Neuroscience and Neurobiology Commons^™

Remote Working And Online Education Among Neurodiverse Individuals, Kendall Smith

Emerging Writers

Many jobs and schools closed in response to the Covid-19 pandemic, and a vast majority of students and employees found it difficult to resume their education and careers online; however, those on the neurodiverse spectrum found it much harder. Upon first glance, it was easy to see how frustrating and stressful online schooling was for special needs students. Many had difficulty concentrating during virtual lectures or lacked motivation to stay on task. Likewise, many neurodiverse employees found that at-home distractions were far worse than in-office ones, and the loneliness from staying home all day was jarring. But after pulling research …

The Effects Of Prenatal And Perinatal Alcohol Exposure On Adult Mouse Behavior, Ericka Ann Schaeffer

Graduate Research Theses & Dissertations

Prenatal alcohol exposure (PAE) is a prevalent phenomenon conserved across cultures which can result in a heterogeneous set of symptoms associated with offspring development. Although there is much research characterizing the extent of disruptions in spatial and motor performance, there appears to be conflicting results dependent on the type of PAE model. Therefore, the current study aimed to investigate a more reliable and translatable model of symptoms associated with fetal alcohol syndrome disorders. The current set of experiments evaluated the effects of alcohol exposure in mice during prenatal (gestation day 4-18) and early postnatal (postnatal day 4-12) development on organization …

Meta-Analytic Connectivity Modelling Of Healthy Swallowing, Chris R. Tilton

Honors Theses and Capstones

A quantitative, voxel-wise meta-analysis was performed to investigate the brain regions involved in healthy human swallowing. Studies included in the meta-analysis (1) examined water swallowing, saliva swallowing, or both, (2) included healthy, normal subjects, and (3) reported stereotaxic brain activation coordinates in standard space. Following these criteria, a systematic literature review identified 8 studies that met the criteria. An activation likelihood estimation (ALE) meta-analysis and meta-analytic connectivity modelling (MACM) analysis were performed with BrainMap software. Ten clusters with high activation likelihood were found in the bilateral precentral gyri, right insula, left declive, right medial frontal gyrus, right dorsal nucleus of …

Individual Behavioral And Neurobiological Markers Associated With A Vulnerable To Ethanol Use Phenotype, Kelsey M. Alimandi

Honors Theses and Capstones

Alcohol use disorder (AUD) is a chronic relapsing brain condition that is characterized by excessive alcohol consumption, continued use when faced with negative consequences, and a negative emotional state associated with withdrawals (anxiety, irritability, depression). The main challenge to treating AUD is preventing relapse. The purpose of this study was to use a prolonged-exposure model to allow rats to self-administer ethanol to determine the brain regions active during relapse events. The rats performed multiple behavioral tests such as economic demand, negative consequences, and an elevated plus maze. These tests determined how hard rats were willing to work for an ethanol …

Role Strain And The Mental Health Of College-Educated African American Women, Andrea Alston-Brundage

Walden Dissertations and Doctoral Studies

AbstractWomen occupy many roles today, including wife, partner, parent, student, employee, and caregiver. This study addressed the effects of multiple roles on degreed African American women. The specific purpose was to assess the relationships between the marital and parental roles and employment status of college-educated African American women and assess mental health impacts as a result of role strain. The theoretical foundation for the study was Goode's role strain theory. The Working Women’s Role Strain Inventory, Patient Health Questionnaire-9, and General Anxiety Disorder-7 were administered to 82 women participants between the ages of 22 and 61 who were involved in …

Mediators Between Job Stress And Health Quality Of Life Among Adults With Irritable Bowel Syndrome, Aida M. Benitez-Rexach

