Developmental Programming Effects Of Maternal Obesity,
2020
Portland State University
Developmental Programming Effects Of Maternal Obesity, Carolle J. Kassab
University Honors Theses
Population studies within the United States indicate increasing rates of obesity, considerably prominent for women within reproductive age. Maternal obesity is associated with the offspring’s hyperlipidemia, diabetes, and cardiovascular disease, which have chronic consequences. Obesity in pregnancy causes metabolic and epigenetic perturbations within the fetal environment, disrupting future health of offspring. This phenomenon is known as developmental programming. Although the relationship between maternal undernutrition and developmental programming has been demonstrated, its relationship to maternal obesity remains understudied.
Mutagenesis Of The Btea Gene Encoding A Bordetella Virulence Protein,
2020
Eastern Washington University
Mutagenesis Of The Btea Gene Encoding A Bordetella Virulence Protein, Xiaolei Mao
2020 Symposium Posters
Bordetella Type III Secretion System Effector A (BteA) is a virulence protein found in members of the genus Bordetella which include important pathogens of humans and other mammals. Bordetella pertussis is a causative agent of the whooping cough, a highly contagious respiratory disease that is especially dangerous, and sometimes deadly, for infants. The BteA protein appears to be an important factor in the ability of these pathogens to cause disease, as it leads to rapid killing of a wide range of mammalian cells. The aim of this project is to determine which regions of the DNA are important for mediating …
Science, But Not Fiction: Colby Researchers Consider How "Extreme-Ophiles" Survive And Thrive In The World's Toughest Places,
2020
Colby College
Science, But Not Fiction: Colby Researchers Consider How "Extreme-Ophiles" Survive And Thrive In The World's Toughest Places, Gerry Boyle
Colby Magazine
"We're exploring how the cell makes the decision to do this," said Assistant Professor of Biology Ron Peck.
Good Works: Giving Back After Cancer,
2020
Colby College
Good Works: Giving Back After Cancer, Gerry Boyle
Colby Magazine
David Pulver '63 turns his experience into a primer for patients
Determining How The Human T-Cell Leukemia Virus Type-1 (Htlv-1) Latency-Maintenance Factor P30ll Modulates Antioxidant- Signaling To Promote Oncogene Activation During Retroviral Carcinogenesis,
2020
Southern Methodist University
Determining How The Human T-Cell Leukemia Virus Type-1 (Htlv-1) Latency-Maintenance Factor P30ll Modulates Antioxidant- Signaling To Promote Oncogene Activation During Retroviral Carcinogenesis, Tetiana Bowley
Biological Sciences Theses and Dissertations
The Human T-cell Leukemia Virus Type-1 (HTLV-1) is a complex oncogenic deltaretrovirus that infects and transforms CD4+ T-lymphocytes and is the etiological agent of Adult T-cell Leukemia/Lymphoma (ATL). HTLV-1 latency-maintenance factor p30II downregulates proviral gene expression at the transcriptional and posttranscriptional levels and aids in immune escape from the host immune surveillance. HTLV-1 p30II competes with HTLV-1 transactivator Tax for binding to CBP/p300 coactivator; this competition determines if there is Tax-mediated transcription initiation or viral gene silencing induced by p30II. Our research group has previously demonstrated that the HTLV-1 p30II accessory protein induces the p53 …
Spreading Mechanics And Differentiation Of Astrocytes During Retinal Development,
2020
University of Florida
Spreading Mechanics And Differentiation Of Astrocytes During Retinal Development, Tracy Stepien, Timothy W. Secomb
Biology and Medicine Through Mathematics Conference
No abstract provided.
Coping With Stress: The Caulobacter Approach,
2020
Virginia Polytechnic Institute and State University
Coping With Stress: The Caulobacter Approach, Bronson R. Weston, Yang Cao, John J. Tyson
Biology and Medicine Through Mathematics Conference
No abstract provided.
Emergence, Mechanics, And Development: How Behavior And Geometry Underlie Cowrie Seashell Form,
2020
University of California Berkeley
Emergence, Mechanics, And Development: How Behavior And Geometry Underlie Cowrie Seashell Form, Michael G. Levy, Michael R. Deweese
Biology and Medicine Through Mathematics Conference
No abstract provided.
