Design of Experiments and Sample Surveys Commons^™

Peer Nutrition Education: A Model For Nutrition Education Among Spanish-Language Participants Of The Special Supplemental Nutrition Program For Women, Infants And Children (Wic), Maximino Alfredo Mejía

Loma Linda University Electronic Theses, Dissertations & Projects

Despite the steady improvement in the health status of Americans, Hispanics are a minority in the United States with greater prevalence of several infectious and chronic diseases and less health knowledge than the average citizen. Nearly half of the Hispanics living in this country die of preventable nutrition-related conditions, with heart disease and cancer being the leading causes. Since this minority has limited access to health care and preventive services, there is a need for an inexpensive, viable model of health education for this underserved segment of the population in order to lower the excess of preventable diseases. We trained …

Anatomy And Three-Dimensional Reconstructions Of The Brain Of A Bottlenose Dolphin (Tursiops Truncatus) From Magnetic Resonance Images, Lori Marino, Keith D. Sudheimer, Timothy L. Murphy, Kristina K. Davis, D. Ann Pabst, William A. Mclellan, James K. Rilling, John I. Johnson

Veterinary Science and Medicine Collection

Cetacean (dolphin, whale, and porpoise) brains are among the least studied mammalian brains because of the formidability of collecting and histologically preparing such relatively rare and large specimens. Magnetic resonance imaging offers a means of observing the internal structure of the brain when traditional histological procedures are not practical. Furthermore, internal structures can be analyzed in their precise anatomic positions, which is difficult to accomplish after the spatial distortions often accompanying histological processing. In this study, images of the brain of an adult bottlenose dolphin, Tursiops truncatus, were scanned in the coronal plane at 148 antero-posterior levels. From these scans …

Empirical Spectral Analysis Of Random Number Generators, David Zeitler

Dissertations

Computer simulation procedures have become a staple of research and development in many fields, including statistics. The generation of pseudo random number sequences is the core of computer simulation procedures. Validity of research results often depend on the underlying validity of the generator being used.

In this work we develop the machinery for a class of tests of spatial uniformity based on a multi-dimensional Fourier transform of the empirical probability density function. The test can be adapted to specific requirements and has the added advantage that it has computational complexity that is relatively independent of the number of data points …

The Differential Impact Of Sexism In Latino Men And Women’S Psychiatric Symptoms, Astrid Magalij Reina-Patton

Loma Linda University Electronic Theses, Dissertations & Projects

The study assessed the reliability of the Spanish and English versions of the Schedule of Sexist Events General Form (SSE-G). The extent to which Spanish and English-speaking men and women differed in their responses on the SSE-G was investigated, as was the degree to which men and women differed in their report of psychiatric symptoms. Further, the extent to which the SSE-G predicted psychiatric symptomology for Spanish and English-speaking men and women was assessed, as was the extent to which sexism (i.e., gender-specific stress) accounted for additional variance in symptoms, above and beyond that accounted for by acculturation, language, and …

Magnetic Resonance Imaging And Three-Dimensional Reconstructions Of The Brain Of A Fetal Common Dolphin, Delphinus Delphis, Lori Marino, Timothy L. Murphy, Lyad Gozal, John I. Johnson

Veterinary Science and Medicine Collection

To demonstrate the kinds of data that can be obtained non-destructively and non-invasively from preserved museum specimens using modern imaging technology the head region of a whole body fetal specimen of the common dolphin, Delphinus delphis, aged 8–9 months post-conception, was scanned using Magnetic Resonance Imaging (MRI). Series of scans were obtained in coronal, sagittal and horizontal planes. A digital three-dimensional reconstruction of the whole brain was prepared from the coronal series of scans. Sectional areas and three-dimensional volumes were obtained of the cerebral hemispheres and of the brainstemplus-cerebellum. Neuroanatomical features identified in the scans include the major sulci of …

A Comparison Of Methods For Detection Of Qualitative Interaction In Multicenter Trials, Boyd Jay Hanson

Dissertations

This research evaluated and compared three methods for the detection of qualitative treatment-by-center interaction proposed by Azzalini and Cox, Gail and Simon and Ciminera et al., through the analysis of simulated data for multicenter studies of two and three centers with two treatments. The effect of unequal sample size and the presence of an overall treatment effect on characteristics of the methods were examined.

