Design of Experiments and Sample Surveys Commons^™

Systematic Reviews Of Animal Experiments Demonstrate Poor Human Clinical And Toxicological Utility, Andrew Knight

Experimentation Collection

The assumption that animal models are reasonably predictive of human outcomes provides the basis for their widespread use in toxicity testing and in biomedical research aimed at developing cures for human diseases. To investigate the validity of this assumption, the comprehensive Scopus biomedical bibliographic databases were searched for published systematic reviews of the human clinical or toxicological utility of animal experiments. In 20 reviews in which clinical utility was examined, the authors concluded that animal models were either significantly useful in contributing to the development of clinical interventions, or were substantially consistent with clinical outcomes, in only two cases, one …

A Study Of The Relationship Between American Evangelicals And Human Rights, Amy Rachel Timmons Stumpf

Loma Linda University Electronic Theses, Dissertations & Projects

Human rights violations and abuses affect every region of the globe. The most recent Amnesty International Annual Report details violations in 149 countries. While there are no simple solutions to a problem of this magnitude and complexity, the support of powerful social groups can help in providing relief to the victims, pressure on abusive governments, legal consequences for abusers, and other resources in combating the violence that seems to chronically plague over our world. One of the most powerful groups, with tremendous social capital, is American evangelicals. Evangelicalism, even given the loose and informal organizational structures, is one of the …

Detailed Version: Analyzing Direct Effects In Randomized Trials With Secondary Interventions: An Application To Hiv Prevention Trials, Michael A. Rosenblum, Nicholas P. Jewell, Mark J. Van Der Laan, Stephen Shiboski, Ariane Van Der Straten, Nancy Padian

U.C. Berkeley Division of Biostatistics Working Paper Series

This is the detailed technical report that accompanies the paper “Analyzing Direct Effects in Randomized Trials with Secondary Interventions: An Application to HIV Prevention Trials” (an unpublished, technical report version of which is available online at http://www.bepress.com/ucbbiostat/paper223).

The version here gives full details of the models for the time-dependent analysis, and presents further results in the data analysis section. The Methods for Improving Reproductive Health in Africa (MIRA) trial is a recently completed randomized trial that investigated the effect of diaphragm and lubricant gel use in reducing HIV infection among susceptible women. 5,045 women were randomly assigned to either the …

An Experimental Technique For The Evaluation Of Strain Dependent Material Properties Of Hard Coatings, Shad A. Reed, Anthony N. Palazotto, William P. Baker

Faculty Publications

A novel vibration experiment consisting of a free-free boundary condition, an electromagnetic excitation source, a vacuum chamber, and a laser vibrometer based surface measurement system has been developed that permits high levels of excitation on highly damped specimens with a minimal amount of unwanted systematic error. While some of the aspects of this experiment are not unique, when combined with a processing technique that accounts for the nonlinearities present in the system, this experiment permits, accurate measurement of strain dependent stiffness and damping properties of hard coatings at high strain levels. This procedure has been demonstrated using a titanium beam …

Analyzing Direct Effects In Randomized Trials With Secondary Interventions , Michael Rosenblum, Nicholas P. Jewell, Mark J. Van Der Laan, Stephen Shiboski, Ariane Van Der Straten, Nancy Padian

U.C. Berkeley Division of Biostatistics Working Paper Series

The Methods for Improving Reproductive Health in Africa (MIRA) trial is a recently completed randomized trial that investigated the effect of diaphragm and lubricant gel use in reducing HIV infection among susceptible women. 5,045 women were randomly assigned to either the active treatment arm or not. Additionally, all subjects in both arms received intensive condom counselling and provision, the "gold standard" HIV prevention barrier method. There was much lower reported condom use in the intervention arm than in the control arm, making it difficult to answer important public health questions based solely on the intention-to-treat analysis. We adapt an analysis …

Predictors Of Emotional Reactions In Women Treated For Breast Cancer, Erin E. Ramirez

Loma Linda University Electronic Theses, Dissertations & Projects

Breast cancer can be a devastating disease that impacts a woman in all spheres of her life (Ingram, 1989). Previous studies have examined the impact of breast cancer on body satisfaction, as well as the impact on emotional well-being. Studies have also examined the role of the coping style that a woman engages in response to the diagnosis and treatment of breast cancer in the woman's psychological adjustment to the disease. However, to date, no research has introduced and tested a multifaceted model.