Effect Of Non-Muscle Myosin Ii Inhibition On Epigenetics During Oligodendrocyte Development,
2020
CUNY Hunter College
Effect Of Non-Muscle Myosin Ii Inhibition On Epigenetics During Oligodendrocyte Development, Amr Almaktari
Theses and Dissertations
Non-Muscle Myosin II (NMII) is a mechanosensitive motor protein implicated in oligodendrocyte (OL) development. The inhibition of NMII is known to promote OL development and maturation. This project found that NMII inhibition does not affect oligodendrocyte development by altering their epigenetic profile.
Patenting Antibodies: A Complication In Written Description Jurisprudence,
2020
DePaul University College of Law
Patenting Antibodies: A Complication In Written Description Jurisprudence, Krisha Yadav-Rajan
DePaul Journal of Health Care Law
No abstract provided.
The Anti-Proliferative Effects Of Methotrexate And Novel Ucp1162 On Acute Myeloid Leukemia Cell Lines,
2020
University of Connecticut, Storrs
The Anti-Proliferative Effects Of Methotrexate And Novel Ucp1162 On Acute Myeloid Leukemia Cell Lines, Jacqueline Klepinger, Charles Giardina, Didem Ozcan
Honors Scholar Theses
Cancer cells proliferate at rapid rates due to the aberrant activity of proteins involved in regulating the cell cycle. This characteristic allows mutated cancer cells to spread and metastasize, causing lesions to form throughout the body. Two treatment conditions, one classical antifolate methotrexate (MTX) and non-classical, novel antifolate UCP1162, were tested on a panel of acute myeloid leukemia (AML) cell lines to determine if UCP1162 has higher anti-proliferative activity. High dose MTX is used as a first line chemotherapy in common childhood malignancies such as acute lymphoid leukemia (ALL). Methotrexate is excluded from acute myeloid leukemia (AML) treatments based on …
Angiopoietin 1 Protects Against Lps-Induced Acute Lung Injury And Alveolar Remodeling In Neonatal Mice,
2020
Childrens Mercy Hospital
Angiopoietin 1 Protects Against Lps-Induced Acute Lung Injury And Alveolar Remodeling In Neonatal Mice, Umar Salimi
Research Days
No abstract provided.
Expression Analyses Of Hippocampal And Cortical Proteins In A Rat Model For Alzheimer’S Disease,
2020
CUNY Hunter College
Expression Analyses Of Hippocampal And Cortical Proteins In A Rat Model For Alzheimer’S Disease, Rangon Islam
Theses and Dissertations
Currently, Alzheimer’s disease (AD) has no cure. Using a rat AD model, we identified aberrantly expressed proteins during pre-pathology as potential biomarkers. The expression of certain biomarkers was reversed by diazoxide, a repurposed hypertension drug. These results suggest that drug repurposing at an early stage of AD has therapeutic potential.
Sexually Dimorphic Alterations In Brain Morphology Of Astrocyte Conditional System Xc- Knockout Mice,
2020
Syracuse University
Sexually Dimorphic Alterations In Brain Morphology Of Astrocyte Conditional System Xc- Knockout Mice, Gabrielle Emily Samulewicz
Biology - All Scholarship
Astrocytes play a vital role in orchestrating the precise brain wiring that occurs during development and are essential for maintaining homeostasis into adulthood. The cystine/glutamate antiporter, system xc-, in the central nervous system is especially abundant in astrocytes and itself is known to contribute importantly to the basal extracellular glutamate concentration as well as the intracellular and extracellular glutathione levels, either of which, if perturbed, could alter brain development and/or contribute to degeneration. Thus, to determine whether loss of astrocyte system xc- might alter brain morphology, I studied a conditional astrocyte system xc- knockout mouse (AcKO). Tissue was harvested from …
Molecular Insights Into Paf-1 Mediated Pancreatic Homeostasis, Stemness, And Cancer Progression,
2020
University of Nebraska Medical Center
Molecular Insights Into Paf-1 Mediated Pancreatic Homeostasis, Stemness, And Cancer Progression, Saswati Karmakar
Theses & Dissertations
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease that has one of the lowest 5-year survival rates among cancers, at just 9%. This grim prognosis is primarily due to the extensive metastatic spread of tumor cells beyond the pancreas at diagnosis and the inability of current therapeutic modalities to treat this aggressive disease effectively. Given that the cancer cells in pancreatic tumors are heterogeneous, the major culprit for cancer initiation, progression, and metastasis remains elusive. Recent studies provide evidence for the existence of highly tumorigenic and drug-resistant cells that are capable of tumor initiation, known as the cancer stem cells …
Sexually Dimorphic Alterations In Brain Morphology Of Astrocyte Conditional System Xc- Knockout Mice,