The approach, underlying assumptions and theory of the three methods differ. For this study, they were adapted to establish a common basis for evaluation, thus allowing a meaningful comparison of the methods. For the test presented …

Hand Intensive Leisure Activities And Repetitive Motion Injuries Of The Distal Upper Extremities, Marilyn Colvin Wright

Loma Linda University Electronic Theses, Dissertations & Projects

Background. The work-relatedness of repetitive motion injuries to the distal upper extremities (RMI-DUEs) has been well documented; however, human occupation extends beyond the job to include self-care and leisure activities. The effects of hand intensive leisure activities (HILAs) such as home computer use and needlework on RMI-DUEs have not been explored. These HILAs require hand usage similar to known work-related risk factors. Additionally, sedentary leisure contributes to obesity thereby increasing the disease burden of women. Health beliefs regarding leisure and fitness among women employed in hand intensive sedentary jobs have not been explored.

Purpose. The purpose of this study was …

Comparative Analysis Of Traditional Versus Computer-Based Survey Instrument Response, Albert E. Franke Iv

Theses and Dissertations

The purpose of this study was to determine if survey medium (paper versus computer) affected responses and response rates in Air Force personnel. The study compared responses and response rates from 900 randomly selected Air Force active-duty members using a paper-based survey, a computer-based survey, and a more complex computer-based survey. The first computer-based survey minimized the differences between itself and the paper-based survey to more accurately quantify any bias due solely to the computer medium. The more complex survey served to maximize differences between itself and the other computer-based survey to more accurately quantify any bias due to programmatic …

Online Survey System (Oss), Hui Min Tan

Student Works (2000-2009)

Online survey system (OSS) is an electronic survey system and productivity tool. The system enables the user to conduct a survey at case which was previously paper-based and which can be tedious and time-consuming. It can be used or administered from anywhere an internet browser is available. The users can create and design their own interactive online survey. OSS provides a fast distribution of survey from to a large geographical area through email. The respondents just need to click on the URL attach with the invitation email to direct them to the survey. After that OSS will generates analysis report …

Computer-Based Methods For Constructing Two-Level Fractional-Factorial Experimental Designs With A Requirement Set, Steven L. Forsythe

Theses and Dissertations

This dissertation developed four methodologies for computer-aided experimental design of two-level fractional factorial designs with requirement sets (DOE/RS). The requirement sets identify all the experimental factors and the appropriate interaction terms to be evaluated in the experiment. Taguchi graphs and similar manual methods provide techniques for solving the DOE/RS problem. Unfortunately, these methods are limited because they become difficult to use as the number of factors or interaction terms exceeds ten. This research showed that the DOE/RS problem belongs to a class of difficult-to-solve problems known as NP-Complete. It is the combinatorial nature of NP-Complete problems that causes them to …

Taking Animal Welfare Seriously: Minimizing Pain And Distress In Research Animals, The Humane Society Of The United States

ANIMAL RESEARCH

Pain and distress caused by specific research models and techniques raise serious concerns for those in the animal welfare community as well as in the scientific community. Yet good estimates of how much animal pain and/or animal distress is caused by particular techniques or methods are not yet available. The HSUS has compiled a preliminary list of research models and techniques that cause pain and distress. Analyses by the USDA and HSUS indicate that the majority of the animals reported in Column E are used in various testing procedures, with vaccine testing prominent among them. More data are needed to …

Evaluation Of Animal Model Research, Kenneth J. Shapiro

Experimentation Collection

It is argued that a concept of evaluation of animal models that is broader and more useful than validation is available. Productive generativity refers to the degree to which a model furthers understanding and leads to more-effective treatment interventions. Results of the application of this novel evaluative frame to several animal models of eating disorders show that this animal-based research has not been productive. The question of the relation between clinic and animal laboratory is discussed.

