Identifying Determinants Of Breast Cancer Screening Through Mammography Among Asian American Women,
2021
University of Nevada, Las Vegas
Identifying Determinants Of Breast Cancer Screening Through Mammography Among Asian American Women, Sayeda Tazim Zaidi, Raisa Kabir, Chia-Liang Dai
Undergraduate Research Symposium Posters
Breast cancer is the most common malignancy affecting women around the world. In the US, approximately 1 in 8 women will develop breast cancer over the course of their lifetime. There is a growing incidence of breast cancer among Asian American (AA) women. Breast cancer screening by mammography is the most effective early detection method to reduce mortality but AA women have the lowest utilization rates. This study aims to identify the determinants affecting mammography among AA women. A literature search in PubMed Central, MEDLINE, and CINAHL was undertaken to include all peer-reviewed studies published within the past 20 years …
Induced Pluripotent Stem Cell Cardiomyocytes Provide An In Vitro Model Of The Myocardial Environment For Investigating Stem Cell Therapies,
2021
Grand Valley State University
Induced Pluripotent Stem Cell Cardiomyocytes Provide An In Vitro Model Of The Myocardial Environment For Investigating Stem Cell Therapies, Jacob M. Gunn
Honors Projects
Ischemic heart disease remains a major cause of death and disability worldwide (Moran Andrew E. et al., 2014). While interventions for heart disease have come a long way, restoring functionality to damaged myocardium remains a challenge. Both mechanical and electrical repair of the host myocardium are essential to salvage the damaged tissue. This is especially difficult following a myocardial infarction (MI) as the infarct area is subject to quick and extensive cell death via necrosis then apoptosis (Prabhu & Frangogiannis, 2016). Stem cells have emerged as a candidate for potential replacement therapies. Adult stem cells (ASCs) are taken from bone …
A Mathematical Model Of Pancreatic Cancer Growth And Response To Treatment,
2021
University of Nebraska - Lincoln
A Mathematical Model Of Pancreatic Cancer Growth And Response To Treatment, Allison Cruikshank
Honors Program: Senior Projects (Public)
Pancreatic cancer is one of the leading causes of death due to cancer in the United States. Analyzing the effects of radiation is extremely valuable in determining when a patient is allowed surgical resection, which is, presently, the only potentially curative treatment for pancreatic cancer. This study examines pancreatic tumor growth and shrinkage to predict tumor response and change of resectability for pancreatic cancer patients undergoing radiation therapy. This is done using ordinary differential equations as a mathematical model. Mathematical models have increasingly been applied to various biological systems/processes to analyze the principles involved. In our project, a population dynamical …
A Qualitative Review On Mammography Interventions Among Asian American Women,
2021
University of Nevada, Las Vegas
A Qualitative Review On Mammography Interventions Among Asian American Women, Sayeda Tazim Zaidi, Raisa Kabir, Chia-Liang Dai
Undergraduate Research Symposium Posters
Breast cancer (BC) is a leading type of malignancy and the second most common cause of cancer-related death among women around the world. The occurrence of BC has been increasing in Asian American (AA) women. Early detection through mammography is an effective means to reduce mortality associated with BC. However, there is a paucity of data and interventions regarding mammography promotion interventions among AA women. The purpose of this study was to evaluate current interventions for promoting mammography among AA women and suggest recommendations for designing successful interventions. A review for peer-reviewed journal articles in PubMed Central, MEDLINE, CINAHL, ERIC, …
The Effect Of A Folate Free Diet On Tumor Burden And Chemotherapy Effectiveness,
2021
University of South Carolina - Columbia
The Effect Of A Folate Free Diet On Tumor Burden And Chemotherapy Effectiveness, Kendall E. Stalls
Senior Theses