Walden Dissertations and Doctoral Studies

Irritable bowel syndrome (IBS) is a functional gastrointestinal affliction that affects millions around the globe, impacting health-related quality of life (HRQoL). The biopsychosocial model, Folkman and Lazarus’ transactional model of stress, Leventhal’s common sense model of self-regulation health and illness, and Bronfenbrenner’s human ecology theory are relevant to conceptualize interactions among environmental factors, biopsychosocial responses, and health-related quality of life (HRQoL). This quantitative, cross-sectional, complex correlational study sought to provide more understanding of how and whether IBS symptoms of pain, cognitive functioning, and interpersonal functioning serve as mediators between work stress and HRQoL. A total of 133 English-speaking volunteers from …

The Influence Of Aging And Cognitive Load On Neural Oscillations: An Analysis Of Resting-State And Task-Related Alpha Waves, Heather Shipley

CMC Senior Theses

Neurodegenerative disease associated with aging can have devastating effects on cognitive function, but of interest is how healthy aging affects cognitive and neural function. One measure of neural function associated with aging and cognitive decline is alpha-band oscillations (8-13 Hz) in electroencephalography data (EEG). Alpha-band oscillations are thought to play a role in complex cognitive function and network coordination through inhibitory processes indexed via alpha suppression. We examined whether the aperiodic component of neural activity, a marker of neural noise, influences findings of age-related differences in alpha-band oscillatory activity. In this study, we examined how aging and increased cognitive load …

Treatment Of Anxiety By Transcutaneous Vagus Nerve Stimulation: A Retrospective Chart Review, Rhea Gandhi

CMC Senior Theses

Surgical vagus nerve stimulation (VNS) was FDA cleared for depression (2005) and epilepsy. (1997). In the surgical procedure, a pacemaker is implanted below the collarbone (clavicle) and connected to the vagus nerve in the neck. Transcutaneous vagus nerve stimulation (tVNS) is a non-surgical alternative to VNS and there is evidence supporting its effectiveness for several conditions. Advantages include lower cost and fewer adverse side effects.

Anxiety is tied to excess or unopposed sympathetic nervous system activity, while the parasympathetic nervous system, especially the vagus nerve, is relatively underactive. This study aimed to investigate a potential impact of regular tVNS stimulation …

The Relationship Between Maternal Emotion Socialization And Child Executive Functioning And Behavior: Exploring The Moderating Role Of Cortisol, Mayela Norwood

CMC Senior Theses

In the early years of life, the development of children’s executive functioning (EF) and behavior regulation are critical to their later growth and self-sufficiency. Previous studies have indicated that one pathway by which children learn to regulate their emotions is through their immediate social environments (de Cock et al., 2017). Parents, in particular, play a significant role in the development of their children‘s emotion regulation and executive functioning (Fernandes et al., 2022). At the same time, physiological responses to stress also matter. Cortisol, the end product of the hypothalamic-pituitary-adrenal axis, has also been associated with children’s executive functioning and behavior …

Visualization And Characterization Of The Immunological Synapse Between Chlorotoxin Chimeric Antigen (Cltx-Car) Redirected T Cells And Targeted Glioblastoma Tumors, Arianna Livi

CMC Senior Theses

Chimeric Antigen Receptor T (CAR-T) cells have demonstrated anti-tumor activity against aggressive and invasive cancers such as glioblastoma (GBM); however, clinical response rates remain low in clinical trial studies. Tumor heterogeneity and tumor microenvironment conditions pose significant challenges for treatment of GBM, thus continuous optimization of CAR-T cell therapies and identification of novel, widely expressed, and highly specific GBM antigens are vital to better patient outcomes. A newly developed CAR-T cell construct incorporating chlorotoxin (CLTX) as the targeting domain exhibited broad GBM-targeting capabilities and elicited potent cytotoxic effects during preclinical studies and is currently being tested in a phase I …

