The Impact Of Chronic Pain On Income And Employment,
2025
Royal College of Surgeons in Ireland
The Impact Of Chronic Pain On Income And Employment, Jordan Vaarsi, Amber Jolly, Karim S. Ladha
SURE Journal: Science Undergraduate Research Experience Journal
No abstract provided.
Living The Life: A Community Approach To Men’S Health And Longevity,
2025
South East Technological University
Living The Life: A Community Approach To Men’S Health And Longevity, Paul Anders, Aisling Mcgrath
SURE Journal: Science Undergraduate Research Experience Journal
No abstract provided.
When Care Can’T Move Forward – The Human And Social Cost Of Freezing Of Gait In Parkinson’S Disease,
2025
University College Cork
When Care Can’T Move Forward – The Human And Social Cost Of Freezing Of Gait In Parkinson’S Disease, Padraig Cronin, Lucy M. Collins, Aideen M. Sullivan
SURE Journal: Science Undergraduate Research Experience Journal
No abstract provided.
Life Under Pressure: How Doubling The Genome Affects The Memory Of Environmental Stress In Worms,
2025
Trinity College Dublin
Life Under Pressure: How Doubling The Genome Affects The Memory Of Environmental Stress In Worms, Aisling Phelan, Emma Bazzani, Clément Verdier, Laetitia Chauve, Aoife Mclysaght
SURE Journal: Science Undergraduate Research Experience Journal
No abstract provided.
Sticky Genes: Can Repeated Dna Sequences Trigger Motor Neurone Disease?,
2025
Trinity College Dublin
Sticky Genes: Can Repeated Dna Sequences Trigger Motor Neurone Disease?, Guste Venslovaite, Russell Mclaughlin
SURE Journal: Science Undergraduate Research Experience Journal
No abstract provided.
Pause For Policy - The Cognitive Cost Of Cannabis Use In Adolescence,
2025
Royal College of Surgeons in Ireland
Pause For Policy - The Cognitive Cost Of Cannabis Use In Adolescence, Michael O'Connor, Linda Kelly, Emma O'Hora, Claire O'Doherty, Ciaran Brown, An Hsu, Sahar Riaz, Frank Crosson, Darren Roddy, Mary Cannon
SURE Journal: Science Undergraduate Research Experience Journal
No abstract provided.
From Recognition To Action: Advancing Nutrition Care In Irish Healthcare,
2025
Atlantic Technological University
From Recognition To Action: Advancing Nutrition Care In Irish Healthcare, Aoife Gillane, Sarah Donovan, Lisa Ryan
SURE Journal: Science Undergraduate Research Experience Journal
No abstract provided.
The Future Of Metabolic Health: A Needle-Free Alternative For Blood Sugar Monitoring,
2025
Atlantic Technological University
The Future Of Metabolic Health: A Needle-Free Alternative For Blood Sugar Monitoring, Conor Cleary, Martin Bradley, Christopher Crosson, John Wade
SURE Journal: Science Undergraduate Research Experience Journal
No abstract provided.
Transforming Plastic For A Sustainable Planet: Next-Generation Materials That Biodegrade Naturally,
2025
Technological University of the Shannon
Transforming Plastic For A Sustainable Planet: Next-Generation Materials That Biodegrade Naturally, Kristof Racz, Clement Higginbotham
SURE Journal: Science Undergraduate Research Experience Journal
No abstract provided.
The Dock Beetle: Reducing Costs And Pesticides In Irish Agriculture,
2025
Technological University of the Shannon, PRISM Research Institute. Applied Polymer Technoloigies Gateway, TUS
The Dock Beetle: Reducing Costs And Pesticides In Irish Agriculture, Bianca Araujo, Daniel P. Fitzpatrick
SURE Journal: Science Undergraduate Research Experience Journal
No abstract provided.