Our research is to understand the effect of the microbiota on colorectal cancer. Evidence has been shown that the microbiota is linked to the development and progression of colorectal cancer. The research focuses on how the gut microbiome influences the effectiveness of colorectal cancer treatments. Specifically, how the composition of the microbiota and the metabolites that it secretes changes the response to chemotherapy. We also research how tumor burden can be altered through changing the composition of the gut bacteria. Our experiments are performed on APC/Min+ mice, that have been genetically altered to have colon cancer. We conducted an experiment …
Association Of Dietary Total Antioxidant Capacity With Bone Mass And Osteoporosis Risk In Korean Women: Analysis Of The Korea National Health And Nutrition Examination Survey 2008-2011,
2021
Hanyang University
Association Of Dietary Total Antioxidant Capacity With Bone Mass And Osteoporosis Risk In Korean Women: Analysis Of The Korea National Health And Nutrition Examination Survey 2008-2011, Donghyun Kim, Anna Han, Yongsoon Park
Department of Cancer Biology Faculty Papers
Antioxidant intake has been suggested to be associated with a reduced osteoporosis risk, but the effect of dietary total antioxidant capacity (TAC) on bone health and the risk of osteoporosis remains unclear. We aimed to assess the hypothesis that dietary TAC is positively associated with bone mass and negatively related to the risk of osteoporosis in Korean women. This cross-sectional study was performed using data from the Korea National Health and Nutrition Examination Survey. Dietary TAC was estimated using task automation and an algorithm with 24-h recall data. In total, 8230 pre-and postmenopausal women were divided into four groups according …
Early Satellite Cell Communication Creates A Permissive Environment For Long-Term Muscle Growth,
2021
University of Kentucky
Early Satellite Cell Communication Creates A Permissive Environment For Long-Term Muscle Growth, Kevin A. Murach, Bailey D. Peck, Robert A. Policastro, Ivan J. Vechetti Jr., Douglas W. Van Pelt, Cory M. Dungan, Lance T. Denes, Xu Fu, Camille R. Brightwell, Gabriel E. Zentner, Esther E. Dupont-Versteegden, Christopher I. Richards, Jeramiah J. Smith, Christopher S. Fry, John J. Mccarthy, Charlotte A. Peterson
Center for Muscle Biology Faculty Publications
Using in vivo muscle stem cell (satellite cell)-specific extracellular vesicle (EV) tracking, satellite cell depletion, in vitro cell culture, and single-cell RNA sequencing, we show satellite cells communicate with other cells in skeletal muscle during mechanical overload. Early satellite cell EV communication primes the muscle milieu for proper long-term extracellular matrix (ECM) deposition and is sufficient to support sustained hypertrophy in adult mice, even in the absence of fusion to muscle fibers. Satellite cells modulate chemokine gene expression across cell types within the first few days of loading, and EV delivery of miR-206 to fibrogenic cells represses Wisp1 expression required …
Synthesis Of Novel Temozolomide-Fatty Acid Imide Hybrid Compounds For The Chemotherapeutic Treatment Of Glioblastoma Multiforme,
2021
Andrews University
Synthesis Of Novel Temozolomide-Fatty Acid Imide Hybrid Compounds For The Chemotherapeutic Treatment Of Glioblastoma Multiforme, Janice Pakkianathan
Honors Scholars & Undergraduate Research Poster Symposium Programs
Glioblastoma multiforme (GBM) is an aggressive form of brain cancer that originates from glial cells, which make up the supportive tissue surrounding neurons. Temozolomide (TMZ) is the current chemotherapeutic drug administered to treat GBM as it works to inhibit the growth of the cancer cells. This research study focuses on developing a method for synthesizing novel hybrid compounds that combines TMZ with various fatty acids known to have anticancer properties, forming a series of imide compounds with potential chemotherapeutic effects. Once the novel hybrid compounds are successfully synthesized, they will be tested for their anticancer properties on glioblastoma cells.
