Design of Experiments and Sample Surveys Commons^™

Initiation And Continuation Of Randomized Trials After The Publication Of A Trial Stopped Early For Benefit Asking The Same Study Question: Stopit-3 Study Design, Gabriela J. Prutsky, Juan Domecq, Patricia J. Erwin, Matthias Briel, Victor M. Montori, Elie A. Akl, Joerg J. Meerpohl, Dirk Bassler, Stefan Schandelmaier, Stephen D. Walter, Qi Zhou, Pablo Coello, Lorenzo Moja, Martin Walter, Kristian Thorlund, Paul Glasziou, Regina Kunz, Ignacio Ferreira-Gonzalez, Jason Busse, Xin Sun, Annette Kristiansen, Benjamin Kasenda, Osama Qasim-Agha, Gennaro Pagano, Hector Pardo-Hernandez, Gerard Urrutia, Mohammad Murad, Gordon Guyatt

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Randomized control trials (RCTs) stopped early for benefit (truncated RCTs) are increasingly common and, on average, overestimate the relative magnitude of benefit by approximately 30%. Investigators stop trials early when they consider it is no longer ethical to enroll patients in a control group. The goal of this systematic review is to determine how investigators of ongoing or planned RCTs respond to the publication of a truncated RCT addressing a similar question.

Methods/design

We will conduct systematic reviews to update the searches of 210 truncated RCTs to identify similar trials ongoing at the time of publication, or started …

Planned Missingness Study Design: Two Methods To Developing The Study Survey Versions, E. Whitney G. Moore

Kinesiology, Health and Sport Studies

A planned missingness data study design takes advantage of modern techniques for handling data missingness that is MCAR (Missing Completely at Random) and MAR (Missing at Random) (Brown, 2006; Enders, 2010). As modern data imputation techniques have improved, this study design option has become a powerful, cost-effective option for collecting the most data across the largest sample possible, while keeping the fatigue effect and expense of the study minimized (Little, 2010a, 2010b, 2012). The purpose of this guide is to provide an applied example for designing the surveys necessary when conducting a planned missingness research study design.

Barriers Encountered During Enrollment In An Internet-Mediated Randomized Controlled Trial, Lorraine R. Buis, Adrienne W. Janney, Michael L. Hess, Silas A. Culver, Caroline R. Richardson

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Online technology is a promising resource for conducting clinical research. While the internet may improve a study's reach, as well as the efficiency of data collection, it may also introduce a number of challenges for participants and investigators. The objective of this research was to determine the challenges that potential participants faced during the enrollment phase of a randomized controlled intervention trial of Stepping Up to Health, an internet-mediated walking program that utilized a multi-step online enrollment process.

Methods

We conducted a quantitative content analysis of 623 help tickets logged in a participant management database during the enrollment …