Ireland’S Energy Transition: Unlocking The Potential Of Offshore Renewables,
2025
Queen's University Belfast
Ireland’S Energy Transition: Unlocking The Potential Of Offshore Renewables, Caoimhe O'Hare, Madjid Karimirad, Gautam Baruah
SURE Journal: Science Undergraduate Research Experience Journal
No abstract provided.
Implementation Of The Nature Restoration Law In The Eu - Pros, Cons And Impossibilities,
2025
Queen's University Belfast
Implementation Of The Nature Restoration Law In The Eu - Pros, Cons And Impossibilities, Emma Mcdonagh, Liam Sunner
SURE Journal: Science Undergraduate Research Experience Journal
No abstract provided.
From Conflict To Connection: Educators Leading The Shift Towards Restorative Practices (Rp) In Deis Primary Schools,
2025
Mary Immaculate College
From Conflict To Connection: Educators Leading The Shift Towards Restorative Practices (Rp) In Deis Primary Schools, Ellen Slattery, Clara Hoyne
SURE Journal: Science Undergraduate Research Experience Journal
No abstract provided.
Bridging The Gap From Preschool To Primary: From Policy To Practice,
2025
Mary Immaculate College
Bridging The Gap From Preschool To Primary: From Policy To Practice, Aimee O'Connor, Cóilín O’ Braonáin
SURE Journal: Science Undergraduate Research Experience Journal
No abstract provided.
Micronuclei As A Marker Of Genotoxicity In An Urban Songbird.,
2025
University of Louisville
Micronuclei As A Marker Of Genotoxicity In An Urban Songbird., Elise Mittlestat
College of Arts & Sciences Senior Theses
A rise in industry and vehicle emissions in the last 20 years has led to an increase in exposure to air pollution. Air pollution has been identified as a major threat to both human and animal health and it has been linked to elevated oxidative stress. One of the most severe consequences of oxidative stress is genotoxic damage. Birds have been identified as promising sentinels for human health, but the effects of air pollution on genotoxicity in birds is understudied. In this study, I evaluated the association between air pollution and markers of genotoxicity in American Robins (Turdus migratorius) to …
Runx2 Cooperates With Srebp1 To Rewire Cancer Metabolism And Promote Aggressiveness,
2025
Thomas Jefferson University
Runx2 Cooperates With Srebp1 To Rewire Cancer Metabolism And Promote Aggressiveness, Emanuele Vitale, Mila Gugnoni, Veronica Manicardi, Silvia Muccioli, Federica Torricelli, Benedetta Donati, Simonetta Piana, Gloria Manzotti, Elisa Salviato, Francesca Reggiani, Cristian Ascione, Rebecca Vezzani, Moira Ragazzi, Mattia Forcato, Oriana Romano, Silvio Bicciato, Aaron Goldman, Marco Tigano, Alessia Ciarrocchi
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
Embryonic Transcription Factors (TFs) are often reactivated in cancer, driving developmental gene programs that support phenotypic plasticity. Metabolic adaptation fuels this plasticity by supplying energy and molecular building blocks for growth. RUNX2, the master regulator of bone morphogenesis, is ectopically expressed in epithelial cancer, promoting metastasis through trans-differentiation processes like Epithelial-to-Mesenchymal Transition (EMT) and osteomimicry. By combining omics data with functional validation, we demonstrated that RUNX2 drives cancer cell metabolic rewiring by repressing mitochondrial respiration while promoting anabolic processes. We showed that RUNX2 upregulates key genes of lipid biosynthesis by regulating and cooperating with SREBP1. In vivo expression analysis in …
Analysis Of Mct-1 Expression In Mouse Neural Retina In Response To Chronic Inflammation,
2025
University of North Florida
Analysis Of Mct-1 Expression In Mouse Neural Retina In Response To Chronic Inflammation, Ian W. Ronson
PANDION: The Osprey Journal of Research and Ideas
