Kshv Infection Of Endothelial Cells Manipulates Cxcr7-Mediated Signaling: Implications For Kaposi’S Sarcoma Progression And Intervention,
2012
Chapman University
Kshv Infection Of Endothelial Cells Manipulates Cxcr7-Mediated Signaling: Implications For Kaposi’S Sarcoma Progression And Intervention, Jennifer Totonchy, Lisa Clepper, Janet Douglas, Liron Pantanowitz, Klaus Fruh, Ashlee V. Moses
Pharmacy Faculty Articles and Research
"CXCR7 was recently characterized as an alternative receptor for the chemokine CXCL12/SDF-1, previously thought to bind and signal exclusively through CXCR4.We recently identified CXCR7 as a key cellular factor in the endothelial cell (EC) dysfunction associated with KSHV infection. CXCL12 signaling is critically associated with tumor growth, angiogenesis and metastasis in several diverse tumors and is one of the most studied chemokine/chemokine receptor interactions in cancer systems. The tumorigenic activity of the CXCL12 signaling axis offers an attractive target for therapeutic intervention in multiple cancers including Kaposi’s Sarcoma (KS). However, most of the research to date was based on the …
Cytoplasmic Sequestration Of The Tumor Suppressor P53 By A Heat Shock Protein 70 Family Member, Mortalin, In Human Colorectal Adenocarcinoma Cell Lines,
2012
West Chester University of Pennsylvania
Cytoplasmic Sequestration Of The Tumor Suppressor P53 By A Heat Shock Protein 70 Family Member, Mortalin, In Human Colorectal Adenocarcinoma Cell Lines, Erin E. Gestl, S. Anne Boettger
Biology Faculty Publications
No abstract provided.
An Exhibit Wordle,
2012
University of South Carolina - Columbia
A Crossword Puzzle For Kids,
2012
University of South Carolina - Columbia
Word Find,
2012
University of South Carolina - Columbia
Images From The Exhibit, Page 1,
2012
University of South Carolina - Columbia
Lesson Plans, Activities, And Further Reading,
2012
University of South Carolina - Columbia
Lesson Plans, Activities, And Further Reading, Allison Marsh
Handouts
No abstract provided.
Why Do We Collect?,
2012
University of South Carolina - Columbia
Why Do We Collect?, Allison Marsh
Section 2: Imaging the Microscopic
No abstract provided.
Spotlight On Usc: A.C. Moore Herbarium,
2012
University of South Carolina - Columbia
Spotlight On Usc: A.C. Moore Herbarium, Allison Marsh
Section 2: Imaging the Microscopic
No abstract provided.
Imaging And Aesthetics,
2012
University of South Carolina - Columbia
Imaging And Aesthetics, Allison Marsh
Section 2: Imaging the Microscopic
No abstract provided.
Listen,
2012
University of South Carolina - Columbia
Spotlight On Usc: Mechanical Engineering,
2012
University of South Carolina - Columbia
Spotlight On Usc: Mechanical Engineering, Allison Marsh
Section 3: Imaging the Fast Moving
No abstract provided.
Photographic Evidence,
2012
University of South Carolina - Columbia
Photographic Evidence, Allison Marsh
Section 3: Imaging the Fast Moving
No abstract provided.
Influencing Art,
2012
University of South Carolina - Columbia
Influencing Art, Allison Marsh
Section 3: Imaging the Fast Moving
No abstract provided.
Conclusion Panel,
2012
University of South Carolina - Columbia
Cancer And You,
2012
Parkland College
Cancer And You, Diah-Aldeen Judeh
A with Honors Projects
This project discusses ways a person can identify cancer and what to do if cancer is present.
The Linkage Between Transcription Control And Epigenetic Regulation: The Snail Story And Beyond,
2012
University of Kentucky
The Linkage Between Transcription Control And Epigenetic Regulation: The Snail Story And Beyond, Yiwei Lin
Theses and Dissertations--Pharmacology and Nutritional Sciences
Epigenetic deregulation contributes significantly to the development of multiple human diseases, including cancer. While great effort has been made to elucidate the underlying mechanism, our knowledge on epigenetic regulation is still fragmentary, an important gap being how the diverse epigenetic events coordinate to control gene transcription. In the first part of our study, we demonstrated an important link between Snail-mediated transcriptional control and epigenetic regulation during cancer development. Specifically, we found that the highly conserved SNAG domain of Snail sequentially and structurally mimics the N-terminal tail of histone H3, thereby functions as a molecular “hook”, or pseudo substrate, for recruiting …
Rhodococcus Equi Infection And Interferon-Gamma Regulation In Foals,
2012
University of Kentucky
Rhodococcus Equi Infection And Interferon-Gamma Regulation In Foals, Lingshuang Sun
Theses and Dissertations--Veterinary Science
Rhodococcus equi (R. equi) is one of the most serious causes of pneumonia in young foals. The clinical disease is of great concern to breeding farms worldwide due to the impact of mortality on economic losses. While adult horses are resistant to R. equi, foals exhibit a distinct age-associated susceptibility. The mechanism underlying this susceptibility in foals is not well understood. Interferon-gamma (IFNg) plays an important role in the clearance of R. equi, but its expression is impaired in neonatal foals. Moreover, the regulation of this age-related IFNg expression in foals remains unknown. In humans, IFNg …
Transient Features In Nanosecond Pulsed Electric Fields Differentially Modulate Mitochondria And Viability,
2012
Old Dominion University
Transient Features In Nanosecond Pulsed Electric Fields Differentially Modulate Mitochondria And Viability, Stephen J. Beebe, Yeong-Jer Chen, Nova M. Sain, Karl H. Schoenbach, Shu Xiao
Bioelectrics Publications
It is hypothesized that high frequency components of nanosecond pulsed electric fields (nsPEFs), determined by transient pulse features, are important for maximizing electric field interactions with intracellular structures. For monopolar square wave pulses, these transient features are determined by the rapid rise and fall of the pulsed electric fields. To determine effects on mitochondria membranes and plasma membranes, N1-S1 hepatocellular carcinoma cells were exposed to single 600 ns pulses with varying electric fields (0-80 kV/cm) and short (15 ns) or long (150 ns) rise and fall times. Plasma membrane effects were evaluated using Fluo-4 to determine calcium influx, the only …
Oxidative Effects Of Nanosecond Pulsed Electric Field Exposure In Cells And Cell-Free Media,
2012
Old Dominion University
Oxidative Effects Of Nanosecond Pulsed Electric Field Exposure In Cells And Cell-Free Media, Olga N. Pakhomova, Vera A. Khorokhorina, Angela M. Bowman, Raminta Rodaitė-Riševičienė, Gintautas Saulis, Shu Xiao, Andrei G. Pakhomov
Bioelectrics Publications
Nanosecond pulsed electric field (nsPEF) is a novel modality for permeabilization of membranous structures and intracellular delivery of xenobiotics. We hypothesized that oxidative effects of nsPEF could be a separate primary mechanism responsible for bioeffects. ROS production in cultured cells and media exposed to 300-ns PEF (1–13 kV/cm) was assessed by oxidation of 2′, 7′-dichlorodihydrofluoresein (H2DCF), dihidroethidium (DHE), or Amplex Red. When a suspension of H2DCF-loaded cells was subjected to nsPEF, the yield of fluorescent 2′,7′dichlorofluorescein (DCF) increased proportionally to the pulse number and cell density. DCF emission increased with time after exposure in nsPEF-sensitive Jurkat …