Radiogenomics Of C9orf72 Expansion Carriers Reveals Global Transposable Element Derepression And Enables Prediction Of Thalamic Atrophy And Clinical Impairment, Luke W. Bonham, Ethan G. Geier, Daniel W. Sirkis, Josiah K. Leong, Eliana Marisa Ramos, Qing Wang, Anna Karydas, Suzee E. Lee, Virginia E. Sturm, Russell P. Sawyer, Adit Friedberg, Justin K. Ichida, Aaron D. Gitler, Leo Sugrue, Michael Cordingley, Walter Bee, Eckard Weber, Joel H. Kramer, Katherine P. Rankin, Howard J. Rosen, Adam L. Boxer, William W. Seeley, John Ravits, Bruce L. Miller, Jennifer S. Yokoyama

Psychological Science Faculty Publications and Presentations

Hexanucleotide repeat expansion (HRE) within C9orf72 is the most common genetic cause of frontotemporal dementia (FTD). Thalamic atrophy occurs in both sporadic and familial FTD but is thought to distinctly affect HRE carriers. Separately, emerging evidence suggests widespread derepression of transposable elements (TEs) in the brain in several neurodegenerative diseases, including C9orf72 HRE-mediated FTD (C9-FTD). Whether TE activation can be measured in peripheral blood and how the reduction in peripheral C9orf72 expression observed in HRE carriers relates to atrophy and clinical impairment remain unknown. We used FreeSurfer software to assess the effects of C9orf72 HRE and clinical diagnosis (n …

American Sign Language (Asl): Linguistically And Cognitively - Why Deaf People Should Learn Asl & Learn It Early, Helena Isabel Berczes

Undergraduate Honors Theses

This thesis presents data supporting the value of including American Sign Language (ASL) in the education of Deaf people. Historically, Deaf education has not fully included or has excluded ASL in an effort to focus on English due to a belief that ASL hinders learning English. ASL must fit within the definition of language with unique linguistic features for its inclusion in language education. Plasticity of the brain lends itself to the ability for language processing networks to form based on language experience. Deaf people can fully access visual language versus auditory language. Therefore, acquiring ASL early in life, during …

Hyperparameter Codependence In Fieldnet: Guidelines For Ann Construction, Seiji Akera

Pitzer Senior Theses

Artificial Neural Networks (ANNs) comprise a non-linear modeling method that is often used to analyze neural data in place of linear models. These networks fall under one of two classifications: pure prediction purposes and improving understanding of the brain through neural interpretability. FieldNet is an ANN designed by Dr. Gautam Agarwal that takes complex valued theta oscillations recorded from implanted multi-electrodes and predicts the rat’s location as it moves throughout a maze. In learning neural features to make this classification, FieldNet appears to reconstruct place fields. The construction of FieldNet has an impact on both the performance and reconstruction capabilities …

Exploring The Molecular Basis Of Touch: A Comparative Analysis Of Gene Expression In Sensory Corpuscle-Rich And Corpuscle-Poor Skin Regions In The Duck, Thomas Hart

Theses and Dissertations--Biology

Cutaneous touch is facilitated by discrete cellular complexes composed of non-neuronal cells associated with mechanoreceptor neuron endings. The non-neuronal cells of these cutaneous end organ complexes (CEOCs) are believed to contribute to touch, but their role in touch sensation remains unclear. To better understand the function of CEOC cells, we sought to characterize the transcriptional profile of CEOC-rich tissue and identify genes expressed in CEOC cells. Bill skin of the tactile foraging Pekin duck (Anas platyrhynchos) is dense with CEOCs, specifically the avian analogs of mammalian Pacinian and Meissner corpuscles, while corpuscles in duck foot skin are scarce. Using RNA …

Therapeutic Implications Of The Gut-Cns Axis In Promoting Recovery Following Cervical Spinal Cord Injury, Jessica Wilson

Theses and Dissertations--Neuroscience

Nearly 60% of all spinal cord injuries (SCI) occur at the cervical level. These high-level injuries can interrupt the descending respiratory pathways required for breathing. Indeed, therapies in animal studies have been successful at restoring breathing after SCI; however, these interventions appear to be more effective at chronic time points. One potential cause for this observation is the impact of the injury on the gut microbiome. Neurotrauma can induce gut dysbiosis, an imbalance of pathogenic and beneficial gut microbiota, which has previously been shown to negatively impact the central nervous system (CNS) and impair recovery. We aimed to build upon …