Chronic inflammation is a current public health concern as it is linked to the etiology and symptoms of numerous diseases, for example diabetic retinopathy (DR). In the case of DR, inflammation leads to dysregulation of the blood retina barrier causing retinal hemorrhage and macular edema leading ultimately to irreversible vision loss. MCT-1 is critical for the survival of photoreceptor cells because MCT-1 forms protein complexes with Basigin, a cell-cell adhesion protein, that enables Müller glial cells to efficiently provide lactate as a high energy fuel source. Previous studies have shown chronic inflammation reduces Basigin expression in the retina and that …
Setdb1 Is Critically Required For Uveal Melanoma Growth And Represents A Promising Therapeutic Target,
2025
Thomas Jefferson University
Setdb1 Is Critically Required For Uveal Melanoma Growth And Represents A Promising Therapeutic Target, Imène Krossa, Céline Pisibon, Yann Cheli, Karine Bille, Mélanie Dalmasso, Sabah Hamadat, Chrystel Husser, Marie Irondelle, Julien Cherfils-Vicini, Frédéric Soysouvanh, Sacha Nahon-Esteve, Arnaud Martel, Sandra Lassalle, Jean-Pierre Caujolle, Célia Maschi, Stéphanie Baillif, Dan Hasson, Saul Carcamo, Andrerw E. Aplin, Irwin Davidson, Emily Bernstein, Valeria Naim, Robert Ballotti, Corine Bertolotto, Thomas Strub
Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers
Metastatic uveal melanomas are highly resistant to all existing treatments. To identify actionable vulnerabilities, we conducted a CRISPR-Cas9 knockout screen using a library composed of chromatin regulators. We revealed that the lysine methyltransferase, SETDB1, plays a critical role in metastatic uveal melanoma cell proliferation and survival. Functionally, SETDB1 deficiency induces a DNA damage response, senescence-like state and growth arrest. Knockdown of SETDB1 is associated with a decreased expression of genes related to replication and cell cycle. Moreover, deficiency in CDC6, an essential regulator of DNA replication, phenocopies SETDB1 inhibition. Using a pre-clinical model, we further demonstrated that anti-SETDB1 therapy impairs …
Alphasperm Data,
2025
Texas Tech University Health Sciences Center
Alphasperm Data, Seth J. Parks, Timothy G. Jenkins
ScholarsArchive Data
Data from a prospective cohort study of sperm DNA methylation, semen analysis, and DNA fragmentation in fertile and infertile men before and after treatment with a male fertility antioxidant supplement.
Molecular Determinants Of Neoadjuvant Chemotherapy Resistance In Breast Cancer: An Analysis Of Gene Expression And Tumor Microenvironment,
2025
Instituto Nacional de Cancerología, Bogotá, Colombia
Molecular Determinants Of Neoadjuvant Chemotherapy Resistance In Breast Cancer: An Analysis Of Gene Expression And Tumor Microenvironment, Hedda Michelle Guevara-Nieto, Carlos A. Orozco-Castaño, Rafael Parra-Medina, Jenny Nathaly Poveda-Garavito, Jone Garai, Jovanny Zabaleta, Liliana López-Kleine, Alba Lucia Combita
School of Graduate Studies Faculty Publications
Neoadjuvant chemotherapy (NAC) is a critical component of breast cancer treatment, but the molecular mechanisms underlying resistance remain poorly understood. This study aimed to identify transcriptomic changes associated with NAC resistance across four breast cancer subtypes: Luminal A, Luminal B/HER2-positive, Luminal B/HER2-negative, and Triple-Negative Breast Cancer (TNBC). RNA-seq analysis was performed on paired pre- and post-NAC breast cancer samples from 32 nonresponders. Differentially expressed genes (DEGs) were identified, and functional enrichment analyses were conducted. Protein-protein interaction (PPI) networks were constructed to identify hub genes. Tumor microenvironment (TME) infiltration was estimated using deconvolution algorithms. The results revealed distinct gene expression profiles …
