Neuroscience and Neurobiology Commons^™

Expression Of Olfactory-Induced Anxiety Behaviors Following Hypoxia Treatment In Adult Zebrafish, Cassidy Larson, Luke Horsburgh, Cameron Houck, Skylar Dewitt

22nd Annual Celebration of Undergraduate Research and Creative Activity (2023)

Exposure to hypoxic conditions leads to neural loss of function or death in the nervous system of mammals. Zebrafish, given their sophisticated neuroregenerative abilities, are able to survive low-oxygen conditions with fewer consequences. These capabilities are crucial for the olfactory system of zebrafish, as their olfactory epithelium is directly exposed to damage and toxins in the environment. Given that olfaction allows for critical behaviors such as foraging, mating, predator detection, and non-visual perception of dead fish, possessing functional olfactory sensation is vital to survival. Cadaverine is a chemical compound that mimics putrescine, the scent of decaying flesh. This scent induces …

Dopaminergic Synapse Loss In 6-Ohda Lesioned Zebrafish, Grace Stalions, Heather Van Dort, Gabriella Taylor

22nd Annual Celebration of Undergraduate Research and Creative Activity (2023)

Parkinson's disease is a neurodegenerative disorder caused by degeneration of dopaminergic neurons, and an early symptom of Parkinson's disease is olfactory dysfunction. A common animal model used in Parkinson's disease research is zebrafish because of their unique neuro-regenerative ability, which is particularly in their olfactory bulb. In order to create a model of the early stages of Parkinson's disease we injected zebrafish with the neurotoxin 6-hydroxydopamine (6-OHDA) to induce the degeneration of dopaminergic neurons in the olfactory bulb. Olfactory system recovery post 6-OHDA injection has been recorded in previous literature, but the state of synaptic dopaminergic synapses post-injection has not …

Effect Of Delaying Hca Exposure On The Development Of Manic/Depressive Behaviors In Sprague Dawley Rats, Eden Comer, Rachel Mast, Natalie Olander, Mackenzie Williams

22nd Annual Celebration of Undergraduate Research and Creative Activity (2023)

Bipolar disorder (BD) is a neuropsychological disorder that is characterized by cyclical periods of depressive and manic behaviors. The Chase lab is focused on developing a reliable animal model for BD in order to characterize the critical neurophysiological and neurochemical changes that trigger BD. Previous studies in the lab have shown that daily injection of rat pups from postnatal day 3 through 19 (P3-P19) with homocysteic acid (HCA) leads to the development of a mixed manic and depressive state after puberty. These behaviors can be reversed by treatment with lithium and involve changes in gene expression in the prefrontal cortex …

Consequences Of Environment And Loss On Maternal Behavior, Anxiety, Boldness, And Memory In Rats, Alayna Skye Palamar

Longwood Senior Thesis Proposal

No abstract provided.

Identifying Functional Imaging Markers In Psychosis Using Fmri, Ruiqi Wang

MUSC Theses and Dissertations

Major types of psychotic disorders include schizophrenia (SCZ), bipolar disorder (BP) and schizoaffective disorder (SZA). These disorders have profound and overlapping symptoms with marked cognitive deficits, and their diagnosis relies on symptom clusters. The treatments for psychosis are usually focused on positive symptoms such as delusions and hallucinations. Although cognitive impairments underlie both positive and negative symptoms, functional brain imaging biomarkers that can reliably predict a patient's cognitive deficits are still lacking. Therefore, this project used functional MRI to explore the feasibility of using functional connectivity (FC) to predict cognitive performance.

A total of 207 subjects (BP: 79, SZ/SZA: 48, …

Mapping Of Corticotropin-Releasing Factor (Crf) Receptors In The Coyote Brain, Rachel Tong

Student Research Symposium

Forming strong social bonds is essential to our everyday life and is part of what makes us human. The loss of a loved one often results in grief, stress, and loneliness, and the stress response system of the body has been implicated in the physiological symptoms associated with grieving. The hormone that initiates the stress response in the body is called corticotropin releasing factor (CRF), which acts via binding to CRF receptors (CRFR). Coyotes are an appropriate animal model to study social bonds and social loss because they display monogamy and pair bonding, which is a trait seen in human …

Comparing Vasopressin Receptor 1a Density In Paired Vs. Widowed Coyote Brains, Jacey Hopkin