The purpose of this study was to develop a model predicting psychological maladjustment in women treated for …

Salivary Characteristics In 3 And 4 Year-Old Children With And Without Visible Caries, Gloria Yañez

Loma Linda University Electronic Theses, Dissertations & Projects

PURPOSE: To compare salivary characteristics in 3 and 4 year-old Head Start children with and without visible caries.

METHODS: This case-control study was performed on 84 healthy 3 and 4 year-old Head Start children. After consent and inclusion criteria were met, each child was screened and assigned to one of two test groups based on their caries status. Group 1 consisted of children with no visible evidence of caries, although non-visible caries may have been present. Group II consisted of children with visible evidence demonstrating three or more carious lesions. Each child's unstimulated and stimulated whole saliva samples were collected …

Refinement Of An Instrument To Assess Readiness For Knowledge Management, Landon C. Bailey

Theses and Dissertations

Academics and practitioners have described knowledge as a primary source for competitive advantage for organizations; however, many attempts at instituting knowledge management programs to increase organizational competitiveness do not succeed. Instituting knowledge management programs generally requires organizations to make significant changes and the concept of readiness has long been believed to be an important precondition for successful organizational change. By linking previous research in enablers for knowledge management and organizational change, it is possible to adapt an established organizational change readiness instrument to measure readiness for knowledge management. This study culminates in the development and field-testing of the resultant knowledge …

Corporate Entrepreneurship Assessment Instrument (Ceai): Refinement And Validation Of A Survey Measure, Michael S. Cates

Theses and Dissertations

The study of corporate entrepreneurship has established itself as a valuable area of research for both public and private-sector organizations. The measurement instrument known as the Corporate Entrepreneurship Assessment Index (CEAI) has been designed to tap the climate-related organizational factors that represent and potentially encourage corporate entrepreneurship. This study is an attempt to refine the CEAI. The core constructs of the CEAI are redefined, the items are tested for content validity, the factor structure is analyzed, and the CEAI is correlated to other known measures to validate the CEAI. Through this testing, the CEAI was refined and found to be …

The Time Invariance Principle, Ecological (Non)Chaos, And A Fundamental Pitfall Of Discrete Modeling, Bo Deng

Department of Mathematics: Faculty Publications

This paper is to show that most discrete models used for population dynamics in ecology are inherently pathological that their predications cannot be independently verified by experiments because they violate a fundamental principle of physics. The result is used to tackle an on-going controversy regarding ecological chaos. Another implication of the result is that all continuous dynamical systems must be modeled by differential equations. As a result it suggests that researches based on discrete modeling must be closely scrutinized and the teaching of calculus and differential equations must be emphasized for students of biology.

A Meta-Analysis Of Questionaire Response Rates In Military Samples, Michael R. Parrish

Theses and Dissertations

The purpose of this research was to examine if factors related to questionnaire response rate in the general public also affect response rate in military-only samples. Very little research pertaining to this specific group was located during the literature review. Four response rate factors taken from studies conducted in the general public were selected for this research topic: questionnaire length, questionnaire delivery mode (postal, e-mail, web-based, direct administration, and mixed mode), use of advance notices, and use of follow-up reminders. Data were gathered for a meta-analysis of 73 previously published studies which utilized a survey or questionnaire to collect data …

Improved Hyperspectral Image Testing Using Synthetic Imagery And Factorial Designed Experiments, Joseph P. Bellucci

Theses and Dissertations

The goal of any remote sensing system is to gather data about the geography it is imaging. In order to gain knowledge of the earth's landscape, post-processing algorithms are developed to extract information from the collected data. The algorithms can be intended to classify the various ground covers in a scene, identify specific targets of interest, or detect anomalies in an image. After the design of an algorithm comes the difficult task of testing and evaluating its performance. Traditionally, algorithms are tested using sets of extensively ground truthed test images. However, the lack of well characterized test data sets and …

Comparison Of Treatment Effects Between Animal Experiments And Clinical Trials: Systematic Review, Pablo Perel, Ian Roberts, Emily Sena, Philipa Wheble, Catherine Briscoe, Peter Sandercock, Malcolm Macleod, Luciano E. Mignini, Pradeep Jayaram, Khalid S. Khan

Validation of Animal Experimentation Collection

Objective To examine concordance between treatment effects in animal experiments and clinical trials.