Age- And Sex-Dependent Alterations In Primary Somatosensory Neuronal Calcium Network Dynamics During Locomotion, Sami L. Case

Theses and Dissertations--Pharmacology and Nutritional Sciences

Over the past 30 years, the calcium (Ca2+) hypothesis of brain aging has provided clear evidence that hippocampal neuronal Ca2+ dysregulation is a key biomarker of aging. Indeed, age-dependent Ca2+-mediated changes in intrinsic excitability, synaptic plasticity, and activity have helped identify some of the mechanisms engaged in memory and cognitive decline. However, much of this work has been done at the single-cell level, mostly in slice preparations, and in restricted structures of the brain. Recently, our lab identified age- and Ca2+-related neuronal network dysregulation in the cortex of the anesthetized animal. Still, investigations in the awake animal are needed to …

Effects Of Traumatic Brain Injury On The Intestinal Tract And Gut Microbiome, Anthony Desana

Theses and Dissertations--Physiology

Traumatic brain injury (TBI) initiates not only complex neurovascular and glial changes within the brain but also pathophysiological responses that extend beyond the central nervous system. The peripheral response to TBI has become an intensive area of research, as these systemic perturbations can induce dysfunction in multiple organ systems. As there are no approved therapeutics for TBI, it is imperative that we investigate the peripheral response to TBI to identify targets for future intervention. Of particular interest is the gastrointestinal (GI) system. Even in the absence of polytrauma, brain-injured individuals are at increased risk of suffering from GI-related morbidity and …

Clinical And Biological Factors Determine Spinal Cord Injury Outcomes: Liquor To Lipids, Ethan Glaser

Theses and Dissertations--Physiology

Spinal cord injuries (SCI) are debilitating and life altering events that can lead to permanent motor and sensory loss. SCI outcomes are impacted by both clinical factors such as blood alcohol content (BAC) at the time of injury as well as biological factors like the lipid-rich myelin debris that accumulates in the injury site. Both clinical and biological factors contribute to SCI recovery, impacting neuroinflammation, locomotor recovery, and histopathology. The purpose of the studies described here is to investigate the role of acute alcohol intoxication and intracellular lipid processing pathways on SCI outcomes in a rodent model.

An elevated BAC …

Assessment Of The Triple Reuptake Inhibitor Diclofensine: Effort-Based Decision-Making In A Rodent Model Of Motivational Dysfunction, Sofia Papanikolaou

Holster Scholar Projects

Serotonin-selective reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressant medications. Despite their popularity, they remain relatively ineffective at treating effort-related motivational symptoms of depression such as fatigue and anergia. Increasing research on triple reuptake inhibitors (TRIs) that target three neurotransmitters—dopamine, serotonin, and norepinephrine—has suggested that TRIs could have efficacy in targeting motivational dysfunction due to their dopaminergic effects. Previous research has shown that the dopamine depleting agent tetrabenazine can reliably induce motivational deficits in rats, as evidenced by a shift towards low-effort behavior in effort-based choice tasks, and provide a validated approach to creating a model of motivational dysfunction. …

Accelerated Forgetting In People With Epilepsy: Pathologic Memory Loss, Its Neural Basis, And Potential Therapies, Sarah Ashley Steimel Phd

Dartmouth College Ph.D Dissertations

While forgetting is vital to human functioning, delineating between normative and disordered forgetting can become incredibly complex. This thesis characterizes a pathologic form of forgetting in epilepsy, identifies a neural basis, and investigates the potential of stimulation as a therapeutic tool. Chapter 2 presents a behavioral characterization of the time course of Accelerated Long-Term Forgetting (ALF) in people with epilepsy (PWE). This chapter shows evidence of ALF on a shorter time scale than previous studies, with a differential impact on recall and recognition. Chapter 3 builds upon the work in Chapter 2 by extending ALF time points and investigating the …