Modulation Of Apoptosis In Breast Cancer Cells Mda-Mb-157, 93a And 93b By Aqueous Extract Of Chinese Medical Herb Scutel,
2021
Andrews University
Modulation Of Apoptosis In Breast Cancer Cells Mda-Mb-157, 93a And 93b By Aqueous Extract Of Chinese Medical Herb Scutel, Nathaly Manrique
Honors Scholars & Undergraduate Research Poster Symposium Programs
Scutellaria barbata (SB), a Chinese medical herb, has been known to contain anti-cancer properties. In this study, the effectiveness of SB in apoptotic modulation of APC-mutant breast cancer cell lines MDA-MB-157, 93A, and 93B were investigated. Assessments were performed using the green/red/blue fluorescent Apoptosis/Necrosis Detection Kit and the Human Apoptosis Antibody Array -Membrane (43 Targets) test by
the Abcam cooperation. Our data demonstrated that 1-hour and 3-hour incubation treatments with aqueous extract of SB induced apoptosis in all cell lines. Additionally, modulation of pro-apoptotic markers (Bad,
Bax, BID, BIM, C3, C8, p53, p27), and anti-apoptotic markers (BcL-2, Bcl-w, p21) were …
The Influence Of Autism Linked Gene Topoisomerase 3b (Top3b) On Neural Development In Zebrafish,
2021
Georgia Southern University
The Influence Of Autism Linked Gene Topoisomerase 3b (Top3b) On Neural Development In Zebrafish, Sydney Doolittle
Honors College Theses
Autism Spectrum Disorder is a class of developmental disabilities characterized by a spectrum of social, communication, and behavioral impairments in affected individuals. Studies have shown these defects stem from abnormal brain development during critical periods during early development. The underlying genetic cause of these impairments is not well understood but is believed to be a combination of a complex pairing of genetic and environmental factors. One of the genetic factors that has been recognized to influence the phenotypic symptoms of ASD is the enzyme topoisomerase 3β (top3β.) Topoisomerases are responsible for the prevention of supercoiling during DNA replication. Top3β is …
Examining The Mechanistic Roles Of Integrin Alpha-6 In Cancer Metastasis.,
2021
Georgia Southern University
Examining The Mechanistic Roles Of Integrin Alpha-6 In Cancer Metastasis., Chase T. Clark
Honors College Theses
Metastasis- the spread of cancer cells from the primary tumor to the surrounding tissues- is responsible for 90% of cancer deaths. Integrin alpha-6 (ITGA6) is a specific transmembrane cell surface protein that functions in cell surface adhesion and signaling. ITGA6 is upregulated in many types of cancers and promotes the migration and invasion of cancer cells to surrounding tissues. It is my objective to determine the mechanism through which ITGA6 facilitates the migration of cancer cells through the extracellular matrix (ECM). These experiments helped to establish the role of ITGA6 in tumor development and provide focus for possible chemotherapeutic treatment. …
Molecular Dynamics Simulations Of Darpins As Potential Inhibitors Against Cancer Associated Protein Kinases,
2021
Universiti Malaya
Molecular Dynamics Simulations Of Darpins As Potential Inhibitors Against Cancer Associated Protein Kinases, Vertika Gautam
Student Works (2020-2029)
Out of all post-translational modifications, Protein phosphorylation is the most common in signal transduction, that occurs through protein kinases. Extracellular Regulated Kinase 2 (ERK2) is a type of protein kinase that undergoes phosphorylation to control various pathological and physiological phenomena. The deregulation of ERK2 often implicated in several types of cancers, for example, pancreatic, lung and breast. The current therapeutic treatment for this type of cancers involves blocking cellular proliferation signals by targeting kinases. However, the drugs developed resistance after prolonged use. Thus, the discovery of alternative ERK2 inhibitors is in need. In the present work, the potential of a …
Establishing And Validating Methods To Assess The Influence Of Exercise On Circulating Exosome Profiles In Sedentary Older Adults,
2021
Louisiana State University and Agricultural and Mechanical College
Establishing And Validating Methods To Assess The Influence Of Exercise On Circulating Exosome Profiles In Sedentary Older Adults, Heather Quiriarte