Study design Systematic review.

Data sources Medline, Embase, SIGLE, NTIS, Science Citation Index, CAB, BIOSIS.

Study selection Animal studies for interventions with unambiguous evidence of a treatment effect (benefit or harm) in clinical trials: head injury, antifibrinolytics in haemorrhage, thrombolysis in acute ischaemic stroke, tirilazad in acute ischaemic stroke, antenatal corticosteroids to prevent neonatal respiratory distress syndrome, and bisphosphonates to treat osteoporosis.

Review methods Data were extracted on study design, allocation concealment, number of randomised animals, type of model, intervention, and outcome.

Results Corticosteroids did not show …

The Poor Contribution Of Chimpanzee Experiments To Biomedical Progress, Andrew Knight

Experimentation Collection

Biomedical research on captive chimpanzees incurs substantial nonhuman animal welfare, ethical, and financial costs that advocates claim result in substantial advancements in biomedical knowledge. However, demonstrating minimal contribution toward the advancement of biomedical knowledge generally, subsequent papers did not cite 49.5% (47/95), of 95 experiments randomly selected from a population of 749 published worldwide between 1995 and 2004. Only 14.7% (14/95) were cited by 27 papers that abstracts indicated described well-developed methods for combating human diseases. However, detailed examination of these medical papers revealed that in vitro studies, human clinical and epidemiological studies, molecular assays and methods, and genomic studies …

Overcoming Ideology: Why It Is Necessary To Create A Culture In Which The Ethical Review Of Protocols Can Flourish, Bernard E. Rollin

Experimentation Collection

My objective in this commentary is to describe and discuss a major threat to the continued thriving of science in our society, which is all the more insidious because it is largely unrecognized by those in the scientific community who are in a position to rectify the problem. Astute people in that community are well aware of many threats to science that include but are not limited to the following: appalling public scientific illiteracy; the unfortunate resurgence of “magic thinking”—reflected in turn in the reappearance of Creationism, which is hostile to evolution—and the billions of dollars spent on evidentially baseless …

An Eye-Opening Approach To Developing And Communicating Integrated Environmental Assessments, Todd R. Lookingbill, William C. Dennison, Tim J.B. Carruthers, Jane M. Hawkey, Shawn L. Carter

Geography and the Environment Faculty Publications

Communication among managers, the public, and scientists is the key to successful ecosystem management; however, the varied perspectives and interests of these groups can make such communication difficult. One way to achieve effective communication is to develop a common knowledge base by combining syntheses of key scientific results with information-rich visual elements. Within a management landscape, integrated environmental assessments provide a useful framework for evaluating resources and directing management efforts. The integrated assessment process involves (1) initial investigation, (2) development of a conceptual framework, (3) data navigation, (4) environmental report cards, and (5) science communication. Each step requires the synthesis …

The Latino Caregiver Experience Among Dementia And Non-Dementia Caregivers : Can Community Based Care Management Improve Caregiver Health?, Catherine Oliveros

Loma Linda University Electronic Theses, Dissertations & Projects

Purpose: This study provides an analysis of the Latino caregiving community in Southeast Texas and the role community based care management plays in influencing caregiver physical and emotional well-being. Design and Methods: A non-random sample of 63 Latino caregivers was interviewed by phone. Caregiver physical and emotional well-being was studied through burden, depression, perceived health status, and resourcefulness. Regression, correlation, and comparison analysis was performed with key variables. Results: Acculturation was positively correlated with care management use. In comparing dementia and non-dementia caregivers both groups had similar levels of depression and burden, however, the dementia group had significantly lower levels …