Predicting Milk And Soft Drink Consumption Among Female Adolescents Using The Theory Of Planned Behavior, Nada Osman Kassem

Loma Linda University Electronic Theses, Dissertations & Projects

A total of 756 female adolescents, aged 13 to 18 years, from five public high schools in Antelope Valley Union High School District located in North Los Angeles County participated in this study between February 1999 and March 1999. The ethnic composition was 53.3% White/Anglo Americans, 19.3% Hispanics or Latinos and 10.2% Black/African Americans. The constructs of the Theory of Planned Behavior (attitude, subjective norm, and perceived behavioral control and their underlying beliefs) were assessed to determine the predictors of low-fat milk and regular soda consumption. A cross-sectional design with group-administered questionnaires was utilized.

Most participants (89.6%, n = 636) …

Efficient Simulation Via Validation And Application Of An External Analytical Model, Thomas H. Irish

Theses and Dissertations

This research makes significant contributions towards improving the efficiency of simulation studies using an external analytical model. The foundation for this research is the analytical control variate (ACV) method. The ACV method can produce significant variance reduction, but the resulting point estimate may exhibit bias. A Monte Carlo sampling method for resolving the bias problem is developed and demonstrated through a queueing network example. The method requires knowledge of the parameters and approximate distributions of the random variables used to produce the ACV. Often, some of these parameters or distributions are not known. Both parametric and non-parametric alternatives to the …

Assessing The Accuracy Of A New Diagnostic Test When A Gold Standard Does Not Exist, Todd A. Alonzo, Margaret S. Pepe

UW Biostatistics Working Paper Series

Often the accuracy of a new diagnostic test must be assessed when a perfect gold standard does not exist. Use of an imperfect test biases the accuracy estimates of the new test. This paper reviews existing approaches to this problem including discrepant resolution and latent class analysis. Deficiencies with these approaches are identified. A new approach is proposed that combines the results of several imperfect reference tests to define a better reference standard. We call this the composite reference standard (CRS). Using the CRS, accuracy can be assessed using multistage sampling designs. Maximum likelihood estimates of accuracy and expressions for …

A Messy, But Instructive, Case Study In Design Of Experiments, Leroy A. Franklin, Belva J. Cooley, Gary Elrod

Mathematical Sciences Technical Reports (MSTR)

A company manufacturing fans wished to conduct an experimental design to determine the best combination of three factors affecting the breaking torque of the fans. Analysis of the data ceased to be straightforward when the authors found that the data failed the test for homogeneity of variances. After unsuccessfully attempting to transform the data and thereby meet the assumptions necessary to carry on the analysis, the authors relied upon a graphical analysis and a careful study of the means for each design point. This paper describes a statistically sound but novel strategy used to complete the analysis.

Unrelieved Pain And Distress In Animals: An Analysis Of Usda Data On Experimental Procedures, Martin Stephens, Philip Mendoza, Adrianna Weaver, Tamara Hamilton

Experimentation Collection

Pain and distress are core issues in the field of animal experimentation and in the controversy that surrounds it. We sought to add to the empirical base of the literature on pain and distress by examining government data on experimental procedures that caused unrelieved pain and distress (UPAD) in animals. Of the species regulated by the U.S. Department of Agriculture (USDA), most of the approximately 100,000 animals subjected to UP AD during the year analyzed (1992) were guinea pigs and hamsters. Most of these animals were used in industry laboratories for various testing procedures, primarily vaccine potency testing. We discuss …

Risk Regulation And The Faces Of Uncertainty, Vern R. Walker

RISK: Health, Safety & Environment (1990-2002)

Dr. Walker addresses the difficulty of regulators' working with potentially inaccurate information and clarifies related aspects of decision making by presenting a taxonomy for the kinds of uncertainty inherent in necessarily incomplete data.