Student Research Symposium

Arginine vasopressin (AVP) is a neuropeptide known for its key role in the formation of social bonds and acts through binding to the AVP 1a receptor (AVPR1a). Most notably, research has demonstrated that monogamous species have higher levels of AVPR1a compared to non-monogamous species. AVPR1a is typically found in brain regions facilitating individual relations, social memory, and interspecies attachment; these areas are closely associated with partner preference and monogamous behavior. In addition, it has been observed in prairie voles that levels of social neuropeptides, such as oxytocin, will decrease when pair-mates are separated for extended time periods. A majority of …

Plants Lack The Functional Neurotransmitters And Signaling Pathways Required For Sentience In Animals, David G. Robinson, Michael R. Blatt, Andreas Draguhn, Lincoln Taiz, Jon Mallatt

Animal Sentience

We cannot agree with Segundo-Ortin and Calvo that plants are sentient organisms. We have critically examined several aspects of their target article, and find their claims are not supported by the published evidence. We address these claims in sections on whether plants have a ‘neurobiology’ analogous to that of animal nervous systems, including neurotransmitters and synaptic receptors that respond to anesthetics; and whether plant signaling resembles neural transmission. For the latter, we especially consider the unique way plants signal their responses to wounding. Although the plant vascular system has been compared to the animal nervous system, animal blood vessels would …

Oxytocin Receptor Binding In The Substantia Nigra In Schizophrenia, Ariel Snowden

Student Research Symposium

Schizophrenia is a chronic, psychiatric disorder characterized by hallucinations, delusions, cognitive deficits, and social cognitive impairments. Although antipsychotic drugs are typically effective in treating psychotic symptoms in schizophrenia, the social cognitive symptoms often persist. As social cognitive functioning is predictive of successful life outcomes in schizophrenia, there is a critical need to determine the biological basis of social cognitive impairments. Due to its ability to affect social behaviors in animals and humans, the oxytocin (OXT) system has become a therapeutic target of interest for schizophrenia. Although several studies examine the OXT system in schizophrenia in the periphery, it is currently …

The Grieving Brain: Effect Of Pairmate Loss On Coyote Oxytocin Receptor Densities, Kaleb Keller

Student Research Symposium

Complicated grief is a severe mental health disorder that can have detrimental effects on individuals who have lost a loved one. Understanding the biological underpinnings of grief is essential in being able to help develop effective treatments and therapies. Oxytocin is heavily implicated in studies about grief and pairmate loss due to its importance in modulating social behavior such as pair bond formation. Previous research has primarily focused on rodents and non-human primates as model organisms of social attachment and studies have shown that monogamous prairie voles showed a decrease in oxytocin receptor (OXTR) binding in the nucleus accumbens after …

Mapping Vasopressin Receptors In Deep Structures Of The Coyote Brain, Maggie Zentner

Student Research Symposium

Vasopressin is a hormone that is integral in memory, social behaviour, aggression, and bonding. Coyotes are monogamous animals with complex societal structure. Thus, it can be assumed that vasopressin is incredibly important in the function of the coyote brain. We looked at the deep structures of the coyote brain using 25 μm slices and mapped the areas of vasopressin binding using 125I-LVA. We found that the most dense areas of binding were in areas of the brain that play a role in learning, memory, cervical and head muscles, and odour discrimination, among others. These functions are largely integral in forming …

Autism, Light, And Rna - A Story In Three Parts, Ethan Dayley

Student Research Symposium

Autism is a neurodevelopmental difference present in about 1 in 36 people. Autistics tend to have differences in social communication, interests, and the ways they process the world around them. Autism is an important research area because many autistics suffer from poor mental health and can have difficulties with obtaining education and maintaining employment. By better understanding how autism works at every level we may be able to help autistics have better outcomes in future. This research is a follow-up to a study published by Freeman et al. in 2018. That study demonstrated differences in oxytocin receptor binding in the …

The Genomics Of Autism-Related Genes Il1rapl1 And Il1rapl2: Insights Into Their Cortical Distribution, Cell-Type Specificity, And Developmental Trajectories, Jacob Weaver

MUSC Theses and Dissertations

Neuropsychiatric disorders have a significant impact on modern society. These disorders affect a large percentage of the population: schizophrenia has a world-wide prevalence of 1% and autism spectrum disorders (ASD) affects 1 in 59 school-aged children in the US. There is substantial evidence that most neuropsychiatric disorders have a genetic component. Thus, with the advent of high throughput sequencing much effort has gone into identifying genetic variants associated with these disorders. The emerging picture from these studies is a complex one where hundreds of genes with small effects interact with a varied landscape of common variants to result in disease. …