LSU Master's Theses
Aging is associated with progressing cellular structural and functional changes, and sedentary behavior can exacerbate these hallmarks of aging. Routine exercise is known to have beneficial effects on physiological systems, but the exact molecular mechanisms behind the health benefits are unclear. Emerging evidence suggests extracellular vesicles called exosomes are involved in the intercommunication between cells and organs following exercise by delivering their cargo such as proteins and miRNAs. miRNA profiles in older adults following acute and chronic exercise need further exploration. Specifically, the effects of regular low-intensity physical activity (LPA) breaks in sedentary time on proteins and miRNA packaged in …
From Cell Death To Regeneration: Rebuilding After Injury,
2021
University of Nevada, Las Vegas
From Cell Death To Regeneration: Rebuilding After Injury, Kelly Tseng, Dylan Guerin, Cindy Kha
Life Sciences Faculty Research
The ability to regrow lost or damaged tissues is widespread, but highly variable among animals. Understanding this variation remains a challenge in regeneration biology. Numerous studies from Hydra to mouse have shown that apoptosis acts as a potent and necessary mechanism in regeneration. Much is known about the involvement of apoptosis during normal development in regulating the number and type of cells in the body. In the context of regeneration, apoptosis also regulates cell number and proliferation in tissue remodeling. Apoptosis acts both early in the process to stimulate regeneration and later to regulate regenerative patterning. Multiple studies indicate that …
Combining Multicolor Fish With Fluorescence Lifetime Imaging For Chromosomal Identification And Chromosomal Sub Structure Investigation,
2021
University College London, London, United Kingdom
Combining Multicolor Fish With Fluorescence Lifetime Imaging For Chromosomal Identification And Chromosomal Sub Structure Investigation, Archana Bhartiya, Ian Robinson, Mohammed Yousuf, Stanley W. Botchway
Centre for Regenerative Medicine & Stem Cell Research
Understanding the structure of chromatin in chromosomes during normal and diseased state of cells is still one of the key challenges in structural biology. Using DAPI staining alone together with Fluorescence lifetime imaging (FLIM), the environment of chromatin in chromosomes can be explored. Fluorescence lifetime can be used to probe the environment of a fluorophore such as energy transfer, pH and viscosity. Multicolor FISH (M-FISH) is a technique that allows individual chromosome identification, classification as well as assessment of the entire genome. Here we describe a combined approach using DAPI as a DNA environment sensor together with FLIM and M-FISH …
Maldi-Tof Ms Biomarker Detection
Models To Distinguish Rtx Toxin
Phenotypes Of Moraxella Bovoculi
Strains Are Enhanced Using Calcium
Chloride Supplemented Agar,
2021
University of Nebraska - Lincoln
Maldi-Tof Ms Biomarker Detection Models To Distinguish Rtx Toxin Phenotypes Of Moraxella Bovoculi Strains Are Enhanced Using Calcium Chloride Supplemented Agar, Matthew M. Hille, Michael L. Clawson, Aaron M. Dickey, Justin H. Lowery, John Dustin Loy
School of Veterinary and Biomedical Sciences: Faculty Publications
Moraxella bovoculi is the bacterium most often cultured from ocular lesions of cattle with infectious bovine keratoconjunctivitis, also known as bovine pinkeye. Some strains of M. bovoculi contain operons encoding for a repeats-in-toxin (RTX) toxin, which is a known virulence factor of multiple veterinary pathogens. We explored the utility of MALDI-TOF MS and biomarker detection models to classify the presence or absence of an RTX phenotype in M. bovoculi. Ninety strains that had undergone whole genome sequencing were classified by the presence or absence of complete RTX operons and confirmed with a visual assessment of hemolysis on blood agar. Strains …
Reducing Seed Coat Fiber Content And Pod Shatter, And Engineering Medium Chain Fatty Acids-Containing Oil, In The Oilseed Crop Pennycress ( Thlaspi Arvense L. ),
2021
Illinois State University
