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Articles 1051 - 1051 of 1051
Full-Text Articles in Pharmaceutics and Drug Design
Glucose Oxidase As A Pharmaceutical Antioxidant, Thomas F. Berg
Glucose Oxidase As A Pharmaceutical Antioxidant, Thomas F. Berg
MUSC Theses and Dissertations
Oxygen sensitive drugs in aqueous solutions are very susceptible to oxidative degradation. Antioxidants are frequently used to protect these drugs from oxidation. A 2-level resolution VI factorial was used to evaluate a glucose oxidase-catalase-glucose system and compare it to commonly used aqueous antioxidants. The drug models used to test the effectiveness of the enzyme system were ascorbic acid, morphine sulfate, and isoproterenol hydrochloride. The glucose oxidase system successfully protected the isoproterenol hydrochloride and was significantly better than the other systems tested. The glucose oxidase system was just as effective as the other antioxidants in protecting morphine sulfate. None of the …