral Responsivity To Variable Social Stressors, Mary R. Shanley
Dissertations, Theses, and Capstone Projects
The behavioral output of different animals, or even the same animal in different contexts, is remarkably variable in response to the same external stimulus. This behavioral diversity is due to the complex integration of external and internal stimuli, through both neuronal and hormonal signals that selects the best behavioral response. By their nature as long-distance signaling molecules, hormones play a critical role in communicating information about internal states across the organism. Many hormones produced in the periphery target the central nervous system to modulate animal behavior, selecting for behaviors that are appropriate over behaviors that are maladaptive in that specific …
Apathy And Brain Atrophy During The First Year Of Moderate-Severe Traumatic Brain Injury: A Longitudinal Study,
2021
CUNY Graduate Center
Apathy And Brain Atrophy During The First Year Of Moderate-Severe Traumatic Brain Injury: A Longitudinal Study, Gulnaz Kudoiarova
Dissertations, Theses, and Capstone Projects
Apathy, defined as disinterest and loss of motivation, is a common complication after moderate-severe traumatic brain injury (msTBI). The existing body of research in various neurological and neurodegenerative disorders suggests that apathetic symptoms may be associated with variation in the volume of the brain regions such as dorsal anterior cingulate cortex and ventral striatum. However, the longitudinal pattern of TBI-induced atrophy in these key regions and its relationship with apathy symptoms remain to be demonstrated. The current study aimed to describe the atrophy pattern in the anterior cingulate gyrus (ACG) and the nucleus accumbens (NAc; part of ventral striatum) after …
Analysis Of Transplantable Photoreceptor Replacement Cell Chemotactic Mechanisms In Retinal Biomimetic Ligand Gradients,
2021
CUNY Graduate Center
Analysis Of Transplantable Photoreceptor Replacement Cell Chemotactic Mechanisms In Retinal Biomimetic Ligand Gradients, Onyekwere Onwumere
Dissertations, Theses, and Capstone Projects
Disease or trauma induced loss of rod and cone photoreceptors is a major cause of vision loss worldwide. To replace lost photoreceptors and restore vision, laboratories around the world are investigating photoreceptor replacement strategies using subretinal injection of photoreceptor precursor cells (PPCs) and retinal progenitor cells (RPCs). A major obstacle in the field is that transplanted photoreceptor replacement cells exhibit extremely limited migration into host retina following injection into the subretinal space. In this work, we show that PPCs and host retinal interaction bioinformatics modeling can identify key pathways involved in photoreceptor replacement cell migration and invasion behaviors. In addition, …
Desire, Culture, And The Body,
2021
CUNY Graduate Center
Desire, Culture, And The Body, Zoey Lavallee
Dissertations, Theses, and Capstone Projects
What is the nature of desire? In this dissertation I develop a theory of desire according to which desires are essentially enculturated states that play the role of presenting favorable outcomes that act as inputs to intention formation, and thereby intentional action. This analysis of desire debunks a common assumption shared by prominent accounts of desire in philosophy of mind, what can be called the dualist assumption: that bodily desires such as urges and appetites differ in kind from conceptual desires that are typically described as higher cognitive attitudes. I argue that the desires traditionally understood as bodily or appetitive …