2020
Syracuse University
Sexually Dimorphic Alterations In Brain Morphology Of Astrocyte Conditional System Xc- Knockout Mice, Gabrielle Emily Samulewicz
Renée Crown University Honors Thesis Projects - All
Astrocytes play a vital role in orchestrating the precise brain wiring that occurs during development and are essential for maintaining homeostasis into adulthood. The cystine/glutamate antiporter, system xc-, in the central nervous system is especially abundant in astrocytes and itself is known to contribute importantly to the basal extracellular glutamate concentration as well as the intracellular and extracellular glutathione levels, either of which, if perturbed, could alter brain development and/or contribute to degeneration. Thus, to determine whether loss of astrocyte system xc- might alter brain morphology, I studied a conditional astrocyte system xc- knockout mouse (AcKO). Tissue was harvested from …
Elucidating The Functional Location Of Platelet-Derived Growth Factor Receptor Alpha, Creation Of A Review Chapter On The Use Of Zebrafish In Studying Congenital Heart Defects, And Using 3d Printing To Create Laboratory Tools,
2020
University of Mississippi
Elucidating The Functional Location Of Platelet-Derived Growth Factor Receptor Alpha, Creation Of A Review Chapter On The Use Of Zebrafish In Studying Congenital Heart Defects, And Using 3d Printing To Create Laboratory Tools, Jaret Lieberth
Honors Theses
Congenital heart defects (CHDs) are currently the most prevalent form of birth defect in the United States. Their combined frequency and severity make necessary a deeper understanding of the molecular underpinnings guiding heart formation. The first major step in cardiac morphogenesis, cardiac fusion, involves the medial movement of bilateral populations of myocardial precursor cells to the embryonic midline, where they merge to form the primitive heart tube. Although crucial to subsequent organogenesis, the precise mechanisms governing cardiac fusion remain unknown. Previous studies have found that a mutation in platelet-derived growth factor receptor alpha (pdgfra), called refuse-to-fuse (ref), results …
Exploring The Role Of Ccdc141 In Zebrafish Heart Development,
2020
University of Mississippi
Exploring The Role Of Ccdc141 In Zebrafish Heart Development, Luci Strong
Honors Theses
Zebrafish are a good model organism in which to identify genes important for heart development because most human genes have a zebrafish ortholog and genes in zebrafish are relatively simple to modify. ccdc141 is a gene with unknown function, which we originally found to be highly expressed in cardiac cells in mouse embryos. In this project, we are seeking to determine the function of ccdc141 using zebrafish. To perform this experiment, we are targeting ccdc141 for mutation using CRISPR/Cas9. In this project we have analyzed ccdc141 to determine regions of conservation, designed CRISPR guides to target those regions (exon 2 …
The Impact Of Age/Rage Signaling On Oxidative Stress Under Diabetic Conditions In Cardiac Fibroblasts,
2020
University of Mississippi
The Impact Of Age/Rage Signaling On Oxidative Stress Under Diabetic Conditions In Cardiac Fibroblasts, Christopher Dorroh
Honors Theses
Diabetes is a major health concern in the United States, with 1.5 million new cases diagnosed each year. Patients who suffer from diabetes have an increased risk of developing heart failure, a form of cardiovascular disease. Heart failure has been shown to result from increased left ventricular stiffness, which in turn is caused by increased remodeling of the extracellular matrix (ECM). This increase in ECM remodeling is a result of AGE/RAGE signaling, which occurs at a heightened level in the cardiac fibroblast cells of diabetics. Studies have shown that diabetics have elevated levels of AGEs (Advanced Glycation End-Products), which bind …
Breast Cancer Sub-Clones That Metastasize To Lung And Bone Exhibit Different Metabolic Preferences,
2020
University of Mississippi
Breast Cancer Sub-Clones That Metastasize To Lung And Bone Exhibit Different Metabolic Preferences, Mollie Merrell
Honors Theses
Metastasis is responsible for the majority of cancer related deaths. In breast cancer the lungs and bones are the major sites for metastasis. Previous studies used the metastatic aggressive MDA-MB-231 breast cancer line to isolate sub-clones that preferentially invade the lungs (LM line) or bones (BoM line). While genes associated with the tissue specific metastasis have been identified, it is unknown if metabolic adaptations contribute to the growth of the LM and BoM lines in their respective organs. The goal of this study was to test the hypothesis that the LM and BoM lines exhibit differences in glucose and glutamine …