Book Review Of Deborah G. Mayo, Error And The Growth Of Experimental Knowledge (University Of Chicago Press 1996), Kristin S. Shrader-Frechette

RISK: Health, Safety & Environment (1990-2002)

Review of the book: Deborah G. Mayo, Error and the Growth of Experimental Knowledge (University of Chicago Press 1996). Figures, index, preface, references. ISBN 0-226-51197-9 [493 pp. $74.00 Cloth; $29.95 Paper. 5801 S. Ellis Ave., Chicago, IL 60637.]

A Cephalometric Study Of The Class Ii Correction Effects Of The Eureka Spring, Ernest L. Stromeyer

Loma Linda University Electronic Theses, Dissertations & Projects

The effect of the Eureka Spring appliance, was investigated on 37 consecutively treated, non compliant, bilateral Class II malocclusions, requiring at least 3 mm or more of additional molar correction. The mean pretreatment age of this sample was 13.9 years. All patients were treated by a single clinician utilizing the Eureka Spring. Lateral cephalographs were taken at start of orthodontic treatment (T1), at insertion of Eureka Springs (T2), and at removal of the Eureka Springs (T3). The average treatment interval between T2 and T3 was 4 months. Class II correction occurred almost entirely by dentoalveolar movement, 33% in the maxilla …

Preference And Motivation Testing, David Fraser, Lindsay R. Matthews

Validation of Animal Experimentation Collection

Since the early 1970s, scientists have used preference tests (tests that require animals to choose between two or more different options or environments) as a means of answering questions about animal welfare. Preference tests have been used to establish animals' preferences for common housing options such as ambient temperature, illumination and preferred types of bedding and flooring; to improve the effectiveness of devices such as loading ramps and nest boxes; and to clarify how strongly animals avoid various aspects of confinement and methods of restraint.

To use preference research to answer questions about animal welfare, three issues need to be …

Institutional Animal Care And Use Committees: A Flawed Paradigm Or Work In Progress?, John P. Gluck, F. Barbara Orlans

Animal Welfare Collection

In his challenging article, Steneck (1997) criticized the creation of the Institutional Animal Care and Use Committee (IACUC) system established by the 1985 amendments to the Animal Welfare Act. He saw the IACUC review and approval of biomedical and behavioral research with animals as an unnecessary "reassignment" of duties from existing animal care programs to IACUC committees. He argued that the committees are unable to do the work expected of them for basically three reasons: (a) the membership lacks the expertise in matters relevant to animal research and care, (b) there exists an inherent and disabling conflict of interest, and …

Effect Of Room Arrangement And Blood Sample Collection Sequence On Serum Thyroid Hormone And Cortisol Concentrations In Cynomolgus Macaques (Macacafascicularis), Bryan L. Flow, John T. Jaques

Research Methodology and Laboratory Animals Collection

We evaluated the relationship, in cynomolgus macaques (Macacafascicularis), between rank for order of blood collection with serum concentrations of 3,5,3'-triiodothyronine (T3), thyroxine (T4), free thyroxine (FT4), and serum cortisol. These relationships were determined for males and females that were housed in two room arrangements. For both room arrangements, males and females were housed separately. For room arrangement 1, macaques were housed on both sides of the animal holding room. The sides of the animal holding room were designated as side A or side B. Blood was initially collected from animals on side A, then from animals on side B. Animals …

Methodological And Substantive Issues In Substance Abuse Prevention Research, C. Anderson Johnson, John W. Farquhar, Steve Sussman

CGU Faculty Publications and Research

This article summarizes current issues in drug abuse prevention research through integration of other articles in this journal and by heeding historical trends in prevention science. Recommendations are made for future research directions. For prevention to advance, iterative processes are needed involving both quasi-experimental and experimental designs and involving both small, simple units and large, complex, interactive units. Accuracy of measurement and replication are of paramount importance.