Reducing Seed Coat Fiber Content And Pod Shatter, And Engineering Medium Chain Fatty Acids-Containing Oil, In The Oilseed Crop Pennycress ( Thlaspi Arvense L. ), Maliheh Esfahanian
Theses and Dissertations
The overall goal of this thesis was to genetically improve agronomic traits of pennycress (Thlaspi arvense L.; Field Pennycress) and demonstrate the production of value-added designer seed oils to domesticate pennycress and enable its establishment as a new winter annual oilseed/meal/cover crop to be grown in temperate regions of the world. In the U.S. Midwest, pennycress can be double cropped on existing farmland during the time between corn harvest and subsequent planting of soybeans the following spring. Pennycress has the potential to produce 2,000 lbs/acre seeds, which at 33% by weight oil content and 20% protein, would yield 85 gallons/acre …
An Improved Clipped Sub-Histogram Equalization Technique Using Optimized Local Contrast Factor For Mammogram Image Analysis,
2021
Universiti Malaya
An Improved Clipped Sub-Histogram Equalization Technique Using Optimized Local Contrast Factor For Mammogram Image Analysis, Nurshafira Hazim Chan
Student Works (2020-2029)
Mammography has been known worldwide as the most common imaging modalities utilized for early detection of breast cancer. The mammographic images produced are in greyscale, however they often produced poor contrast images, non-uniform illumination, and the image often contain artefacts and noise. These limitations can be overcame during the pre-processing stage by improving the image enhancement process. Therefore, in this research an optimized enhancement framework is developed where the local contrast factor is manipulated to preserve details of the image. This technique aims to improve the overall image visibility without altering histogram of the original image, which will affect the …
Tea Polyphenol Epigallocatechin-3-Gallate Inhibits Cell Proliferation In A Patient-Derived Triple-Negative Breast Cancer Xenograft Mouse Model Via Inhibition Of Proline-Dehydrogenase-Induced Effects,
2021
The Ph.D. Program for Neural Regenerative Medicine, TMU
Tea Polyphenol Epigallocatechin-3-Gallate Inhibits Cell Proliferation In A Patient-Derived Triple-Negative Breast Cancer Xenograft Mouse Model Via Inhibition Of Proline-Dehydrogenase-Induced Effects, Wen-Jui Lee, Tzu-Chun Cheng, Yun Yen, Chia-Lang Fang, You-Cheng Liao, Ching-Chuan Kuo, Shih-Hsin Tu, Li-Cheng Lin, Hui-Wen Chang, Li-Ching Chen, Yuan-Soon Ho
Journal of Food and Drug Analysis
Triple-negative breast cancers (TNBCs) lack specific targeted therapy options and have evolved into highly chemo-resistant tumors that metastasize to multiple organs. The present study demonstrated that the proline dehydrogenase (PRODH) mRNA level in paired (tumor vs. normal) human breast tissue samples (n=234) was 6.6-fold greater than normal cells (*p=0.021). We established stable PRODH-overexpressing TNBC (HS578T) cells, and the malignant phenotypes were evaluated using soft agar colony formation and Transwell migration assays. The results demonstrated that PRODH induced epithelial-mesenchymal transition in cancer cells and increased cell proliferation. The present study found that the tea polyphenol epigallocatechin-3-gallate (EGCG) significantly inhibited …
Expression And Function Of Transcription Factors Foxa1, Hoxb13 And Cdx2 In Prostate Cancer,
2021
Portland State University
Expression And Function Of Transcription Factors Foxa1, Hoxb13 And Cdx2 In Prostate Cancer, Hamsat B. Anwar
University Honors Theses
Prostate cancer (PC) is the second leading cause of death in men, affecting around 190 thousand patients in 2020 alone (National Institute of Cancer, 2020). Much of the current research focuses on treatments for advanced PC, which is problematic due to the rapid evolution of tumors and development of treatment resistance. Cancer early detection presents a better approach to control and treat patients before they acquire an incurable disease. Earlier diagnosis of patients leads to better prognosis and a more comfortable treatment process (Etzioni et al., 2003). However, we currently lack molecular markers to stratify PC during its early stages. …