Consciousness, Evolution, And The Self-Organizing Brain, Karen Seymour

Journal of Conscious Evolution

While evolution is guided by natural selection, it is internally driven by self-organizing processes. The brain encompasses these complementary forces and dynamics of evolution in both its structure and dynamics by embodying a historical record of the factors that have shaped it throughout its evolutionary past, as well as by being shaped by selective parameters in real time. Self-organization is evident in not only the brain’s structure and form, but also in the processes that support consciousness. From the convergence of complex structure and the novelty-generating dynamics of chaos that both characterize the brain arises the experience of explicit consciousness, …

Evaluation Of Concussion Assessment Tools For Collegiate Athletes, Jacqueline D. Villanueva Arevalo, Emily R. Brown

Student Scholar Showcase

BACKGROUND: Due to the increase in sports-related concussions in the United States, there is a rising concern about concussion assessments in collegiate athletes with regard to long term vestibular ocular motor dysfunction and post-concussion syndrome.

PURPOSE: Due to varying practices in concussion diagnosis, this systematic review analyzed three concussion diagnostic instruments, The King Devick, Screening Concussion Assessment Tool (SCAT-5), and Vestibular Oculomotor Screening Tool (VOMS), to determine the most appropriate instrument(s) for reducing vestibular ocular-motor dysfunction and post-concussion symptoms in collegiate athletes.

METHODS: Nested Knowledge was used to identify articles from PubMed, Europe Pubmed Central, and ClinicalTrials.gov databases. Key search …

The Role Of The Pcc And Acc In Autism Spectrum Disorder: A Functional Connectivity Study, Claudia Gonzalez

Honors Theses

Background: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that impacts behavior control and social skills. Currently, ASD diagnoses are largely qualitative; thus, having more quantitative means of identification would aid in earlier diagnosis of ASD. However, more research is needed to pinpoint observable neurobiological markers of ASD. Our study focused on the posterior cingulate cortex (PCC) due to past evidence suggesting its involvement in ASD symptomatology. The PCC has been linked to behavioral control and executive functioning. Moreover, previous studies support executive functioning’s responsibility for the repetitive and restricted behaviors (RRB) in ASD.

Method: Our study sought to …

Questions About Sentience Are Not Scientific But Cultural, Yoram Gutfreund

Animal Sentience

Abstract: The findings of complex cognitive-like behaviours in plants are surprising and exciting. However, they do not provide a scientific reason for ascribing sentience to plants. The target article, in trying to provide evidence for sentience in plants, exposes the weakness of the science of animal consciousness in general. In this commentary, I try to explain why the scientific method is incapable of resolving the question of which organisms or systems are sentient.

Effects Of Withania Somnifera On Zebrafish, Diyari Bekhtyar

Student Works

Withania somnifera (commonly known as Ashwagandha), is a plant in which its root powder is sold as a dietary supplement. It is being commonly used as an anti-anxiety supplement to combat stress. While the sale of Withania somnifera is widely accessible and available throughout the U.S., it is concerning that a number of teens and young adults are taking this supplement without consulting a physician. Previous studies and claims conclude that Withania somnifera has both neuroprotective and antiinflammatory properties in human neuronal cells. We have chosen to test Withania somnifera’s effects on early embryonic development using Danio rerio, zebrafish, as …

Novel Model For Tau Protein Expression And Function: The Honeybee Brain, Abdallah F. Sher

2023 Midwest Ecology & Evolution Conference

Scientists have long attempted to understand the mechanisms by which senescence occurs. Leading theories suggest that aging is an emergent property of natural selection’s prioritization of reproductive ability. Social insects, such as the honeybee (Apis mellifera) challenge this idea, separating colonies into reproductive and non-reproductive castes. Worker honeybees do not reproduce, suggesting that selection prioritizes tasks other than reproduction. Forager honeybees, for example, display improved cognitive and immune function compared to other behavioral phenotypes of bees, likely to support their ability to perform tasks such as navigating complex environments or making context-dependent decisions while foraging. Foragers are normally older honeybees, …

Effects Of Diet On Lcn2 Expression And Onset Of Neuroinflammation In An Alzheimer’S Disease Mice Model, Abdirahman A. Hayir

Neuroscience Honors Projects

This project covers the findings regarding the impact of diet on lipocalin 2 (LCN2) and the effects it has on neuroinflammation Alzheimer’s Disease (AD). LCN2 is a protein that is critical to the functionality of mitochondria and inflammatory responses. Evidence has shown that mitochondrial dysfunction is a potential central event in driving AD pathogenesis and contributing to formation of pathological hallmarks such as chronic inflammation. Furthermore, studies have shown that LCN2 can be deficient under metabolic conditions such as high-fat-diet (HFD). This study investigates if HFD induces LCN2 deficiency and increased neuroinflammation in an AD mice model.