Sources Of Epidemiological Equivocacy, Timothy Sly

RISK: Health, Safety & Environment (1990-2002)

Mr. Sly discusses five sources of uncertainty and ambiguity in health and medical research that can interfere with decision making.

A Study Of Cumulative Trauma Disorders Of The Upper Extremities And Occupation In Wright-Patterson Adir Force Base Civilian Personnel, Scott T. Hillstead

Theses and Dissertations

This study utilized a case-control methodology to describe and analyze the 115 cases of occupational illnesses reported by civilian employees of Wright-Patterson Air Force Base (AFB) between 1990 and 1995. Determining if a statistically significant association existed between age and duration of employment risk factors and cumulative trauma disorders (CTDs) was a primary objective. The frequency of CTDs among the various organizations at Wright-Patterson AFB are also described. The research could not prove the existence of a significant association for the 44 subjects and 176 controls matched on occupational group. However, the demographic and other descriptive results may form a …

A Preliminary Analysis Of The Theoretical Parameters Of Organizational Learning, Jeffery D. Loyd

Theses and Dissertations

The goal of this research was to develop an instrument capable of measuring the theoretical parameters of organizational learning that could be used as a diagnostic tool to measure an organization's learning potential. This goal was accomplished by developing a pilot questionnaire based on 27 potential learning parameters. The potential parameters of learning were extracted from the literature. A scale of behavioral statements was developed for each potential parameter. The pilot questionnaire was completed by 108 Air Force personnel in Air Force Institute of Technology (AFIT) graduate education programs. The results confirmed 85% of the original scales. Ten refined scales …

Examination Of Knowledge And Attitudes About Human Sexuality As Predictors Of Adolescent Sexual Behavior, Diane Waymire

Loma Linda University Electronic Theses, Dissertations & Projects

This study investigated the variables influencing adolescent sexual behavior. Using cognitive learning theory, social learning theory, and social development as an organizing framework, factors influencing adolescent sexual behavior and the respondent's personal demographics were examined for their contribution to explaining adolescent decision-making about sexual activity.

A convenience sample of high school students from a Riverside county school district provided data for the study. Data was gathered by using a self-administered questionnaire. A total of 55 students from two of the three school sites within the district participated in the study during the winter quarter of 1995.

The findings of the …

Space Closure Efficiency With Modified Ceramic Brackets : A Comparative Study, Kirk A. Specht

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to determine if the rate of extraction site closure was determined by the type of ceramic bracket used. A new ceramic bracket with a metal archwire slot was compared with a conventional ceramic bracket. Twenty patients were randomly assigned the metal slot ceramic bracket and conventional ceramic to one half of their maxillary arch respectively. The distribution was even left and right.

Retraction was started and completed on an 0.016" stainless steel round continuous archwire. One hundred gram sentalloy springs provided a uniform retraction force and were reactivated every four weeks to maintain a …

Measurement Of Blood Flow In Reflected Muco-Gingival Tissue Flaps In Cats : Using The Radiolabeled Microsphere Method, Gary T. Wuchenrich

Loma Linda University Electronic Theses, Dissertations & Projects

Blood flow to the maxilla and mandible may vary due to differences in vascular supply and in physiologic, metabolic and pathologic conditions. In general it is accepted that oral tissues have an abundant blood supply; however, there is little information quantifying blood flow to these regions. In this study, the maxillary tissues were chosen to measure the blood flow in attached and reflected gingival tissue in adult cats using the radiolabeled microsphere method.

Sixteen cats with permanent dentition, clean mouths, and without inflamed gingiva upon visual inspection were used and divided into two groups. Group 1 consisted of six cats …